• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Loa-0604
ROCK1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Rho-associated protein kinase
Gene Name: ROCK1
Ensembl Gene: ENSLAFG00000015369.3
Ensembl Protein: ENSLAFP00000023241.1
Organism: Loxodonta africana
Taxa ID: 9785
LLPS Type: Others


▼ PROPERTY


▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole body, Stress granule, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSSGDSFETR  FEKIDNLLRD  PKSEVNSDCL  LDGLDALVYD  LDFPALRKNK  NIDNFLSRYK  60
61    DTINKIRDLR  MKAEDYEVVK  VIGRGAFGEV  QLVRHKSSRK  VYAMKLLSKF  EMIKRSDSAF  120
121   FWEERDIMAF  ANSPWVVQLF  YAFQDDRYLY  MVMEYMPGGD  LVNLMSNYDV  PEKWARFYTA  180
181   EVVLALDAIH  SMGFIHRDVK  PDNMLLDKSG  HLKLADFGTC  MKMNKEGMVR  CDTAVGTPDY  240
241   ISPEVLKSQG  GDGYYGRECD  WWSVGVFLYE  MLVGDTPFYA  DSLVGTYSKI  MNHKNSLTFP  300
301   DDNDISKEAK  NLICAFLTDR  EVRLGRNGVE  EIKRHLFFKN  DQWAWETLRD  TVAPVVPDLS  360
361   SDIDTSNFDD  LEEDKGDEET  FPIPKAFVGN  QLPFVGFTYY  SNRRYLSSAN  PNDNRTSSNV  420
421   DKNLQESLQK  TIYKLEEQLH  NEMQLKDEME  QKCRTSNIKL  DKIMKELDEE  GSQRRNLEST  480
481   VSQMEKEKML  LQHRINEYQR  KAEQENEKRR  NVENEVSTLK  DQLEDLKKVS  QNSQLANEKL  540
541   AQLQKQLEEA  NDLLRTESDT  AARLRKSHTE  MSKSISQLES  LNIELQERNR  ILENSKTQTD  600
601   KDYYQLQAVL  DAERRDRGHD  SEMIGDLQAR  ITSSQEEVKH  LKHNLERLEG  ERKEAQDMLN  660
661   HSEKEKNNLE  IDLNYKLKSL  QQRLEQEVNE  HKVTKARLTD  KHQSIEEAKS  VAMCEMEKKL  720
721   KEEREAREKA  ENRVVQIEKQ  CSMLDVDLKQ  SQQKLEHLTE  NKERMEEEVK  NLTLQLEQES  780
781   NKRLLLQNEL  KTQAFEADNL  KGLEKQMKQE  INTLLEAKRL  LEFELAQLTK  QYRGNEGQMR  840
841   ELQDQLEAEQ  YFSTLYKTQV  KELKEEIQEK  NRENLKKIQE  LQNEKETLAT  QLDLAETKAE  900
901   SEQLARGLLE  EQYFELTQES  KKAASRNRQE  ITDKDHTVSR  LEEMNSMLTR  DIELLRKENE  960
961   ELTENMRKTE  EEYKLKKEEE  ISNLKAAFEK  NINTERTLKT  QAVNKLAEIM  NRKDFKIDRK  1020
1021  KANTQDLRKK  EKENRKLQLE  LNQEREKFNQ  MVVKHQKELN  DMQAQLVEEC  THKNELQMQL  1080
1081  ASKESDIEQL  RAKLLDLSDS  TSVASFPSAD  ETDGNLPESR  IEGWLSVPNR  GNIKRYGWKK  1140
1141  QYVVVSSKKI  LFYNDEQEKE  QSNPSMVLDI  DKLFHVRPVT  QGDVYRAETE  EIPKIFQILY  1200
1201  ANEGECRKEV  EMEPVQQAEK  TNFQNHKGHE  FIPTLYHFPA  NCEACAKPLW  HVFKPPPALE  1260
1261  CRRCHVKCHR  DHLDKKEDLI  SPCKVSYDVT  SARDMLLLAC  SQDEQKKWVT  HLVKKIPKNP  1320
1321  PSGFVRASPR  TLSTRSTANQ  SFRKVVKNTS  GKTR  1354
Nucleotide CDS Sequence (FASTA)
1     ATGTCGTCTG  GGGACAGTTT  TGAGACTCGG  TTTGAAAAAA  TCGACAACCT  GCTGCGGGAT  60
61    CCCAAATCGG  AAGTGAATTC  GGATTGTTTG  CTGGATGGAT  TGGATGCTTT  GGTATATGAT  120
121   TTGGATTTTC  CTGCATTAAG  AAAAAACAAA  AATATTGACA  ACTTTTTAAG  CAGATATAAA  180
181   GACACAATAA  ATAAAATTAG  AGATTTACGC  ATGAAAGCTG  AAGACTATGA  AGTAGTGAAG  240
241   GTGATTGGTA  GAGGTGCATT  TGGAGAAGTT  CAATTGGTAA  GACATAAATC  CAGCAGGAAG  300
301   GTATATGCTA  TGAAGCTTCT  TAGCAAATTT  GAGATGATCA  AGAGATCTGA  TTCAGCTTTT  360
361   TTCTGGGAAG  AAAGAGACAT  CATGGCTTTT  GCTAACAGCC  CTTGGGTTGT  TCAGCTTTTC  420
421   TATGCATTCC  AAGATGATCG  TTATCTCTAC  ATGGTGATGG  AATACATGCC  TGGTGGAGAT  480
481   CTTGTAAACT  TAATGAGCAA  CTATGATGTG  CCTGAAAAAT  GGGCGCGGTT  TTATACTGCA  540
541   GAAGTAGTTC  TTGCATTGGA  TGCAATCCAT  TCCATGGGTT  TTATTCATAG  AGATGTGAAG  600
601   CCTGATAATA  TGCTGCTGGA  TAAGTCTGGA  CATTTGAAGT  TAGCAGATTT  TGGTACTTGT  660
661   ATGAAGATGA  ATAAGGAAGG  CATGGTACGA  TGTGACACAG  CAGTTGGAAC  ACCTGATTAT  720
721   ATTTCCCCTG  AAGTATTAAA  ATCCCAAGGC  GGTGATGGTT  ATTATGGACG  AGAATGTGAC  780
781   TGGTGGTCAG  TTGGGGTATT  TTTATATGAA  ATGCTTGTAG  GTGATACACC  TTTTTATGCA  840
841   GATTCTTTGG  TTGGGACTTA  CAGTAAGATT  ATGAACCATA  AAAATTCACT  TACCTTCCCT  900
901   GATGATAATG  ACATATCAAA  AGAAGCAAAA  AATCTTATTT  GTGCCTTCCT  TACTGACAGA  960
961   GAAGTGAGAT  TAGGGCGAAA  TGGTGTAGAA  GAAATCAAAC  GACATCTCTT  CTTCAAAAAT  1020
1021  GATCAATGGG  CTTGGGAAAC  ACTTCGAGAC  ACTGTAGCAC  CAGTTGTACC  TGATTTAAGT  1080
1081  AGTGACATTG  ATACAAGTAA  TTTTGATGAC  TTGGAAGAAG  ACAAGGGAGA  TGAAGAAACA  1140
1141  TTCCCTATTC  CTAAAGCTTT  TGTTGGCAAT  CAGCTACCTT  TTGTAGGATT  TACGTATTAT  1200
1201  AGCAATCGTA  GGTACTTATC  TTCAGCAAAT  CCTAATGATA  ACAGAACTAG  TTCCAATGTG  1260
1261  GATAAAAATT  TGCAGGAAAG  TTTGCAGAAA  ACAATCTACA  AGTTGGAAGA  ACAACTACAT  1320
1321  AATGAAATGC  AATTAAAAGA  TGAAATGGAG  CAGAAGTGCA  GAACTTCAAA  CATAAAACTA  1380
1381  GACAAGATAA  TGAAAGAATT  GGATGAAGAG  GGGAGCCAAA  GAAGGAATCT  AGAATCTACA  1440
1441  GTGTCACAGA  TGGAGAAGGA  GAAAATGTTG  CTACAGCATA  GAATTAATGA  GTACCAAAGA  1500
1501  AAAGCTGAAC  AGGAAAATGA  GAAGAGAAGG  AATGTAGAAA  ATGAAGTTTC  TACGTTAAAG  1560
1561  GATCAGTTGG  AAGACTTAAA  GAAAGTCAGT  CAGAATTCAC  AGCTTGCTAA  TGAGAAATTG  1620
1621  GCACAATTAC  AAAAGCAGCT  AGAAGAAGCC  AATGACTTAC  TTAGGACAGA  GTCAGACACA  1680
1681  GCTGCAAGAT  TAAGGAAGAG  TCACACAGAG  ATGAGCAAGT  CGATTAGTCA  GCTAGAGTCC  1740
1741  CTGAACATAG  AATTGCAGGA  GAGAAATAGA  ATTTTAGAGA  ATTCCAAGAC  ACAAACGGAC  1800
1801  AAGGATTATT  ACCAGCTGCA  AGCTGTATTA  GACGCTGAAC  GAAGAGACAG  AGGCCATGAT  1860
1861  TCTGAGATGA  TTGGAGACCT  TCAAGCTCGA  ATTACATCTT  CACAAGAGGA  GGTGAAGCAT  1920
1921  CTCAAACACA  ATCTTGAAAG  GCTGGAAGGA  GAAAGAAAAG  AGGCTCAAGA  CATGCTTAAT  1980
1981  CATTCAGAAA  AGGAAAAGAA  TAACTTAGAG  ATAGATTTAA  ACTACAAGCT  TAAATCATTA  2040
2041  CAACAACGGT  TAGAACAAGA  AGTAAATGAA  CATAAAGTAA  CCAAAGCTCG  TTTAACTGAC  2100
2101  AAACATCAAT  CTATTGAAGA  GGCAAAGTCT  GTTGCAATGT  GTGAGATGGA  AAAAAAGCTG  2160
2161  AAGGAAGAAA  GAGAAGCCCG  AGAGAAGGCT  GAAAATAGGG  TTGTTCAGAT  TGAGAAACAA  2220
2221  TGTTCCATGC  TCGATGTTGA  TCTAAAGCAA  TCTCAGCAGA  AGCTAGAGCA  TTTGACTGAA  2280
2281  AATAAAGAAA  GAATGGAGGA  AGAAGTTAAG  AATCTAACCC  TACAACTGGA  GCAGGAATCA  2340
2341  AATAAGCGAC  TGCTATTACA  AAATGAATTG  AAGACACAAG  CTTTTGAGGC  AGACAATTTA  2400
2401  AAAGGTTTAG  AGAAGCAGAT  GAAACAGGAA  ATAAATACAT  TATTGGAAGC  AAAGAGATTA  2460
2461  TTAGAATTTG  AGTTAGCTCA  GCTTACAAAA  CAATATAGAG  GAAACGAAGG  ACAGATGCGG  2520
2521  GAGCTACAAG  ATCAGCTTGA  AGCTGAGCAG  TATTTCTCGA  CGCTTTATAA  AACCCAGGTG  2580
2581  AAGGAACTTA  AGGAAGAAAT  TCAAGAAAAA  AACAGAGAAA  ATTTAAAGAA  AATACAGGAA  2640
2641  CTACAAAATG  AAAAAGAAAC  TCTTGCTACT  CAATTGGATC  TAGCAGAAAC  GAAAGCTGAG  2700
2701  TCTGAGCAGT  TAGCTCGAGG  GCTTTTGGAA  GAACAGTATT  TTGAATTGAC  CCAAGAAAGC  2760
2761  AAGAAAGCTG  CTTCAAGAAA  CAGACAAGAG  ATTACAGATA  AAGATCACAC  TGTTAGTCGG  2820
2821  CTAGAAGAAA  TGAACAGCAT  GCTAACGAGA  GATATTGAAT  TACTAAGAAA  AGAAAATGAA  2880
2881  GAGCTAACTG  AAAACATGAG  GAAGACAGAG  GAAGAATATA  AATTGAAGAA  GGAAGAGGAG  2940
2941  ATCAGTAATC  TTAAGGCTGC  CTTTGAAAAG  AATATCAATA  CAGAACGAAC  CCTCAAAACA  3000
3001  CAGGCTGTTA  ACAAGTTGGC  AGAAATAATG  AATCGAAAAG  ATTTTAAAAT  TGATAGAAAG  3060
3061  AAAGCTAATA  CTCAAGATTT  AAGAAAGAAG  GAAAAGGAAA  ATCGAAAACT  ACAACTGGAA  3120
3121  CTCAACCAAG  AAAGAGAGAA  ATTCAACCAG  ATGGTAGTGA  AACACCAGAA  GGAACTGAAT  3180
3181  GACATGCAGG  CGCAATTAGT  GGAAGAATGT  ACACATAAGA  ATGAGCTTCA  GATGCAGTTG  3240
3241  GCTAGCAAAG  AGAGTGATAT  TGAGCAACTG  CGTGCTAAAC  TTTTGGACCT  TTCGGATTCT  3300
3301  ACAAGTGTTG  CTAGTTTTCC  TAGTGCCGAT  GAAACTGATG  GAAACCTTCC  AGAGTCAAGA  3360
3361  ATTGAAGGTT  GGCTTTCAGT  ACCAAACAGA  GGGAATATTA  AGCGATATGG  CTGGAAGAAA  3420
3421  CAGTATGTTG  TGGTAAGCAG  CAAAAAAATT  TTGTTCTACA  ATGATGAACA  AGAAAAGGAA  3480
3481  CAATCCAATC  CGTCTATGGT  GTTGGACATA  GATAAACTGT  TTCATGTTCG  ACCTGTAACC  3540
3541  CAAGGGGATG  TGTATAGAGC  TGAAACTGAA  GAAATTCCTA  AAATATTCCA  GATATTATAT  3600
3601  GCAAACGAAG  GTGAATGTAG  AAAAGAAGTA  GAGATGGAAC  CAGTACAACA  AGCTGAAAAA  3660
3661  ACTAATTTTC  AAAATCACAA  AGGCCATGAG  TTCATTCCGA  CACTCTACCA  CTTCCCAGCC  3720
3721  AACTGTGAGG  CCTGTGCCAA  ACCTCTCTGG  CATGTTTTCA  AGCCACCCCC  TGCCCTAGAA  3780
3781  TGTCGAAGAT  GCCATGTTAA  GTGCCACAGA  GACCATTTAG  ATAAGAAAGA  GGACTTGATT  3840
3841  TCTCCCTGTA  AAGTAAGTTA  TGATGTAACA  TCAGCAAGAG  ATATGCTGCT  GTTAGCATGT  3900
3901  TCTCAGGATG  AACAAAAGAA  ATGGGTAACT  CATTTAGTAA  AGAAGATCCC  CAAAAATCCA  3960
3961  CCCTCCGGTT  TTGTTCGCGC  ATCCCCTCGA  ACCCTTTCTA  CAAGATCTAC  TGCAAACCAG  4020
4021  TCTTTCAGGA  AAGTGGTCAA  AAATACATCT  GGAAAAACTA  GG  4062

▼ KEYWORD

ID
Family
ATP-binding
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Kinase
Magnesium
Metal-binding
Nucleotide-binding
Reference proteome
Serine/threonine-protein kinase
Transferase
Zinc
Zinc-finger

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Amyloid-beta complex
Cellular Component
Cytoplasmic stress granule
Cellular Component
Cytoskeleton
Cellular Component
Lamellipodium
Cellular Component
Plasma membrane
Cellular Component
Ruffle
Molecular Function
ATP binding
Molecular Function
GTP-Rho binding
Molecular Function
Metal ion binding
Molecular Function
Rho-dependent protein serine/threonine kinase activity
Biological Process
Apical constriction
Biological Process
Bleb assembly
Biological Process
Cortical actin cytoskeleton organization
Biological Process
I-kappaB kinase/NF-kappaB signaling
Biological Process
Leukocyte tethering or rolling
Biological Process
Membrane to membrane docking
Biological Process
MRNA destabilization
Biological Process
Myoblast migration
Biological Process
Negative regulation of amyloid-beta formation
Biological Process
Negative regulation of angiogenesis
Biological Process
Negative regulation of bicellular tight junction assembly
Biological Process
Negative regulation of myosin-light-chain-phosphatase activity
Biological Process
Negative regulation of neuron apoptotic process
Biological Process
Negative regulation of protein binding
Biological Process
Neuron projection arborization
Biological Process
Peptidyl-serine phosphorylation
Biological Process
Positive regulation of amyloid-beta clearance
Biological Process
Positive regulation of autophagy
Biological Process
Positive regulation of cardiac muscle hypertrophy
Biological Process
Positive regulation of connective tissue replacement
Biological Process
Positive regulation of focal adhesion assembly
Biological Process
Positive regulation of gene expression
Biological Process
Positive regulation of MAPK cascade
Biological Process
Protein localization to plasma membrane
Biological Process
Regulation of angiotensin-activated signaling pathway
Biological Process
Regulation of blood vessel diameter
Biological Process
Regulation of establishment of cell polarity
Biological Process
Regulation of establishment of endothelial barrier
Biological Process
Regulation of keratinocyte differentiation
Biological Process
Regulation of neuron differentiation
Biological Process
Regulation of stress fiber assembly
Biological Process
Regulation of synaptic vesicle endocytosis
Biological Process
Response to angiotensin
Biological Process
Response to transforming growth factor beta
Biological Process
Rho protein signal transduction

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Aim-3818Ailuropoda melanoleuca97.780.02625
LLPS-Urm-0250Ursus maritimus97.710.02623
LLPS-Orc-4281Oryctolagus cuniculus97.660.02480
LLPS-Eqc-2537Equus caballus97.560.02620
LLPS-Chs-0201Chlorocebus sabaeus97.490.02620
LLPS-Sus-2119Sus scrofa97.490.02616
LLPS-Hos-1271Homo sapiens97.490.02620
LLPS-Caf-3604Canis familiaris97.410.02618
LLPS-Gog-4213Gorilla gorilla97.350.02468
LLPS-Fec-4390Felis catus97.340.02615
LLPS-Bot-4568Bos taurus97.270.02614
LLPS-Myl-2254Myotis lucifugus97.270.02615
LLPS-Mup-1890Mustela putorius furo97.20.02400
LLPS-Ova-0633Ovis aries97.120.02605
LLPS-Pat-1004Pan troglodytes96.350.02603
LLPS-Cas-4026Carlito syrichta96.270.02593
LLPS-Ict-2459Ictidomys tridecemlineatus96.270.02597
LLPS-Maf-0925Macaca fascicularis96.20.02602
LLPS-Paa-4483Papio anubis96.20.02598
LLPS-Mal-2884Mandrillus leucophaeus96.20.02598
LLPS-Pap-2952Pan paniscus96.20.02600
LLPS-Man-3462Macaca nemestrina96.20.02598
LLPS-Mum-3635Mus musculus96.160.02590
LLPS-Dio-2952Dipodomys ordii96.130.02595
LLPS-Mam-1197Macaca mulatta96.130.02598
LLPS-Caj-0663Callithrix jacchus95.910.02594
LLPS-Aon-4208Aotus nancymaae95.850.02603
LLPS-Cap-3286Cavia porcellus95.610.02588
LLPS-Fud-1957Fukomys damarensis95.390.02584
LLPS-Mea-4419Mesocricetus auratus95.250.02580
LLPS-Ran-4690Rattus norvegicus94.890.02578
LLPS-Nol-3613Nomascus leucogenys94.880.02540
LLPS-Rhb-3737Rhinopithecus bieti94.080.02518
LLPS-Cea-3778Cercocebus atys93.610.02506
LLPS-Poa-4384Pongo abelii93.270.02460
LLPS-Otg-3249Otolemur garnettii91.970.02465
LLPS-Mod-1092Monodelphis domestica90.190.02412
LLPS-Anp-0041Anas platyrhynchos87.520.02338
LLPS-Pes-1850Pelodiscus sinensis86.820.02340
LLPS-Tag-0434Taeniopygia guttata86.530.02316
LLPS-Gaga-0788Gallus gallus86.460.02365
LLPS-Anc-1141Anolis carolinensis86.160.02320
LLPS-Meg-0756Meleagris gallopavo85.440.02305
LLPS-Fia-0187Ficedula albicollis84.660.01910
LLPS-Xet-1031Xenopus tropicalis82.550.02199
LLPS-Leo-0228Lepisosteus oculatus78.550.01287
LLPS-Lac-3125Latimeria chalumnae78.030.02061
LLPS-Tar-2982Takifugu rubripes75.370.02068
LLPS-Gaa-3344Gasterosteus aculeatus75.260.02027
LLPS-Scf-3295Scleropages formosus75.110.02029
LLPS-Orn-2727Oreochromis niloticus75.00.02054
LLPS-Xim-3806Xiphophorus maculatus74.910.02059
LLPS-Dar-3921Danio rerio74.710.02049
LLPS-Scm-0989Scophthalmus maximus74.710.02035
LLPS-Ten-1324Tetraodon nigroviridis74.550.02029
LLPS-Pof-0556Poecilia formosa73.940.02023
LLPS-Icp-1987Ictalurus punctatus73.810.02024
LLPS-Orl-3533Oryzias latipes73.790.02028
LLPS-Cae-0735Caenorhabditis elegans63.713e-172 552
LLPS-Asm-2691Astyanax mexicanus54.040.01362
LLPS-Put-0632Puccinia triticina43.652e-76 262
LLPS-Spr-0331Sporisorium reilianum43.493e-85 298
LLPS-Usm-0691Ustilago maydis43.466e-86 301
LLPS-Tum-0580Tuber melanosporum43.214e-92 315
LLPS-Mel-0807Melampsora laricipopulina42.755e-90 306
LLPS-Sah-0265Sarcophilus harrisii41.933e-96 347
LLPS-Yal-1495Yarrowia lipolytica41.851e-67 246
LLPS-Pug-0507Puccinia graminis40.963e-89 303
LLPS-Miv-0258Microbotryum violaceum40.934e-91 312
LLPS-Crn-0726Cryptococcus neoformans40.056e-83 288
LLPS-Drm-0211Drosophila melanogaster39.497e-83 304
LLPS-Trv-0668Trichoderma virens39.412e-62 231
LLPS-Org-1517Oryza glaberrima39.275e-89 305
LLPS-Scc-0960Schizosaccharomyces cryophilus39.23e-64 234
LLPS-Sob-1641Sorghum bicolor39.026e-88 302
LLPS-Brd-0179Brachypodium distachyon38.938e-89 305
LLPS-Orb-1320Oryza barthii38.71e-86 298
LLPS-Orr-1623Oryza rufipogon38.71e-86 298
LLPS-Nec-0765Neurospora crassa38.62e-62 231
LLPS-Sac-0660Saccharomyces cerevisiae38.151e-63 236
LLPS-Kop-1137Komagataella pastoris38.071e-76 273
LLPS-Cogr-0691Colletotrichum graminicola37.944e-62 230
LLPS-Ora-3494Ornithorhynchus anatinus37.912e-63 226
LLPS-Asg-1095Ashbya gossypii37.75e-66 244
LLPS-Orm-0457Oryza meridionalis37.569e-81 281
LLPS-Abg-1404Absidia glauca36.993e-62 228