LLPS-Orn-2727
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Rho-associated protein kinase |
| Ensembl Gene: | ENSONIG00000009417.1 |
| Ensembl Protein: | ENSONIP00000011836.1 |
| Organism: | Oreochromis niloticus |
| Taxa ID: | 8128 |
| LLPS Type: | Others |
▼ PROPERTY
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body, Stress granule, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSONIT00000011845.1 | ENSONIP00000011836.1 |
| UniProt | I3JSJ1, I3JSJ1_ORENI | |
| GeneBank | AERX01000980 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 AKMSAGDTME ARFEKIDAML KDPKSEINTD CLLDGLDALV YDLDFPALRK NKSIDNFLNR 60 61 YKETISKIRD LRMKAVDYEV VKVIGRGAFG EVQLVRHKAT SKVYAMKLLS KFEMIKRSDS 120 121 AFFWEERDIM AFANSSWVVQ LFFAFQDDRY LYMVMEYMPG GDLVNLMSNY DVPEKWARFY 180 181 TAEVVLALDG IHSMGFIHRD VKPDNMLLDK AGHLKLADFG TCMKMNKDGM VRCDTAVGTP 240 241 DYISPEVLKS QGGDGYYGRE CDWWSVGVFL YEMLVGIGDT PFYADSLVGT YSKIMNHKNA 300 301 LTFPDDSDIS NDAKNLICAF LTDREVRLGR NGVDEIKRHP FFKNDQWTWE NIRETAAPVV 360 361 PELSSDTDTS NFDDIEEDRG EEETFPIPKA FVGNQLPFVG FTYYSNQHLL RRSAGTKSSD 420 421 KRSSSTKEDK SHLENLQKRI YQLEEQLHSE MQLKDELEQK CRTSNTKIEK MMKELDEEAN 480 481 LRKSAEASLS LLEKDKLMQQ HRFTEYQRKA DQEAEKRRNL ENEVSNLKEQ LEDMKKISQN 540 541 SQASNDKIAQ LQNQDWQLEE ANDLLRAESD TAGRLRKSHT EMTKSMTHLE NLNRELQERS 600 601 RAVEGEKALL EKELLLLQST LDSERRNYSQ DSEEIRELQV LARLSGLQED NKNLKLSLSK 660 661 MEAERKQAQE RSNNLEKEKN NLEIDLNYKL KTLQQRLEQE QTEHRVTRAQ LTDKYESIEE 720 721 AKSAAMSAVQ QKMSEETGAR MRAESRVVEV EKQCSMLEFD LKQSVQKMEQ LMKQKERLED 780 781 EVKNLQIQVE QESSKRIQIQ NDLKTRMQEM DRLRCSEKQL KQEINTSLES KRSLEFQLAQ 840 841 LSKQYRGNEG QMRELQDQLE AEQYFSTLYK TQVKELKEEI EERNRQTQEA NKKVQDLCNE 900 901 RDSLSAQLDL TVTKAESEQL ARALQEEQYF ELSQENKKAV TRHKQEIGEK EATIARLEES 960 961 CKTLTKDVEN LSREKTELSE KLRIQDEEYT AQKEEIEKSI KANYEKVLYT ERTLKTQAVN 1020 1021 KLAEIMNRKD MKLDQKKKGS TADLRKKEKE NRKLQLELNQ EKEKFNHMAI KYQKELSEMQ 1080 1081 AQLSEESTYR NELQMQLDSK ESDIEQLREK LNDLQQRMDN SSVTSLQTDE TDSNIAESRL 1140 1141 EGWLSIPNRA NIKRYGWKKQ YVVVSSKKIL FYNDEQDKEQ SNPSMVLDID KLFHVRPVTQ 1200 1201 GDVYRAETDE IPRIFQILYA NEGECRKEAD LETVPQGDKT NCLPHKGHEF IPTLYHFPSN 1260 1261 CEACAKPLWH VFKPPPALEC RRCHVKCHKD HLDKKEDVIA PCKVNYDVTS ARDMLLLALT 1320 1321 QDEQKKWIGH LGKKIPKTPP STFTRASPRS MSTRSGPNQS FRKNPKSNTG KLR 1373 |
| Nucleotide CDS Sequence (FASTA) |
1 GCAAAAATGT CTGCTGGGGA TACCATGGAG GCTCGATTTG AAAAGATCGA TGCCATGTTG 60 61 AAAGACCCAA AGTCAGAAAT AAACACGGAT TGTCTGCTGG ATGGCTTGGA TGCACTGGTG 120 121 TATGACCTTG ACTTCCCCGC CCTGAGGAAA AACAAGAGCA TTGACAACTT TTTGAATAGA 180 181 TACAAAGAGA CGATTAGTAA AATTCGTGAT CTGCGAATGA AAGCAGTGGA CTATGAGGTG 240 241 GTTAAAGTTA TTGGGAGGGG TGCATTTGGA GAGGTGCAGT TGGTAAGACA TAAAGCCACA 300 301 AGCAAAGTAT ATGCCATGAA GCTGCTGAGT AAGTTTGAGA TGATCAAGAG GTCAGACTCT 360 361 GCTTTCTTCT GGGAGGAGAG GGACATCATG GCCTTTGCCA ATAGTTCATG GGTCGTTCAG 420 421 CTCTTTTTTG CATTCCAAGA TGACCGCTAC CTCTACATGG TGATGGAGTA CATGCCTGGC 480 481 GGTGATTTGG TTAACTTGAT GAGCAACTAT GACGTCCCAG AGAAGTGGGC TCGCTTTTAC 540 541 ACAGCCGAGG TAGTCCTGGC CCTGGATGGA ATCCACTCTA TGGGCTTCAT TCACAGAGAT 600 601 GTCAAGCCTG ATAACATGTT GCTTGACAAA GCAGGCCACT TAAAGCTCGC AGACTTTGGG 660 661 ACCTGCATGA AAATGAACAA GGACGGTATG GTACGATGTG ACACAGCAGT GGGAACTCCA 720 721 GACTACATTT CACCTGAGGT ACTGAAATCC CAAGGAGGAG ATGGCTATTA TGGCAGAGAG 780 781 TGCGACTGGT GGTCAGTGGG AGTGTTTCTG TATGAAATGT TAGTTGGCAT AGGCGACACT 840 841 CCTTTCTATG CAGACTCACT AGTGGGGACC TATAGCAAAA TTATGAACCA CAAGAATGCG 900 901 CTGACCTTCC CTGATGACAG CGACATATCC AATGATGCCA AGAATTTGAT CTGTGCTTTC 960 961 CTGACCGACA GGGAAGTTCG ACTTGGCCGT AATGGTGTAG ATGAAATCAA GAGGCATCCC 1020 1021 TTCTTCAAGA ATGACCAGTG GACGTGGGAG AACATCAGAG AGACGGCCGC CCCTGTAGTC 1080 1081 CCCGAACTTA GCAGTGACAC CGACACCAGT AACTTTGACG ACATCGAGGA GGATCGGGGA 1140 1141 GAGGAGGAGA CCTTTCCCAT ACCAAAGGCC TTTGTGGGCA ACCAGCTCCC GTTTGTAGGC 1200 1201 TTCACCTATT ACAGTAATCA ACACCTTTTG CGAAGGTCCG CTGGCACGAA GAGCAGTGAC 1260 1261 AAGCGTAGCA GTTCCACAAA AGAAGATAAG AGTCATTTGG AGAACCTGCA AAAACGAATC 1320 1321 TACCAGCTAG AGGAGCAGCT GCACAGTGAA ATGCAGCTGA AAGATGAGTT GGAGCAGAAA 1380 1381 TGCAGGACAT CAAACACCAA GATTGAAAAG ATGATGAAAG AGCTGGATGA AGAGGCAAAC 1440 1441 CTGAGGAAGA GCGCTGAGGC CAGCTTGTCT CTGCTGGAGA AGGACAAGCT TATGCAGCAG 1500 1501 CACAGATTCA CAGAGTACCA AAGAAAAGCC GACCAGGAGG CAGAGAAGAG ACGCAATTTG 1560 1561 GAAAACGAAG TGTCAAATTT GAAGGAGCAG TTGGAAGATA TGAAGAAAAT CAGTCAGAAC 1620 1621 TCGCAAGCCT CAAATGACAA GATTGCCCAG CTTCAGAATC AGGATTGGCA GCTGGAAGAG 1680 1681 GCCAATGACT TGCTGCGTGC AGAGTCAGAC ACAGCGGGGA GACTGAGGAA GAGCCACACG 1740 1741 GAGATGACCA AGTCAATGAC ACATTTGGAG AATTTGAACC GTGAGCTGCA GGAGAGGAGC 1800 1801 CGCGCAGTAG AAGGAGAGAA GGCGCTGCTG GAGAAGGAGC TCCTGCTTCT ACAGAGCACC 1860 1861 CTGGACTCTG AACGGAGGAA CTACAGTCAG GACTCAGAGG AGATCAGGGA GCTGCAAGTC 1920 1921 TTAGCGAGAT TGTCGGGGTT GCAAGAGGAT AACAAAAACT TGAAGCTTAG TCTGTCCAAG 1980 1981 ATGGAAGCGG AACGCAAACA GGCCCAGGAA AGAAGCAATA ATTTGGAGAA GGAAAAGAAC 2040 2041 AATTTGGAGA TAGACCTGAA TTACAAACTG AAGACCTTGC AGCAGCGTCT GGAGCAGGAA 2100 2101 CAGACGGAGC ACAGGGTGAC GCGGGCACAG CTCACTGACA AATACGAGTC TATCGAAGAA 2160 2161 GCCAAATCAG CTGCCATGTC TGCTGTTCAG CAGAAGATGT CGGAGGAGAC GGGAGCAAGG 2220 2221 ATGAGGGCAG AGAGCCGGGT GGTGGAGGTT GAGAAGCAGT GCTCAATGTT GGAGTTTGAC 2280 2281 CTTAAGCAGT CGGTGCAGAA AATGGAGCAG CTGATGAAGC AAAAGGAACG GCTGGAGGAT 2340 2341 GAGGTGAAGA ATCTGCAGAT TCAGGTAGAG CAGGAGTCAA GCAAACGCAT CCAGATTCAG 2400 2401 AACGACCTGA AGACCCGCAT GCAGGAGATG GATCGTCTTA GGTGTTCGGA GAAACAGCTC 2460 2461 AAACAAGAGA TCAACACATC ACTGGAGAGT AAACGCTCAC TGGAGTTTCA GCTGGCACAG 2520 2521 CTGTCCAAAC AATACAGAGG CAACGAGGGA CAGATGAGGG AACTTCAGGA CCAGCTTGAG 2580 2581 GCTGAACAGT ATTTTTCTAC GCTTTACAAA ACTCAGGTCA AAGAACTAAA AGAGGAGATT 2640 2641 GAGGAAAGGA ACCGGCAGAC ACAGGAGGCT AATAAGAAGG TGCAGGATTT GTGCAATGAA 2700 2701 AGGGATTCCT TGTCTGCACA GCTGGATCTG ACAGTGACCA AGGCCGAGTC AGAACAGCTT 2760 2761 GCTCGGGCGC TTCAGGAGGA GCAGTATTTC GAGCTCAGCC AAGAGAACAA GAAAGCAGTG 2820 2821 ACAAGGCATA AGCAGGAGAT TGGGGAGAAA GAGGCTACTA TTGCACGGCT TGAGGAATCC 2880 2881 TGTAAAACTC TGACCAAAGA TGTGGAGAAC CTCAGCAGAG AGAAGACGGA GTTAAGTGAG 2940 2941 AAGCTTCGTA TTCAGGATGA AGAATATACA GCTCAGAAGG AAGAAATTGA AAAATCAATC 3000 3001 AAGGCCAACT ACGAAAAGGT CCTCTACACA GAGCGCACAC TGAAGACTCA GGCGGTGAAC 3060 3061 AAACTGGCAG AGATCATGAA TCGTAAAGAC ATGAAGCTGG ACCAGAAGAA GAAGGGTAGC 3120 3121 ACAGCTGACC TGCGGAAAAA GGAGAAGGAA AACCGCAAGC TTCAGCTGGA GCTTAATCAG 3180 3181 GAGAAGGAAA AGTTTAACCA CATGGCTATC AAATACCAGA AGGAGCTGAG CGAGATGCAG 3240 3241 GCGCAATTGT CAGAGGAAAG CACGTATCGC AACGAGCTGC AGATGCAGCT GGACAGCAAG 3300 3301 GAGAGCGACA TCGAGCAGCT CCGGGAGAAA CTGAATGACC TGCAGCAGCG CATGGATAAC 3360 3361 TCCAGCGTCA CCAGCCTGCA GACGGACGAG ACGGACAGTA ATATCGCAGA GTCCAGATTG 3420 3421 GAGGGCTGGC TGTCTATTCC TAATCGTGCT AATATCAAAA GATACGGATG GAAGAAGCAG 3480 3481 TATGTGGTGG TGAGCAGTAA GAAGATTCTG TTCTACAATG ACGAGCAGGA TAAGGAGCAG 3540 3541 TCCAACCCCT CGATGGTACT GGATATCGAC AAACTGTTTC ATGTGAGGCC AGTCACGCAA 3600 3601 GGAGATGTGT ACCGAGCTGA GACGGATGAG ATTCCAAGGA TTTTCCAGAT TTTGTATGCT 3660 3661 AATGAGGGAG AGTGCAGGAA GGAGGCGGAT CTAGAGACAG TCCCTCAGGG CGACAAGACC 3720 3721 AACTGTCTCC CACACAAAGG CCACGAGTTC ATCCCCACGT TATATCACTT CCCTTCAAAC 3780 3781 TGCGAGGCCT GTGCCAAGCC TCTGTGGCAC GTCTTCAAGC CGCCTCCGGC CCTGGAGTGT 3840 3841 CGCCGCTGCC ACGTGAAGTG CCACAAGGAC CACCTCGACA AAAAGGAGGA TGTTATTGCT 3900 3901 CCTTGCAAAG TAAACTACGA CGTGACCTCT GCCCGGGACA TGCTGCTGCT GGCTCTGACC 3960 3961 CAAGACGAGC AGAAGAAATG GATCGGCCAC CTCGGAAAGA AGATTCCCAA GACCCCGCCG 4020 4021 TCGACATTCA CAAGAGCCTC GCCGCGGTCC ATGTCCACTC GCTCTGGACC CAACCAATCC 4080 4081 TTCCGCAAGA ACCCTAAAAG CAATACGGGA AAGCTGAGGT AA 4122 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoskeleton | |
Molecular Function | ATP binding | |
Molecular Function | GTP-Rho binding | |
Molecular Function | Metal ion binding | |
Molecular Function | Protein serine/threonine kinase activity | |
Biological Process | Actin cytoskeleton organization | |
Biological Process | Epicardial cell to mesenchymal cell transition | |
Biological Process | Negative regulation of adherens junction organization | |
Biological Process | Positive regulation of stress fiber assembly | |
Biological Process | Regulation of establishment of cell polarity | |
Biological Process | Rho protein signal transduction |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Gaa-3344 | Gasterosteus aculeatus | 91.55 | 0.0 | 2460 |
| LLPS-Tar-2982 | Takifugu rubripes | 91.17 | 0.0 | 2476 |
| LLPS-Xim-3806 | Xiphophorus maculatus | 91.02 | 0.0 | 2469 |
| LLPS-Scm-0989 | Scophthalmus maximus | 90.06 | 0.0 | 2444 |
| LLPS-Ten-1324 | Tetraodon nigroviridis | 89.93 | 0.0 | 2429 |
| LLPS-Pof-0556 | Poecilia formosa | 89.86 | 0.0 | 2440 |
| LLPS-Orl-3533 | Oryzias latipes | 89.27 | 0.0 | 2408 |
| LLPS-Scf-3295 | Scleropages formosus | 86.49 | 0.0 | 2319 |
| LLPS-Icp-1987 | Ictalurus punctatus | 85.83 | 0.0 | 2320 |
| LLPS-Dar-3921 | Danio rerio | 85.1 | 0.0 | 2311 |
| LLPS-Gog-4298 | Gorilla gorilla | 82.73 | 0.0 | 737 |
| LLPS-Anp-0041 | Anas platyrhynchos | 76.01 | 0.0 | 2028 |
| LLPS-Anc-1141 | Anolis carolinensis | 75.89 | 0.0 | 2044 |
| LLPS-Pes-1850 | Pelodiscus sinensis | 75.68 | 0.0 | 2047 |
| LLPS-Tag-0434 | Taeniopygia guttata | 75.65 | 0.0 | 2046 |
| LLPS-Gaga-0788 | Gallus gallus | 75.64 | 0.0 | 2071 |
| LLPS-Eqc-2537 | Equus caballus | 75.62 | 0.0 | 2020 |
| LLPS-Sus-2119 | Sus scrofa | 75.55 | 0.0 | 2016 |
| LLPS-Aim-3818 | Ailuropoda melanoleuca | 75.55 | 0.0 | 2014 |
| LLPS-Fec-4390 | Felis catus | 75.55 | 0.0 | 2013 |
| LLPS-Chs-0201 | Chlorocebus sabaeus | 75.47 | 0.0 | 2012 |
| LLPS-Urm-0250 | Ursus maritimus | 75.47 | 0.0 | 2010 |
| LLPS-Caf-3604 | Canis familiaris | 75.47 | 0.0 | 2009 |
| LLPS-Bot-4568 | Bos taurus | 75.44 | 0.0 | 2029 |
| LLPS-Hos-1271 | Homo sapiens | 75.4 | 0.0 | 2012 |
| LLPS-Orc-4281 | Oryctolagus cuniculus | 75.38 | 0.0 | 1912 |
| LLPS-Ova-0633 | Ovis aries | 75.33 | 0.0 | 2011 |
| LLPS-Myl-2254 | Myotis lucifugus | 75.29 | 0.0 | 2028 |
| LLPS-Loa-0604 | Loxodonta africana | 74.85 | 0.0 | 2026 |
| LLPS-Meg-0756 | Meleagris gallopavo | 74.85 | 0.0 | 2007 |
| LLPS-Lac-3125 | Latimeria chalumnae | 74.72 | 0.0 | 1944 |
| LLPS-Mum-3635 | Mus musculus | 74.67 | 0.0 | 2004 |
| LLPS-Cas-4026 | Carlito syrichta | 74.6 | 0.0 | 1994 |
| LLPS-Aon-4208 | Aotus nancymaae | 74.55 | 0.0 | 2003 |
| LLPS-Mup-1890 | Mustela putorius furo | 74.51 | 0.0 | 1827 |
| LLPS-Caj-0663 | Callithrix jacchus | 74.46 | 0.0 | 1994 |
| LLPS-Pap-2952 | Pan paniscus | 74.46 | 0.0 | 1995 |
| LLPS-Pat-1004 | Pan troglodytes | 74.46 | 0.0 | 1995 |
| LLPS-Maf-0925 | Macaca fascicularis | 74.39 | 0.0 | 1992 |
| LLPS-Dio-2952 | Dipodomys ordii | 74.39 | 0.0 | 1992 |
| LLPS-Paa-4483 | Papio anubis | 74.39 | 0.0 | 1991 |
| LLPS-Mal-2884 | Mandrillus leucophaeus | 74.39 | 0.0 | 1991 |
| LLPS-Man-3462 | Macaca nemestrina | 74.39 | 0.0 | 1991 |
| LLPS-Mam-1197 | Macaca mulatta | 74.39 | 0.0 | 1991 |
| LLPS-Leo-0228 | Lepisosteus oculatus | 74.32 | 0.0 | 1955 |
| LLPS-Fud-1957 | Fukomys damarensis | 74.24 | 0.0 | 2007 |
| LLPS-Ict-2459 | Ictidomys tridecemlineatus | 74.17 | 0.0 | 1990 |
| LLPS-Mea-4419 | Mesocricetus auratus | 74.1 | 0.0 | 1986 |
| LLPS-Ran-4690 | Rattus norvegicus | 74.04 | 0.0 | 1991 |
| LLPS-Cap-3286 | Cavia porcellus | 74.03 | 0.0 | 1998 |
| LLPS-Xet-1031 | Xenopus tropicalis | 73.94 | 0.0 | 1955 |
| LLPS-Nol-3613 | Nomascus leucogenys | 73.23 | 0.0 | 1938 |
| LLPS-Fia-0187 | Ficedula albicollis | 72.99 | 0.0 | 1646 |
| LLPS-Rhb-3737 | Rhinopithecus bieti | 72.66 | 0.0 | 1922 |
| LLPS-Cea-3778 | Cercocebus atys | 72.3 | 0.0 | 1917 |
| LLPS-Otg-3249 | Otolemur garnettii | 71.9 | 0.0 | 1932 |
| LLPS-Mod-1092 | Monodelphis domestica | 71.79 | 0.0 | 1915 |
| LLPS-Poa-4384 | Pongo abelii | 71.53 | 0.0 | 1870 |
| LLPS-Cae-0735 | Caenorhabditis elegans | 63.33 | 3e-173 | 555 |
| LLPS-Asm-2691 | Astyanax mexicanus | 54.85 | 0.0 | 1380 |
| LLPS-Spr-0331 | Sporisorium reilianum | 42.82 | 1e-83 | 294 |
| LLPS-Tum-0580 | Tuber melanosporum | 42.34 | 1e-91 | 313 |
| LLPS-Usm-0691 | Ustilago maydis | 42.29 | 2e-82 | 291 |
| LLPS-Put-0632 | Puccinia triticina | 42.22 | 7e-70 | 243 |
| LLPS-Yal-1495 | Yarrowia lipolytica | 41.97 | 2e-66 | 243 |
| LLPS-Miv-0258 | Microbotryum violaceum | 41.49 | 7e-86 | 297 |
| LLPS-Mel-0807 | Melampsora laricipopulina | 40.84 | 1e-85 | 293 |
| LLPS-Sah-0207 | Sarcophilus harrisii | 40.57 | 2e-87 | 298 |
| LLPS-Scc-0960 | Schizosaccharomyces cryophilus | 40.27 | 3e-63 | 232 |
| LLPS-Kop-1137 | Komagataella pastoris | 40.05 | 5e-81 | 285 |
| LLPS-Org-1517 | Oryza glaberrima | 39.79 | 1e-86 | 299 |
| LLPS-Pug-0507 | Puccinia graminis | 39.56 | 8e-81 | 280 |
| LLPS-Drm-0211 | Drosophila melanogaster | 39.29 | 5e-83 | 305 |
| LLPS-Asg-1095 | Ashbya gossypii | 39.23 | 4e-63 | 235 |
| LLPS-Orb-1320 | Oryza barthii | 39.18 | 3e-84 | 292 |
| LLPS-Orr-1623 | Oryza rufipogon | 39.18 | 3e-84 | 292 |
| LLPS-Crn-0726 | Cryptococcus neoformans | 38.97 | 6e-79 | 277 |
| LLPS-Orp-2054 | Oryza punctata | 38.52 | 5e-86 | 297 |
| LLPS-Orm-0457 | Oryza meridionalis | 37.96 | 1e-79 | 278 |
| LLPS-Sac-0660 | Saccharomyces cerevisiae | 37.81 | 6e-63 | 234 |