• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Otg-4405
PISD

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Phosphatidylserine decarboxylase proenzyme, mitochondrial
Gene Name: PISD
Ensembl Gene: ENSOGAG00000034158.1
Ensembl Protein: ENSOGAP00000017812.1
Organism: Otolemur garnettii
Taxa ID: 30611
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAASVGHRCL  WLLHGVALWR  SSLLHCENTA  PSYFLQSLQK  LPRRAFRTDA  RKVHTAPART  60
61    FSLLRPLPIL  LATGGGYTGY  RQYEKYRERE  MEKLGLEIPP  KLAGHWEVAL  YKSVPTRLLS  120
121   RAWGRLNQVE  LPYWLRGPVY  SLYIWTFGVN  MKEAAVEDLY  HYRNLSEFFR  RKLKPQARPV  180
181   CGLHSVISPS  DGKILNFGQV  KNCEVEQVKG  VTYSLESFLG  PRTCTEDLPF  PAATSCDSFK  240
241   NQLVTREGNE  LYHCVIYLAP  GDYHCFHSPT  DWTISHRRHF  PGSLMSVNPG  MARWIKELFC  300
301   HNERVVLTGD  WKHGFFSLTA  VGATNVGSIR  IYFDQDLHTN  SPRYSKGSYN  DFSFVTHANK  360
361   EGIPMRKGEH  LGEFNLGSTI  VLIFEAPKDF  NFQLKAGQKI  HFGEALGSL  409
Nucleotide CDS Sequence (FASTA)
1     ATGGCGGCGT  CCGTGGGGCA  CCGGTGTCTG  TGGTTACTAC  ATGGGGTCGC  GCTGTGGAGG  60
61    AGCAGCCTCC  TCCACTGTGA  GAACACTGCC  CCAAGCTACT  TCCTACAGTC  TTTACAGAAG  120
121   CTGCCTCGTA  GAGCCTTTCG  AACAGATGCC  AGAAAAGTCC  ACACTGCCCC  TGCACGAACC  180
181   TTCTCCCTGC  TGCGCCCCCT  GCCCATTCTG  TTGGCAACAG  GTGGCGGTTA  CACAGGGTAC  240
241   CGGCAGTATG  AGAAGTACAG  AGAGCGAGAG  ATGGAGAAGT  TGGGATTGGA  GATCCCACCC  300
301   AAACTCGCTG  GTCACTGGGA  GGTGGCCCTA  TACAAGTCAG  TGCCTACACG  TCTACTCTCA  360
361   CGGGCCTGGG  GCCGCCTCAA  CCAGGTGGAG  CTGCCATACT  GGCTGCGTGG  GCCTGTCTAC  420
421   AGCCTGTACA  TCTGGACCTT  CGGGGTGAAC  ATGAAGGAAG  CCGCTGTGGA  GGATCTGTAC  480
481   CACTACCGCA  ACCTCAGCGA  GTTCTTCCGG  CGCAAGCTGA  AGCCGCAGGC  CCGGCCTGTG  540
541   TGTGGCCTGC  ACAGCGTGAT  CAGCCCATCA  GATGGGAAGA  TCCTCAATTT  TGGGCAGGTG  600
601   AAGAACTGCG  AGGTAGAACA  GGTGAAGGGG  GTTACCTACT  CCCTGGAGTC  ATTCCTGGGC  660
661   CCACGCACCT  GCACAGAAGA  CCTGCCCTTC  CCAGCAGCTA  CCTCATGTGA  CTCCTTCAAG  720
721   AACCAGCTGG  TCACTCGGGA  AGGGAATGAG  CTCTACCACT  GTGTCATCTA  CTTGGCCCCC  780
781   GGGGACTACC  ACTGCTTTCA  CTCCCCCACT  GACTGGACCA  TTTCCCACCG  GCGACACTTC  840
841   CCAGGCTCCC  TGATGTCGGT  GAACCCTGGC  ATGGCTCGCT  GGATCAAAGA  GCTCTTCTGC  900
901   CACAATGAGC  GAGTAGTCCT  GACCGGGGAC  TGGAAACACG  GCTTCTTCTC  ACTAACGGCT  960
961   GTGGGGGCCA  CCAATGTGGG  CTCCATTCGC  ATCTACTTTG  ATCAGGACCT  GCACACAAAC  1020
1021  AGCCCGAGGT  ACAGCAAGGG  CTCCTACAAT  GACTTCAGCT  TCGTGACACA  CGCCAACAAG  1080
1081  GAGGGCATCC  CCATGCGCAA  GGGCGAGCAC  CTGGGTGAGT  TCAACCTGGG  CTCTACCATT  1140
1141  GTGCTCATCT  TCGAAGCCCC  CAAAGACTTC  AACTTCCAGC  TGAAAGCAGG  ACAGAAAATC  1200
1201  CACTTTGGGG  AGGCCCTGGG  CTCTCTGTAG  1230

▼ KEYWORD

ID
Family
Complete proteome
Decarboxylase
Lipid biosynthesis
Lipid metabolism
Lyase
Membrane
Mitochondrion
Mitochondrion inner membrane
Phospholipid biosynthesis
Phospholipid metabolism
Pyruvate
Reference proteome
Signal
Transmembrane
Transmembrane helix
Zymogen

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Integral component of mitochondrial inner membrane
Cellular Component
Nucleus
Molecular Function
Phosphatidylserine decarboxylase activity
Biological Process
Phosphatidylethanolamine biosynthetic process
Biological Process
Protein autoprocessing

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Caj-3700Callithrix jacchus95.70.0 609
LLPS-Cap-1816Cavia porcellus95.030.0 602
LLPS-Mup-3379Mustela putorius furo94.390.0 599
LLPS-Sus-4646Sus scrofa94.060.0 597
LLPS-Orc-0596Oryctolagus cuniculus94.040.0 594
LLPS-Cas-3654Carlito syrichta93.640.0 793
LLPS-Poa-1890Pongo abelii92.670.0 787
LLPS-Gog-2690Gorilla gorilla92.420.0 785
LLPS-Maf-1246Macaca fascicularis92.420.0 776
LLPS-Dio-1745Dipodomys ordii92.420.0 699
LLPS-Pat-1873Pan troglodytes92.420.0 785
LLPS-Man-4433Macaca nemestrina92.420.0 774
LLPS-Fud-3645Fukomys damarensis92.410.0 737
LLPS-Chs-1613Chlorocebus sabaeus92.180.0 773
LLPS-Cea-2577Cercocebus atys92.180.0 773
LLPS-Paa-3921Papio anubis92.180.0 772
LLPS-Pap-3116Pan paniscus92.180.0 781
LLPS-Mam-1894Macaca mulatta92.180.0 773
LLPS-Ora-2313Ornithorhynchus anatinus92.050.0 585
LLPS-Mal-3234Mandrillus leucophaeus91.930.0 771
LLPS-Hos-4056Homo sapiens91.930.0 781
LLPS-Aon-1582Aotus nancymaae91.440.0 777
LLPS-Rhb-2623Rhinopithecus bieti91.440.0 769
LLPS-Fec-1834Felis catus91.440.0 773
LLPS-Caf-2049Canis familiaris91.440.0 773
LLPS-Anp-2220Anas platyrhynchos90.490.0 568
LLPS-Tut-2297Tursiops truncatus90.460.0 747
LLPS-Fia-0834Ficedula albicollis90.40.0 577
LLPS-Ict-3372Ictidomys tridecemlineatus90.220.0 765
LLPS-Eqc-3732Equus caballus90.220.0 764
LLPS-Aim-3256Ailuropoda melanoleuca90.170.0 744
LLPS-Myl-2408Myotis lucifugus88.540.0 746
LLPS-Loa-4192Loxodonta africana87.530.0 636
LLPS-Ran-2115Rattus norvegicus86.310.0 723
LLPS-Mum-4884Mus musculus86.060.0 718
LLPS-Tag-2618Taeniopygia guttata84.530.0 648
LLPS-Xet-1684Xenopus tropicalis84.110.0 530
LLPS-Ova-0369Ovis aries83.370.0 689
LLPS-Leo-1839Lepisosteus oculatus83.220.0 529
LLPS-Pes-3056Pelodiscus sinensis82.470.0 622
LLPS-Scf-3146Scleropages formosus81.130.0 528
LLPS-Asm-3205Astyanax mexicanus78.953e-179 514
LLPS-Lac-2857Latimeria chalumnae78.930.0 617
LLPS-Mod-4155Monodelphis domestica78.640.0 673
LLPS-Icp-0151Ictalurus punctatus78.556e-178 511
LLPS-Gaga-3089Gallus gallus78.50.0 647
LLPS-Dar-1854Danio rerio78.363e-178 511
LLPS-Scm-1463Scophthalmus maximus74.141e-50 174
LLPS-Orn-0221Oreochromis niloticus69.351e-152 443
LLPS-Sah-2136Sarcophilus harrisii69.332e-171 491
LLPS-Ten-2217Tetraodon nigroviridis68.981e-153 446
LLPS-Tar-3684Takifugu rubripes67.882e-58 196
LLPS-Gaa-3464Gasterosteus aculeatus67.812e-151 441
LLPS-Pof-2277Poecilia formosa66.237e-149 434
LLPS-Orl-4096Oryzias latipes65.831e-152 444
LLPS-Xim-1482Xiphophorus maculatus63.143e-157 459
LLPS-Anc-0251Anolis carolinensis61.994e-71 228
LLPS-Spr-1574Sporisorium reilianum57.233e-53 193
LLPS-Usm-1434Ustilago maydis55.236e-51 186
LLPS-Asg-1337Ashbya gossypii51.222e-42 161
LLPS-Asf-1540Aspergillus flavus50.816e-33 134
LLPS-Aso-1519Aspergillus oryzae50.816e-33 134
LLPS-Scs-0721Sclerotinia sclerotiorum50.431e-29 123
LLPS-Cii-1309Ciona intestinalis47.886e-90 284
LLPS-Drm-1921Drosophila melanogaster47.811e-88 283
LLPS-Sac-0203Saccharomyces cerevisiae46.076e-45 168
LLPS-Zyt-1185Zymoseptoria tritici45.381e-28 121
LLPS-Blg-1023Blumeria graminis45.324e-29 122
LLPS-Beb-0396Beauveria bassiana44.654e-33 134
LLPS-Dos-1144Dothistroma septosporum44.623e-39 152
LLPS-Cis-2041Ciona savignyi43.632e-83 264
LLPS-Scj-1475Schizosaccharomyces japonicus42.92e-89 284
LLPS-Tum-1328Tuber melanosporum42.865e-79 256
LLPS-Scc-0198Schizosaccharomyces cryophilus40.211e-85 275
LLPS-Pug-1090Puccinia graminis39.366e-82 265
LLPS-Abg-0870Absidia glauca39.233e-85 275
LLPS-Put-0489Puccinia triticina39.12e-70 232
LLPS-Scp-1541Schizosaccharomyces pombe38.931e-83 269
LLPS-Nec-1365Neurospora crassa38.914e-40 154
LLPS-Miv-1493Microbotryum violaceum38.321e-78 262
LLPS-Mel-0754Melampsora laricipopulina38.11e-85 273
LLPS-Php-0507Physcomitrella patens38.089e-68 228
LLPS-Asni-0498Aspergillus niger38.051e-74 248
LLPS-Asc-0338Aspergillus clavatus37.95e-70 236
LLPS-Yal-1486Yarrowia lipolytica37.744e-81 266
LLPS-Dac-1342Daucus carota37.76e-68 229
LLPS-Asn-1316Aspergillus nidulans37.661e-73 246
LLPS-Kop-1476Komagataella pastoris37.531e-78 259
LLPS-Sot-0833Solanum tuberosum37.32e-61 211
LLPS-Sem-2243Selaginella moellendorffii37.294e-63 213
LLPS-Met-1918Medicago truncatula37.272e-66 224
LLPS-Ast-1212Aspergillus terreus37.252e-67 229
LLPS-Glm-0650Glycine max37.126e-67 226
LLPS-Bro-0182Brassica oleracea37.114e-67 226
LLPS-Cus-2086Cucumis sativus37.18e-70 233
LLPS-Orbr-0589Oryza brachyantha36.892e-67 226
LLPS-Gor-0984Gossypium raimondii36.892e-64 219
LLPS-Orb-0696Oryza barthii36.722e-58 206
LLPS-Cogr-1501Colletotrichum graminicola36.633e-71 239
LLPS-Hea-0195Helianthus annuus36.615e-67 226
LLPS-Brn-2306Brassica napus36.515e-67 226
LLPS-Orgl-1646Oryza glumaepatula36.489e-53 188
LLPS-Orr-0104Oryza rufipogon36.487e-53 189
LLPS-Mua-2368Musa acuminata36.468e-61 208
LLPS-Orp-1654Oryza punctata36.348e-67 225
LLPS-Lep-0410Leersia perrieri36.246e-51 183
LLPS-Brr-2274Brassica rapa36.241e-66 225
LLPS-Ori-1898Oryza indica36.124e-65 221
LLPS-Ors-1813Oryza sativa36.124e-65 221
LLPS-Org-0710Oryza glaberrima36.124e-65 221
LLPS-Asfu-1428Aspergillus fumigatus36.13e-67 229
LLPS-Fuv-0270Fusarium verticillioides36.01e-75 251
LLPS-Fuo-0455Fusarium oxysporum36.02e-75 251
LLPS-Nia-2631Nicotiana attenuata35.972e-46 172
LLPS-Fus-1426Fusarium solani35.942e-76 253
LLPS-Nef-1004Neosartorya fischeri35.872e-66 227
LLPS-Mae-1476Manihot esculenta35.713e-61 211
LLPS-Via-2403Vigna angularis35.69e-63 214
LLPS-Phn-1492Phaeosphaeria nodorum35.569e-69 229
LLPS-Art-1947Arabidopsis thaliana35.542e-62 214
LLPS-Trv-1426Trichoderma virens35.521e-66 226
LLPS-Cae-1950Caenorhabditis elegans35.512e-68 228
LLPS-Gag-0929Gaeumannomyces graminis35.414e-74 246
LLPS-Pot-1272Populus trichocarpa35.377e-60 207
LLPS-Crn-1104Cryptococcus neoformans35.179e-66 225
LLPS-Pytr-0012Pyrenophora triticirepentis35.141e-66 224
LLPS-Arl-2694Arabidopsis lyrata35.014e-62 213
LLPS-Coo-1437Colletotrichum orbiculare34.954e-73 244
LLPS-Tra-0881Triticum aestivum34.891e-63 216
LLPS-Tru-2041Triticum urartu34.82e-55 204
LLPS-Mao-1381Magnaporthe oryzae34.731e-72 243
LLPS-Brd-2298Brachypodium distachyon34.64e-63 215
LLPS-Hov-1684Hordeum vulgare34.436e-64 218
LLPS-Pyt-0084Pyrenophora teres34.46e-71 239
LLPS-Trr-1603Trichoderma reesei34.353e-68 230
LLPS-Amt-1973Amborella trichopoda34.332e-57 201
LLPS-Cog-1075Colletotrichum gloeosporioides33.992e-57 201
LLPS-Sol-0530Solanum lycopersicum33.958e-58 207
LLPS-Viv-0586Vitis vinifera33.783e-54 192
LLPS-Phv-2286Phaseolus vulgaris33.734e-34 134
LLPS-Thc-1686Theobroma cacao33.599e-59 204
LLPS-Sei-1830Setaria italica33.427e-63 214
LLPS-Prp-1274Prunus persica33.046e-60 207
LLPS-Ved-0993Verticillium dahliae32.712e-62 216
LLPS-Vir-1900Vigna radiata31.983e-44 163
LLPS-Chc-1203Chondrus crispus31.335e-44 162
LLPS-Cym-1084Cyanidioschyzon merolae31.211e-44 165
LLPS-Map-0987Magnaporthe poae29.826e-36 142