LLPS-Orl-4096
pisd
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Phosphatidylserine decarboxylase proenzyme, mitochondrial |
| Gene Name: | pisd, PISD |
| Ensembl Gene: | ENSORLG00000019626.2 |
| Ensembl Protein: | ENSORLP00000024412.2 |
| Organism: | Oryzias latipes |
| Taxa ID: | 8090 |
| LLPS Type: | Regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSORLT00000024413.2 | ENSORLP00000024412.2 |
| Ensembl | ENSORLT00000024409.2 | ENSORLP00000024408.2 |
| UniProt | H2MZC2, H2MZC2_ORYLA | |
| RefSeq | XM_004084567.2 | XP_004084615.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MRAYIISADS MAAALRRLIS GGRVVCRTCW QRSLSTGRGL IPRPRPFALL LGTGGGYLGY 60 61 QHYKKKFQQD EETSPHLATP TQVALYRSFP TRFLSRAWGR LNEMNLPTWL RKPIYSLYIW 120 121 TFGVNMQEAA VEDLHHYRNL GEFFRRRLKP AVRPVCAASH LTSPADGKIL HFGRVKNSEV 180 181 EQVKGVTYSL EHFLGPQSME QLDSSSSFRD VLLSSPDSDL FHVVVYLAPG DYHCFHSPAD 240 241 WKVELRRHFP GSLMSVNPGV ARWVKELFCL NERVVLSGQW QHGFFSLTAV GATNVGSIRL 300 301 YFDQELQTNA PRYRKGSFYD RSYVATGNQV LQRTSEGGVA LQKGEAIGEF NLGSTIVLLF 360 361 EAPKDFVFKL QPGQRIRVGE GLGAH 385 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCGTGCTT ACATCATATC CGCAGACAGC ATGGCGGCGG CGCTCCGGAG GCTCATTAGC 60 61 GGCGGCAGAG TTGTGTGTCG GACCTGCTGG CAGCGCAGCC TGAGCACAGG GCGGGGCCTC 120 121 ATTCCCCGCC CCCGGCCCTT TGCTCTCCTG TTAGGGACTG GGGGTGGTTA TCTTGGCTAC 180 181 CAGCACTACA AGAAGAAGTT TCAACAGGAT GAGGAAACGT CACCCCATTT GGCCACACCC 240 241 ACACAGGTGG CGTTGTACCG CTCCTTTCCA ACTCGTTTCC TCTCCCGAGC CTGGGGTCGT 300 301 CTAAACGAGA TGAATCTACC CACATGGCTC AGGAAACCCA TCTACTCTCT GTACATCTGG 360 361 ACGTTTGGAG TCAATATGCA GGAAGCAGCG GTTGAAGACT TGCATCATTA TAGAAATCTA 420 421 GGAGAATTTT TCCGGCGGCG CCTCAAACCT GCTGTCCGCC CTGTATGTGC GGCCTCCCAC 480 481 CTGACATCTC CAGCTGATGG AAAGATTCTC CATTTTGGTC GTGTGAAGAA CTCTGAAGTG 540 541 GAACAAGTTA AAGGTGTCAC CTATAGTCTG GAGCACTTCC TGGGTCCACA GTCCATGGAA 600 601 CAACTGGATT CATCCTCATC TTTTCGGGAC GTCCTGCTGT CGTCTCCTGA CAGTGACCTT 660 661 TTCCACGTGG TGGTTTACCT GGCTCCTGGG GACTATCACT GCTTCCATTC CCCTGCTGAC 720 721 TGGAAGGTGG AGCTCCGGCG GCACTTCCCA GGCTCGTTGA TGTCTGTGAA CCCGGGTGTG 780 781 GCTCGCTGGG TCAAAGAACT GTTCTGCCTG AATGAGCGTG TGGTGTTGAG CGGCCAATGG 840 841 CAGCACGGTT TCTTCTCACT GACGGCAGTT GGTGCCACAA ATGTGGGTTC CATCAGACTG 900 901 TATTTTGACC AGGAGCTGCA GACCAACGCT CCCCGCTACA GGAAAGGCTC CTTCTATGAC 960 961 CGCAGCTATG TTGCCACGGG CAACCAGGTC TTGCAGAGGA CAAGTGAAGG AGGTGTGGCC 1020 1021 TTACAAAAAG CCAGGACAGC GAATCAGAGT GGGCGAAGGC CTCGGCGCCC ACTGAGGACT 1080 1081 GAAGGCTCCA CGCTTCAGAG GCACAAGAAG GCCATGATGT GA 1122 |
▼ KEYWORD
ID | Family |
Complete proteome | |
Decarboxylase | |
Lipid biosynthesis | |
Lipid metabolism | |
Lyase | |
Membrane | |
Mitochondrion | |
Mitochondrion inner membrane | |
Phospholipid biosynthesis | |
Phospholipid metabolism | |
Pyruvate | |
Reference proteome | |
Transmembrane | |
Transmembrane helix | |
Zymogen
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Integral component of mitochondrial inner membrane | |
Cellular Component | Mitochondrion | |
Molecular Function | Phosphatidylserine decarboxylase activity | |
Biological Process | Phosphatidylethanolamine biosynthetic process | |
Biological Process | Protein autoprocessing |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Orn-0221 | Oreochromis niloticus | 85.57 | 0.0 | 519 |
| LLPS-Pof-2277 | Poecilia formosa | 85.1 | 1e-180 | 514 |
| LLPS-Tar-3684 | Takifugu rubripes | 83.06 | 3e-67 | 218 |
| LLPS-Ten-2217 | Tetraodon nigroviridis | 82.85 | 2e-176 | 503 |
| LLPS-Scm-1463 | Scophthalmus maximus | 80.17 | 3e-58 | 193 |
| LLPS-Xim-1482 | Xiphophorus maculatus | 79.21 | 0.0 | 568 |
| LLPS-Gaa-3464 | Gasterosteus aculeatus | 78.06 | 2e-171 | 491 |
| LLPS-Scf-3146 | Scleropages formosus | 71.61 | 4e-156 | 452 |
| LLPS-Asm-3205 | Astyanax mexicanus | 69.77 | 3e-152 | 444 |
| LLPS-Xet-1684 | Xenopus tropicalis | 69.51 | 1e-152 | 444 |
| LLPS-Leo-1839 | Lepisosteus oculatus | 69.13 | 1e-152 | 443 |
| LLPS-Icp-0151 | Ictalurus punctatus | 69.03 | 3e-151 | 442 |
| LLPS-Dar-1854 | Danio rerio | 68.49 | 2e-153 | 447 |
| LLPS-Cap-1816 | Cavia porcellus | 68.39 | 1e-146 | 429 |
| LLPS-Ora-2313 | Ornithorhynchus anatinus | 68.39 | 8e-151 | 438 |
| LLPS-Eqc-3732 | Equus caballus | 68.15 | 4e-150 | 438 |
| LLPS-Lac-2857 | Latimeria chalumnae | 67.92 | 3e-153 | 452 |
| LLPS-Orc-0596 | Oryctolagus cuniculus | 67.74 | 1e-147 | 432 |
| LLPS-Fia-0834 | Ficedula albicollis | 67.74 | 7e-151 | 439 |
| LLPS-Mup-3379 | Mustela putorius furo | 67.74 | 2e-147 | 429 |
| LLPS-Sus-4646 | Sus scrofa | 67.74 | 2e-147 | 431 |
| LLPS-Anp-2220 | Anas platyrhynchos | 67.63 | 2e-147 | 432 |
| LLPS-Gaga-3089 | Gallus gallus | 67.52 | 3e-151 | 441 |
| LLPS-Ict-3372 | Ictidomys tridecemlineatus | 67.4 | 6e-148 | 432 |
| LLPS-Fec-1834 | Felis catus | 67.4 | 2e-150 | 439 |
| LLPS-Cas-3654 | Carlito syrichta | 66.77 | 9e-150 | 437 |
| LLPS-Paa-3921 | Papio anubis | 66.77 | 6e-149 | 435 |
| LLPS-Aim-3256 | Ailuropoda melanoleuca | 66.77 | 3e-149 | 436 |
| LLPS-Fud-3645 | Fukomys damarensis | 66.77 | 3e-149 | 435 |
| LLPS-Caj-3700 | Callithrix jacchus | 66.77 | 2e-145 | 426 |
| LLPS-Poa-1890 | Pongo abelii | 66.46 | 2e-148 | 434 |
| LLPS-Mam-1894 | Macaca mulatta | 66.46 | 4e-148 | 432 |
| LLPS-Man-4433 | Macaca nemestrina | 66.46 | 4e-148 | 433 |
| LLPS-Mal-3234 | Mandrillus leucophaeus | 66.46 | 4e-148 | 433 |
| LLPS-Maf-1246 | Macaca fascicularis | 66.46 | 5e-148 | 432 |
| LLPS-Mum-4884 | Mus musculus | 66.46 | 1e-147 | 431 |
| LLPS-Chs-1613 | Chlorocebus sabaeus | 66.46 | 4e-148 | 432 |
| LLPS-Aon-1582 | Aotus nancymaae | 66.46 | 1e-147 | 432 |
| LLPS-Cea-2577 | Cercocebus atys | 66.46 | 4e-148 | 432 |
| LLPS-Rhb-2623 | Rhinopithecus bieti | 66.14 | 2e-147 | 431 |
| LLPS-Hos-4056 | Homo sapiens | 66.14 | 4e-147 | 430 |
| LLPS-Pat-1873 | Pan troglodytes | 66.14 | 9e-148 | 432 |
| LLPS-Pap-3116 | Pan paniscus | 66.14 | 1e-147 | 432 |
| LLPS-Gog-2690 | Gorilla gorilla | 66.14 | 9e-148 | 432 |
| LLPS-Caf-2049 | Canis familiaris | 65.83 | 4e-149 | 435 |
| LLPS-Otg-4405 | Otolemur garnettii | 65.83 | 1e-147 | 432 |
| LLPS-Tut-2297 | Tursiops truncatus | 65.66 | 5e-149 | 435 |
| LLPS-Ran-2115 | Rattus norvegicus | 65.52 | 5e-145 | 425 |
| LLPS-Dio-1745 | Dipodomys ordii | 65.24 | 7e-149 | 439 |
| LLPS-Myl-2408 | Myotis lucifugus | 64.77 | 1e-151 | 442 |
| LLPS-Pes-3056 | Pelodiscus sinensis | 64.37 | 4e-148 | 431 |
| LLPS-Tag-2618 | Taeniopygia guttata | 63.87 | 4e-151 | 439 |
| LLPS-Map-0987 | Magnaporthe poae | 63.86 | 1e-26 | 114 |
| LLPS-Mod-4155 | Monodelphis domestica | 63.1 | 4e-147 | 432 |
| LLPS-Loa-4192 | Loxodonta africana | 62.93 | 8e-131 | 387 |
| LLPS-Ova-0369 | Ovis aries | 62.38 | 5e-131 | 389 |
| LLPS-Anc-0251 | Anolis carolinensis | 60.29 | 5e-48 | 167 |
| LLPS-Spr-1574 | Sporisorium reilianum | 54.82 | 7e-48 | 177 |
| LLPS-Miv-1493 | Microbotryum violaceum | 53.61 | 3e-47 | 175 |
| LLPS-Pytr-0012 | Pyrenophora triticirepentis | 53.21 | 4e-30 | 124 |
| LLPS-Usm-1434 | Ustilago maydis | 53.01 | 1e-46 | 173 |
| LLPS-Ast-1212 | Aspergillus terreus | 52.99 | 6e-31 | 127 |
| LLPS-Phn-1492 | Phaeosphaeria nodorum | 52.29 | 2e-29 | 122 |
| LLPS-Asfu-1428 | Aspergillus fumigatus | 52.14 | 2e-31 | 129 |
| LLPS-Nef-1004 | Neosartorya fischeri | 52.14 | 3e-31 | 128 |
| LLPS-Asn-1316 | Aspergillus nidulans | 52.03 | 3e-32 | 131 |
| LLPS-Asg-1337 | Ashbya gossypii | 51.48 | 8e-46 | 170 |
| LLPS-Asf-1540 | Aspergillus flavus | 51.28 | 3e-30 | 125 |
| LLPS-Aso-1519 | Aspergillus oryzae | 51.28 | 3e-30 | 125 |
| LLPS-Asc-0338 | Aspergillus clavatus | 51.28 | 2e-30 | 125 |
| LLPS-Sac-0203 | Saccharomyces cerevisiae | 51.18 | 3e-46 | 171 |
| LLPS-Asni-0498 | Aspergillus niger | 50.83 | 5e-31 | 127 |
| LLPS-Scs-0721 | Sclerotinia sclerotiorum | 50.43 | 1e-28 | 120 |
| LLPS-Crn-1104 | Cryptococcus neoformans | 49.58 | 1e-26 | 114 |
| LLPS-Pyt-0084 | Pyrenophora teres | 49.57 | 2e-29 | 122 |
| LLPS-Drm-1921 | Drosophila melanogaster | 48.92 | 8e-94 | 295 |
| LLPS-Blg-1023 | Blumeria graminis | 48.72 | 9e-28 | 118 |
| LLPS-Coo-1437 | Colletotrichum orbiculare | 48.72 | 9e-31 | 126 |
| LLPS-Sah-2136 | Sarcophilus harrisii | 48.5 | 1e-87 | 277 |
| LLPS-Cogr-1501 | Colletotrichum graminicola | 47.86 | 3e-30 | 125 |
| LLPS-Fuo-0455 | Fusarium oxysporum | 47.86 | 6e-30 | 124 |
| LLPS-Beb-0396 | Beauveria bassiana | 47.86 | 1e-28 | 120 |
| LLPS-Fuv-0270 | Fusarium verticillioides | 47.86 | 5e-30 | 124 |
| LLPS-Zyt-1185 | Zymoseptoria tritici | 47.5 | 2e-27 | 117 |
| LLPS-Dos-1144 | Dothistroma septosporum | 47.06 | 2e-26 | 114 |
| LLPS-Trv-1426 | Trichoderma virens | 47.01 | 2e-28 | 119 |
| LLPS-Gag-0929 | Gaeumannomyces graminis | 47.01 | 3e-28 | 119 |
| LLPS-Ved-0993 | Verticillium dahliae | 46.67 | 2e-29 | 123 |
| LLPS-Nec-1365 | Neurospora crassa | 46.67 | 4e-29 | 122 |
| LLPS-Trr-1603 | Trichoderma reesei | 46.32 | 9e-39 | 150 |
| LLPS-Cii-1309 | Ciona intestinalis | 44.84 | 1e-85 | 272 |
| LLPS-Cis-2041 | Ciona savignyi | 42.95 | 2e-79 | 253 |
| LLPS-Thc-1686 | Theobroma cacao | 42.78 | 4e-40 | 153 |
| LLPS-Tum-1328 | Tuber melanosporum | 41.44 | 2e-75 | 245 |
| LLPS-Put-0489 | Puccinia triticina | 40.35 | 2e-69 | 228 |
| LLPS-Cae-1950 | Caenorhabditis elegans | 39.87 | 1e-68 | 228 |
| LLPS-Scj-1475 | Schizosaccharomyces japonicus | 39.11 | 5e-76 | 248 |
| LLPS-Glm-0650 | Glycine max | 39.07 | 1e-62 | 214 |
| LLPS-Bro-0182 | Brassica oleracea | 38.87 | 4e-64 | 218 |
| LLPS-Brr-2274 | Brassica rapa | 38.87 | 6e-64 | 217 |
| LLPS-Brn-2306 | Brassica napus | 38.87 | 6e-64 | 217 |
| LLPS-Pug-1090 | Puccinia graminis | 38.85 | 9e-77 | 251 |
| LLPS-Met-1918 | Medicago truncatula | 38.74 | 4e-65 | 220 |
| LLPS-Mua-2368 | Musa acuminata | 38.66 | 6e-61 | 208 |
| LLPS-Prp-1274 | Prunus persica | 38.48 | 1e-58 | 202 |
| LLPS-Mel-0754 | Melampsora laricipopulina | 38.4 | 1e-81 | 263 |
| LLPS-Dac-1342 | Daucus carota | 38.3 | 3e-63 | 215 |
| LLPS-Lep-0410 | Leersia perrieri | 38.16 | 2e-49 | 178 |
| LLPS-Orr-0104 | Oryza rufipogon | 38.08 | 6e-53 | 188 |
| LLPS-Orgl-1646 | Oryza glumaepatula | 38.08 | 6e-53 | 188 |
| LLPS-Orb-0696 | Oryza barthii | 37.92 | 1e-56 | 201 |
| LLPS-Orp-1654 | Oryza punctata | 37.71 | 2e-64 | 218 |
| LLPS-Scc-0198 | Schizosaccharomyces cryophilus | 37.67 | 5e-71 | 235 |
| LLPS-Arl-2694 | Arabidopsis lyrata | 37.57 | 2e-59 | 206 |
| LLPS-Via-2403 | Vigna angularis | 37.57 | 4e-60 | 207 |
| LLPS-Hea-0195 | Helianthus annuus | 37.5 | 2e-62 | 213 |
| LLPS-Art-1947 | Arabidopsis thaliana | 37.35 | 5e-60 | 207 |
| LLPS-Sol-0530 | Solanum lycopersicum | 37.32 | 2e-55 | 199 |
| LLPS-Sot-0833 | Solanum tuberosum | 37.28 | 1e-56 | 198 |
| LLPS-Org-0710 | Oryza glaberrima | 37.19 | 1e-62 | 214 |
| LLPS-Ors-1813 | Oryza sativa | 37.19 | 1e-62 | 214 |
| LLPS-Ori-1898 | Oryza indica | 37.19 | 1e-62 | 214 |
| LLPS-Viv-0586 | Vitis vinifera | 37.13 | 5e-53 | 187 |
| LLPS-Php-0507 | Physcomitrella patens | 37.09 | 4e-60 | 207 |
| LLPS-Pot-1272 | Populus trichocarpa | 37.07 | 2e-60 | 207 |
| LLPS-Mae-1476 | Manihot esculenta | 36.86 | 9e-61 | 209 |
| LLPS-Yal-1486 | Yarrowia lipolytica | 36.78 | 2e-78 | 258 |
| LLPS-Scp-1541 | Schizosaccharomyces pombe | 36.65 | 1e-70 | 234 |
| LLPS-Sem-2243 | Selaginella moellendorffii | 36.52 | 5e-62 | 210 |
| LLPS-Abg-0870 | Absidia glauca | 36.5 | 5e-71 | 237 |
| LLPS-Gor-0984 | Gossypium raimondii | 36.49 | 2e-62 | 213 |
| LLPS-Nia-2631 | Nicotiana attenuata | 36.42 | 6e-45 | 167 |
| LLPS-Tru-2041 | Triticum urartu | 36.31 | 1e-54 | 201 |
| LLPS-Orbr-0589 | Oryza brachyantha | 36.21 | 7e-61 | 209 |
| LLPS-Hov-1684 | Hordeum vulgare | 36.01 | 2e-60 | 208 |
| LLPS-Sei-1830 | Setaria italica | 35.77 | 5e-59 | 204 |
| LLPS-Vir-1900 | Vigna radiata | 35.56 | 2e-45 | 166 |
| LLPS-Tra-0881 | Triticum aestivum | 35.46 | 2e-59 | 204 |
| LLPS-Cus-2086 | Cucumis sativus | 35.34 | 1e-63 | 216 |
| LLPS-Brd-2298 | Brachypodium distachyon | 35.33 | 3e-60 | 207 |
| LLPS-Fus-1426 | Fusarium solani | 35.15 | 9e-63 | 216 |
| LLPS-Mao-1381 | Magnaporthe oryzae | 35.15 | 1e-64 | 221 |
| LLPS-Phv-2286 | Phaseolus vulgaris | 34.53 | 2e-31 | 126 |
| LLPS-Amt-1973 | Amborella trichopoda | 34.42 | 5e-53 | 189 |
| LLPS-Kop-1476 | Komagataella pastoris | 34.38 | 7e-73 | 243 |
| LLPS-Chc-1203 | Chondrus crispus | 32.78 | 1e-39 | 150 |
| LLPS-Cog-1075 | Colletotrichum gloeosporioides | 32.56 | 1e-53 | 190 |
| LLPS-Cym-1084 | Cyanidioschyzon merolae | 31.91 | 9e-45 | 164 |