• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Gog-2690
PISD

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Phosphatidylserine decarboxylase proenzyme, mitochondrial
Gene Name: PISD
Ensembl Gene: ENSGGOG00000007841.3
Ensembl Protein: ENSGGOP00000051068.1
Organism: Gorilla gorilla
Taxa ID: 9595
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MATSVGHRCL  GLLHGVAPWR  SSLHPCEITA  LSQSLQPLRK  LPFRAFRTDA  RKIHTAPART  60
61    MFLLRPLPIL  LATGGGYAGY  RQYEKYRERE  LEKLGLEIPP  KLAGHWEVAL  YKSVPTRLLS  120
121   RAWGRLNQVE  LPHWLRRPVY  SLYIWTFGVN  MKEAAVEDLH  HYRNLSEFFR  RKLKPQARPV  180
181   CGLHSVISPS  DGRILNFGQV  KNCEVEQVKG  VTYSLESFLG  PRTCTEDLPF  PPAASCDSFK  240
241   NQLVTREGNE  LYHCVIYLAP  GDYHCFHSPT  DWTVSHRRHF  PGSLMSVNPG  MARWIKELFC  300
301   HNERVVLTGD  WKHGFFSLTA  VGATNVGSIR  IYFDRDLHTN  SPRHSKGSYN  DFSFVTHTNR  360
361   EGVPMRKGEH  LGEFNLGSTI  VLIFEAPKDF  NFQLKTGQKI  RFGEALGSL  409
Nucleotide CDS Sequence (FASTA)
1     ATGGCGACGT  CCGTGGGGCA  CCGATGCCTG  GGATTACTGC  ACGGGGTCGC  GCCGTGGCGG  60
61    AGCAGCCTCC  ATCCCTGTGA  GATCACTGCC  CTGAGCCAAT  CCCTACAGCC  CTTACGGAAG  120
121   CTGCCTTTTA  GAGCCTTTCG  CACAGATGCC  AGAAAAATCC  ACACTGCCCC  TGCCCGAACC  180
181   ATGTTCCTGC  TGCGTCCCCT  GCCCATTCTG  TTGGCGACAG  GTGGCGGGTA  TGCAGGGTAC  240
241   CGGCAGTATG  AGAAGTACAG  GGAGCGAGAG  CTGGAGAAGC  TGGGATTGGA  GATTCCACCC  300
301   AAACTTGCTG  GTCACTGGGA  GGTGGCTTTG  TACAAGTCAG  TGCCAACGCG  CTTGCTGTCA  360
361   CGGGCCTGGG  GTCGCCTCAA  TCAGGTGGAG  CTGCCACACT  GGCTGCGCAG  GCCTGTCTAC  420
421   AGCCTGTACA  TCTGGACGTT  TGGGGTGAAC  ATGAAAGAGG  CCGCTGTGGA  GGACCTGCAT  480
481   CACTACCGCA  ACCTCAGCGA  GTTCTTCCGG  CGCAAGCTGA  AGCCGCAGGC  CCGGCCTGTC  540
541   TGTGGCCTGC  ACAGCGTGAT  TAGCCCATCG  GATGGAAGGA  TCCTCAACTT  TGGGCAGGTG  600
601   AAGAACTGTG  AGGTGGAGCA  GGTAAAGGGG  GTCACCTACT  CCCTGGAGTC  GTTCCTGGGC  660
661   CCGCGTACCT  GCACAGAGGA  CCTGCCCTTC  CCCCCAGCCG  CGTCGTGTGA  CTCCTTCAAG  720
721   AACCAGCTGG  TCACCCGGGA  AGGGAATGAG  CTCTATCACT  GTGTTATCTA  CCTGGCCCCT  780
781   GGGGACTACC  ACTGCTTCCA  CTCCCCCACC  GACTGGACTG  TCTCCCACCG  GCGCCACTTC  840
841   CCAGGCTCCC  TGATGTCAGT  GAACCCTGGC  ATGGCTCGCT  GGATCAAAGA  GCTCTTCTGC  900
901   CATAACGAGC  GGGTGGTCCT  GACGGGGGAC  TGGAAACATG  GCTTCTTCTC  ACTGACAGCT  960
961   GTGGGGGCCA  CCAACGTGGG  CTCCATTCGC  ATCTACTTTG  ACCGGGACCT  GCACACAAAC  1020
1021  AGCCCAAGGC  ACAGCAAGGG  CTCCTACAAT  GACTTCAGCT  TCGTGACGCA  CACCAACAGA  1080
1081  GAGGGCGTCC  CCATGCGTAA  GGGCGAGCAC  CTGGGCGAGT  TCAACCTGGG  CTCCACCATC  1140
1141  GTGCTCATCT  TCGAGGCCCC  CAAGGACTTC  AATTTCCAGC  TGAAAACAGG  ACAGAAAATC  1200
1201  CGCTTTGGGG  AAGCCCTGGG  CTCGCTCTAG  1230

▼ KEYWORD

ID
Family
Complete proteome
Decarboxylase
Lipid biosynthesis
Lipid metabolism
Lyase
Membrane
Mitochondrion
Mitochondrion inner membrane
Phospholipid biosynthesis
Phospholipid metabolism
Pyruvate
Reference proteome
Transmembrane
Transmembrane helix
Zymogen

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Integral component of mitochondrial inner membrane
Cellular Component
Mitochondrion
Molecular Function
Phosphatidylserine decarboxylase activity
Biological Process
Phosphatidylethanolamine biosynthetic process
Biological Process
Protein autoprocessing

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pat-1873Pan troglodytes100.00.0 849
LLPS-Pap-3116Pan paniscus99.760.0 846
LLPS-Caj-3700Callithrix jacchus99.670.0 628
LLPS-Hos-4056Homo sapiens99.510.0 847
LLPS-Poa-1890Pongo abelii99.270.0 846
LLPS-Rhb-2623Rhinopithecus bieti97.80.0 821
LLPS-Maf-1246Macaca fascicularis97.80.0 826
LLPS-Mam-1894Macaca mulatta97.560.0 822
LLPS-Chs-1613Chlorocebus sabaeus97.560.0 822
LLPS-Cea-2577Cercocebus atys97.560.0 822
LLPS-Man-4433Macaca nemestrina97.310.0 820
LLPS-Mal-3234Mandrillus leucophaeus97.310.0 820
LLPS-Paa-3921Papio anubis97.070.0 817
LLPS-Aon-1582Aotus nancymaae96.820.0 818
LLPS-Cap-1816Cavia porcellus96.030.0 607
LLPS-Mup-3379Mustela putorius furo95.70.0 608
LLPS-Orc-0596Oryctolagus cuniculus94.370.0 597
LLPS-Sus-4646Sus scrofa94.370.0 600
LLPS-Dio-1745Dipodomys ordii93.820.0 709
LLPS-Fud-3645Fukomys damarensis93.440.0 744
LLPS-Cas-3654Carlito syrichta93.150.0 791
LLPS-Otg-4405Otolemur garnettii92.420.0 785
LLPS-Ora-2313Ornithorhynchus anatinus92.050.0 589
LLPS-Caf-2049Canis familiaris91.440.0 779
LLPS-Fec-1834Felis catus91.440.0 773
LLPS-Ict-3372Ictidomys tridecemlineatus90.950.0 769
LLPS-Eqc-3732Equus caballus90.220.0 766
LLPS-Aim-3256Ailuropoda melanoleuca89.930.0 742
LLPS-Anp-2220Anas platyrhynchos89.80.0 566
LLPS-Myl-2408Myotis lucifugus89.760.0 761
LLPS-Tut-2297Tursiops truncatus89.730.0 748
LLPS-Fia-0834Ficedula albicollis89.40.0 575
LLPS-Loa-4192Loxodonta africana86.150.0 634
LLPS-Mum-4884Mus musculus84.910.0 709
LLPS-Ran-2115Rattus norvegicus84.840.0 712
LLPS-Tag-2618Taeniopygia guttata83.980.0 648
LLPS-Leo-1839Lepisosteus oculatus83.880.0 532
LLPS-Xet-1684Xenopus tropicalis83.770.0 528
LLPS-Ova-0369Ovis aries83.740.0 688
LLPS-Gaga-3089Gallus gallus83.290.0 650
LLPS-Pes-3056Pelodiscus sinensis82.420.0 630
LLPS-Scf-3146Scleropages formosus81.790.0 531
LLPS-Asm-3205Astyanax mexicanus78.881e-177 509
LLPS-Mod-4155Monodelphis domestica78.640.0 683
LLPS-Icp-0151Ictalurus punctatus78.551e-177 510
LLPS-Dar-1854Danio rerio77.567e-178 510
LLPS-Lac-2857Latimeria chalumnae76.590.0 619
LLPS-Scm-1463Scophthalmus maximus75.862e-52 179
LLPS-Orn-0221Oreochromis niloticus70.239e-153 444
LLPS-Ten-2217Tetraodon nigroviridis69.645e-154 447
LLPS-Sah-2136Sarcophilus harrisii69.075e-173 496
LLPS-Tar-3684Takifugu rubripes68.612e-59 199
LLPS-Gaa-3464Gasterosteus aculeatus67.817e-150 437
LLPS-Pof-2277Poecilia formosa67.217e-151 439
LLPS-Orl-4096Oryzias latipes66.142e-152 444
LLPS-Xim-1482Xiphophorus maculatus63.712e-158 462
LLPS-Anc-0251Anolis carolinensis63.164e-71 228
LLPS-Spr-1574Sporisorium reilianum55.818e-53 192
LLPS-Usm-1434Ustilago maydis53.81e-50 185
LLPS-Asf-1540Aspergillus flavus51.615e-33 134
LLPS-Aso-1519Aspergillus oryzae51.615e-33 134
LLPS-Scs-0721Sclerotinia sclerotiorum51.32e-30 125
LLPS-Sac-0203Saccharomyces cerevisiae48.098e-45 167
LLPS-Cii-1309Ciona intestinalis47.392e-90 286
LLPS-Dos-1144Dothistroma septosporum47.123e-41 158
LLPS-Drm-1921Drosophila melanogaster46.391e-90 288
LLPS-Zyt-1185Zymoseptoria tritici46.353e-42 160
LLPS-Cis-2041Ciona savignyi44.594e-84 266
LLPS-Beb-0396Beauveria bassiana44.334e-41 157
LLPS-Blg-1023Blumeria graminis44.041e-37 147
LLPS-Tum-1328Tuber melanosporum43.143e-82 264
LLPS-Scj-1475Schizosaccharomyces japonicus42.92e-88 281
LLPS-Put-0489Puccinia triticina40.01e-70 233
LLPS-Scc-0198Schizosaccharomyces cryophilus39.957e-85 272
LLPS-Pug-1090Puccinia graminis39.891e-82 267
LLPS-Scp-1541Schizosaccharomyces pombe39.399e-85 272
LLPS-Mel-0754Melampsora laricipopulina39.17e-88 280
LLPS-Asn-1316Aspergillus nidulans39.021e-73 246
LLPS-Abg-0870Absidia glauca38.986e-84 271
LLPS-Miv-1493Microbotryum violaceum38.831e-80 267
LLPS-Asni-0498Aspergillus niger38.546e-76 252
LLPS-Prp-1274Prunus persica38.516e-60 207
LLPS-Asc-0338Aspergillus clavatus38.142e-70 238
LLPS-Gor-0984Gossypium raimondii37.981e-64 219
LLPS-Cae-1950Caenorhabditis elegans37.981e-67 226
LLPS-Ast-1212Aspergillus terreus37.752e-67 230
LLPS-Dac-1342Daucus carota37.673e-67 227
LLPS-Bro-0182Brassica oleracea37.576e-68 228
LLPS-Met-1918Medicago truncatula37.579e-66 223
LLPS-Sot-0833Solanum tuberosum37.573e-60 208
LLPS-Sol-0530Solanum lycopersicum37.571e-57 206
LLPS-Brn-2306Brassica napus37.578e-68 228
LLPS-Hea-0195Helianthus annuus37.433e-67 226
LLPS-Cogr-1501Colletotrichum graminicola37.389e-73 243
LLPS-Nia-2631Nicotiana attenuata37.383e-48 177
LLPS-Brr-2274Brassica rapa37.144e-67 226
LLPS-Cus-2086Cucumis sativus36.865e-69 231
LLPS-Kop-1476Komagataella pastoris36.785e-77 255
LLPS-Glm-0650Glycine max36.644e-66 223
LLPS-Arl-2694Arabidopsis lyrata36.634e-63 216
LLPS-Asfu-1428Aspergillus fumigatus36.583e-68 232
LLPS-Nef-1004Neosartorya fischeri36.342e-67 230
LLPS-Php-0507Physcomitrella patens36.251e-67 228
LLPS-Mae-1476Manihot esculenta36.241e-61 212
LLPS-Gag-0929Gaeumannomyces graminis36.249e-76 251
LLPS-Art-1947Arabidopsis thaliana36.221e-63 218
LLPS-Fuo-0455Fusarium oxysporum36.162e-76 253
LLPS-Orbr-0589Oryza brachyantha36.163e-66 223
LLPS-Fuv-0270Fusarium verticillioides36.162e-76 253
LLPS-Trv-1426Trichoderma virens36.124e-67 228
LLPS-Phn-1492Phaeosphaeria nodorum36.052e-70 234
LLPS-Orr-0104Oryza rufipogon36.051e-51 185
LLPS-Orgl-1646Oryza glumaepatula36.051e-51 185
LLPS-Sem-2243Selaginella moellendorffii36.034e-63 213
LLPS-Mua-2368Musa acuminata35.998e-62 211
LLPS-Crn-1104Cryptococcus neoformans35.995e-67 228
LLPS-Lep-0410Leersia perrieri35.914e-50 181
LLPS-Orp-1654Oryza punctata35.878e-65 219
LLPS-Coo-1437Colletotrichum orbiculare35.861e-73 244
LLPS-Pot-1272Populus trichocarpa35.852e-59 206
LLPS-Org-0710Oryza glaberrima35.753e-63 216
LLPS-Ors-1813Oryza sativa35.753e-63 216
LLPS-Ori-1898Oryza indica35.753e-63 216
LLPS-Pytr-0012Pyrenophora triticirepentis35.632e-67 226
LLPS-Mao-1381Magnaporthe oryzae35.324e-73 244
LLPS-Via-2403Vigna angularis35.299e-62 212
LLPS-Asg-1337Ashbya gossypii35.274e-65 223
LLPS-Thc-1686Theobroma cacao35.168e-59 205
LLPS-Amt-1973Amborella trichopoda35.076e-58 202
LLPS-Orb-0696Oryza barthii34.992e-56 201
LLPS-Fus-1426Fusarium solani34.987e-73 244
LLPS-Ved-0993Verticillium dahliae34.952e-64 221
LLPS-Trr-1603Trichoderma reesei34.954e-68 230
LLPS-Tru-2041Triticum urartu34.61e-54 202
LLPS-Viv-0586Vitis vinifera34.581e-54 193
LLPS-Tra-0881Triticum aestivum34.561e-62 213
LLPS-Brd-2298Brachypodium distachyon34.332e-61 211
LLPS-Hov-1684Hordeum vulgare34.31e-62 215
LLPS-Cog-1075Colletotrichum gloeosporioides33.87e-63 215
LLPS-Sei-1830Setaria italica33.661e-61 211
LLPS-Nec-1365Neurospora crassa33.624e-63 218
LLPS-Yal-1486Yarrowia lipolytica33.622e-75 251
LLPS-Pyt-0084Pyrenophora teres33.542e-70 238
LLPS-Chc-1203Chondrus crispus33.231e-45 167
LLPS-Vir-1900Vigna radiata32.273e-44 163
LLPS-Cym-1084Cyanidioschyzon merolae32.273e-46 169
LLPS-Phv-2286Phaseolus vulgaris32.162e-33 132
LLPS-Map-0987Magnaporthe poae30.891e-36 144