• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Orc-2707
SNRPC

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: U1 small nuclear ribonucleoprotein C
Gene Name: SNRPC
Ensembl Gene: ENSOCUG00000023292.1
Ensembl Protein: ENSOCUP00000020427.1
Organism: Oryctolagus cuniculus
Taxa ID: 9986
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
P-bodyPredicted from orthologs(View)

▼ FUNCTION

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSOCUT00000025866.1ENSOCUP00000020427.1
UniProtG1TTQ6, G1TTQ6_RABIT
GeneBankAAGW02054860

▼ SEQUENCE

Protein Sequence (FASTA)
1     MPKFYCDYCD  TYLTHDSPSV  RKTHCSGRKH  KENVKDYYQK  WMEEQAQSLI  DKTAAAFQQG  60
61    KIPPTPFSAP  PPAGAMIPPP  PSLLGPPRPG  MMPAPHMGGP  PMMPMMGPPP  PGMMPVGPVP  120
121   GMRPPMGGHM  PMMPGPPMMR  PPARPMMVPT  HPGMTRPDR  159
Nucleotide CDS Sequence (FASTA)
1     ATGCCCAAGT  TTTACTGTGA  CTACTGCGAT  ACGTACCTCA  CCCATGATTC  CCCATCTGTG  60
61    AGAAAGACGC  ACTGCAGTGG  TAGGAAACAC  AAAGAGAATG  TGAAAGACTA  CTATCAGAAA  120
121   TGGATGGAAG  AGCAGGCTCA  GAGCCTGATC  GACAAAACAG  CGGCTGCATT  TCAACAAGGA  180
181   AAGATACCGC  CTACTCCATT  CTCTGCTCCT  CCTCCTGCAG  GAGCGATGAT  CCCACCTCCC  240
241   CCCAGTCTCC  TGGGTCCTCC  TCGCCCTGGT  ATGATGCCTG  CACCCCATAT  GGGAGGCCCT  300
301   CCCATGATGC  CAATGATGGG  CCCTCCTCCT  CCTGGGATGA  TGCCAGTGGG  ACCTGTTCCT  360
361   GGAATGAGGC  CACCCATGGG  AGGCCATATG  CCAATGATGC  CAGGGCCCCC  AATGATGAGA  420
421   CCTCCTGCCC  GTCCCATGAT  GGTGCCCACT  CATCCAGGAA  TGACTCGGCC  GGACAGATAA  480

▼ KEYWORD

ID
Family
Complete proteome
Metal-binding
Nucleus
Reference proteome
Ribonucleoprotein
RNA-binding
Zinc
Zinc-finger

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Commitment complex
Cellular Component
U1 snRNP
Cellular Component
U2-type prespliceosome
Molecular Function
MRNA binding
Molecular Function
U1 snRNA binding
Molecular Function
Zinc ion binding
Biological Process
MRNA 5'-splice site recognition
Biological Process
Spliceosomal snRNP assembly

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Gaga-0797Gallus gallus98.413e-36 129
LLPS-Sus-0385Sus scrofa98.393e-40 140
LLPS-Aon-4460Aotus nancymaae98.398e-40 138
LLPS-Chs-0409Chlorocebus sabaeus98.393e-40 140
LLPS-Maf-1985Macaca fascicularis98.392e-40 139
LLPS-Caj-3838Callithrix jacchus98.393e-40 139
LLPS-Icp-0909Ictalurus punctatus98.396e-40 138
LLPS-Fud-1400Fukomys damarensis98.391e-40 140
LLPS-Asm-1099Astyanax mexicanus98.395e-39 137
LLPS-Gog-2228Gorilla gorilla98.391e-40 140
LLPS-Bot-1307Bos taurus98.393e-40 140
LLPS-Tar-2658Takifugu rubripes98.395e-40 138
LLPS-Xim-0187Xiphophorus maculatus98.395e-40 138
LLPS-Ova-0876Ovis aries98.391e-40 140
LLPS-Ran-1498Rattus norvegicus98.391e-40 140
LLPS-Loa-0554Loxodonta africana98.391e-40 140
LLPS-Mod-1345Monodelphis domestica98.391e-40 140
LLPS-Scm-2692Scophthalmus maximus98.395e-40 138
LLPS-Lac-0427Latimeria chalumnae98.394e-40 140
LLPS-Dar-3281Danio rerio98.393e-40 139
LLPS-Pap-1080Pan paniscus98.391e-40 140
LLPS-Urm-0872Ursus maritimus98.393e-40 139
LLPS-Pof-0303Poecilia formosa98.395e-40 138
LLPS-Pat-0788Pan troglodytes98.391e-40 140
LLPS-Rhb-2018Rhinopithecus bieti98.391e-40 140
LLPS-Orn-0178Oreochromis niloticus98.393e-40 139
LLPS-Fia-2645Ficedula albicollis98.391e-40 140
LLPS-Cap-0529Cavia porcellus98.391e-40 140
LLPS-Eqc-2252Equus caballus98.394e-40 139
LLPS-Ten-0032Tetraodon nigroviridis98.392e-39 137
LLPS-Poa-4533Pongo abelii98.391e-38 133
LLPS-Ict-1398Ictidomys tridecemlineatus98.391e-40 140
LLPS-Cas-1016Carlito syrichta98.391e-40 140
LLPS-Xet-0099Xenopus tropicalis98.392e-40 139
LLPS-Mum-0964Mus musculus98.315e-38 134
LLPS-Otg-3029Otolemur garnettii98.288e-34 123
LLPS-Nol-0102Nomascus leucogenys98.289e-34 123
LLPS-Scf-1094Scleropages formosus96.778e-38 133
LLPS-Dio-4359Dipodomys ordii96.772e-37 131
LLPS-Fec-1261Felis catus96.771e-37 133
LLPS-Mam-1030Macaca mulatta96.773e-37 131
LLPS-Caf-3721Canis familiaris96.771e-36 130
LLPS-Sah-3884Sarcophilus harrisii96.673e-35 127
LLPS-Cea-0150Cercocebus atys96.674e-35 126
LLPS-Orl-1191Oryzias latipes96.672e-37 134
LLPS-Gaa-0599Gasterosteus aculeatus96.672e-35 126
LLPS-Paa-1618Papio anubis96.674e-35 126
LLPS-Mal-0618Mandrillus leucophaeus96.673e-35 127
LLPS-Anp-1377Anas platyrhynchos96.672e-35 126
LLPS-Man-4225Macaca nemestrina96.674e-35 127
LLPS-Hos-0959Homo sapiens96.673e-35 127
LLPS-Pes-0245Pelodiscus sinensis96.675e-35 127
LLPS-Anc-2565Anolis carolinensis96.673e-35 127
LLPS-Meg-0907Meleagris gallopavo96.552e-36 130
LLPS-Tag-2652Taeniopygia guttata95.163e-36 129
LLPS-Tut-1666Tursiops truncatus93.553e-35 127
LLPS-Myl-1149Myotis lucifugus93.551e-35 127
LLPS-Aim-0849Ailuropoda melanoleuca93.552e-35 127
LLPS-Mup-0135Mustela putorius furo93.551e-35 127
LLPS-Ora-1923Ornithorhynchus anatinus91.848e-2291.3
LLPS-Cii-0744Ciona intestinalis83.877e-32 116
LLPS-Drm-0795Drosophila melanogaster83.874e-32 118
LLPS-Sob-0021Sorghum bicolor71.432e-1884.0
LLPS-Php-0766Physcomitrella patens71.151e-1575.9
LLPS-Arl-0319Arabidopsis lyrata71.157e-2087.0
LLPS-Art-2677Arabidopsis thaliana71.158e-2087.0
LLPS-Prp-1410Prunus persica71.152e-2089.0
LLPS-Zem-1165Zea mays71.152e-2089.7
LLPS-Cae-0213Caenorhabditis elegans70.979e-27 103
LLPS-Glm-0700Glycine max65.158e-2292.4
LLPS-Via-0252Vigna angularis65.158e-2292.4
LLPS-Met-0197Medicago truncatula65.152e-2191.7
LLPS-Cus-0351Cucumis sativus65.154e-2292.8
LLPS-Gor-0108Gossypium raimondii65.154e-2293.2
LLPS-Phv-1032Phaseolus vulgaris65.159e-2292.4
LLPS-Coc-0789Corchorus capsularis65.154e-2293.2
LLPS-Mua-1515Musa acuminata64.622e-2191.3
LLPS-Ori-0787Oryza indica64.187e-2293.2
LLPS-Orb-0033Oryza barthii64.184e-2293.6
LLPS-Orni-0671Oryza nivara64.184e-2293.6
LLPS-Lep-1288Leersia perrieri64.186e-2293.2
LLPS-Orgl-0942Oryza glumaepatula64.184e-2293.6
LLPS-Tra-2955Triticum aestivum64.183e-2293.6
LLPS-Sei-1841Setaria italica64.181e-2192.8
LLPS-Orp-0902Oryza punctata64.184e-2293.6
LLPS-Ors-1881Oryza sativa64.184e-2293.6
LLPS-Orr-0987Oryza rufipogon64.184e-2293.6
LLPS-Org-0717Oryza glaberrima64.184e-2293.6
LLPS-Thc-0348Theobroma cacao64.065e-2087.4
LLPS-Brr-1093Brassica rapa63.649e-2189.4
LLPS-Viv-0342Vitis vinifera63.641e-2192.0
LLPS-Mae-1606Manihot esculenta63.641e-2192.0
LLPS-Amt-1071Amborella trichopoda63.641e-2192.0
LLPS-Bro-0756Brassica oleracea63.645e-2189.7
LLPS-Fuv-0472Fusarium verticillioides63.163e-1882.8
LLPS-Coo-1211Colletotrichum orbiculare63.167e-1882.0
LLPS-Tum-0551Tuber melanosporum63.161e-1884.0
LLPS-Nec-0284Neurospora crassa63.164e-1882.8
LLPS-Beb-0029Beauveria bassiana63.163e-1882.4
LLPS-Fus-0465Fusarium solani63.163e-1882.8
LLPS-Trr-1173Trichoderma reesei63.164e-1882.8
LLPS-Cog-1367Colletotrichum gloeosporioides63.163e-1882.4
LLPS-Fuo-0789Fusarium oxysporum63.163e-1882.4
LLPS-Trv-0934Trichoderma virens63.162e-1882.8
LLPS-Cogr-0051Colletotrichum graminicola63.163e-1882.4
LLPS-Chr-1297Chlamydomonas reinhardtii62.796e-1367.8
LLPS-Brd-1941Brachypodium distachyon62.691e-2192.0
LLPS-Brn-1963Brassica napus62.54e-1984.7
LLPS-Nia-0387Nicotiana attenuata62.51e-1986.3
LLPS-Sem-1552Selaginella moellendorffii62.38e-1782.0
LLPS-Sot-0375Solanum tuberosum62.124e-2087.4
LLPS-Pot-0952Populus trichocarpa62.121e-2089.4
LLPS-Crn-0623Cryptococcus neoformans61.541e-1575.9
LLPS-Scs-0159Sclerotinia sclerotiorum61.44e-1573.6
LLPS-Gag-0329Gaeumannomyces graminis61.41e-1781.3
LLPS-Mao-0594Magnaporthe oryzae61.41e-1780.9
LLPS-Blg-0339Blumeria graminis61.46e-1573.2
LLPS-Zyt-1097Zymoseptoria tritici61.44e-1882.4
LLPS-Dos-0535Dothistroma septosporum61.44e-1882.0
LLPS-Dac-0747Daucus carota61.115e-1779.3
LLPS-Sol-0716Solanum lycopersicum60.611e-1986.3
LLPS-Hea-0645Helianthus annuus60.611e-1986.7
LLPS-Asc-1618Aspergillus clavatus58.822e-1369.3
LLPS-Asni-0184Aspergillus niger57.893e-1471.2
LLPS-Usm-1200Ustilago maydis57.412e-1368.9
LLPS-Vir-0305Vigna radiata57.146e-0853.9
LLPS-Osl-0211Ostreococcus lucimarinus57.143e-1160.5
LLPS-Kop-0943Komagataella pastoris55.13e-0955.8
LLPS-Lem-0654Leptosphaeria maculans54.393e-1574.3
LLPS-Scc-0232Schizosaccharomyces cryophilus53.852e-1368.6
LLPS-Pyt-1414Pyrenophora teres53.459e-1472.8
LLPS-Pytr-0808Pyrenophora triticirepentis53.454e-1472.8
LLPS-Phn-0722Phaeosphaeria nodorum53.459e-1674.3
LLPS-Pug-1128Puccinia graminis53.338e-1675.5
LLPS-Spr-0727Sporisorium reilianum53.231e-1472.4
LLPS-Scp-1219Schizosaccharomyces pombe51.796e-1470.1
LLPS-Mel-0935Melampsora laricipopulina50.02e-1574.7
LLPS-Hov-0433Hordeum vulgare49.215e-1162.4
LLPS-Chc-0836Chondrus crispus49.155e-1264.3
LLPS-Gas-1140Galdieria sulphuraria49.153e-1470.5
LLPS-Tru-0632Triticum urartu46.244e-1676.6
LLPS-Asg-0227Ashbya gossypii43.556e-1058.9
LLPS-Abg-0494Absidia glauca40.858e-1263.9