DrLLPS - Data resource of LLPS

LLPS-Tag-2652
SNRPC

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	U1 small nuclear ribonucleoprotein C
Gene Name:	SNRPC
Ensembl Gene:	ENSTGUG00000001773.1
Ensembl Protein:	ENSTGUP00000001830.1
Organism:	Taeniopygia guttata
Taxa ID:	59729
LLPS Type:	LLPS regulator

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Nuclear speckle, Nucleolus, P-body	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Caenorhabditis elegans	LLPS-Cae-0213	P90815	Regulator	P-body	66.13	8e-25	99.0
Mus musculus	LLPS-Mum-0964	Q62241	Client	Nuclear speckle, Nucleolus	100.00	3e-39	137
Homo sapiens	LLPS-Hos-0959	P09234	Client	Nucleolus	100.00	3e-38	135

▼ FUNCTION

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSTGUT00000001847.1	ENSTGUP00000001830.1
UniProt		H0YU62, H0YU62_TAEGU
GeneBank	ABQF01054421, ABQF01054422

▼ SEQUENCE

Protein Sequence (FASTA)
1 FPRFYCDYCD TYLTHDSPSV RKTHCSGRKH KENVKDYYQK WMEEQAQSLI DKTTAAFQQG 60 61 KIPPTPFSAP PPAGAMIPPP PSIPGPPRPG MMPAPHMGGP PMMPMMGPPP PGMMPVGPAP 120 121 GMRPPMGGHM PMMPGPPMMR PPSRPMMVPT RPGMTRPDR 159
Nucleotide CDS Sequence (FASTA)
1 TTCCCCAGGT TTTACTGTGA TTACTGTGAC ACGTACCTCA CCCATGACTC GCCCTCCGTG 60 61 AGAAAAACCC ACTGCAGTGG TCGGAAGCAC AAGGAGAACG TGAAGGATTA TTACCAGAAA 120 121 TGGATGGAGG AGCAAGCCCA GAGCCTGATT GACAAAACAA CGGCTGCATT CCAGCAAGGG 180 181 AAAATTCCAC CGACGCCGTT CTCGGCACCG CCTCCGGCTG GAGCCATGAT TCCACCTCCT 240 241 CCCAGCATCC CTGGCCCCCC CCGGCCCGGC ATGATGCCAG CCCCACACAT GGGGGGGCCC 300 301 CCGATGATGC CAATGATGGG CCCACCCCCA CCGGGAATGA TGCCAGTTGG ACCTGCTCCT 360 361 GGGATGAGGC CGCCCATGGG AGGACACATG CCAATGATGC CAGGGCCCCC AATGATGAGA 420 421 CCCCCCTCCA GACCCATGAT GGTGCCAACC AGGCCAGGAA TGACCCGTCC AGACAGATAA 480

▼ KEYWORD

ID	Family
KW-0181	Complete proteome
KW-0479	Metal-binding
KW-0539	Nucleus
KW-1185	Reference proteome
KW-0687	Ribonucleoprotein
KW-0694	RNA-binding
KW-0862	Zinc
KW-0863	Zinc-finger

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0015030	Cellular Component	Cajal body
GO:0000243	Cellular Component	Commitment complex
GO:0005685	Cellular Component	U1 snRNP
GO:0071004	Cellular Component	U2-type prespliceosome
GO:0003729	Molecular Function	MRNA binding
GO:0042803	Molecular Function	Protein homodimerization activity
GO:0003727	Molecular Function	Single-stranded RNA binding
GO:0030619	Molecular Function	U1 snRNA binding
GO:0008270	Molecular Function	Zinc ion binding
GO:0000395	Biological Process	MRNA 5'-splice site recognition
GO:0000387	Biological Process	Spliceosomal snRNP assembly

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Pes-0245	Pelodiscus sinensis	100.0	7e-39	137
LLPS-Otg-3029	Otolemur garnettii	100.0	4e-39	137
LLPS-Rhb-0610	Rhinopithecus bieti	100.0	3e-39	137
LLPS-Hos-0959	Homo sapiens	100.0	2e-39	137
LLPS-Anp-1377	Anas platyrhynchos	100.0	5e-40	138
LLPS-Man-4225	Macaca nemestrina	100.0	3e-39	137
LLPS-Anc-2565	Anolis carolinensis	100.0	2e-39	138
LLPS-Nol-0102	Nomascus leucogenys	100.0	3e-39	137
LLPS-Mam-1603	Macaca mulatta	100.0	3e-39	137
LLPS-Caj-0058	Callithrix jacchus	100.0	2e-39	137
LLPS-Mum-0964	Mus musculus	100.0	6e-39	136
LLPS-Aon-1684	Aotus nancymaae	100.0	2e-39	137
LLPS-Cea-0150	Cercocebus atys	100.0	3e-39	137
LLPS-Sah-3884	Sarcophilus harrisii	100.0	2e-39	137
LLPS-Orl-1191	Oryzias latipes	100.0	3e-38	136
LLPS-Aim-0849	Ailuropoda melanoleuca	100.0	3e-39	137
LLPS-Mup-0135	Mustela putorius furo	100.0	4e-40	139
LLPS-Myl-1149	Myotis lucifugus	100.0	4e-40	139
LLPS-Paa-1618	Papio anubis	100.0	3e-39	137
LLPS-Mal-0618	Mandrillus leucophaeus	100.0	2e-39	137
LLPS-Tut-1666	Tursiops truncatus	100.0	4e-39	137
LLPS-Scf-2731	Scleropages formosus	100.0	5e-38	135
LLPS-Gaa-0599	Gasterosteus aculeatus	100.0	2e-39	137
LLPS-Meg-0907	Meleagris gallopavo	98.28	3e-37	132
LLPS-Orn-0178	Oreochromis niloticus	96.77	4e-40	138
LLPS-Fia-2645	Ficedula albicollis	96.77	2e-40	140
LLPS-Orc-2670	Oryctolagus cuniculus	96.77	2e-40	140
LLPS-Lac-0427	Latimeria chalumnae	96.77	4e-40	139
LLPS-Mod-1345	Monodelphis domestica	96.77	2e-40	140
LLPS-Scm-2692	Scophthalmus maximus	96.77	6e-40	138
LLPS-Pof-0303	Poecilia formosa	96.77	7e-40	138
LLPS-Pat-0788	Pan troglodytes	96.77	2e-40	140
LLPS-Pap-1080	Pan paniscus	96.77	2e-40	140
LLPS-Urm-0872	Ursus maritimus	96.77	3e-40	139
LLPS-Dar-3281	Danio rerio	96.77	4e-40	139
LLPS-Loa-0554	Loxodonta africana	96.77	2e-40	140
LLPS-Xet-0099	Xenopus tropicalis	96.77	2e-40	139
LLPS-Cas-1016	Carlito syrichta	96.77	2e-40	140
LLPS-Ict-1398	Ictidomys tridecemlineatus	96.77	2e-40	140
LLPS-Eqc-2252	Equus caballus	96.77	4e-40	139
LLPS-Cap-0529	Cavia porcellus	96.77	2e-40	140
LLPS-Poa-4533	Pongo abelii	96.77	3e-38	132
LLPS-Ten-0032	Tetraodon nigroviridis	96.77	3e-39	137
LLPS-Gog-2228	Gorilla gorilla	96.77	2e-40	140
LLPS-Icp-0909	Ictalurus punctatus	96.77	7e-40	138
LLPS-Fud-1400	Fukomys damarensis	96.77	2e-40	140
LLPS-Asm-1099	Astyanax mexicanus	96.77	7e-39	136
LLPS-Chs-0409	Chlorocebus sabaeus	96.77	3e-40	140
LLPS-Maf-1985	Macaca fascicularis	96.77	3e-40	139
LLPS-Sus-0385	Sus scrofa	96.77	3e-40	140
LLPS-Ran-1498	Rattus norvegicus	96.77	2e-40	140
LLPS-Ova-0876	Ovis aries	96.77	2e-40	140
LLPS-Tar-2658	Takifugu rubripes	96.77	7e-40	138
LLPS-Xim-0187	Xiphophorus maculatus	96.77	7e-40	138
LLPS-Bot-1307	Bos taurus	96.77	3e-40	140
LLPS-Fec-1261	Felis catus	95.16	2e-37	132
LLPS-Caf-1882	Canis familiaris	95.16	2e-36	129
LLPS-Gaga-0797	Gallus gallus	93.65	1e-34	125
LLPS-Dio-4359	Dipodomys ordii	93.55	2e-36	129
LLPS-Ora-1923	Ornithorhynchus anatinus	91.84	7e-22	91.3
LLPS-Cii-0744	Ciona intestinalis	82.26	2e-31	115
LLPS-Drm-0795	Drosophila melanogaster	82.26	7e-32	117
LLPS-Brr-1093	Brassica rapa	73.08	3e-20	87.8
LLPS-Bro-0756	Brassica oleracea	73.08	2e-20	88.6
LLPS-Brn-3340	Brassica napus	73.08	1e-19	86.7
LLPS-Sob-0021	Sorghum bicolor	71.43	2e-18	84.0
LLPS-Zem-1165	Zea mays	71.15	3e-20	89.0
LLPS-Prp-1410	Prunus persica	71.15	2e-20	88.6
LLPS-Php-0766	Physcomitrella patens	71.15	1e-15	75.5
LLPS-Arl-0319	Arabidopsis lyrata	71.15	1e-19	86.7
LLPS-Sot-0375	Solanum tuberosum	71.15	9e-20	86.7
LLPS-Sol-0716	Solanum lycopersicum	69.23	2e-19	85.5
LLPS-Cae-0213	Caenorhabditis elegans	66.13	7e-25	99.0
LLPS-Amt-1071	Amborella trichopoda	65.15	5e-22	93.2
LLPS-Mae-1606	Manihot esculenta	65.15	4e-22	93.6
LLPS-Viv-0342	Vitis vinifera	65.15	3e-22	93.6
LLPS-Thc-0348	Theobroma cacao	64.06	7e-20	87.4
LLPS-Phv-1032	Phaseolus vulgaris	63.64	5e-21	90.1
LLPS-Gor-0108	Gossypium raimondii	63.64	3e-21	90.9
LLPS-Pot-0952	Populus trichocarpa	63.64	4e-21	90.5
LLPS-Coc-0789	Corchorus capsularis	63.64	3e-21	90.9
LLPS-Glm-0780	Glycine max	63.64	7e-21	90.1
LLPS-Cus-0351	Cucumis sativus	63.64	3e-21	90.9
LLPS-Met-0197	Medicago truncatula	63.64	1e-20	89.4
LLPS-Via-0252	Vigna angularis	63.64	6e-21	90.1
LLPS-Scs-0159	Sclerotinia sclerotiorum	63.46	3e-15	73.9
LLPS-Blg-0339	Blumeria graminis	63.46	4e-15	73.6
LLPS-Mua-1515	Musa acuminata	63.08	1e-20	89.4
LLPS-Tra-2110	Triticum aestivum	63.08	3e-20	88.6
LLPS-Chr-1297	Chlamydomonas reinhardtii	62.79	1e-12	67.0
LLPS-Ors-1881	Oryza sativa	62.69	3e-21	91.7
LLPS-Orp-0902	Oryza punctata	62.69	3e-21	91.3
LLPS-Org-0717	Oryza glaberrima	62.69	3e-21	91.7
LLPS-Orr-0987	Oryza rufipogon	62.69	2e-21	91.7
LLPS-Orni-0671	Oryza nivara	62.69	3e-21	91.7
LLPS-Ori-0787	Oryza indica	62.69	4e-21	90.9
LLPS-Orb-0033	Oryza barthii	62.69	3e-21	91.7
LLPS-Sei-1841	Setaria italica	62.69	8e-21	90.1
LLPS-Orgl-0942	Oryza glumaepatula	62.69	3e-21	91.7
LLPS-Lep-1288	Leersia perrieri	62.69	4e-21	90.9
LLPS-Nia-0387	Nicotiana attenuata	62.5	1e-19	86.3
LLPS-Tum-0551	Tuber melanosporum	62.5	3e-18	82.8
LLPS-Sem-1552	Selaginella moellendorffii	62.3	7e-17	82.0
LLPS-Trr-1173	Trichoderma reesei	61.4	1e-17	81.3
LLPS-Cog-1367	Colletotrichum gloeosporioides	61.4	7e-18	81.6
LLPS-Fus-0465	Fusarium solani	61.4	8e-18	81.6
LLPS-Beb-0029	Beauveria bassiana	61.4	9e-18	81.3
LLPS-Cogr-0051	Colletotrichum graminicola	61.4	8e-18	81.3
LLPS-Fuo-0789	Fusarium oxysporum	61.4	7e-18	81.6
LLPS-Trv-0934	Trichoderma virens	61.4	6e-18	81.6
LLPS-Coo-1211	Colletotrichum orbiculare	61.4	2e-17	80.9
LLPS-Fuv-0472	Fusarium verticillioides	61.4	7e-18	81.6
LLPS-Nec-0284	Neurospora crassa	61.4	8e-18	81.6
LLPS-Brd-1941	Brachypodium distachyon	61.19	1e-20	89.7
LLPS-Asc-1618	Aspergillus clavatus	60.78	3e-14	71.6
LLPS-Art-2677	Arabidopsis thaliana	60.61	1e-19	86.7
LLPS-Crn-0623	Cryptococcus neoformans	60.0	4e-15	73.9
LLPS-Dos-0535	Dothistroma septosporum	59.65	1e-17	81.3
LLPS-Mao-0594	Magnaporthe oryzae	59.65	3e-17	80.1
LLPS-Gag-0329	Gaeumannomyces graminis	59.65	2e-17	80.1
LLPS-Zyt-1097	Zymoseptoria tritici	59.65	8e-18	81.6
LLPS-Spr-0727	Sporisorium reilianum	59.18	2e-13	69.3
LLPS-Hea-0645	Helianthus annuus	59.09	4e-19	85.1
LLPS-Asni-0184	Aspergillus niger	58.49	2e-14	71.6
LLPS-Dac-0747	Daucus carota	57.81	1e-17	81.3
LLPS-Osl-0211	Ostreococcus lucimarinus	57.14	6e-11	59.3
LLPS-Usm-1200	Ustilago maydis	57.14	2e-12	66.2
LLPS-Vir-0305	Vigna radiata	55.1	2e-07	52.0
LLPS-Lem-0654	Leptosphaeria maculans	53.57	1e-14	72.8
LLPS-Pug-1128	Puccinia graminis	53.45	5e-16	76.3
LLPS-Phn-0722	Phaeosphaeria nodorum	51.72	2e-15	73.6
LLPS-Pytr-0808	Pyrenophora triticirepentis	51.72	1e-13	71.2
LLPS-Scp-1219	Schizosaccharomyces pombe	51.72	3e-13	68.2
LLPS-Pyt-1414	Pyrenophora teres	51.72	3e-13	71.2
LLPS-Kop-0943	Komagataella pastoris	51.02	3e-08	53.1
LLPS-Mel-0935	Melampsora laricipopulina	50.0	2e-15	75.1
LLPS-Scc-0232	Schizosaccharomyces cryophilus	50.0	3e-12	65.5
LLPS-Chc-0836	Chondrus crispus	49.09	3e-11	61.6
LLPS-Gas-1140	Galdieria sulphuraria	48.21	2e-13	67.8
LLPS-Hov-0433	Hordeum vulgare	47.62	2e-10	60.5
LLPS-Tru-0632	Triticum urartu	45.16	2e-15	74.3
LLPS-Asg-0227	Ashbya gossypii	45.0	8e-10	58.5
LLPS-Abg-0494	Absidia glauca	39.44	2e-11	63.2

LLPS-Tag-2652SNRPC

Protein Sequence

Nucleotide Sequence

LLPS-Tag-2652
SNRPC