• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Nol-2757
CTPS2

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: CTP synthase; UTP--ammonia ligase
Gene Name: CTPS2
Ensembl Gene: ENSNLEG00000009514.3
Ensembl Protein: ENSNLEP00000011604.1
Organism: Nomascus leucogenys
Taxa ID: 61853
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, P-bodyPredicted from orthologs(View)

▼ FUNCTION

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MKYILVTGGV  ISGIGKGIIA  SSIGTILKSC  GLRVTAIKID  PYINIDAGTF  SPYEHGEVFV  60
61    LNDGGEVDLD  LGNYERFLDI  NLYKDNNITT  GKIYQHVINK  ERRGDYLGKT  VQVVPHITDA  120
121   VQEWVMNQAK  VPVDGNKEEP  QICVIELGGT  IGDIEGMPFV  EAFRQFQFKA  KRENFCNIHV  180
181   SLVPQLSATG  EQKTKPTQNS  VRALRGLGLS  PDLIVCRSST  PIEMAVKEKI  SMFCHVNPEQ  240
241   VICIHDVSST  YRVPVLLEEQ  GIVKYFKERL  HLPIGDSASN  LLFKWRNMAD  RYERLQKICS  300
301   IALVGKYTKL  RDCYASVFKA  LEHSALAINH  KLNLMYIDSI  DLEKITETED  PVKFHEAWQK  360
361   LCKADGILVP  GGFGIRGTLG  KLQAISWART  KKIPFLGVCL  GMQLAVIEFA  RNCLNLKDAD  420
421   STEFRPNAPV  PLVIDMPEHN  PGNLGGTMRL  GIRRTVFKTE  NSILRKLYGD  VPFIEERHRH  480
481   RFEVNPNLIN  QFEQNDLNFV  GQDVDGDRME  IIELANHPYF  VGVQFHPEFS  SRPMKPSPPY  540
541   LGLLLAATGN  LNAYLQQGCK  LSSSDRYSDA  SDDSFSEPRI  AELEIS  586
Nucleotide CDS Sequence (FASTA)
1     ATGAAGTACA  TCCTGGTCAC  GGGTGGGGTC  ATCTCAGGCA  TTGGTAAAGG  GATCATTGCC  60
61    AGCAGCATTG  GAACGATTCT  AAAATCATGC  GGACTCCGAG  TTACTGCCAT  AAAAATCGAC  120
121   CCCTATATTA  ACATCGATGC  TGGCACTTTT  TCACCTTATG  AACACGGTGA  AGTCTTCGTC  180
181   TTAAATGATG  GTGGAGAAGT  TGATTTAGAC  CTTGGAAATT  ATGAAAGATT  TTTGGATATT  240
241   AATCTTTATA  AAGACAACAA  TATCACCACG  GGGAAGATAT  ATCAGCATGT  GATCAATAAA  300
301   GAGAGGCGTG  GTGATTACCT  GGGGAAAACA  GTGCAAGTTG  TCCCTCACAT  TACTGATGCT  360
361   GTCCAGGAGT  GGGTTATGAA  TCAAGCCAAG  GTGCCGGTGG  ATGGTAATAA  GGAAGAGCCC  420
421   CAAATATGCG  TTATTGAGCT  GGGAGGCACC  ATTGGAGACA  TCGAAGGAAT  GCCGTTTGTG  480
481   GAAGCGTTTA  GACAATTCCA  GTTTAAGGCG  AAAAGAGAGA  ATTTCTGTAA  TATCCACGTT  540
541   AGCCTTGTCC  CACAGCTCAG  TGCTACCGGA  GAACAAAAAA  CCAAACCCAC  CCAAAACAGC  600
601   GTCCGCGCGC  TGAGAGGGTT  AGGCCTGTCT  CCAGATCTGA  TTGTCTGCCG  AAGTTCAACG  660
661   CCCATTGAGA  TGGCCGTGAA  GGAGAAGATT  TCTATGTTTT  GTCACGTGAA  CCCTGAACAG  720
721   GTCATATGTA  TCCATGATGT  TTCTTCCACA  TACCGAGTTC  CTGTGCTTTT  GGAGGAACAA  780
781   GGCATTGTGA  AATATTTTAA  GGAGAGATTG  CACCTGCCCA  TTGGTGATTC  TGCAAGTAAT  840
841   TTGCTTTTTA  AGTGGAGAAA  TATGGCTGAC  AGGTATGAAA  GGTTACAGAA  AATATGCTCC  900
901   ATAGCCCTGG  TTGGCAAATA  CACCAAGCTC  AGAGACTGCT  ATGCCTCTGT  GTTCAAAGCC  960
961   CTGGAACACT  CAGCCCTGGC  CATCAACCAC  AAGTTGAATC  TGATGTACAT  AGACTCCATT  1020
1021  GATCTGGAGA  AGATCACCGA  AACCGAGGAC  CCTGTGAAAT  TTCATGAAGC  TTGGCAGAAG  1080
1081  CTATGCAAAG  CTGATGGTAT  TCTTGTGCCT  GGAGGCTTTG  GAATCAGAGG  AACATTGGGA  1140
1141  AAACTCCAGG  CGATTTCTTG  GGCGAGGACA  AAGAAGATTC  CTTTTCTGGG  AGTTTGTCTT  1200
1201  GGGATGCAAC  TAGCAGTGAT  AGAGTTTGCA  AGAAACTGCC  TTAACTTGAA  AGATGCTGAT  1260
1261  TCTACAGAAT  TTAGGCCAAA  TGCCCCAGTT  CCTCTGGTGA  TTGATATGCC  CGAGCACAAC  1320
1321  CCTGGCAATT  TGGGAGGAAC  AATGAGACTG  GGAATAAGAA  GAACTGTTTT  CAAAACTGAA  1380
1381  AATTCAATAT  TAAGGAAACT  TTATGGTGAT  GTTCCTTTTA  TAGAAGAAAG  ACACAGACAT  1440
1441  CGGTTTGAGG  TAAACCCTAA  CCTGATCAAC  CAATTTGAGC  AGAATGACTT  AAATTTTGTA  1500
1501  GGTCAGGATG  TTGATGGAGA  CAGGATGGAA  ATCATTGAAC  TGGCAAATCA  TCCTTATTTT  1560
1561  GTTGGTGTCC  AGTTCCATCC  TGAGTTTTCT  TCTAGGCCGA  TGAAGCCTTC  CCCTCCGTAT  1620
1621  CTGGGGCTGT  TACTTGCGGC  AACTGGGAAC  CTGAATGCCT  ACTTGCAACA  GGGTTGCAAA  1680
1681  CTATCTTCCA  GTGATAGATA  CAGTGATGCC  AGTGATGACA  GCTTTTCAGA  GCCAAGGATA  1740
1741  GCTGAGTTGG  AAATAAGCTG  A  1761

▼ KEYWORD

ID
Family
ATP-binding
Complete proteome
Glutamine amidotransferase
Ligase
Nucleotide-binding
Pyrimidine biosynthesis
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Molecular Function
ATP binding
Molecular Function
CTP synthase activity
Biological Process
'de novo' CTP biosynthetic process
Biological Process
Glutamine metabolic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Gog-2769Gorilla gorilla99.660.01094
LLPS-Hos-1508Homo sapiens99.490.01092
LLPS-Maf-4017Macaca fascicularis99.430.01021
LLPS-Mam-1217Macaca mulatta99.350.0 879
LLPS-Poa-0321Pongo abelii99.320.01092
LLPS-Pat-2054Pan troglodytes99.320.01092
LLPS-Pap-4331Pan paniscus99.320.01092
LLPS-Chs-3305Chlorocebus sabaeus99.320.01091
LLPS-Cea-0960Cercocebus atys99.320.01091
LLPS-Mal-0237Mandrillus leucophaeus98.840.01014
LLPS-Cas-0454Carlito syrichta97.10.0 933
LLPS-Urm-3721Ursus maritimus96.420.01061
LLPS-Caf-0492Canis familiaris96.250.01059
LLPS-Aim-1223Ailuropoda melanoleuca96.250.01060
LLPS-Sus-2406Sus scrofa96.250.01055
LLPS-Myl-2765Myotis lucifugus96.080.01053
LLPS-Ict-0345Ictidomys tridecemlineatus95.90.01055
LLPS-Fec-0686Felis catus95.90.01060
LLPS-Mup-2896Mustela putorius furo95.90.01058
LLPS-Ova-2958Ovis aries95.90.01053
LLPS-Bot-3347Bos taurus95.520.01040
LLPS-Eqc-1695Equus caballus95.270.01053
LLPS-Orc-0591Oryctolagus cuniculus95.050.01047
LLPS-Dio-1866Dipodomys ordii94.470.01023
LLPS-Aon-1017Aotus nancymaae94.370.01041
LLPS-Man-4240Macaca nemestrina94.070.01011
LLPS-Caj-4381Callithrix jacchus94.030.01038
LLPS-Loa-2141Loxodonta africana92.660.01030
LLPS-Ran-3287Rattus norvegicus90.960.01008
LLPS-Mum-4312Mus musculus90.780.01005
LLPS-Fud-0542Fukomys damarensis90.350.0 991
LLPS-Ora-2544Ornithorhynchus anatinus89.660.0 969
LLPS-Mea-1468Mesocricetus auratus89.250.0 993
LLPS-Sah-0315Sarcophilus harrisii88.70.0 978
LLPS-Mod-4387Monodelphis domestica87.920.0 958
LLPS-Pes-0339Pelodiscus sinensis87.70.0 954
LLPS-Anp-1088Anas platyrhynchos87.520.0 948
LLPS-Cap-3294Cavia porcellus87.350.0 967
LLPS-Gaga-3451Gallus gallus87.340.0 948
LLPS-Fia-3673Ficedula albicollis87.170.0 941
LLPS-Anc-3047Anolis carolinensis86.450.0 936
LLPS-Tag-2415Taeniopygia guttata86.30.0 931
LLPS-Otg-0137Otolemur garnettii85.230.0 927
LLPS-Meg-0164Meleagris gallopavo83.480.0 890
LLPS-Xet-1192Xenopus tropicalis82.530.0 919
LLPS-Asm-1171Astyanax mexicanus77.360.0 848
LLPS-Icp-0444Ictalurus punctatus77.010.0 840
LLPS-Xim-0625Xiphophorus maculatus76.650.0 850
LLPS-Scf-0999Scleropages formosus76.580.0 857
LLPS-Dar-3272Danio rerio76.470.0 830
LLPS-Pof-3154Poecilia formosa76.160.0 844
LLPS-Leo-0675Lepisosteus oculatus76.070.0 859
LLPS-Orn-0242Oreochromis niloticus75.940.0 815
LLPS-Gaa-1522Gasterosteus aculeatus75.580.0 829
LLPS-Rhb-1359Rhinopithecus bieti75.510.0 855
LLPS-Paa-2541Papio anubis75.340.0 855
LLPS-Orl-3087Oryzias latipes75.040.0 825
LLPS-Cii-1306Ciona intestinalis75.02e-0655.1
LLPS-Scm-2419Scophthalmus maximus74.870.0 840
LLPS-Tut-2449Tursiops truncatus74.870.0 840
LLPS-Tar-0121Takifugu rubripes74.360.0 838
LLPS-Ten-2481Tetraodon nigroviridis73.470.0 823
LLPS-Lac-0326Latimeria chalumnae72.140.0 795
LLPS-Drm-2201Drosophila melanogaster66.190.0 720
LLPS-Cis-0032Ciona savignyi64.390.0 740
LLPS-Viv-1269Vitis vinifera61.270.0 632
LLPS-Sol-0641Solanum lycopersicum61.270.0 623
LLPS-Prp-0783Prunus persica60.520.0 634
LLPS-Nia-1784Nicotiana attenuata60.340.0 615
LLPS-Dac-1425Daucus carota60.340.0 634
LLPS-Mua-0003Musa acuminata60.340.0 645
LLPS-Sem-0584Selaginella moellendorffii60.110.0 630
LLPS-Via-2368Vigna angularis60.040.0 638
LLPS-Abg-0386Absidia glauca59.960.0 655
LLPS-Lep-1579Leersia perrieri59.850.0 632
LLPS-Sob-0316Sorghum bicolor59.810.0 630
LLPS-Bro-1873Brassica oleracea59.780.0 621
LLPS-Phv-0477Phaseolus vulgaris59.780.0 634
LLPS-Sot-1028Solanum tuberosum59.780.0 635
LLPS-Cus-0365Cucumis sativus59.70.0 620
LLPS-Brr-2316Brassica rapa59.590.0 616
LLPS-Brn-2300Brassica napus59.590.0 617
LLPS-Php-2049Physcomitrella patens59.480.0 639
LLPS-Coc-1341Corchorus capsularis59.40.0 627
LLPS-Mae-2133Manihot esculenta59.40.0 628
LLPS-Gor-0674Gossypium raimondii59.290.0 619
LLPS-Org-1388Oryza glaberrima59.260.0 629
LLPS-Zem-0184Zea mays59.260.0 629
LLPS-Orr-0385Oryza rufipogon59.260.0 615
LLPS-Ors-0140Oryza sativa59.070.0 626
LLPS-Orgl-1519Oryza glumaepatula59.070.0 629
LLPS-Orni-2224Oryza nivara59.070.0 627
LLPS-Tra-2871Triticum aestivum59.00.0 629
LLPS-Orbr-0784Oryza brachyantha58.920.0 627
LLPS-Hea-0627Helianthus annuus58.850.0 630
LLPS-Orm-0563Oryza meridionalis58.740.0 623
LLPS-Sei-1109Setaria italica58.70.0 627
LLPS-Art-2157Arabidopsis thaliana58.660.0 609
LLPS-Thc-0464Theobroma cacao58.660.0 619
LLPS-Brd-0862Brachypodium distachyon58.520.0 620
LLPS-Pot-2410Populus trichocarpa58.490.0 613
LLPS-Amt-2261Amborella trichopoda58.470.0 625
LLPS-Orp-0451Oryza punctata58.360.0 616
LLPS-Glm-0420Glycine max58.360.0 615
LLPS-Chr-0284Chlamydomonas reinhardtii58.30.0 627
LLPS-Crn-1100Cryptococcus neoformans58.290.0 637
LLPS-Arl-1597Arabidopsis lyrata58.120.0 616
LLPS-Scc-1552Schizosaccharomyces cryophilus58.030.0 612
LLPS-Ori-1348Oryza indica57.960.0 615
LLPS-Miv-0800Microbotryum violaceum57.950.0 624
LLPS-Tru-1996Triticum urartu57.850.0 617
LLPS-Scp-1118Schizosaccharomyces pombe57.660.0 617
LLPS-Met-2082Medicago truncatula57.620.0 611
LLPS-Hov-0762Hordeum vulgare57.590.0 613
LLPS-Yal-1152Yarrowia lipolytica57.30.0 634
LLPS-Osl-0918Ostreococcus lucimarinus56.840.0 604
LLPS-Mel-0255Melampsora laricipopulina56.620.0 594
LLPS-Blg-0572Blumeria graminis56.480.0 609
LLPS-Ast-0178Aspergillus terreus56.410.0 598
LLPS-Asfu-0662Aspergillus fumigatus56.230.0 589
LLPS-Asc-0543Aspergillus clavatus56.230.0 596
LLPS-Asg-0630Ashbya gossypii56.180.0 622
LLPS-Asni-0665Aspergillus niger56.10.0 592
LLPS-Nef-0712Neosartorya fischeri56.040.0 588
LLPS-Orb-0864Oryza barthii56.020.0 605
LLPS-Kop-0752Komagataella pastoris56.00.0 604
LLPS-Sac-0023Saccharomyces cerevisiae55.880.0 613
LLPS-Vir-0803Vigna radiata55.760.0 581
LLPS-Usm-0070Ustilago maydis55.20.0 632
LLPS-Nec-1361Neurospora crassa54.780.0 581
LLPS-Spr-0096Sporisorium reilianum54.470.0 623
LLPS-Asn-0932Aspergillus nidulans53.850.0 572
LLPS-Ved-1101Verticillium dahliae53.680.0 561
LLPS-Cog-0803Colletotrichum gloeosporioides53.480.0 562
LLPS-Pyt-0548Pyrenophora teres53.450.0 579
LLPS-Lem-0573Leptosphaeria maculans52.680.0 573
LLPS-Pytr-1332Pyrenophora triticirepentis52.660.0 570
LLPS-Gas-0463Galdieria sulphuraria52.370.0 568