• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Aim-1223
CTPS2

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: CTP synthase; UTP--ammonia ligase
Gene Name: CTPS2
Ensembl Gene: ENSAMEG00000010316.1
Ensembl Protein: ENSAMEP00000010907.1
Organism: Ailuropoda melanoleuca
Taxa ID: 9646
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, P-bodyPredicted from orthologs(View)

▼ FUNCTION

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MKYILVTGGV  ISGIGKGIIA  SSIGTILKSC  GLRVTAIKID  PYINIDAGTF  SPYEHGEVFV  60
61    LNDGGEVDLD  LGNYERFLDI  NLYKDNNITT  GKIYQHVINK  ERRGDYLGKT  VQVVPHITDA  120
121   VQEWVMNQAM  VPVDGHKEEP  QICVIELGGT  IGDIEGMPFV  EAFRQFQFKA  KKENFCNIHV  180
181   SLVPQPSATG  EQKTKPTQNS  VRALRGLGLS  PDLIVCRSST  PIEMAVKEKI  SMFCHVNPEQ  240
241   VICIHDVSST  YRVPVLLEEQ  GIVKYFKERL  DLPIGDSASN  LLFKWRNMAD  RYERLQKTCS  300
301   IALVGKYTKL  RDCYASVFKA  LEHSALAINH  KLNLMYIDSI  DLEQTTETED  PVKFHEAWQK  360
361   LCKADGVLVP  GGFGIRGTLG  KLQAISWARA  KKIPFLGVCL  GMQLAVIEFA  RNCLNLKDAD  420
421   STEFEPNAHV  PVVIDMPEHN  PGNLGGTMRL  GIRRTVFKTE  NSILRKLYGD  VPFIEERHRH  480
481   RYEVNPSLIS  QLEKNDLRFV  GQDVDGERME  IIELANHPYF  VGVQFHPEFS  SRPMKPSPPY  540
541   LGLLLAATGS  LHAYLQQGCK  LSSSDRYSDA  SDDSFSEPRI  AELEIS  586
Nucleotide CDS Sequence (FASTA)
1     ATGAAGTACA  TTCTGGTCAC  TGGAGGGGTC  ATCTCAGGCA  TTGGTAAAGG  GATCATTGCA  60
61    AGCAGCATTG  GGACGATTCT  AAAATCATGT  GGACTCCGAG  TTACTGCCAT  CAAAATTGAC  120
121   CCCTATATTA  ACATCGATGC  GGGCACTTTT  TCACCTTACG  AGCACGGTGA  GGTGTTTGTC  180
181   TTAAATGATG  GTGGAGAAGT  TGATTTAGAC  CTTGGAAATT  ATGAACGGTT  CTTGGATATC  240
241   AACCTTTATA  AAGACAACAA  CATCACCACT  GGGAAGATAT  ATCAGCATGT  GATCAATAAA  300
301   GAGAGGCGTG  GCGATTACCT  GGGGAAAACA  GTACAAGTTG  TCCCTCACAT  TACTGATGCT  360
361   GTCCAGGAAT  GGGTTATGAA  TCAAGCTATG  GTGCCCGTGG  ACGGTCATAA  GGAAGAGCCC  420
421   CAAATATGCG  TTATTGAGTT  GGGTGGCACC  ATTGGAGACA  TTGAAGGGAT  GCCGTTTGTG  480
481   GAAGCATTCA  GACAATTCCA  GTTTAAAGCA  AAAAAAGAGA  ATTTCTGTAA  CATCCATGTT  540
541   AGCCTTGTCC  CACAGCCCAG  TGCTACCGGA  GAACAAAAAA  CCAAACCCAC  ACAAAACAGT  600
601   GTCCGTGCGC  TGAGGGGCTT  AGGCCTGTCT  CCTGATCTGA  TTGTCTGCCG  AAGTTCAACG  660
661   CCCATCGAGA  TGGCTGTGAA  GGAAAAGATT  TCTATGTTTT  GTCACGTGAA  CCCCGAGCAG  720
721   GTCATATGTA  TCCATGATGT  TTCGTCCACA  TATCGAGTGC  CTGTGCTTTT  GGAGGAACAA  780
781   GGCATTGTTA  AATATTTTAA  AGAGAGATTG  GATCTGCCCA  TTGGTGATTC  TGCAAGTAAT  840
841   TTGCTTTTCA  AGTGGAGAAA  TATGGCTGAC  AGGTATGAAA  GGCTGCAGAA  AACGTGCTCC  900
901   ATAGCCTTGG  TTGGCAAATA  TACCAAGCTC  AGGGACTGCT  ACGCCTCCGT  GTTCAAAGCC  960
961   CTGGAACATT  CAGCCTTGGC  CATCAACCAC  AAGTTGAATC  TGATGTACAT  AGACTCCATT  1020
1021  GATCTGGAGC  AGACCACCGA  AACTGAGGAC  CCTGTGAAAT  TCCACGAAGC  TTGGCAGAAG  1080
1081  CTATGCAAAG  CTGATGGCGT  TCTTGTGCCG  GGAGGCTTTG  GAATCCGAGG  AACATTGGGA  1140
1141  AAACTCCAGG  CCATTTCTTG  GGCACGGGCA  AAGAAGATCC  CTTTCCTGGG  AGTTTGCCTC  1200
1201  GGGATGCAAC  TAGCAGTGAT  AGAGTTTGCA  AGAAACTGCC  TTAACTTGAA  AGATGCTGAT  1260
1261  TCCACAGAAT  TTGAGCCAAA  TGCCCATGTT  CCTGTGGTGA  TTGATATGCC  TGAACACAAC  1320
1321  CCCGGCAATT  TGGGAGGAAC  GATGAGGCTG  GGAATCCGAA  GAACTGTTTT  CAAAACAGAA  1380
1381  AATTCAATAT  TAAGGAAACT  TTATGGTGAT  GTTCCTTTTA  TAGAAGAAAG  ACACAGACAT  1440
1441  CGGTATGAGG  TGAACCCAAG  CCTGATCAGT  CAGTTGGAGA  AGAATGACTT  ACGTTTTGTA  1500
1501  GGTCAGGATG  TTGATGGAGA  GAGGATGGAA  ATCATTGAAC  TGGCAAATCA  CCCCTATTTT  1560
1561  GTTGGTGTCC  AATTCCATCC  TGAGTTTTCT  TCTAGGCCGA  TGAAGCCTTC  CCCTCCGTAC  1620
1621  CTGGGCCTAT  TACTTGCTGC  AACCGGGAGC  CTGCATGCCT  ACTTGCAACA  GGGATGCAAG  1680
1681  CTGTCTTCGA  GTGATAGATA  CAGCGACGCC  AGTGATGACA  GTTTTTCAGA  GCCAAGAATA  1740
1741  GCCGAGTTGG  AAATAAGCTG  A  1761

▼ KEYWORD

ID
Family
ATP-binding
Complete proteome
Glutamine amidotransferase
Ligase
Nucleotide-binding
Pyrimidine biosynthesis
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Molecular Function
ATP binding
Molecular Function
CTP synthase activity
Biological Process
'de novo' CTP biosynthetic process
Biological Process
Glutamine metabolic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Urm-3721Ursus maritimus99.660.01133
LLPS-Mup-2896Mustela putorius furo98.630.01123
LLPS-Caf-0492Canis familiaris98.460.01121
LLPS-Ova-2958Ovis aries97.950.01116
LLPS-Sus-2406Sus scrofa97.780.01113
LLPS-Fec-0686Felis catus97.610.01116
LLPS-Bot-3347Bos taurus97.420.01101
LLPS-Cas-0454Carlito syrichta97.310.0 938
LLPS-Eqc-1695Equus caballus96.960.01111
LLPS-Myl-2765Myotis lucifugus96.590.01101
LLPS-Nol-2757Nomascus leucogenys96.250.01094
LLPS-Gog-2769Gorilla gorilla96.250.01094
LLPS-Hos-1508Homo sapiens96.080.01092
LLPS-Cea-0960Cercocebus atys96.080.01094
LLPS-Chs-3305Chlorocebus sabaeus96.080.01094
LLPS-Poa-0321Pongo abelii95.90.01092
LLPS-Pat-2054Pan troglodytes95.90.01092
LLPS-Pap-4331Pan paniscus95.90.01092
LLPS-Maf-4017Macaca fascicularis95.850.01026
LLPS-Mal-0237Mandrillus leucophaeus95.540.0 986
LLPS-Mam-1217Macaca mulatta95.230.0 882
LLPS-Ict-0345Ictidomys tridecemlineatus95.050.01085
LLPS-Orc-0591Oryctolagus cuniculus94.710.01084
LLPS-Dio-1866Dipodomys ordii93.050.01051
LLPS-Loa-2141Loxodonta africana92.830.01068
LLPS-Aon-1017Aotus nancymaae92.490.01054
LLPS-Caj-4381Callithrix jacchus91.980.01052
LLPS-Man-4240Macaca nemestrina90.850.01014
LLPS-Fud-0542Fukomys damarensis90.480.01024
LLPS-Ora-2544Ornithorhynchus anatinus89.840.01008
LLPS-Ran-3287Rattus norvegicus89.420.01026
LLPS-Mum-4312Mus musculus89.420.01026
LLPS-Sah-0315Sarcophilus harrisii89.210.01023
LLPS-Mea-1468Mesocricetus auratus88.40.01019
LLPS-Mod-4387Monodelphis domestica88.270.01003
LLPS-Pes-0339Pelodiscus sinensis87.520.0 988
LLPS-Anp-1088Anas platyrhynchos86.990.0 981
LLPS-Cap-3294Cavia porcellus86.840.0 996
LLPS-Gaga-3451Gallus gallus86.810.0 981
LLPS-Anc-3047Anolis carolinensis86.630.0 975
LLPS-Fia-3673Ficedula albicollis86.630.0 974
LLPS-Tag-2415Taeniopygia guttata85.770.0 964
LLPS-Otg-0137Otolemur garnettii84.880.0 958
LLPS-Meg-0164Meleagris gallopavo82.770.0 921
LLPS-Xet-1192Xenopus tropicalis82.350.0 954
LLPS-Icp-0444Ictalurus punctatus77.720.0 877
LLPS-Asm-1171Astyanax mexicanus77.540.0 878
LLPS-Xim-0625Xiphophorus maculatus77.180.0 887
LLPS-Dar-3272Danio rerio76.830.0 865
LLPS-Leo-0675Lepisosteus oculatus76.750.0 898
LLPS-Scf-0999Scleropages formosus76.580.0 885
LLPS-Pof-3154Poecilia formosa76.510.0 878
LLPS-Orn-0242Oreochromis niloticus76.110.0 845
LLPS-Gaa-1522Gasterosteus aculeatus75.940.0 859
LLPS-Paa-2541Papio anubis75.90.0 892
LLPS-Rhb-1359Rhinopithecus bieti75.730.0 890
LLPS-Tut-2449Tursiops truncatus75.730.0 884
LLPS-Orl-3087Oryzias latipes75.220.0 857
LLPS-Scm-2419Scophthalmus maximus75.040.0 876
LLPS-Tar-0121Takifugu rubripes74.70.0 873
LLPS-Ten-2481Tetraodon nigroviridis73.980.0 860
LLPS-Lac-0326Latimeria chalumnae73.80.0 835
LLPS-Cii-1306Ciona intestinalis70.910.0 709
LLPS-Drm-2201Drosophila melanogaster66.190.0 749
LLPS-Cis-0032Ciona savignyi64.550.0 766
LLPS-Sol-0641Solanum lycopersicum60.750.0 648
LLPS-Viv-1736Vitis vinifera60.690.0 644
LLPS-Abg-0386Absidia glauca60.390.0 674
LLPS-Dac-1425Daucus carota60.390.0 657
LLPS-Prp-0783Prunus persica60.360.0 654
LLPS-Via-2368Vigna angularis60.220.0 647
LLPS-Mua-0003Musa acuminata60.070.0 665
LLPS-Sob-0316Sorghum bicolor60.040.0 649
LLPS-Phv-0477Phaseolus vulgaris59.850.0 642
LLPS-Sem-0584Selaginella moellendorffii59.820.0 634
LLPS-Nia-1784Nicotiana attenuata59.780.0 641
LLPS-Coc-1341Corchorus capsularis59.640.0 650
LLPS-Gor-0674Gossypium raimondii59.570.0 644
LLPS-Php-2049Physcomitrella patens59.350.0 659
LLPS-Mae-2133Manihot esculenta59.250.0 647
LLPS-Hea-0627Helianthus annuus59.250.0 656
LLPS-Thc-0464Theobroma cacao59.170.0 642
LLPS-Bro-2815Brassica oleracea59.00.0 638
LLPS-Brn-2300Brassica napus59.00.0 639
LLPS-Zem-1649Zea mays58.930.0 644
LLPS-Crn-1100Cryptococcus neoformans58.860.0 652
LLPS-Orr-0385Oryza rufipogon58.820.0 639
LLPS-Org-1388Oryza glaberrima58.820.0 651
LLPS-Brr-2316Brassica rapa58.820.0 636
LLPS-Cus-0365Cucumis sativus58.710.0 637
LLPS-Lep-1579Leersia perrieri58.680.0 650
LLPS-Tra-2871Triticum aestivum58.680.0 651
LLPS-Ors-0140Oryza sativa58.650.0 649
LLPS-Orgl-1519Oryza glumaepatula58.650.0 650
LLPS-Orni-2224Oryza nivara58.650.0 650
LLPS-Orbr-0784Oryza brachyantha58.630.0 645
LLPS-Sot-1028Solanum tuberosum58.60.0 649
LLPS-Glm-0420Glycine max58.530.0 635
LLPS-Pot-2410Populus trichocarpa58.360.0 632
LLPS-Orm-0563Oryza meridionalis58.320.0 646
LLPS-Art-2157Arabidopsis thaliana58.290.0 634
LLPS-Sei-1109Setaria italica58.290.0 650
LLPS-Ori-1348Oryza indica58.060.0 641
LLPS-Amt-2261Amborella trichopoda58.050.0 639
LLPS-Orp-0451Oryza punctata57.960.0 639
LLPS-Brd-0862Brachypodium distachyon57.960.0 638
LLPS-Arl-2001Arabidopsis lyrata57.870.0 645
LLPS-Hov-0762Hordeum vulgare57.710.0 635
LLPS-Chr-0284Chlamydomonas reinhardtii57.680.0 639
LLPS-Mel-0255Melampsora laricipopulina57.610.0 609
LLPS-Scp-1118Schizosaccharomyces pombe57.50.0 636
LLPS-Miv-0800Microbotryum violaceum57.420.0 637
LLPS-Met-2082Medicago truncatula57.320.0 630
LLPS-Scc-1552Schizosaccharomyces cryophilus57.320.0 625
LLPS-Tru-1996Triticum urartu57.140.0 637
LLPS-Yal-1152Yarrowia lipolytica57.140.0 646
LLPS-Asni-0665Aspergillus niger57.010.0 600
LLPS-Ast-0178Aspergillus terreus56.960.0 602
LLPS-Osl-0918Ostreococcus lucimarinus56.820.0 622
LLPS-Blg-0572Blumeria graminis56.710.0 626
LLPS-Orb-1003Oryza barthii56.330.0 634
LLPS-Asg-0630Ashbya gossypii56.010.0 631
LLPS-Asc-0543Aspergillus clavatus55.890.0 603
LLPS-Vir-0803Vigna radiata55.80.0 588
LLPS-Sac-0023Saccharomyces cerevisiae55.790.0 628
LLPS-Asfu-0662Aspergillus fumigatus55.710.0 594
LLPS-Nef-0712Neosartorya fischeri55.540.0 593
LLPS-Nec-1361Neurospora crassa55.430.0 599
LLPS-Kop-0752Komagataella pastoris55.070.0 615
LLPS-Usm-0070Ustilago maydis54.890.0 646
LLPS-Spr-0096Sporisorium reilianum54.350.0 639
LLPS-Dos-0000Dothistroma septosporum54.350.0 579
LLPS-Asn-0932Aspergillus nidulans53.930.0 585
LLPS-Pyt-0548Pyrenophora teres53.750.0 592
LLPS-Lem-0573Leptosphaeria maculans53.180.0 588
LLPS-Pytr-1332Pyrenophora triticirepentis52.550.0 586
LLPS-Gas-0463Galdieria sulphuraria52.160.0 580
LLPS-Cae-0055Caenorhabditis elegans51.470.0 583