• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Nia-0587
A4A49_09252

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Inosine-5'-monophosphate dehydrogenase
Gene Name: A4A49_09252
Ensembl Gene: A4A49_09252
Ensembl Protein: OIS97018
Organism: Nicotiana attenuata
Taxa ID: 49451
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MNDDGFPAER  LFNQGYSYTY  DDVIFLPGYI  DFPVDDVNLS  TKLSRNIPLS  IPCVASPMDT  60
61    VTETSMAVAM  AALGGIGIVH  YNNTISQQAS  IIRTAKSHKF  PFSADLIFAS  PSDSIHSADE  120
121   FANSPCIFVT  ESGNKQSKLL  GHVSKSDWKN  LSNKEARISA  YMNTSPVTLP  SSYDFNDVAG  180
181   YMASKKLDFV  ALVNEEEENG  EVVNLVTSAD  MERIKGLPKL  GLPSLGEDGK  FLVGAAVGTR  240
241   ESDKERLEHL  VKEGINAVVI  DSSQGNSLYQ  INMIKHVKHT  YPHLDVIGGN  VVTNYQAENL  300
301   IKQGVDGLRV  GMGSGSICTT  QEVCAVGRGQ  ATAVYKVSSI  AEQHGIPVIA  DGGISNSGHI  360
361   VKALSLGAST  VMMGSFLAGS  NEAPGTYEYK  NGLRVKKYRG  MGSLEAMTKG  SDARYLGDTA  420
421   KLKIAQGVVG  SVADKGSILK  FIPYTMQAVK  QGFQDLGASS  LQSAHHLLKS  GKLRLEVRTG  480
481   AAQVEGGVHG  LVGYEKRYF  499
Nucleotide CDS Sequence (FASTA)
1     ATGAACGACG  ACGGATTTCC  AGCTGAGAGA  TTGTTCAACC  AAGGCTACTC  CTACACTTAC  60
61    GATGATGTCA  TCTTTCTCCC  TGGCTACATC  GACTTCCCCG  TCGACGACGT  CAACCTCTCC  120
121   ACTAAGCTCA  GCCGCAACAT  CCCCCTCTCC  ATCCCCTGCG  TCGCTTCTCC  TATGGACACC  180
181   GTCACCGAGA  CCTCCATGGC  CGTTGCCATG  GCGGCGCTCG  GCGGAATAGG  TATCGTTCAC  240
241   TACAACAACA  CTATCTCTCA  ACAAGCATCC  ATCATCCGTA  CTGCCAAATC  TCATAAATTC  300
301   CCTTTCTCCG  CCGACTTAAT  CTTCGCTTCT  CCCTCGGATT  CAATCCATTC  CGCCGATGAA  360
361   TTCGCTAACT  CCCCTTGCAT  TTTCGTCACC  GAGTCAGGGA  ACAAACAATC  CAAACTGTTA  420
421   GGACACGTGT  CAAAGTCTGA  TTGGAAGAAC  TTGAGCAATA  AGGAAGCTAG  GATTTCTGCT  480
481   TATATGAACA  CTTCTCCCGT  TACTCTGCCT  TCGAGTTATG  ATTTCAATGA  CGTGGCAGGC  540
541   TACATGGCAT  CTAAAAAGCT  GGACTTTGTT  GCATTAGTAA  ACGAGGAGGA  GGAAAACGGG  600
601   GAAGTAGTCA  ATTTAGTCAC  GAGTGCTGAC  ATGGAGAGAA  TAAAGGGACT  TCCGAAATTG  660
661   GGTTTGCCAT  CTTTAGGGGA  AGACGGGAAG  TTCTTAGTGG  GGGCAGCGGT  GGGGACAAGG  720
721   GAATCAGATA  AAGAGAGGCT  GGAGCATTTG  GTGAAAGAAG  GGATTAATGC  TGTGGTGATT  780
781   GATAGCTCGC  AAGGGAATTC  GCTGTACCAG  ATTAATATGA  TCAAGCATGT  GAAACATACT  840
841   TACCCTCACT  TGGATGTGAT  TGGTGGAAAT  GTAGTCACTA  ATTACCAAGC  TGAGAACTTA  900
901   ATTAAGCAGG  GAGTTGATGG  ATTGAGGGTT  GGTATGGGAT  CTGGGTCCAT  CTGTACCACT  960
961   CAAGAAGTTT  GCGCTGTGGG  TCGCGGTCAG  GCAACTGCTG  TTTACAAGGT  GTCATCAATT  1020
1021  GCTGAGCAGC  ATGGTATCCC  TGTGATTGCT  GATGGTGGGA  TTTCAAATTC  TGGCCATATC  1080
1081  GTGAAGGCAT  TGTCCCTTGG  AGCATCAACT  GTCATGATGG  GAAGCTTCTT  GGCTGGTAGT  1140
1141  AATGAAGCTC  CTGGCACATA  TGAATATAAG  AATGGTCTGC  GTGTGAAAAA  ATATCGAGGT  1200
1201  ATGGGATCCC  TGGAAGCAAT  GACAAAAGGG  AGTGATGCAA  GATACTTGGG  TGATACTGCT  1260
1261  AAACTAAAGA  TTGCTCAGGG  AGTTGTCGGT  TCAGTTGCTG  ATAAAGGTTC  TATTCTGAAG  1320
1321  TTCATTCCCT  ATACAATGCA  AGCTGTAAAG  CAAGGATTCC  AGGATCTAGG  TGCTTCCTCC  1380
1381  TTGCAATCTG  CTCATCATCT  TTTAAAATCA  GGCAAATTGA  GGCTAGAGGT  CCGAACAGGA  1440
1441  GCCGCACAAG  TTGAAGGAGG  GGTTCATGGT  CTCGTCGGTT  ATGAGAAGAG  ATACTTCTGA  1500

▼ KEYWORD

ID
Family
CBS domain
Complete proteome
Cytoplasm
GMP biosynthesis
Metal-binding
NAD
Oxidoreductase
Potassium
Purine biosynthesis
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Molecular Function
IMP dehydrogenase activity
Molecular Function
Metal ion binding
Molecular Function
Nucleotide binding
Biological Process
GMP biosynthetic process

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Sot-1900Solanum tuberosum87.370.0 862
LLPS-Sol-1041Solanum lycopersicum86.970.0 856
LLPS-Tru-1749Triticum urartu78.683e-141 418
LLPS-Viv-0614Vitis vinifera73.040.0 709
LLPS-Sem-2172Selaginella moellendorffii72.897e-138 410
LLPS-Dac-1684Daucus carota72.340.0 722
LLPS-Mua-2443Musa acuminata70.820.0 687
LLPS-Coc-1687Corchorus capsularis69.940.0 645
LLPS-Gor-1048Gossypium raimondii69.940.0 660
LLPS-Thc-1411Theobroma cacao69.940.0 639
LLPS-Pot-1500Populus trichocarpa69.520.0 669
LLPS-Met-0026Medicago truncatula69.480.0 674
LLPS-Cus-1084Cucumis sativus69.420.0 681
LLPS-Arl-0147Arabidopsis lyrata69.380.0 643
LLPS-Bro-1340Brassica oleracea69.320.0 659
LLPS-Art-0358Arabidopsis thaliana69.320.0 663
LLPS-Brr-2683Brassica rapa69.320.0 659
LLPS-Brn-0303Brassica napus69.320.0 659
LLPS-Mae-2041Manihot esculenta69.260.0 666
LLPS-Prp-2478Prunus persica69.140.0 670
LLPS-Org-1496Oryza glaberrima67.540.0 628
LLPS-Orp-1928Oryza punctata67.540.0 628
LLPS-Sei-0343Setaria italica67.540.0 623
LLPS-Orm-0602Oryza meridionalis67.470.0 626
LLPS-Via-0475Vigna angularis67.470.0 643
LLPS-Lep-1656Leersia perrieri67.40.0 604
LLPS-Orr-0835Oryza rufipogon67.330.0 628
LLPS-Tra-0216Triticum aestivum67.330.0 633
LLPS-Orbr-2163Oryza brachyantha67.130.0 626
LLPS-Phv-0678Phaseolus vulgaris67.070.0 640
LLPS-Hov-1155Hordeum vulgare67.00.0 628
LLPS-Orni-1065Oryza nivara66.930.0 623
LLPS-Glm-2946Glycine max66.60.0 644
LLPS-Ors-1156Oryza sativa66.460.0 586
LLPS-Sob-1270Sorghum bicolor66.270.0 599
LLPS-Zem-0780Zea mays66.070.0 600
LLPS-Brd-1981Brachypodium distachyon65.730.0 609
LLPS-Vir-1499Vigna radiata64.390.0 593
LLPS-Lac-1456Latimeria chalumnae63.681e-93 301
LLPS-Amt-2341Amborella trichopoda62.930.0 610
LLPS-Ori-2103Oryza indica62.150.0 604
LLPS-Php-1610Physcomitrella patens59.320.0 557
LLPS-Cii-2005Ciona intestinalis58.913e-108 334
LLPS-Asn-1194Aspergillus nidulans53.682e-96 300
LLPS-Put-0803Puccinia triticina52.822e-98 312
LLPS-Chr-0294Chlamydomonas reinhardtii52.46e-162 476
LLPS-Meg-3337Meleagris gallopavo48.733e-133 401
LLPS-Ere-0480Erinaceus europaeus48.622e-149 444
LLPS-Ova-1936Ovis aries48.621e-147 440
LLPS-Tut-1963Tursiops truncatus48.623e-148 442
LLPS-Orc-3916Oryctolagus cuniculus48.552e-148 442
LLPS-Mod-1573Monodelphis domestica48.551e-148 442
LLPS-Ran-1891Rattus norvegicus48.555e-149 443
LLPS-Cap-4421Cavia porcellus48.431e-148 442
LLPS-Fec-4086Felis catus48.434e-148 441
LLPS-Aim-1379Ailuropoda melanoleuca48.436e-148 441
LLPS-Dio-2098Dipodomys ordii48.437e-149 443
LLPS-Fud-3363Fukomys damarensis48.431e-148 442
LLPS-Man-3472Macaca nemestrina48.363e-149 444
LLPS-Myl-3325Myotis lucifugus48.363e-148 441
LLPS-Mum-4373Mus musculus48.368e-148 440
LLPS-Asm-2637Astyanax mexicanus48.266e-145 436
LLPS-Orl-1912Oryzias latipes48.263e-145 437
LLPS-Cas-1262Carlito syrichta48.164e-148 441
LLPS-Nol-2537Nomascus leucogenys48.164e-148 441
LLPS-Poa-1510Pongo abelii48.162e-148 442
LLPS-Otg-4452Otolemur garnettii48.161e-148 442
LLPS-Pat-0353Pan troglodytes48.164e-148 441
LLPS-Pap-4652Pan paniscus48.164e-148 441
LLPS-Hos-2963Homo sapiens48.164e-148 441
LLPS-Loa-2952Loxodonta africana48.167e-148 441
LLPS-Mal-4014Mandrillus leucophaeus48.162e-148 442
LLPS-Gog-3571Gorilla gorilla48.164e-148 441
LLPS-Caj-3657Callithrix jacchus48.162e-148 442
LLPS-Mea-0572Mesocricetus auratus48.162e-147 439
LLPS-Maf-3593Macaca fascicularis48.162e-148 442
LLPS-Chs-4463Chlorocebus sabaeus48.162e-148 442
LLPS-Cea-3370Cercocebus atys48.162e-148 442
LLPS-Orn-3216Oreochromis niloticus48.141e-145 436
LLPS-Dar-1093Danio rerio48.061e-146 438
LLPS-Scm-0704Scophthalmus maximus48.062e-143 433
LLPS-Tag-2241Taeniopygia guttata47.982e-140 421
LLPS-Ten-2052Tetraodon nigroviridis47.952e-144 432
LLPS-Scf-3575Scleropages formosus47.933e-141 436
LLPS-Xet-1886Xenopus tropicalis47.91e-142 427
LLPS-Ora-1639Ornithorhynchus anatinus47.92e-140 421
LLPS-Pof-3852Poecilia formosa47.864e-144 432
LLPS-Icp-1661Ictalurus punctatus47.852e-142 430
LLPS-Rhb-1813Rhinopithecus bieti47.757e-147 438
LLPS-Gaa-1905Gasterosteus aculeatus47.752e-143 430
LLPS-Eqc-2573Equus caballus47.731e-145 437
LLPS-Leo-0021Lepisosteus oculatus47.671e-139 423
LLPS-Anc-3648Anolis carolinensis47.621e-130 397
LLPS-Mam-1098Macaca mulatta47.616e-146 436
LLPS-Paa-4246Papio anubis47.616e-146 436
LLPS-Caf-3929Canis familiaris47.61e-141 425
LLPS-Mup-1939Mustela putorius furo47.532e-145 436
LLPS-Bot-2386Bos taurus47.532e-145 436
LLPS-Sus-4230Sus scrofa47.532e-145 436
LLPS-Xim-4119Xiphophorus maculatus47.487e-144 431
LLPS-Tar-1055Takifugu rubripes47.482e-143 430
LLPS-Drm-2362Drosophila melanogaster47.252e-145 435
LLPS-Sah-3301Sarcophilus harrisii47.181e-140 424
LLPS-Chc-0907Chondrus crispus47.082e-147 440
LLPS-Gaga-3548Gallus gallus46.542e-144 432
LLPS-Urm-2015Ursus maritimus46.245e-142 426
LLPS-Aon-3984Aotus nancymaae46.217e-143 429
LLPS-Fia-3852Ficedula albicollis45.839e-121 369
LLPS-Ict-1434Ictidomys tridecemlineatus45.663e-141 424
LLPS-Cym-0707Cyanidioschyzon merolae45.63e-143 430
LLPS-Mel-1002Melampsora laricipopulina45.291e-134 407
LLPS-Yal-1185Yarrowia lipolytica45.291e-133 404
LLPS-Anp-1202Anas platyrhynchos45.226e-113 348
LLPS-Zyt-0349Zymoseptoria tritici44.916e-134 406
LLPS-Pes-1464Pelodiscus sinensis44.832e-114 353
LLPS-Ved-1272Verticillium dahliae44.824e-125 383
LLPS-Lem-1293Leptosphaeria maculans44.553e-129 394
LLPS-Nec-1177Neurospora crassa44.533e-125 383
LLPS-Abg-0843Absidia glauca44.491e-139 420
LLPS-Sac-0949Saccharomyces cerevisiae44.441e-133 404
LLPS-Miv-0947Microbotryum violaceum44.311e-129 395
LLPS-Dos-1395Dothistroma septosporum44.053e-130 397
LLPS-Crn-1469Cryptococcus neoformans44.023e-132 401
LLPS-Gas-0386Galdieria sulphuraria43.898e-141 422
LLPS-Pyt-1585Pyrenophora teres43.761e-125 385
LLPS-Cog-1015Colletotrichum gloeosporioides43.631e-121 374
LLPS-Beb-1173Beauveria bassiana43.638e-122 374
LLPS-Pytr-1585Pyrenophora triticirepentis43.562e-125 384
LLPS-Nef-1260Neosartorya fischeri43.552e-125 384
LLPS-Ast-1484Aspergillus terreus43.554e-128 391
LLPS-Asf-0995Aspergillus flavus43.553e-129 394
LLPS-Aso-1291Aspergillus oryzae43.553e-129 394
LLPS-Gag-0551Gaeumannomyces graminis43.553e-123 378
LLPS-Fus-0898Fusarium solani43.432e-119 368
LLPS-Tum-0212Tuber melanosporum43.388e-129 392
LLPS-Asni-0780Aspergillus niger43.353e-129 393
LLPS-Map-1261Magnaporthe poae43.354e-124 380
LLPS-Cogr-0871Colletotrichum graminicola43.032e-123 379
LLPS-Asg-0453Ashbya gossypii42.942e-131 399
LLPS-Pug-1147Puccinia graminis42.861e-128 392
LLPS-Fuo-1028Fusarium oxysporum42.833e-116 360
LLPS-Coo-1623Colletotrichum orbiculare42.831e-118 366
LLPS-Fuv-0743Fusarium verticillioides42.833e-116 360
LLPS-Mao-0089Magnaporthe oryzae42.772e-122 376
LLPS-Phn-0109Phaeosphaeria nodorum42.584e-122 376
LLPS-Usm-1282Ustilago maydis42.46e-129 393
LLPS-Spr-0999Sporisorium reilianum42.236e-129 393
LLPS-Blg-1418Blumeria graminis42.126e-120 369
LLPS-Scj-1026Schizosaccharomyces japonicus41.686e-121 372
LLPS-Scs-0688Sclerotinia sclerotiorum41.632e-118 366
LLPS-Trv-0093Trichoderma virens41.433e-118 365
LLPS-Trr-1016Trichoderma reesei41.237e-118 364
LLPS-Scp-1424Schizosaccharomyces pombe41.186e-123 377
LLPS-Scc-0322Schizosaccharomyces cryophilus41.181e-122 376
LLPS-Cis-0076Ciona savignyi38.098e-100 318