LLPS-Fud-3363
IMPDH
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Inosine-5'-monophosphate dehydrogenase |
| Gene Name: | IMPDH, H920_20035 |
| Ensembl Gene: | ENSFDAG00000018541.1 |
| Ensembl Protein: | ENSFDAP00000010898.1 |
| Organism: | Fukomys damarensis |
| Taxa ID: | 885580 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSFDAT00000023729.1 | ENSFDAP00000010898.1 |
| UniProt | A0A091CLD3, A0A091CLD3_FUKDA | |
| GeneBank | KN125357 | KFO18607.1 |
| RefSeq | XM_010615606.2 | XP_010613908.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MADYLISGGT SYVPDDGLTA QQLFNCGDGL TYNDFLILPG YIDFTADQVD LTSALTKKIT 60 61 LKTPLVSSPM DTVTEAGMAI AMALTGGIGF IHHNCTPEFQ ANEVRKVKKY EQGFITDPVV 120 121 LSPKDRVRDV FEAKARHGFC GIPITDTGRM GSRLVGIISS RDIDFLKEEE HDRFLEEIMT 180 181 KREDLVVAPA GITLKEANEI LQRSKKGKLP IVNEDDELVA IIARTDLKKN RDYPLASKDA 240 241 KKQLLCGAAI GTHEDDKYRL DLLAQSGVDV VVLDSSQGNS IFQINMIKYI KEKYPNLQVI 300 301 GGNVVTAAQA KNLIDAGVDA LRVGMGSGSI CITQEVLACG RPQATAVYKV SEYARRFGVP 360 361 VIADGGIQNV GHIAKALALG ASTVMMGSLL AATTEAPGEY FFSDGIRLKK YRGMGSLDAM 420 421 DKHLSSQNRY FSEADKIKVA QGVSGAVQDK GSIHKFVPYL IAGIQHSCQD IGAKSLTQVR 480 481 AMMYSGELKF EKRTSSAQVE GGVHSLHSYE KRLF 514 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCTGACT ACCTGATTAG CGGGGGCACA TCCTATGTGC CGGACGACGG ACTCACGGCA 60 61 CAGCAGCTCT TCAACTGCGG TGACGGCCTC ACCTACAACG ATTTCCTCAT TCTCCCTGGA 120 121 TACATCGACT TCACTGCAGA CCAGGTGGAC CTTACTTCTG CTCTGACCAA GAAGATCACA 180 181 CTCAAGACCC CACTGGTTTC CTCCCCCATG GATACAGTCA CAGAGGCTGG AATGGCCATT 240 241 GCCATGGCGC TCACAGGAGG TATTGGTTTC ATCCACCACA ACTGTACACC TGAATTCCAG 300 301 GCCAATGAAG TTCGTAAAGT GAAGAAATAT GAGCAGGGAT TCATCACAGA CCCTGTGGTT 360 361 CTCAGCCCCA AGGATCGCGT GAGGGATGTT TTTGAGGCTA AGGCTCGGCA TGGCTTCTGT 420 421 GGCATCCCCA TCACAGATAC AGGCCGCATG GGGAGCCGCT TAGTGGGCAT CATTTCATCA 480 481 AGAGATATCG ATTTTCTCAA GGAAGAGGAA CATGACCGGT TTCTGGAAGA GATCATGACA 540 541 AAGAGGGAAG ACTTGGTAGT AGCCCCTGCA GGCATCACAT TAAAGGAAGC AAATGAAATT 600 601 TTGCAGCGTA GCAAGAAGGG AAAGTTACCG ATTGTAAATG AAGATGATGA GCTGGTGGCC 660 661 ATCATTGCTC GGACGGATCT GAAGAAGAAC AGGGATTACC CACTTGCCTC CAAAGATGCC 720 721 AAGAAGCAAC TGCTGTGTGG GGCAGCCATT GGTACTCATG AAGATGACAA GTATAGGCTG 780 781 GACTTGTTAG CCCAGTCTGG TGTGGATGTA GTAGTTTTGG ACTCTTCCCA GGGCAACTCC 840 841 ATCTTCCAAA TCAATATGAT CAAGTACATC AAAGAAAAAT ACCCCAATCT CCAAGTCATT 900 901 GGAGGCAATG TGGTCACCGC AGCTCAGGCC AAGAACCTCA TCGACGCAGG TGTAGATGCT 960 961 CTGCGGGTGG GCATGGGAAG CGGCTCCATC TGCATCACCC AGGAAGTGTT AGCCTGTGGA 1020 1021 AGGCCGCAAG CAACAGCAGT GTACAAGGTG TCAGAGTATG CACGGCGCTT TGGCGTTCCT 1080 1081 GTCATCGCTG ATGGAGGAAT CCAAAACGTG GGCCATATTG CCAAAGCTTT GGCCCTGGGG 1140 1141 GCATCCACAG TCATGATGGG CTCCCTCCTG GCTGCCACCA CTGAAGCCCC TGGGGAATAC 1200 1201 TTCTTCTCTG ATGGGATCCG GCTAAAGAAA TATCGTGGCA TGGGTTCTCT TGATGCCATG 1260 1261 GACAAGCATC TCAGCAGCCA GAACCGCTAT TTCAGTGAAG CTGACAAAAT CAAAGTAGCC 1320 1321 CAAGGGGTTT CAGGAGCTGT GCAAGACAAA GGGTCCATCC ACAAGTTTGT TCCTTACTTG 1380 1381 ATTGCTGGCA TCCAGCACTC CTGCCAGGAC ATTGGTGCCA AGAGCTTGAC CCAAGTCCGA 1440 1441 GCCATGATGT ACTCTGGGGA GCTTAAGTTT GAGAAGAGAA CGTCTTCGGC CCAGGTGGAA 1500 1501 GGTGGTGTCC ACAGCCTTCA CTCGTATGAG AAGCGGCTTT TCTGA 1545 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Nucleus | |
Molecular Function | IMP dehydrogenase activity | |
Molecular Function | Metal ion binding | |
Molecular Function | Nucleotide binding | |
Biological Process | Cellular response to interleukin-4 | |
Biological Process | Circadian rhythm | |
Biological Process | GMP biosynthetic process | |
Biological Process | Lymphocyte proliferation |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Cap-4421 | Cavia porcellus | 100.0 | 0.0 | 1055 |
| LLPS-Poa-1510 | Pongo abelii | 99.61 | 0.0 | 1050 |
| LLPS-Fec-4086 | Felis catus | 99.61 | 0.0 | 1052 |
| LLPS-Dio-2098 | Dipodomys ordii | 99.61 | 0.0 | 1052 |
| LLPS-Caj-3657 | Callithrix jacchus | 99.61 | 0.0 | 1050 |
| LLPS-Cas-1262 | Carlito syrichta | 99.42 | 0.0 | 1048 |
| LLPS-Nol-2537 | Nomascus leucogenys | 99.42 | 0.0 | 1048 |
| LLPS-Pat-0353 | Pan troglodytes | 99.42 | 0.0 | 1048 |
| LLPS-Pap-4652 | Pan paniscus | 99.42 | 0.0 | 1048 |
| LLPS-Hos-2963 | Homo sapiens | 99.42 | 0.0 | 1048 |
| LLPS-Otg-4452 | Otolemur garnettii | 99.42 | 0.0 | 1049 |
| LLPS-Aim-1379 | Ailuropoda melanoleuca | 99.42 | 0.0 | 1051 |
| LLPS-Myl-3325 | Myotis lucifugus | 99.42 | 0.0 | 1052 |
| LLPS-Mal-4014 | Mandrillus leucophaeus | 99.42 | 0.0 | 1048 |
| LLPS-Chs-4463 | Chlorocebus sabaeus | 99.42 | 0.0 | 1048 |
| LLPS-Maf-3593 | Macaca fascicularis | 99.42 | 0.0 | 1048 |
| LLPS-Cea-3370 | Cercocebus atys | 99.42 | 0.0 | 1048 |
| LLPS-Gog-3571 | Gorilla gorilla | 99.42 | 0.0 | 1048 |
| LLPS-Man-3472 | Macaca nemestrina | 99.22 | 0.0 | 1046 |
| LLPS-Rhb-1813 | Rhinopithecus bieti | 99.22 | 0.0 | 1044 |
| LLPS-Tut-1963 | Tursiops truncatus | 99.22 | 0.0 | 1046 |
| LLPS-Mum-4373 | Mus musculus | 99.03 | 0.0 | 1047 |
| LLPS-Loa-2952 | Loxodonta africana | 98.83 | 0.0 | 1041 |
| LLPS-Orc-3916 | Oryctolagus cuniculus | 98.83 | 0.0 | 1045 |
| LLPS-Ran-1891 | Rattus norvegicus | 98.83 | 0.0 | 1045 |
| LLPS-Mea-0572 | Mesocricetus auratus | 98.83 | 0.0 | 1045 |
| LLPS-Ere-0480 | Erinaceus europaeus | 98.64 | 0.0 | 1043 |
| LLPS-Ova-1936 | Ovis aries | 98.44 | 0.0 | 1040 |
| LLPS-Mam-1098 | Macaca mulatta | 98.27 | 0.0 | 1043 |
| LLPS-Paa-4246 | Papio anubis | 98.27 | 0.0 | 1043 |
| LLPS-Mod-1573 | Monodelphis domestica | 97.67 | 0.0 | 1033 |
| LLPS-Ora-1639 | Ornithorhynchus anatinus | 96.07 | 0.0 | 955 |
| LLPS-Aon-3984 | Aotus nancymaae | 95.17 | 0.0 | 1035 |
| LLPS-Urm-2015 | Ursus maritimus | 94.98 | 0.0 | 1034 |
| LLPS-Tag-2241 | Taeniopygia guttata | 94.97 | 0.0 | 972 |
| LLPS-Ict-1434 | Ictidomys tridecemlineatus | 94.61 | 0.0 | 1030 |
| LLPS-Meg-3337 | Meleagris gallopavo | 94.42 | 0.0 | 899 |
| LLPS-Anp-1202 | Anas platyrhynchos | 91.54 | 0.0 | 837 |
| LLPS-Gaga-3548 | Gallus gallus | 90.52 | 0.0 | 991 |
| LLPS-Fia-3852 | Ficedula albicollis | 88.27 | 0.0 | 840 |
| LLPS-Pes-1464 | Pelodiscus sinensis | 88.16 | 0.0 | 837 |
| LLPS-Leo-0021 | Lepisosteus oculatus | 85.71 | 0.0 | 914 |
| LLPS-Gaa-1905 | Gasterosteus aculeatus | 85.66 | 0.0 | 914 |
| LLPS-Ten-2052 | Tetraodon nigroviridis | 85.46 | 0.0 | 914 |
| LLPS-Icp-1661 | Ictalurus punctatus | 85.46 | 0.0 | 914 |
| LLPS-Orn-3216 | Oreochromis niloticus | 85.27 | 0.0 | 906 |
| LLPS-Anc-3648 | Anolis carolinensis | 84.97 | 0.0 | 812 |
| LLPS-Lac-3283 | Latimeria chalumnae | 84.85 | 0.0 | 861 |
| LLPS-Xet-1886 | Xenopus tropicalis | 84.27 | 0.0 | 907 |
| LLPS-Bot-2386 | Bos taurus | 84.05 | 0.0 | 909 |
| LLPS-Sus-4230 | Sus scrofa | 84.05 | 0.0 | 907 |
| LLPS-Mup-1939 | Mustela putorius furo | 83.85 | 0.0 | 908 |
| LLPS-Eqc-2573 | Equus caballus | 83.66 | 0.0 | 907 |
| LLPS-Caf-3929 | Canis familiaris | 83.61 | 0.0 | 849 |
| LLPS-Scf-3575 | Scleropages formosus | 81.82 | 0.0 | 913 |
| LLPS-Dar-1093 | Danio rerio | 81.26 | 0.0 | 913 |
| LLPS-Orl-1912 | Oryzias latipes | 81.11 | 0.0 | 917 |
| LLPS-Pof-3852 | Poecilia formosa | 80.96 | 0.0 | 912 |
| LLPS-Sah-3301 | Sarcophilus harrisii | 80.93 | 0.0 | 858 |
| LLPS-Xim-4119 | Xiphophorus maculatus | 80.78 | 0.0 | 913 |
| LLPS-Tar-1055 | Takifugu rubripes | 80.74 | 0.0 | 907 |
| LLPS-Asm-2637 | Astyanax mexicanus | 80.74 | 0.0 | 908 |
| LLPS-Scm-0704 | Scophthalmus maximus | 80.41 | 0.0 | 905 |
| LLPS-Cii-2005 | Ciona intestinalis | 74.74 | 0.0 | 608 |
| LLPS-Drm-2362 | Drosophila melanogaster | 68.99 | 0.0 | 719 |
| LLPS-Abg-0843 | Absidia glauca | 63.8 | 0.0 | 649 |
| LLPS-Asg-0453 | Ashbya gossypii | 63.8 | 0.0 | 655 |
| LLPS-Cis-0076 | Ciona savignyi | 63.27 | 0.0 | 654 |
| LLPS-Mel-1002 | Melampsora laricipopulina | 62.52 | 0.0 | 649 |
| LLPS-Sac-0949 | Saccharomyces cerevisiae | 62.23 | 0.0 | 653 |
| LLPS-Yal-1185 | Yarrowia lipolytica | 62.04 | 0.0 | 625 |
| LLPS-Miv-0947 | Microbotryum violaceum | 61.8 | 0.0 | 659 |
| LLPS-Asn-1194 | Aspergillus nidulans | 61.67 | 3e-124 | 373 |
| LLPS-Sem-2172 | Selaginella moellendorffii | 61.21 | 5e-110 | 339 |
| LLPS-Tum-0212 | Tuber melanosporum | 60.95 | 0.0 | 614 |
| LLPS-Pug-1147 | Puccinia graminis | 60.75 | 0.0 | 646 |
| LLPS-Gas-0386 | Galdieria sulphuraria | 59.88 | 0.0 | 598 |
| LLPS-Usm-1282 | Ustilago maydis | 59.62 | 0.0 | 628 |
| LLPS-Asni-0780 | Aspergillus niger | 59.42 | 0.0 | 607 |
| LLPS-Dos-1395 | Dothistroma septosporum | 59.36 | 0.0 | 593 |
| LLPS-Aso-1291 | Aspergillus oryzae | 59.34 | 0.0 | 601 |
| LLPS-Asf-0995 | Aspergillus flavus | 59.34 | 0.0 | 601 |
| LLPS-Gag-0551 | Gaeumannomyces graminis | 59.34 | 0.0 | 593 |
| LLPS-Mao-0089 | Magnaporthe oryzae | 59.34 | 0.0 | 585 |
| LLPS-Put-0803 | Puccinia triticina | 59.22 | 0.0 | 539 |
| LLPS-Pyt-1585 | Pyrenophora teres | 59.12 | 0.0 | 590 |
| LLPS-Crn-1469 | Cryptococcus neoformans | 59.12 | 0.0 | 610 |
| LLPS-Lem-1293 | Leptosphaeria maculans | 59.04 | 0.0 | 599 |
| LLPS-Nec-1177 | Neurospora crassa | 58.96 | 0.0 | 588 |
| LLPS-Cym-0707 | Cyanidioschyzon merolae | 58.84 | 0.0 | 593 |
| LLPS-Scc-0322 | Schizosaccharomyces cryophilus | 58.82 | 0.0 | 598 |
| LLPS-Trv-0093 | Trichoderma virens | 58.77 | 0.0 | 594 |
| LLPS-Scs-0688 | Sclerotinia sclerotiorum | 58.77 | 0.0 | 582 |
| LLPS-Pytr-1585 | Pyrenophora triticirepentis | 58.73 | 0.0 | 588 |
| LLPS-Nef-1260 | Neosartorya fischeri | 58.57 | 0.0 | 585 |
| LLPS-Map-1261 | Magnaporthe poae | 58.57 | 0.0 | 586 |
| LLPS-Spr-0999 | Sporisorium reilianum | 58.49 | 0.0 | 619 |
| LLPS-Fuo-1028 | Fusarium oxysporum | 58.43 | 0.0 | 564 |
| LLPS-Fuv-0743 | Fusarium verticillioides | 58.43 | 0.0 | 564 |
| LLPS-Trr-1016 | Trichoderma reesei | 58.38 | 0.0 | 595 |
| LLPS-Scp-1424 | Schizosaccharomyces pombe | 58.24 | 0.0 | 597 |
| LLPS-Phn-0109 | Phaeosphaeria nodorum | 58.22 | 0.0 | 582 |
| LLPS-Beb-1173 | Beauveria bassiana | 58.19 | 0.0 | 583 |
| LLPS-Fus-0898 | Fusarium solani | 58.19 | 0.0 | 591 |
| LLPS-Blg-1418 | Blumeria graminis | 58.0 | 0.0 | 587 |
| LLPS-Chc-0907 | Chondrus crispus | 57.83 | 0.0 | 583 |
| LLPS-Cogr-0871 | Colletotrichum graminicola | 57.8 | 0.0 | 593 |
| LLPS-Ast-1484 | Aspergillus terreus | 57.8 | 0.0 | 596 |
| LLPS-Cog-1015 | Colletotrichum gloeosporioides | 57.8 | 0.0 | 588 |
| LLPS-Zyt-0349 | Zymoseptoria tritici | 57.47 | 0.0 | 599 |
| LLPS-Scj-1026 | Schizosaccharomyces japonicus | 57.45 | 0.0 | 589 |
| LLPS-Ved-1272 | Verticillium dahliae | 57.23 | 0.0 | 584 |
| LLPS-Coo-1623 | Colletotrichum orbiculare | 57.23 | 0.0 | 578 |
| LLPS-Tru-1749 | Triticum urartu | 54.01 | 5e-96 | 302 |
| LLPS-Chr-0294 | Chlamydomonas reinhardtii | 53.88 | 4e-177 | 515 |
| LLPS-Amt-2341 | Amborella trichopoda | 51.38 | 1e-165 | 486 |
| LLPS-Php-1610 | Physcomitrella patens | 50.87 | 1e-174 | 509 |
| LLPS-Prp-2478 | Prunus persica | 50.59 | 7e-157 | 464 |
| LLPS-Cus-1084 | Cucumis sativus | 50.3 | 2e-152 | 452 |
| LLPS-Coc-1687 | Corchorus capsularis | 50.1 | 9e-149 | 442 |
| LLPS-Gor-1048 | Gossypium raimondii | 50.1 | 6e-154 | 456 |
| LLPS-Thc-1411 | Theobroma cacao | 50.1 | 5e-150 | 446 |
| LLPS-Mua-2443 | Musa acuminata | 50.1 | 2e-156 | 462 |
| LLPS-Met-0026 | Medicago truncatula | 49.41 | 8e-156 | 461 |
| LLPS-Glm-2946 | Glycine max | 49.41 | 3e-149 | 444 |
| LLPS-Viv-0614 | Vitis vinifera | 49.22 | 3e-148 | 444 |
| LLPS-Pot-1500 | Populus trichocarpa | 49.11 | 3e-151 | 449 |
| LLPS-Brn-0303 | Brassica napus | 49.11 | 2e-150 | 447 |
| LLPS-Dac-1684 | Daucus carota | 48.92 | 1e-157 | 466 |
| LLPS-Brr-2683 | Brassica rapa | 48.91 | 2e-149 | 445 |
| LLPS-Phv-0678 | Phaseolus vulgaris | 48.83 | 2e-151 | 450 |
| LLPS-Bro-1340 | Brassica oleracea | 48.81 | 3e-150 | 447 |
| LLPS-Via-0475 | Vigna angularis | 48.72 | 6e-154 | 456 |
| LLPS-Sot-1900 | Solanum tuberosum | 48.72 | 2e-155 | 459 |
| LLPS-Mae-2041 | Manihot esculenta | 48.71 | 5e-152 | 451 |
| LLPS-Nia-0587 | Nicotiana attenuata | 48.54 | 4e-152 | 451 |
| LLPS-Arl-0147 | Arabidopsis lyrata | 48.02 | 5e-145 | 433 |
| LLPS-Org-1496 | Oryza glaberrima | 47.93 | 7e-141 | 422 |
| LLPS-Sol-1041 | Solanum lycopersicum | 47.93 | 6e-154 | 456 |
| LLPS-Orm-0602 | Oryza meridionalis | 47.91 | 4e-141 | 423 |
| LLPS-Orp-1928 | Oryza punctata | 47.91 | 9e-141 | 422 |
| LLPS-Zem-0780 | Zea mays | 47.63 | 3e-136 | 410 |
| LLPS-Tra-0216 | Triticum aestivum | 47.63 | 1e-143 | 429 |
| LLPS-Hov-1155 | Hordeum vulgare | 47.63 | 6e-142 | 425 |
| LLPS-Art-0358 | Arabidopsis thaliana | 47.62 | 2e-150 | 447 |
| LLPS-Orr-0835 | Oryza rufipogon | 47.53 | 3e-141 | 424 |
| LLPS-Orbr-2163 | Oryza brachyantha | 47.34 | 3e-138 | 416 |
| LLPS-Orni-1065 | Oryza nivara | 47.34 | 1e-139 | 420 |
| LLPS-Sei-0343 | Setaria italica | 47.32 | 1e-141 | 425 |
| LLPS-Sob-1270 | Sorghum bicolor | 47.12 | 1e-136 | 412 |
| LLPS-Ors-1156 | Oryza sativa | 47.11 | 7e-130 | 394 |
| LLPS-Lep-1656 | Leersia perrieri | 46.93 | 2e-138 | 416 |
| LLPS-Brd-1981 | Brachypodium distachyon | 46.93 | 3e-141 | 424 |
| LLPS-Vir-1499 | Vigna radiata | 46.05 | 3e-137 | 412 |
| LLPS-Ori-2103 | Oryza indica | 44.42 | 4e-133 | 404 |