LLPS-Cas-1262
IMPDH2
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Inosine-5'-monophosphate dehydrogenase |
| Gene Name: | IMPDH2, IMPDH |
| Ensembl Gene: | ENSTSYG00000013437.2 |
| Ensembl Protein: | ENSTSYP00000012327.2 |
| Organism: | Carlito syrichta |
| Taxa ID: | 1868482 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSTSYT00000013437.2 | ENSTSYP00000012327.2 |
| UniProt | A0A1U7UM06, A0A1U7UM06_TARSY | |
| RefSeq | , XM_008068151.1 | , XP_008066342.1, XP_008066342.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MADYLISGGT SYVPDDGLTA QQLFNCGDGL TYNDFLILPG YIDFTADQVD LTSALTKKIT 60 61 LKTPLVSSPM DTVTEAGMAI AMALTGGIGF IHHNCTPEFQ ANEVRKVKKY EQGFITDPVV 120 121 LSPKDRVRDV FEAKARHGFC GIPITDTGRM GSRLVGIISS RDIDFLKEEE HDCFLEEIMT 180 181 KREDLVVAPA GITLKEANEI LQRSKKGKLP IVNEDDELVA IIARTDLKKN RDYPLASKDA 240 241 KKQLLCGAAI GTHEDDKYRL DLLAQAGVDV VVLDSSQGNS IFQINMIKYI KEKYPSLQVI 300 301 GGNVVTAAQA KNLIDAGVDA LRVGMGSGSI CITQEVLACG RPQATAVYKV SEYARRFGVP 360 361 VIADGGIQNV GHIAKALALG ASTVMMGSLL AATTEAPGEY FFSDGIRLKK YRGMGSLDAM 420 421 DKHLSSQNRY FSEADKIKVA QGVSGAVQDK GSIHKFVPYL IAGIQHSCQD IGAKSLTQVR 480 481 AMMYSGELKF EKRTSSAQVE GGVHSLHSYE KRLF 514 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCGACT ACCTGATTAG TGGAGGCACG TCCTATGTGC CGGACGACGG ACTCACAGCA 60 61 CAGCAGCTCT TCAACTGCGG GGATGGCCTA ACCTACAACG ATTTTCTCAT TCTCCCTGGG 120 121 TACATCGACT TCACTGCAGA TCAGGTGGAC CTGACCTCGG CTTTGACCAA AAAGATCACT 180 181 CTGAAGACCC CGCTGGTTTC CTCCCCCATG GACACAGTCA CAGAGGCTGG GATGGCCATA 240 241 GCAATGGCGC TCACAGGAGG TATTGGCTTC ATCCACCACA ACTGTACACC TGAATTCCAG 300 301 GCCAATGAAG TTCGGAAAGT GAAGAAATAC GAGCAGGGAT TCATCACAGA CCCTGTGGTT 360 361 CTCAGCCCCA AGGATCGTGT GCGGGATGTT TTTGAGGCCA AGGCCCGACA TGGTTTCTGT 420 421 GGTATCCCAA TCACAGACAC AGGCCGGATG GGTAGCCGCT TGGTGGGCAT CATCTCCTCA 480 481 AGAGACATTG ATTTTCTCAA GGAGGAGGAG CATGACTGTT TCTTGGAAGA GATCATGACA 540 541 AAGAGGGAGG ATTTGGTGGT AGCTCCTGCA GGCATCACAC TGAAGGAAGC AAACGAAATT 600 601 CTGCAGCGCA GCAAGAAGGG AAAGTTGCCC ATTGTAAATG AAGACGACGA GCTGGTAGCC 660 661 ATCATTGCCC GGACAGACTT GAAAAAGAAC CGGGATTACC CACTGGCCTC TAAAGATGCC 720 721 AAGAAACAGC TGCTGTGTGG GGCAGCCATT GGGACTCATG AGGATGACAA GTACAGACTA 780 781 GACTTGCTTG CCCAGGCTGG TGTGGATGTA GTGGTTTTGG ATTCTTCCCA GGGAAACTCC 840 841 ATCTTCCAGA TCAATATGAT CAAGTACATC AAAGAGAAAT ACCCTAGTCT CCAAGTCATT 900 901 GGAGGCAATG TGGTCACTGC TGCTCAGGCC AAGAACCTCA TTGATGCCGG TGTGGATGCC 960 961 CTGCGTGTGG GCATGGGGAG TGGCTCCATC TGCATCACCC AGGAAGTGCT GGCCTGTGGA 1020 1021 CGGCCCCAAG CAACAGCAGT ATACAAGGTG TCAGAGTATG CAAGACGCTT CGGTGTTCCT 1080 1081 GTCATTGCTG ATGGAGGAAT CCAAAATGTG GGCCACATTG CCAAAGCCTT GGCCCTTGGA 1140 1141 GCCTCCACAG TCATGATGGG CTCCCTCCTG GCTGCCACCA CTGAGGCCCC TGGTGAGTAC 1200 1201 TTCTTCTCTG ACGGGATCCG GCTAAAGAAA TATCGTGGTA TGGGTTCTCT TGATGCCATG 1260 1261 GATAAGCACC TCAGTAGCCA GAACCGATAT TTCAGTGAAG CTGACAAAAT CAAAGTGGCT 1320 1321 CAGGGTGTGT CTGGGGCTGT GCAGGACAAA GGATCCATCC ACAAATTTGT TCCCTACCTG 1380 1381 ATTGCCGGCA TCCAACACTC CTGCCAGGAC ATTGGTGCCA AGAGCTTGAC CCAAGTCCGA 1440 1441 GCCATGATGT ACTCTGGGGA GCTTAAGTTT GAGAAAAGAA CATCATCAGC TCAGGTGGAA 1500 1501 GGTGGCGTCC ACAGTCTCCA TTCGTATGAG AAGCGGCTTT TCTGA 1545 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Nucleus | |
Molecular Function | IMP dehydrogenase activity | |
Molecular Function | Metal ion binding | |
Molecular Function | Nucleotide binding | |
Biological Process | GMP biosynthetic process |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Caj-3657 | Callithrix jacchus | 99.81 | 0.0 | 1053 |
| LLPS-Fec-4086 | Felis catus | 99.81 | 0.0 | 1050 |
| LLPS-Poa-1510 | Pongo abelii | 99.81 | 0.0 | 1053 |
| LLPS-Gog-3571 | Gorilla gorilla | 99.61 | 0.0 | 1051 |
| LLPS-Maf-3593 | Macaca fascicularis | 99.61 | 0.0 | 1051 |
| LLPS-Chs-4463 | Chlorocebus sabaeus | 99.61 | 0.0 | 1051 |
| LLPS-Cea-3370 | Cercocebus atys | 99.61 | 0.0 | 1051 |
| LLPS-Mal-4014 | Mandrillus leucophaeus | 99.61 | 0.0 | 1051 |
| LLPS-Myl-3325 | Myotis lucifugus | 99.61 | 0.0 | 1049 |
| LLPS-Aim-1379 | Ailuropoda melanoleuca | 99.61 | 0.0 | 1048 |
| LLPS-Hos-2963 | Homo sapiens | 99.61 | 0.0 | 1051 |
| LLPS-Pap-4652 | Pan paniscus | 99.61 | 0.0 | 1051 |
| LLPS-Pat-0353 | Pan troglodytes | 99.61 | 0.0 | 1051 |
| LLPS-Nol-2537 | Nomascus leucogenys | 99.61 | 0.0 | 1052 |
| LLPS-Fud-3363 | Fukomys damarensis | 99.42 | 0.0 | 1048 |
| LLPS-Tut-1963 | Tursiops truncatus | 99.42 | 0.0 | 1044 |
| LLPS-Dio-2098 | Dipodomys ordii | 99.42 | 0.0 | 1047 |
| LLPS-Otg-4452 | Otolemur garnettii | 99.42 | 0.0 | 1048 |
| LLPS-Rhb-1813 | Rhinopithecus bieti | 99.42 | 0.0 | 1048 |
| LLPS-Man-3472 | Macaca nemestrina | 99.42 | 0.0 | 1050 |
| LLPS-Cap-4421 | Cavia porcellus | 99.42 | 0.0 | 1048 |
| LLPS-Mum-4373 | Mus musculus | 99.22 | 0.0 | 1045 |
| LLPS-Loa-2952 | Loxodonta africana | 99.03 | 0.0 | 1039 |
| LLPS-Ere-0480 | Erinaceus europaeus | 98.83 | 0.0 | 1042 |
| LLPS-Orc-3916 | Oryctolagus cuniculus | 98.83 | 0.0 | 1043 |
| LLPS-Mea-0572 | Mesocricetus auratus | 98.64 | 0.0 | 1040 |
| LLPS-Ran-1891 | Rattus norvegicus | 98.64 | 0.0 | 1040 |
| LLPS-Ova-1936 | Ovis aries | 98.64 | 0.0 | 1040 |
| LLPS-Paa-4246 | Papio anubis | 98.46 | 0.0 | 1046 |
| LLPS-Mam-1098 | Macaca mulatta | 98.46 | 0.0 | 1046 |
| LLPS-Mod-1573 | Monodelphis domestica | 97.47 | 0.0 | 1028 |
| LLPS-Ora-1639 | Ornithorhynchus anatinus | 96.07 | 0.0 | 954 |
| LLPS-Aon-3984 | Aotus nancymaae | 95.35 | 0.0 | 1038 |
| LLPS-Urm-2015 | Ursus maritimus | 95.17 | 0.0 | 1033 |
| LLPS-Tag-2241 | Taeniopygia guttata | 94.97 | 0.0 | 971 |
| LLPS-Meg-3337 | Meleagris gallopavo | 94.85 | 0.0 | 902 |
| LLPS-Ict-1434 | Ictidomys tridecemlineatus | 94.61 | 0.0 | 1028 |
| LLPS-Anp-1202 | Anas platyrhynchos | 91.54 | 0.0 | 836 |
| LLPS-Gaga-3548 | Gallus gallus | 90.52 | 0.0 | 991 |
| LLPS-Fia-3852 | Ficedula albicollis | 88.27 | 0.0 | 839 |
| LLPS-Pes-1464 | Pelodiscus sinensis | 87.95 | 0.0 | 835 |
| LLPS-Leo-0021 | Lepisosteus oculatus | 85.91 | 0.0 | 915 |
| LLPS-Gaa-1905 | Gasterosteus aculeatus | 85.66 | 0.0 | 912 |
| LLPS-Icp-1661 | Ictalurus punctatus | 85.46 | 0.0 | 912 |
| LLPS-Orn-3216 | Oreochromis niloticus | 85.46 | 0.0 | 905 |
| LLPS-Ten-2052 | Tetraodon nigroviridis | 85.46 | 0.0 | 911 |
| LLPS-Anc-3648 | Anolis carolinensis | 85.19 | 0.0 | 813 |
| LLPS-Lac-3283 | Latimeria chalumnae | 84.65 | 0.0 | 860 |
| LLPS-Xet-1886 | Xenopus tropicalis | 84.47 | 0.0 | 907 |
| LLPS-Sus-4230 | Sus scrofa | 84.24 | 0.0 | 908 |
| LLPS-Bot-2386 | Bos taurus | 84.24 | 0.0 | 909 |
| LLPS-Mup-1939 | Mustela putorius furo | 84.05 | 0.0 | 907 |
| LLPS-Eqc-2573 | Equus caballus | 83.85 | 0.0 | 907 |
| LLPS-Caf-3929 | Canis familiaris | 83.82 | 0.0 | 850 |
| LLPS-Scf-3575 | Scleropages formosus | 81.82 | 0.0 | 910 |
| LLPS-Orl-1912 | Oryzias latipes | 81.3 | 0.0 | 916 |
| LLPS-Pof-3852 | Poecilia formosa | 81.15 | 0.0 | 911 |
| LLPS-Sah-3301 | Sarcophilus harrisii | 81.13 | 0.0 | 858 |
| LLPS-Dar-1093 | Danio rerio | 81.08 | 0.0 | 909 |
| LLPS-Xim-4119 | Xiphophorus maculatus | 80.96 | 0.0 | 912 |
| LLPS-Tar-1055 | Takifugu rubripes | 80.93 | 0.0 | 905 |
| LLPS-Scm-0704 | Scophthalmus maximus | 80.59 | 0.0 | 904 |
| LLPS-Asm-2637 | Astyanax mexicanus | 80.37 | 0.0 | 903 |
| LLPS-Cii-2005 | Ciona intestinalis | 75.0 | 0.0 | 608 |
| LLPS-Drm-2362 | Drosophila melanogaster | 68.99 | 0.0 | 719 |
| LLPS-Abg-0843 | Absidia glauca | 64.19 | 0.0 | 652 |
| LLPS-Asg-0453 | Ashbya gossypii | 63.99 | 0.0 | 656 |
| LLPS-Cis-0076 | Ciona savignyi | 63.46 | 0.0 | 655 |
| LLPS-Mel-1002 | Melampsora laricipopulina | 62.72 | 0.0 | 649 |
| LLPS-Sac-0949 | Saccharomyces cerevisiae | 62.43 | 0.0 | 653 |
| LLPS-Yal-1185 | Yarrowia lipolytica | 62.23 | 0.0 | 627 |
| LLPS-Asn-1194 | Aspergillus nidulans | 62.0 | 1e-124 | 374 |
| LLPS-Miv-0947 | Microbotryum violaceum | 62.0 | 0.0 | 660 |
| LLPS-Sem-2172 | Selaginella moellendorffii | 61.57 | 2e-110 | 340 |
| LLPS-Tum-0212 | Tuber melanosporum | 61.14 | 0.0 | 615 |
| LLPS-Pug-1147 | Puccinia graminis | 60.93 | 0.0 | 646 |
| LLPS-Gas-0386 | Galdieria sulphuraria | 59.88 | 0.0 | 598 |
| LLPS-Usm-1282 | Ustilago maydis | 59.81 | 0.0 | 630 |
| LLPS-Asni-0780 | Aspergillus niger | 59.62 | 0.0 | 607 |
| LLPS-Dos-1395 | Dothistroma septosporum | 59.56 | 0.0 | 595 |
| LLPS-Mao-0089 | Magnaporthe oryzae | 59.54 | 0.0 | 586 |
| LLPS-Gag-0551 | Gaeumannomyces graminis | 59.54 | 0.0 | 594 |
| LLPS-Asf-0995 | Aspergillus flavus | 59.54 | 0.0 | 603 |
| LLPS-Aso-1291 | Aspergillus oryzae | 59.54 | 0.0 | 603 |
| LLPS-Put-0803 | Puccinia triticina | 59.44 | 0.0 | 540 |
| LLPS-Lem-1293 | Leptosphaeria maculans | 59.34 | 0.0 | 599 |
| LLPS-Crn-1469 | Cryptococcus neoformans | 59.31 | 0.0 | 612 |
| LLPS-Pyt-1585 | Pyrenophora teres | 59.31 | 0.0 | 589 |
| LLPS-Nec-1177 | Neurospora crassa | 59.15 | 0.0 | 587 |
| LLPS-Scc-0322 | Schizosaccharomyces cryophilus | 59.02 | 0.0 | 599 |
| LLPS-Scs-0688 | Sclerotinia sclerotiorum | 58.96 | 0.0 | 583 |
| LLPS-Pytr-1585 | Pyrenophora triticirepentis | 58.93 | 0.0 | 587 |
| LLPS-Cym-0707 | Cyanidioschyzon merolae | 58.84 | 0.0 | 593 |
| LLPS-Map-1261 | Magnaporthe poae | 58.77 | 0.0 | 588 |
| LLPS-Nef-1260 | Neosartorya fischeri | 58.77 | 0.0 | 585 |
| LLPS-Trv-0093 | Trichoderma virens | 58.77 | 0.0 | 594 |
| LLPS-Spr-0999 | Sporisorium reilianum | 58.68 | 0.0 | 620 |
| LLPS-Fuv-0743 | Fusarium verticillioides | 58.62 | 0.0 | 564 |
| LLPS-Fuo-1028 | Fusarium oxysporum | 58.62 | 0.0 | 564 |
| LLPS-Phn-0109 | Phaeosphaeria nodorum | 58.52 | 0.0 | 582 |
| LLPS-Scp-1424 | Schizosaccharomyces pombe | 58.43 | 0.0 | 598 |
| LLPS-Trr-1016 | Trichoderma reesei | 58.38 | 0.0 | 594 |
| LLPS-Fus-0898 | Fusarium solani | 58.38 | 0.0 | 591 |
| LLPS-Beb-1173 | Beauveria bassiana | 58.38 | 0.0 | 585 |
| LLPS-Cog-1015 | Colletotrichum gloeosporioides | 58.0 | 0.0 | 588 |
| LLPS-Ast-1484 | Aspergillus terreus | 58.0 | 0.0 | 596 |
| LLPS-Cogr-0871 | Colletotrichum graminicola | 58.0 | 0.0 | 592 |
| LLPS-Chc-0907 | Chondrus crispus | 57.83 | 0.0 | 583 |
| LLPS-Blg-1418 | Blumeria graminis | 57.8 | 0.0 | 583 |
| LLPS-Zyt-0349 | Zymoseptoria tritici | 57.66 | 0.0 | 602 |
| LLPS-Scj-1026 | Schizosaccharomyces japonicus | 57.65 | 0.0 | 590 |
| LLPS-Coo-1623 | Colletotrichum orbiculare | 57.42 | 0.0 | 578 |
| LLPS-Ved-1272 | Verticillium dahliae | 57.42 | 0.0 | 586 |
| LLPS-Tru-1749 | Triticum urartu | 54.36 | 2e-96 | 303 |
| LLPS-Chr-0294 | Chlamydomonas reinhardtii | 54.08 | 2e-177 | 516 |
| LLPS-Amt-2341 | Amborella trichopoda | 51.58 | 4e-166 | 487 |
| LLPS-Php-1610 | Physcomitrella patens | 51.07 | 6e-175 | 510 |
| LLPS-Prp-2478 | Prunus persica | 50.59 | 8e-157 | 464 |
| LLPS-Cus-1084 | Cucumis sativus | 50.5 | 3e-153 | 454 |
| LLPS-Thc-1411 | Theobroma cacao | 50.3 | 4e-150 | 446 |
| LLPS-Coc-1687 | Corchorus capsularis | 50.3 | 3e-149 | 444 |
| LLPS-Mua-2443 | Musa acuminata | 50.29 | 4e-157 | 464 |
| LLPS-Gor-1048 | Gossypium raimondii | 50.0 | 4e-155 | 459 |
| LLPS-Glm-2946 | Glycine max | 49.6 | 5e-150 | 446 |
| LLPS-Met-0026 | Medicago truncatula | 49.6 | 2e-156 | 462 |
| LLPS-Viv-0614 | Vitis vinifera | 49.42 | 4e-148 | 444 |
| LLPS-Brn-0303 | Brassica napus | 49.31 | 1e-150 | 447 |
| LLPS-Pot-1500 | Populus trichocarpa | 49.31 | 7e-152 | 451 |
| LLPS-Dac-1684 | Daucus carota | 49.11 | 5e-157 | 464 |
| LLPS-Brr-2683 | Brassica rapa | 49.11 | 1e-149 | 445 |
| LLPS-Bro-1340 | Brassica oleracea | 49.01 | 2e-150 | 447 |
| LLPS-Via-0475 | Vigna angularis | 48.92 | 9e-155 | 458 |
| LLPS-Sot-1900 | Solanum tuberosum | 48.92 | 6e-156 | 461 |
| LLPS-Mae-2041 | Manihot esculenta | 48.91 | 9e-153 | 453 |
| LLPS-Phv-0678 | Phaseolus vulgaris | 48.83 | 4e-152 | 451 |
| LLPS-Nia-0587 | Nicotiana attenuata | 48.54 | 9e-152 | 451 |
| LLPS-Arl-0147 | Arabidopsis lyrata | 48.22 | 2e-145 | 434 |
| LLPS-Sol-1041 | Solanum lycopersicum | 48.13 | 2e-154 | 457 |
| LLPS-Orp-1928 | Oryza punctata | 48.11 | 3e-141 | 424 |
| LLPS-Org-1496 | Oryza glaberrima | 48.11 | 2e-141 | 424 |
| LLPS-Orm-0602 | Oryza meridionalis | 48.11 | 1e-141 | 424 |
| LLPS-Hov-1155 | Hordeum vulgare | 47.83 | 9e-143 | 427 |
| LLPS-Tra-0216 | Triticum aestivum | 47.83 | 3e-144 | 431 |
| LLPS-Zem-0780 | Zea mays | 47.83 | 6e-137 | 412 |
| LLPS-Art-0358 | Arabidopsis thaliana | 47.82 | 3e-151 | 449 |
| LLPS-Lep-1656 | Leersia perrieri | 47.72 | 2e-138 | 416 |
| LLPS-Orr-0835 | Oryza rufipogon | 47.71 | 1e-141 | 424 |
| LLPS-Orni-1065 | Oryza nivara | 47.51 | 3e-140 | 421 |
| LLPS-Sei-0343 | Setaria italica | 47.51 | 3e-142 | 426 |
| LLPS-Orbr-2163 | Oryza brachyantha | 47.34 | 2e-138 | 416 |
| LLPS-Sob-1270 | Sorghum bicolor | 47.32 | 4e-137 | 413 |
| LLPS-Ors-1156 | Oryza sativa | 47.29 | 4e-130 | 395 |
| LLPS-Brd-1981 | Brachypodium distachyon | 47.13 | 1e-141 | 425 |
| LLPS-Vir-1499 | Vigna radiata | 46.05 | 4e-138 | 414 |
| LLPS-Ori-2103 | Oryza indica | 44.57 | 2e-133 | 405 |