LLPS-Mal-4014
IMPDH2
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Inosine-5'-monophosphate dehydrogenase |
| Gene Name: | IMPDH2, IMPDH |
| Ensembl Gene: | ENSMLEG00000038550.1 |
| Ensembl Protein: | ENSMLEP00000028697.1 |
| Organism: | Mandrillus leucophaeus |
| Taxa ID: | 9568 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMLET00000052250.1 | ENSMLEP00000028697.1 |
| UniProt | A0A2K5ZLJ4, A0A2K5ZLJ4_MANLE | |
| RefSeq | XM_011980954.1 | XP_011836344.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MADYLISGGT SYVPDDGLTA QQLFNCGDGL TYNDFLILPG YIDFTADQVD LTSALTKKIT 60 61 LKTPLVSSPM DTVTEAGMAI AMALTGGIGF IHHNCTPEFQ ANEVRKVKKY EQGFITDPVV 120 121 LSPKDRVRDV FEAKARHGFC GIPITDTGRM GSRLVGIISS RDIDFLKEEE HDCLLEEIMT 180 181 KREDLVVAPA GITLKEANEI LQRSKKGKLP IVNEDDELVA IIARTDLKKN RDYPLASKDA 240 241 KKQLLCGAAI GTHEDDKYRL DLLAQAGVDV VVLDSSQGNS IFQINMIKYI KEKYPNLQVI 300 301 GGNVVTAAQA KNLIDAGVDA LRVGMGSGSI CITQEVLACG RPQATAVYKV SEYARRFGVP 360 361 VIADGGIQNV GHIAKALALG ASTVMMGSLL AATTEAPGEY FFSDGIRLKK YRGMGSLDAM 420 421 DKHLSSQNRY FSEADKIKVA QGVSGAVQDK GSIHKFVPYL IAGIQHSCQD IGAKSLTQVR 480 481 AMMYSGELKF EKRTSSAQVE GGVHSLHSYE KRLF 514 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCGACT ACCTGATTAG TGGGGGCACG TCCTACGTGC CAGACGACGG ACTCACAGCA 60 61 CAGCAGCTCT TCAACTGCGG AGACGGCCTC ACCTACAATG ACTTTCTCAT TCTCCCTGGG 120 121 TACATCGACT TCACTGCAGA CCAGGTGGAC CTGACTTCTG CTCTGACCAA GAAAATCACT 180 181 CTTAAGACCC CACTGGTTTC CTCTCCCATG GACACAGTCA CAGAGGCTGG GATGGCCATA 240 241 GCAATGGCGC TTACAGGTGG TATTGGCTTC ATCCACCACA ACTGTACACC TGAATTCCAG 300 301 GCCAATGAAG TTCGGAAAGT GAAGAAATAC GAACAGGGAT TCATCACAGA CCCTGTGGTC 360 361 CTCAGTCCCA AGGATCGTGT GCGGGATGTT TTTGAGGCCA AGGCCCGGCA TGGTTTCTGC 420 421 GGTATCCCAA TCACAGACAC AGGCCGGATG GGGAGCCGCT TGGTGGGCAT CATCTCCTCC 480 481 AGGGATATTG ATTTTCTCAA AGAGGAGGAA CATGACTGTT TATTGGAAGA GATAATGACA 540 541 AAGAGGGAAG ACTTGGTGGT AGCCCCTGCA GGCATCACAC TGAAGGAGGC AAACGAAATT 600 601 CTGCAGCGCA GCAAGAAGGG AAAGTTGCCC ATTGTAAATG AAGATGATGA GCTTGTGGCC 660 661 ATCATTGCCC GGACGGACCT GAAGAAGAAC CGGGACTACC CACTAGCCTC CAAAGATGCC 720 721 AAGAAACAGC TGCTGTGTGG GGCAGCCATT GGCACTCATG AAGATGACAA GTATAGGCTG 780 781 GACTTGCTCG CCCAGGCTGG TGTGGATGTA GTGGTTTTGG ACTCTTCCCA GGGAAATTCC 840 841 ATCTTCCAGA TCAATATGAT CAAGTACATC AAAGAGAAAT ACCCCAATCT CCAAGTCATT 900 901 GGAGGCAATG TGGTCACTGC TGCCCAGGCC AAGAACCTCA TTGATGCAGG TGTGGATGCC 960 961 CTGCGGGTGG GCATGGGAAG TGGCTCCATC TGCATTACCC AGGAAGTGCT GGCCTGTGGG 1020 1021 CGGCCCCAAG CAACAGCAGT GTACAAGGTG TCAGAGTATG CACGGCGCTT TGGTGTTCCA 1080 1081 GTCATCGCTG ATGGAGGAAT CCAAAATGTG GGTCATATTG CGAAAGCTTT GGCCCTTGGG 1140 1141 GCTTCCACAG TCATGATGGG CTCTCTCCTG GCTGCCACCA CTGAGGCCCC TGGTGAGTAC 1200 1201 TTCTTTTCCG ATGGGATCCG ACTAAAGAAA TATCGCGGTA TGGGTTCTCT TGATGCCATG 1260 1261 GACAAGCACC TCAGCAGCCA GAACAGATAT TTCAGTGAAG CTGACAAAAT CAAAGTGGCC 1320 1321 CAGGGGGTGT CTGGTGCTGT GCAGGACAAA GGGTCCATCC ACAAATTTGT CCCTTACCTG 1380 1381 ATTGCTGGCA TCCAACACTC ATGCCAGGAC ATTGGTGCCA AGAGCTTGAC CCAAGTCCGA 1440 1441 GCCATGATGT ACTCTGGGGA GCTTAAGTTT GAGAAGAGAA CGTCCTCAGC CCAGGTGGAA 1500 1501 GGTGGTGTCC ATAGCCTCCA TTCGTATGAG AAGCGGCTTT TCTGA 1545 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Nucleus | |
Molecular Function | IMP dehydrogenase activity | |
Molecular Function | Metal ion binding | |
Molecular Function | Nucleotide binding | |
Biological Process | Cellular response to interleukin-4 | |
Biological Process | Circadian rhythm | |
Biological Process | GMP biosynthetic process | |
Biological Process | Lymphocyte proliferation |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Maf-3593 | Macaca fascicularis | 100.0 | 0.0 | 1055 |
| LLPS-Chs-4463 | Chlorocebus sabaeus | 100.0 | 0.0 | 1055 |
| LLPS-Cea-3370 | Cercocebus atys | 100.0 | 0.0 | 1055 |
| LLPS-Caj-3657 | Callithrix jacchus | 99.81 | 0.0 | 1053 |
| LLPS-Dio-2098 | Dipodomys ordii | 99.81 | 0.0 | 1051 |
| LLPS-Rhb-1813 | Rhinopithecus bieti | 99.81 | 0.0 | 1051 |
| LLPS-Man-3472 | Macaca nemestrina | 99.81 | 0.0 | 1053 |
| LLPS-Poa-1510 | Pongo abelii | 99.81 | 0.0 | 1053 |
| LLPS-Gog-3571 | Gorilla gorilla | 99.61 | 0.0 | 1051 |
| LLPS-Pat-0353 | Pan troglodytes | 99.61 | 0.0 | 1051 |
| LLPS-Pap-4652 | Pan paniscus | 99.61 | 0.0 | 1051 |
| LLPS-Hos-2963 | Homo sapiens | 99.61 | 0.0 | 1051 |
| LLPS-Cas-1262 | Carlito syrichta | 99.61 | 0.0 | 1051 |
| LLPS-Nol-2537 | Nomascus leucogenys | 99.61 | 0.0 | 1052 |
| LLPS-Fud-3363 | Fukomys damarensis | 99.42 | 0.0 | 1048 |
| LLPS-Otg-4452 | Otolemur garnettii | 99.42 | 0.0 | 1048 |
| LLPS-Fec-4086 | Felis catus | 99.42 | 0.0 | 1047 |
| LLPS-Cap-4421 | Cavia porcellus | 99.42 | 0.0 | 1048 |
| LLPS-Aim-1379 | Ailuropoda melanoleuca | 99.22 | 0.0 | 1046 |
| LLPS-Myl-3325 | Myotis lucifugus | 99.22 | 0.0 | 1046 |
| LLPS-Tut-1963 | Tursiops truncatus | 99.03 | 0.0 | 1041 |
| LLPS-Paa-4246 | Papio anubis | 98.85 | 0.0 | 1049 |
| LLPS-Mam-1098 | Macaca mulatta | 98.85 | 0.0 | 1049 |
| LLPS-Mum-4373 | Mus musculus | 98.83 | 0.0 | 1042 |
| LLPS-Ere-0480 | Erinaceus europaeus | 98.83 | 0.0 | 1042 |
| LLPS-Loa-2952 | Loxodonta africana | 98.83 | 0.0 | 1039 |
| LLPS-Mea-0572 | Mesocricetus auratus | 98.64 | 0.0 | 1041 |
| LLPS-Ran-1891 | Rattus norvegicus | 98.64 | 0.0 | 1040 |
| LLPS-Ova-1936 | Ovis aries | 98.64 | 0.0 | 1040 |
| LLPS-Orc-3916 | Oryctolagus cuniculus | 98.64 | 0.0 | 1041 |
| LLPS-Mod-1573 | Monodelphis domestica | 97.47 | 0.0 | 1028 |
| LLPS-Ora-1639 | Ornithorhynchus anatinus | 96.28 | 0.0 | 955 |
| LLPS-Aon-3984 | Aotus nancymaae | 95.35 | 0.0 | 1038 |
| LLPS-Tag-2241 | Taeniopygia guttata | 95.17 | 0.0 | 973 |
| LLPS-Urm-2015 | Ursus maritimus | 94.8 | 0.0 | 1029 |
| LLPS-Meg-3337 | Meleagris gallopavo | 94.64 | 0.0 | 901 |
| LLPS-Ict-1434 | Ictidomys tridecemlineatus | 94.61 | 0.0 | 1028 |
| LLPS-Anp-1202 | Anas platyrhynchos | 91.76 | 0.0 | 839 |
| LLPS-Gaga-3548 | Gallus gallus | 90.71 | 0.0 | 993 |
| LLPS-Fia-3852 | Ficedula albicollis | 88.49 | 0.0 | 842 |
| LLPS-Pes-1464 | Pelodiscus sinensis | 87.95 | 0.0 | 835 |
| LLPS-Leo-0021 | Lepisosteus oculatus | 85.91 | 0.0 | 915 |
| LLPS-Gaa-1905 | Gasterosteus aculeatus | 85.66 | 0.0 | 912 |
| LLPS-Icp-1661 | Ictalurus punctatus | 85.46 | 0.0 | 912 |
| LLPS-Orn-3216 | Oreochromis niloticus | 85.46 | 0.0 | 906 |
| LLPS-Ten-2052 | Tetraodon nigroviridis | 85.46 | 0.0 | 912 |
| LLPS-Anc-3648 | Anolis carolinensis | 85.19 | 0.0 | 814 |
| LLPS-Lac-3283 | Latimeria chalumnae | 84.65 | 0.0 | 859 |
| LLPS-Xet-1886 | Xenopus tropicalis | 84.47 | 0.0 | 905 |
| LLPS-Sus-4230 | Sus scrofa | 84.44 | 0.0 | 910 |
| LLPS-Bot-2386 | Bos taurus | 84.44 | 0.0 | 911 |
| LLPS-Mup-1939 | Mustela putorius furo | 84.24 | 0.0 | 910 |
| LLPS-Eqc-2573 | Equus caballus | 84.05 | 0.0 | 909 |
| LLPS-Caf-3929 | Canis familiaris | 84.02 | 0.0 | 852 |
| LLPS-Scf-3575 | Scleropages formosus | 81.82 | 0.0 | 910 |
| LLPS-Orl-1912 | Oryzias latipes | 81.3 | 0.0 | 914 |
| LLPS-Pof-3852 | Poecilia formosa | 81.15 | 0.0 | 911 |
| LLPS-Sah-3301 | Sarcophilus harrisii | 81.13 | 0.0 | 859 |
| LLPS-Dar-1093 | Danio rerio | 81.08 | 0.0 | 907 |
| LLPS-Xim-4119 | Xiphophorus maculatus | 80.96 | 0.0 | 912 |
| LLPS-Tar-1055 | Takifugu rubripes | 80.93 | 0.0 | 906 |
| LLPS-Scm-0704 | Scophthalmus maximus | 80.59 | 0.0 | 904 |
| LLPS-Asm-2637 | Astyanax mexicanus | 80.37 | 0.0 | 903 |
| LLPS-Cii-2005 | Ciona intestinalis | 75.0 | 0.0 | 609 |
| LLPS-Drm-2362 | Drosophila melanogaster | 69.18 | 0.0 | 721 |
| LLPS-Asg-0453 | Ashbya gossypii | 64.19 | 0.0 | 658 |
| LLPS-Abg-0843 | Absidia glauca | 63.99 | 0.0 | 651 |
| LLPS-Cis-0076 | Ciona savignyi | 63.65 | 0.0 | 657 |
| LLPS-Mel-1002 | Melampsora laricipopulina | 62.72 | 0.0 | 649 |
| LLPS-Sac-0949 | Saccharomyces cerevisiae | 62.43 | 0.0 | 654 |
| LLPS-Yal-1185 | Yarrowia lipolytica | 62.23 | 0.0 | 627 |
| LLPS-Asn-1194 | Aspergillus nidulans | 62.0 | 1e-124 | 374 |
| LLPS-Miv-0947 | Microbotryum violaceum | 62.0 | 0.0 | 662 |
| LLPS-Sem-2172 | Selaginella moellendorffii | 61.57 | 2e-110 | 340 |
| LLPS-Tum-0212 | Tuber melanosporum | 61.14 | 0.0 | 616 |
| LLPS-Pug-1147 | Puccinia graminis | 60.93 | 0.0 | 646 |
| LLPS-Gas-0386 | Galdieria sulphuraria | 59.88 | 0.0 | 598 |
| LLPS-Usm-1282 | Ustilago maydis | 59.81 | 0.0 | 630 |
| LLPS-Asni-0780 | Aspergillus niger | 59.62 | 0.0 | 607 |
| LLPS-Dos-1395 | Dothistroma septosporum | 59.56 | 0.0 | 595 |
| LLPS-Mao-0089 | Magnaporthe oryzae | 59.54 | 0.0 | 586 |
| LLPS-Gag-0551 | Gaeumannomyces graminis | 59.54 | 0.0 | 594 |
| LLPS-Asf-0995 | Aspergillus flavus | 59.54 | 0.0 | 603 |
| LLPS-Aso-1291 | Aspergillus oryzae | 59.54 | 0.0 | 603 |
| LLPS-Put-0803 | Puccinia triticina | 59.44 | 0.0 | 540 |
| LLPS-Lem-1293 | Leptosphaeria maculans | 59.42 | 0.0 | 600 |
| LLPS-Nec-1177 | Neurospora crassa | 59.15 | 0.0 | 587 |
| LLPS-Pyt-1585 | Pyrenophora teres | 59.04 | 0.0 | 590 |
| LLPS-Scc-0322 | Schizosaccharomyces cryophilus | 59.02 | 0.0 | 599 |
| LLPS-Scs-0688 | Sclerotinia sclerotiorum | 58.96 | 0.0 | 584 |
| LLPS-Trv-0093 | Trichoderma virens | 58.96 | 0.0 | 597 |
| LLPS-Crn-1469 | Cryptococcus neoformans | 58.93 | 0.0 | 612 |
| LLPS-Cym-0707 | Cyanidioschyzon merolae | 58.84 | 0.0 | 594 |
| LLPS-Map-1261 | Magnaporthe poae | 58.77 | 0.0 | 588 |
| LLPS-Spr-0999 | Sporisorium reilianum | 58.68 | 0.0 | 621 |
| LLPS-Nef-1260 | Neosartorya fischeri | 58.65 | 0.0 | 586 |
| LLPS-Pytr-1585 | Pyrenophora triticirepentis | 58.65 | 0.0 | 588 |
| LLPS-Fuv-0743 | Fusarium verticillioides | 58.62 | 0.0 | 565 |
| LLPS-Fuo-1028 | Fusarium oxysporum | 58.62 | 0.0 | 565 |
| LLPS-Phn-0109 | Phaeosphaeria nodorum | 58.6 | 0.0 | 582 |
| LLPS-Trr-1016 | Trichoderma reesei | 58.57 | 0.0 | 597 |
| LLPS-Scp-1424 | Schizosaccharomyces pombe | 58.43 | 0.0 | 598 |
| LLPS-Fus-0898 | Fusarium solani | 58.38 | 0.0 | 591 |
| LLPS-Beb-1173 | Beauveria bassiana | 58.38 | 0.0 | 585 |
| LLPS-Blg-1418 | Blumeria graminis | 58.19 | 0.0 | 586 |
| LLPS-Cog-1015 | Colletotrichum gloeosporioides | 58.0 | 0.0 | 587 |
| LLPS-Ast-1484 | Aspergillus terreus | 58.0 | 0.0 | 597 |
| LLPS-Cogr-0871 | Colletotrichum graminicola | 58.0 | 0.0 | 593 |
| LLPS-Chc-0907 | Chondrus crispus | 57.83 | 0.0 | 584 |
| LLPS-Zyt-0349 | Zymoseptoria tritici | 57.66 | 0.0 | 602 |
| LLPS-Scj-1026 | Schizosaccharomyces japonicus | 57.65 | 0.0 | 590 |
| LLPS-Coo-1623 | Colletotrichum orbiculare | 57.42 | 0.0 | 578 |
| LLPS-Ved-1272 | Verticillium dahliae | 57.42 | 0.0 | 585 |
| LLPS-Tru-1749 | Triticum urartu | 54.36 | 2e-96 | 304 |
| LLPS-Chr-0294 | Chlamydomonas reinhardtii | 54.08 | 2e-177 | 516 |
| LLPS-Amt-2341 | Amborella trichopoda | 51.58 | 2e-166 | 488 |
| LLPS-Php-1610 | Physcomitrella patens | 51.07 | 5e-175 | 510 |
| LLPS-Prp-2478 | Prunus persica | 50.78 | 1e-157 | 466 |
| LLPS-Cus-1084 | Cucumis sativus | 50.5 | 1e-153 | 455 |
| LLPS-Mua-2443 | Musa acuminata | 50.29 | 2e-157 | 465 |
| LLPS-Coc-1687 | Corchorus capsularis | 50.1 | 3e-148 | 441 |
| LLPS-Gor-1048 | Gossypium raimondii | 50.0 | 4e-155 | 459 |
| LLPS-Thc-1411 | Theobroma cacao | 49.61 | 5e-150 | 446 |
| LLPS-Glm-2946 | Glycine max | 49.6 | 4e-150 | 446 |
| LLPS-Met-0026 | Medicago truncatula | 49.6 | 2e-156 | 462 |
| LLPS-Viv-0614 | Vitis vinifera | 49.42 | 1e-148 | 445 |
| LLPS-Brn-0303 | Brassica napus | 49.31 | 7e-151 | 448 |
| LLPS-Pot-1500 | Populus trichocarpa | 49.31 | 6e-152 | 451 |
| LLPS-Brr-2683 | Brassica rapa | 49.11 | 6e-150 | 446 |
| LLPS-Bro-1340 | Brassica oleracea | 49.01 | 8e-151 | 448 |
| LLPS-Dac-1684 | Daucus carota | 48.92 | 5e-157 | 464 |
| LLPS-Via-0475 | Vigna angularis | 48.92 | 9e-155 | 458 |
| LLPS-Sot-1900 | Solanum tuberosum | 48.92 | 4e-156 | 461 |
| LLPS-Mae-2041 | Manihot esculenta | 48.91 | 7e-153 | 453 |
| LLPS-Phv-0678 | Phaseolus vulgaris | 48.83 | 3e-152 | 452 |
| LLPS-Nia-0587 | Nicotiana attenuata | 48.54 | 4e-152 | 451 |
| LLPS-Arl-0147 | Arabidopsis lyrata | 48.22 | 2e-145 | 434 |
| LLPS-Sol-1041 | Solanum lycopersicum | 48.13 | 1e-154 | 458 |
| LLPS-Orp-1928 | Oryza punctata | 48.11 | 9e-142 | 425 |
| LLPS-Org-1496 | Oryza glaberrima | 48.11 | 1e-141 | 424 |
| LLPS-Orm-0602 | Oryza meridionalis | 48.11 | 8e-142 | 425 |
| LLPS-Hov-1155 | Hordeum vulgare | 47.83 | 6e-143 | 428 |
| LLPS-Tra-0216 | Triticum aestivum | 47.83 | 1e-144 | 432 |
| LLPS-Zem-0780 | Zea mays | 47.83 | 6e-137 | 412 |
| LLPS-Art-0358 | Arabidopsis thaliana | 47.82 | 2e-151 | 450 |
| LLPS-Lep-1656 | Leersia perrieri | 47.72 | 7e-139 | 417 |
| LLPS-Orr-0835 | Oryza rufipogon | 47.71 | 8e-142 | 425 |
| LLPS-Orni-1065 | Oryza nivara | 47.51 | 2e-140 | 422 |
| LLPS-Sei-0343 | Setaria italica | 47.51 | 2e-142 | 426 |
| LLPS-Orbr-2163 | Oryza brachyantha | 47.34 | 1e-138 | 417 |
| LLPS-Sob-1270 | Sorghum bicolor | 47.32 | 3e-137 | 413 |
| LLPS-Ors-1156 | Oryza sativa | 47.29 | 3e-130 | 395 |
| LLPS-Brd-1981 | Brachypodium distachyon | 47.13 | 5e-142 | 426 |
| LLPS-Vir-1499 | Vigna radiata | 46.05 | 3e-138 | 415 |
| LLPS-Ori-2103 | Oryza indica | 44.57 | 1e-133 | 405 |