• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Myl-4117
VPS11

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Vacuolar protein sorting-associated protein 11 homolog
Gene Name: VPS11
Ensembl Gene: ENSMLUG00000004793.2
Ensembl Protein: ENSMLUP00000004370.2
Organism: Myotis lucifugus
Taxa ID: 59463
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Postsynaptic density, OthersPredicted from orthologs(View)

▼ FUNCTION

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSMLUT00000004798.2ENSMLUP00000004370.2
UniProtG1P387, G1P387_MYOLU
GeneBankAAPE02053861

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAAYLQWRRF  VFFDKEVVKE  PLGSDGPAPG  PAPAAGPAAS  KLLCLPPGIT  VCDSGRGSLV  60
61    FGDNMEGQVW  FLSRSLQLTG  FQAYKLRVTH  LYQLKQHNIL  ASVGEDEQGI  NPLVKIWNLE  120
121   KRDGGNPLCT  RIFPAIPGTE  PTVVSCLTVH  ENLNFMAIGF  TDGSVTLNKG  DITRDRHSKT  180
181   QILHKGNYPV  TGLAFRQAGK  NTHLFVVTTE  NVQSYIVSGK  DYPRVELDTH  GCGLRCSALS  240
241   DPSQDLQFIV  AGDECVYLYQ  PDERGPCFAF  EGHKLIAHWF  RGYLVIVSRD  RKVSPKSEFT  300
301   NRDSQSSDKQ  ILNIYDLCNK  FIAYSAVFED  VVDVLAEWGS  LYVLTRDGRV  HALQEKDTQT  360
361   KLEMLFKKNL  FEMAINLAKS  QHLDSDGLAQ  IFMQYGDHLY  SKGNHDGAVQ  QYIRTIGKLE  420
421   PSYVIRKFLD  AQRIHNLTAY  LQTLHRQSLA  NADHTTLLLN  CYTKLKDSLR  LEEFIKTKSE  480
481   SEVHFDVETA  IRVLRQAGYY  SHALYLAEHH  AHHEWYLKIQ  LEDIKNYQEA  LRYIGKLPFE  540
541   QAESNMKRYG  KILMHHIPEQ  MTQLLKGLCT  NYRPSFEGQG  DRESPGRRAN  SEEFIPIFAN  600
601   NPRELKAFLE  HMSAVQPDSP  QGIYDTLLEL  RLQNWAHEKD  PQVKEKLHAE  AISLLKSGRF  660
661   CDVFDKALVL  CQMHDFQDGV  LHLYEQGKLY  QQMMHYYMQH  EQYRQVIEVC  ERHGEQEPSL  720
721   WEQALSYFAR  KEEDCKEYVA  AVLKHIENKN  LMPPLLVVQT  LAHNSTATLS  VIRDYLVQKL  780
781   QKQSQQIAQD  ELRVRRYREE  TTRIRQEIQE  LKASPKIFQK  TKCSICNSAL  ELPSVHFLCG  840
841   HSFHQHCFES  YSESDADCPT  CLPENRKVMD  MIRAQEQKRD  LHDQFQHQLK  CSNDSFSVIA  900
901   DYFGRGVFNK  LTLLTDPPTA  RLAGSLESGL  QRDLLVHSRR  GT  942
Nucleotide CDS Sequence (FASTA)
1     ATGGCGGCCT  ACCTGCAGTG  GCGGCGCTTC  GTTTTCTTCG  ACAAGGAGGT  GGTGAAGGAA  60
61    CCGCTGGGCA  GCGATGGGCC  CGCTCCCGGG  CCCGCGCCTG  CCGCTGGGCC  CGCTGCTTCC  120
121   AAGCTCCTCT  GCCTCCCTCC  TGGCATCACT  GTCTGCGACT  CAGGCCGAGG  GAGCCTTGTC  180
181   TTTGGAGATA  ATATGGAAGG  TCAGGTCTGG  TTCTTGTCGC  GCTCCCTCCA  GCTTACGGGC  240
241   TTCCAAGCCT  ACAAACTACG  GGTGACACAC  CTGTACCAAC  TGAAGCAGCA  CAACATTCTG  300
301   GCATCTGTTG  GTGAGGATGA  ACAGGGCATC  AACCCCCTGG  TGAAAATCTG  GAACCTCGAG  360
361   AAGAGAGATG  GTGGCAATCC  ACTCTGTACT  CGAATCTTCC  CTGCCATCCC  TGGAACAGAG  420
421   CCCACTGTTG  TGTCCTGTTT  GACTGTCCAT  GAAAATCTCA  ATTTTATGGC  CATCGGTTTC  480
481   ACGGATGGCA  GTGTTACCTT  GAACAAAGGA  GACATCACTC  GGGACCGGCA  TAGCAAGACC  540
541   CAGATTTTGC  ACAAGGGCAA  CTACCCTGTA  ACGGGACTGG  CCTTTCGCCA  AGCGGGAAAG  600
601   AACACTCACT  TGTTTGTTGT  GACGACAGAG  AACGTTCAGT  CCTATATAGT  TTCTGGAAAG  660
661   GACTACCCTC  GTGTGGAGTT  GGATACCCAC  GGTTGTGGCC  TGCGCTGCTC  AGCCCTCAGT  720
721   GACCCTTCTC  AGGACCTGCA  GTTCATTGTG  GCCGGGGATG  AGTGTGTCTA  CTTGTACCAG  780
781   CCTGATGAAC  GTGGGCCCTG  CTTCGCCTTT  GAGGGCCATA  AACTCATTGC  TCACTGGTTT  840
841   AGAGGCTACC  TTGTCATTGT  CTCCCGTGAC  CGGAAGGTTT  CTCCCAAGTC  AGAGTTTACC  900
901   AACAGGGACT  CACAGAGCTC  CGACAAGCAG  ATTCTCAACA  TCTATGACCT  GTGCAACAAG  960
961   TTTATAGCCT  ATAGCGCTGT  CTTTGAGGAT  GTAGTGGATG  TGCTTGCTGA  GTGGGGCTCC  1020
1021  CTGTACGTGC  TGACGCGGGA  TGGGCGGGTC  CACGCACTGC  AGGAGAAGGA  CACACAGACC  1080
1081  AAACTGGAGA  TGCTGTTTAA  GAAGAACCTA  TTTGAGATGG  CGATTAACCT  GGCCAAGAGC  1140
1141  CAGCACCTGG  ATAGTGATGG  GTTGGCCCAG  ATCTTCATGC  AGTACGGGGA  CCATCTCTAC  1200
1201  AGCAAGGGCA  ACCATGATGG  GGCAGTCCAG  CAGTATATCC  GAACCATTGG  AAAGTTGGAA  1260
1261  CCGTCATATG  TGATCCGCAA  GTTTCTGGAT  GCCCAGCGTA  TCCACAACCT  GACCGCCTAC  1320
1321  CTGCAGACCC  TGCACCGGCA  GTCCCTGGCC  AATGCCGACC  ACACCACCCT  GCTGCTCAAC  1380
1381  TGCTACACCA  AGCTCAAGGA  CAGCTTGAGG  CTAGAGGAGT  TCATCAAGAC  AAAGAGCGAG  1440
1441  AGTGAAGTCC  ACTTTGACGT  GGAGACAGCC  ATCAGGGTGC  TGCGGCAGGC  TGGCTACTAC  1500
1501  TCCCACGCCC  TCTACTTGGC  CGAGCACCAT  GCACACCACG  AGTGGTACTT  GAAGATCCAG  1560
1561  CTAGAGGACA  TCAAGAACTA  CCAGGAAGCC  CTTAGGTACA  TTGGCAAGCT  GCCTTTTGAG  1620
1621  CAGGCAGAGA  GCAACATGAA  GCGCTATGGC  AAGATCCTCA  TGCACCACAT  ACCAGAGCAG  1680
1681  ATGACCCAGT  TGCTGAAGGG  ACTTTGTACC  AACTATCGGC  CCAGCTTTGA  AGGTCAAGGT  1740
1741  GACAGGGAGT  CACCAGGCCG  CAGGGCCAAC  TCAGAGGAGT  TCATCCCCAT  CTTTGCCAAC  1800
1801  AACCCACGAG  AGTTGAAAGC  TTTCCTAGAG  CACATGAGTG  CAGTACAGCC  CGACTCACCA  1860
1861  CAGGGCATCT  ACGACACGCT  CCTTGAACTA  CGACTACAGA  ACTGGGCCCA  TGAGAAGGAT  1920
1921  CCACAGGTCA  AAGAGAAGCT  GCACGCAGAG  GCGATCTCCC  TCCTGAAGAG  TGGCCGCTTC  1980
1981  TGCGACGTCT  TTGACAAGGC  CCTGGTCCTA  TGCCAGATGC  ACGACTTCCA  GGATGGGGTC  2040
2041  CTGCACCTCT  ACGAGCAGGG  GAAGCTGTAT  CAGCAGATGA  TGCACTACTA  CATGCAGCAT  2100
2101  GAGCAGTACC  GGCAGGTGAT  CGAGGTGTGC  GAGCGCCATG  GGGAGCAGGA  GCCCTCTCTG  2160
2161  TGGGAACAGG  CGCTCAGCTA  CTTTGCCCGC  AAGGAGGAGG  ACTGCAAGGA  GTACGTGGCA  2220
2221  GCTGTGCTCA  AGCATATTGA  GAACAAGAAC  CTCATGCCAC  CACTTCTAGT  GGTGCAGACC  2280
2281  CTGGCCCACA  ACTCCACCGC  CACCCTATCT  GTCATCCGGG  ACTACCTGGT  CCAGAAACTG  2340
2341  CAGAAACAGA  GCCAGCAGAT  TGCACAGGAC  GAGCTCCGGG  TGCGGCGGTA  CCGAGAGGAG  2400
2401  ACCACCCGCA  TCCGCCAGGA  GATCCAGGAG  CTCAAGGCGA  GTCCGAAGAT  TTTCCAGAAG  2460
2461  ACCAAGTGCA  GCATCTGTAA  CAGTGCCTTG  GAATTGCCCT  CAGTCCACTT  TCTCTGTGGA  2520
2521  CACTCTTTCC  ACCAACACTG  CTTTGAGAGT  TACTCGGAAA  GTGATGCTGA  CTGCCCCACC  2580
2581  TGCCTCCCTG  AAAACCGGAA  GGTCATGGAT  ATGATCCGGG  CCCAGGAACA  GAAACGCGAT  2640
2641  CTCCACGATC  AGTTCCAGCA  CCAGCTCAAG  TGCTCCAACG  ACAGCTTCTC  GGTCATCGCT  2700
2701  GACTACTTCG  GCCGAGGCGT  TTTCAACAAA  CTGACCCTGC  TCACTGACCC  TCCCACGGCC  2760
2761  AGGCTGGCTG  GAAGCTTGGA  GTCTGGGCTG  CAGCGGGACC  TGCTGGTGCA  CTCCAGGAGG  2820
2821  GGCACTTGA  2829

▼ KEYWORD

ID
Family
Autophagy
Coiled coil
Complete proteome
Cytoplasmic vesicle
Endosome
Lysosome
Membrane
Metal-binding
Protein transport
Reference proteome
Transport
Zinc
Zinc-finger

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Actin filament
Cellular Component
AP-3 adaptor complex
Cellular Component
Autophagosome
Cellular Component
Clathrin-coated vesicle
Cellular Component
CORVET complex
Cellular Component
Early endosome
Cellular Component
HOPS complex
Cellular Component
Late endosome membrane
Cellular Component
Lysosomal membrane
Cellular Component
Presynaptic active zone
Molecular Function
Protein binding, bridging
Biological Process
Autophagy
Biological Process
Endosome organization
Biological Process
Intracellular protein transport
Biological Process
Lysosome organization
Biological Process
Toxin transport
Biological Process
Vesicle docking involved in exocytosis

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mam-3632Macaca mulatta96.380.01678
LLPS-Fec-4801Felis catus96.280.01759
LLPS-Ran-3329Rattus norvegicus96.240.01667
LLPS-Aim-3924Ailuropoda melanoleuca96.190.01769
LLPS-Paa-2475Papio anubis96.180.01771
LLPS-Mal-4065Mandrillus leucophaeus96.180.01771
LLPS-Chs-3258Chlorocebus sabaeus96.180.01771
LLPS-Maf-4690Macaca fascicularis96.180.01770
LLPS-Cea-2481Cercocebus atys96.180.01768
LLPS-Pap-1816Pan paniscus96.150.01676
LLPS-Pat-1884Pan troglodytes96.150.01676
LLPS-Aon-0114Aotus nancymaae96.070.01757
LLPS-Sus-2430Sus scrofa96.070.01761
LLPS-Eqc-3154Equus caballus96.070.01764
LLPS-Caf-4362Canis familiaris96.070.01762
LLPS-Urm-2653Ursus maritimus96.070.01767
LLPS-Orc-2327Oryctolagus cuniculus96.060.01479
LLPS-Nol-4503Nomascus leucogenys96.040.01674
LLPS-Man-4600Macaca nemestrina95.970.01765
LLPS-Mup-1430Mustela putorius furo95.860.01763
LLPS-Bot-1348Bos taurus95.860.01761
LLPS-Caj-4223Callithrix jacchus95.860.01757
LLPS-Poa-4152Pongo abelii95.860.01766
LLPS-Gog-1064Gorilla gorilla95.750.01766
LLPS-Cas-0424Carlito syrichta95.750.01761
LLPS-Hos-3249Homo sapiens95.750.01765
LLPS-Mea-3919Mesocricetus auratus95.440.01755
LLPS-Otg-1230Otolemur garnettii95.440.01759
LLPS-Dio-4321Dipodomys ordii95.010.01749
LLPS-Mum-3904Mus musculus95.010.01750
LLPS-Cap-4437Cavia porcellus95.010.01749
LLPS-Loa-1140Loxodonta africana95.010.01738
LLPS-Fud-2228Fukomys damarensis94.690.01735
LLPS-Ict-3926Ictidomys tridecemlineatus94.690.01741
LLPS-Ova-1915Ovis aries93.420.01704
LLPS-Mod-3783Monodelphis domestica91.510.01686
LLPS-Sah-3026Sarcophilus harrisii91.080.01693
LLPS-Anc-2499Anolis carolinensis84.972e-78 259
LLPS-Pes-2443Pelodiscus sinensis84.620.01497
LLPS-Meg-2356Meleagris gallopavo83.020.01221
LLPS-Ora-2420Ornithorhynchus anatinus82.930.0 575
LLPS-Fia-2908Ficedula albicollis82.170.01560
LLPS-Tag-2224Taeniopygia guttata82.030.01549
LLPS-Anp-1341Anas platyrhynchos80.880.01478
LLPS-Gaga-3899Gallus gallus79.690.01533
LLPS-Lac-2844Latimeria chalumnae76.110.01419
LLPS-Scf-1772Scleropages formosus74.230.01390
LLPS-Leo-1958Lepisosteus oculatus74.00.01384
LLPS-Scm-2945Scophthalmus maximus73.830.01384
LLPS-Icp-2720Ictalurus punctatus73.710.01368
LLPS-Asm-1598Astyanax mexicanus73.710.01387
LLPS-Tar-0007Takifugu rubripes73.70.01371
LLPS-Xet-0994Xenopus tropicalis73.620.01353
LLPS-Gaa-2083Gasterosteus aculeatus73.260.01358
LLPS-Xim-3928Xiphophorus maculatus73.090.01363
LLPS-Dar-0551Danio rerio73.070.01367
LLPS-Pof-3575Poecilia formosa72.880.01357
LLPS-Orn-2414Oreochromis niloticus72.340.01361
LLPS-Ten-2684Tetraodon nigroviridis72.080.01329
LLPS-Orl-3149Oryzias latipes71.280.01326
LLPS-Scs-0909Sclerotinia sclerotiorum53.693e-38 157
LLPS-Cis-0681Ciona savignyi48.080.0 800
LLPS-Php-1146Physcomitrella patens46.89e-60 225
LLPS-Cii-1628Ciona intestinalis42.233e-88 292
LLPS-Abg-1959Absidia glauca41.522e-125 411
LLPS-Coc-0827Corchorus capsularis41.220.0 585
LLPS-Art-2578Arabidopsis thaliana40.30.0 591
LLPS-Mua-1715Musa acuminata39.960.0 593
LLPS-Bro-1155Brassica oleracea39.880.0 593
LLPS-Dac-1137Daucus carota39.80.0 598
LLPS-Gor-2739Gossypium raimondii39.730.0 589
LLPS-Vir-0252Vigna radiata39.490.0 587
LLPS-Sol-2387Solanum lycopersicum39.460.0 598
LLPS-Viv-1155Vitis vinifera39.460.0 590
LLPS-Via-1536Vigna angularis39.410.0 583
LLPS-Brn-1053Brassica napus39.410.0 587
LLPS-Met-0997Medicago truncatula39.370.0 592
LLPS-Glm-2864Glycine max39.370.0 578
LLPS-Cus-0852Cucumis sativus39.350.0 596
LLPS-Phv-0719Phaseolus vulgaris39.310.0 581
LLPS-Thc-0629Theobroma cacao39.280.0 592
LLPS-Pot-1880Populus trichocarpa39.250.0 592
LLPS-Zyt-1220Zymoseptoria tritici39.222e-84 298
LLPS-Sot-1583Solanum tuberosum39.220.0 593
LLPS-Brr-0946Brassica rapa39.210.0 588
LLPS-Sem-1586Selaginella moellendorffii39.20.0 581
LLPS-Mae-0213Manihot esculenta39.130.0 585
LLPS-Hea-0213Helianthus annuus39.110.0 559
LLPS-Hov-1262Hordeum vulgare39.040.0 563
LLPS-Prp-1964Prunus persica39.020.0 583
LLPS-Crn-0508Cryptococcus neoformans38.873e-110 372
LLPS-Tru-0920Triticum urartu38.832e-169 544
LLPS-Arl-1786Arabidopsis lyrata38.730.0 591
LLPS-Spr-1395Sporisorium reilianum38.624e-68 253
LLPS-Nia-0019Nicotiana attenuata38.620.0 583
LLPS-Zem-2255Zea mays38.520.0 578
LLPS-Amt-0603Amborella trichopoda38.450.0 592
LLPS-Sei-0783Setaria italica38.340.0 570
LLPS-Sob-0980Sorghum bicolor38.110.0 570
LLPS-Tra-2963Triticum aestivum38.090.0 570
LLPS-Orni-1056Oryza nivara37.830.0 577
LLPS-Ori-1386Oryza indica37.830.0 577
LLPS-Orb-0972Oryza barthii37.830.0 577
LLPS-Org-0541Oryza glaberrima37.830.0 577
LLPS-Orm-1945Oryza meridionalis37.830.0 579
LLPS-Orr-0677Oryza rufipogon37.830.0 577
LLPS-Ors-2085Oryza sativa37.830.0 578
LLPS-Orp-0474Oryza punctata37.830.0 577
LLPS-Orbr-0434Oryza brachyantha37.820.0 581
LLPS-Orgl-0441Oryza glumaepatula37.730.0 574
LLPS-Lep-1421Leersia perrieri37.680.0 573
LLPS-Brd-1097Brachypodium distachyon37.320.0 561
LLPS-Usm-0566Ustilago maydis37.138e-69 255
LLPS-Pyt-0893Pyrenophora teres36.463e-96 331
LLPS-Put-1133Puccinia triticina36.452e-94 328
LLPS-Phn-0439Phaeosphaeria nodorum36.432e-90 315
LLPS-Pytr-1474Pyrenophora triticirepentis36.362e-96 332
LLPS-Asc-1468Aspergillus clavatus35.062e-153 484
LLPS-Ved-1327Verticillium dahliae34.844e-91 313
LLPS-Mao-0485Magnaporthe oryzae34.63e-88 310
LLPS-Lem-0858Leptosphaeria maculans34.481e-88 310
LLPS-Cogr-1307Colletotrichum graminicola34.224e-81 289
LLPS-Nec-0717Neurospora crassa34.142e-92 322
LLPS-Beb-0669Beauveria bassiana34.064e-81 289
LLPS-Cog-0487Colletotrichum gloeosporioides34.021e-78 286
LLPS-Fus-1287Fusarium solani33.92e-80 286
LLPS-Nef-1665Neosartorya fischeri33.771e-153 484
LLPS-Coo-1027Colletotrichum orbiculare33.674e-78 285
LLPS-Chr-1416Chlamydomonas reinhardtii33.082e-44 179
LLPS-Asfu-1538Aspergillus fumigatus33.067e-154 486
LLPS-Asf-1226Aspergillus flavus33.017e-148 471
LLPS-Asni-1296Aspergillus niger32.697e-143 456
LLPS-Blg-1249Blumeria graminis32.529e-133 430
LLPS-Ast-1182Aspergillus terreus32.481e-142 456
LLPS-Aso-0967Aspergillus oryzae32.419e-150 475
LLPS-Tum-1310Tuber melanosporum32.383e-140 449
LLPS-Asn-0788Aspergillus nidulans32.032e-113 387
LLPS-Gag-1230Gaeumannomyces graminis31.942e-144 461
LLPS-Dos-0485Dothistroma septosporum31.791e-141 454
LLPS-Trv-1650Trichoderma virens30.769e-134 433
LLPS-Pug-0350Puccinia graminis30.582e-114 384
LLPS-Map-1355Magnaporthe poae30.111e-88 306
LLPS-Mel-1382Melampsora laricipopulina29.495e-108 364
LLPS-Trr-1188Trichoderma reesei29.281e-125 410
LLPS-Fuv-1344Fusarium verticillioides28.973e-106 358
LLPS-Fuo-0454Fusarium oxysporum28.672e-104 353
LLPS-Sac-1244Saccharomyces cerevisiae27.44e-1274.7
LLPS-Cae-0071Caenorhabditis elegans27.333e-90 315
LLPS-Yal-1383Yarrowia lipolytica26.941e-92 322
LLPS-Gas-1364Galdieria sulphuraria26.637e-2099.8
LLPS-Scj-0504Schizosaccharomyces japonicus25.292e-38 159
LLPS-Asg-1215Ashbya gossypii25.237e-1687.0
LLPS-Drm-0912Drosophila melanogaster24.291e-27 124
LLPS-Kop-0840Komagataella pastoris24.043e-72 263
LLPS-Scp-1579Schizosaccharomyces pombe24.019e-41 166
LLPS-Scc-0799Schizosaccharomyces cryophilus23.141e-42 172
LLPS-Chc-1151Chondrus crispus21.545e-21 103