• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Leo-1958

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Vacuolar protein sorting-associated protein 11 homolog
Ensembl Gene: ENSLOCG00000005692.1
Ensembl Protein: ENSLOCP00000006888.1
Organism: Lepisosteus oculatus
Taxa ID: 7918
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Postsynaptic density, OthersPredicted from orthologs(View)

▼ FUNCTION

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSLOCT00000006896.1ENSLOCP00000006888.1
UniProtW5MES9, W5MES9_LEPOC
GeneBankAHAT01018479

▼ SEQUENCE

Protein Sequence (FASTA)
1     MTRRGSHDPP  PQLQSDRGKM  AAFLQWRRFV  FFDKETVKDP  ADNGKNFALP  VGICACDSGR  60
61    GHIVLGDLEG  QIWFLTRSLQ  LTSFQAYKLQ  VTHLYQLKQH  SILVSVGLDE  HGINPLVKVW  120
121   NLDKRDSGNP  LCTRIFPAIP  GNKPTEVSCL  SVHENLNFMA  IGFTDGSVVL  TKGDITRDRH  180
181   SKTLTLHEGT  CPITGLAFRQ  AGKVTHLFVA  TLEKVQCYTL  SVKEYPHLEL  DTHGCALRCA  240
241   ALTDPSQDSQ  FIVAGDECVY  LYQPDERGPC  FAFEGHKLLV  HWHRGYLVLL  TRDAKSPNKP  300
301   EFPSREASPT  EKQVLTVYDL  DNKFIAYSAA  FNDIVDVLAE  WGSLYILTQD  RKMYVLQEKD  360
361   TQTKLEMLFK  KNLFVMAINL  AKSHHLDSDG  LSEIFRQYGD  HLYVKGDHDG  AIQQYIRTIG  420
421   KLEPSYVIRK  FLDAQRIHNL  TAYLQALHRQ  SLANADHTTL  LLNCYTKLKD  SSKLEEFIKS  480
481   SESEVHFDVE  IAIKVLRQAG  YHSHAVFLAE  KHEHHEWYLK  IQLEDLKNYQ  EALRYIGRLP  540
541   FEQAESNMKR  YGKTLMHHVP  EETTLLLKGL  CTDYQPRRDS  ADRDSLGSKA  NSEEFIPIFA  600
601   NNPHELRAFL  EHMIEVEPRS  PQGVYDTLLE  LRLQDWAHEQ  DPQKKSALQD  AALCLLKSDY  660
661   TVFDKALVLC  QMHNFKEGVL  YLYEKGKLYQ  QIMHYHMQNE  EYAKVVEACK  RYGEQEACLW  720
721   EQALGYFARK  EEDCKTYISQ  VLHHIDRNNL  MPPLLVVQTL  AHNSSATLSV  IKDYLISKLQ  780
781   RESEQIEDDE  RKIRQYREDT  AQLRTEIQEL  KNSAKIFQKT  KCSMCNSPLE  LPSVHFLCGH  840
841   SFHQHCFESY  AESEAECPTC  TPDNRKVMDM  LRAQDQKRDL  HENFARQLRC  SNDGFSVVAD  900
901   YFGRGVFNKL  TLITDLPGGK  PGGSGGGGLE  ADLQRDLLIH  TKRNA  945
Nucleotide CDS Sequence (FASTA)
1     ATGACACGGC  GGGGGTCACA  TGATCCCCCC  CCCCAGCTGC  AGAGTGACAG  GGGGAAAATG  60
61    GCAGCGTTCT  TGCAGTGGCG  AAGATTTGTA  TTTTTCGATA  AAGAAACGGT  GAAGGATCCT  120
121   GCGGACAATG  GGAAAAATTT  CGCGCTCCCG  GTCGGTATCT  GTGCCTGCGA  CTCGGGCCGA  180
181   GGTCACATCG  TGCTGGGAGA  TCTGGAGGGT  CAGATCTGGT  TCCTGACACG  CTCCCTGCAG  240
241   CTAACGTCCT  TTCAGGCATA  CAAACTACAA  GTGACTCACC  TCTACCAGCT  GAAACAGCAC  300
301   AGCATCCTGG  TGTCAGTGGG  ATTGGACGAG  CACGGAATCA  ACCCACTGGT  CAAGGTGTGG  360
361   AACCTGGACA  AGCGCGACAG  TGGGAACCCT  CTCTGCACTC  GGATCTTCCC  GGCCATCCCA  420
421   GGGAACAAAC  CCACAGAGGT  GTCCTGCCTC  AGCGTGCACG  AGAACCTCAA  CTTCATGGCC  480
481   ATCGGCTTCA  CAGACGGCAG  CGTGGTTCTG  ACCAAGGGCG  ACATCACCAG  AGATCGCCAC  540
541   AGCAAAACCC  TCACCCTGCA  CGAGGGCACC  TGCCCCATCA  CCGGGCTTGC  TTTCCGGCAG  600
601   GCGGGCAAAG  TCACGCACCT  GTTTGTCGCC  ACCCTGGAGA  AAGTCCAGTG  CTACACCCTC  660
661   TCCGTGAAGG  AGTACCCGCA  CCTGGAGCTG  GACACACACG  GCTGTGCCCT  GCGCTGCGCC  720
721   GCGCTGACCG  ACCCCTCCCA  GGACTCCCAG  TTCATCGTGG  CGGGTGACGA  GTGTGTGTAC  780
781   CTCTACCAGC  CCGACGAGAG  GGGCCCCTGC  TTCGCCTTCG  AGGGGCACAA  GCTGCTGGTG  840
841   CACTGGCACC  GCGGGTATCT  GGTGCTGCTC  ACACGCGACG  CCAAGTCGCC  GAACAAGCCC  900
901   GAGTTTCCGA  GCCGGGAGGC  CTCCCCCACA  GAGAAGCAGG  TCCTGACCGT  CTACGACTTG  960
961   GACAACAAGT  TCATTGCGTA  CAGCGCTGCG  TTCAACGACA  TCGTCGATGT  GCTGGCGGAG  1020
1021  TGGGGCTCGC  TGTACATCCT  GACCCAGGAC  CGCAAGATGT  ATGTGCTGCA  GGAGAAAGAC  1080
1081  ACTCAGACCA  AGCTGGAGAT  GCTCTTCAAG  AAGAACCTGT  TTGTAATGGC  CATTAACCTG  1140
1141  GCCAAGAGCC  ACCACCTAGA  CAGCGACGGG  CTGTCCGAGA  TCTTCCGTCA  GTATGGGGAC  1200
1201  CACCTGTATG  TCAAGGGAGA  CCACGATGGA  GCCATTCAGC  AGTACATCCG  CACCATTGGG  1260
1261  AAGCTGGAGC  CCTCCTATGT  GATTCGGAAG  TTCTTGGATG  CTCAGAGGAT  CCACAACCTG  1320
1321  ACAGCATACC  TGCAGGCCCT  GCACAGGCAG  TCCCTGGCAA  ATGCTGACCA  CACCACCCTG  1380
1381  CTGCTCAACT  GCTACACCAA  GCTGAAGGAC  AGCTCCAAAC  TGGAGGAGTT  CATCAAGAGC  1440
1441  AGCGAGAGTG  AGGTGCATTT  CGACGTGGAG  ATCGCCATTA  AGGTTCTCCG  GCAGGCCGGC  1500
1501  TACCACAGCC  ATGCGGTCTT  CCTGGCGGAG  AAGCACGAAC  ACCATGAGTG  GTACCTCAAG  1560
1561  ATCCAGCTTG  AAGACCTCAA  GAACTACCAG  GAGGCCCTGC  GGTACATCGG  GCGGCTGCCC  1620
1621  TTCGAGCAGG  CGGAGAGCAA  CATGAAGCGC  TATGGGAAGA  CGCTGATGCA  CCACGTCCCC  1680
1681  GAGGAGACCA  CCCTGCTGCT  GAAGGGTCTG  TGTACCGACT  ACCAGCCACG  CCGGGACTCC  1740
1741  GCCGACAGAG  ACAGCCTGGG  CAGCAAGGCG  AACTCGGAGG  AGTTCATCCC  CATCTTCGCC  1800
1801  AACAACCCTC  ACGAGCTGCG  GGCCTTCCTG  GAGCACATGA  TCGAAGTGGA  GCCACGGTCT  1860
1861  CCCCAGGGGG  TCTATGACAC  CCTGCTGGAG  CTCCGGCTGC  AGGACTGGGC  ACATGAGCAA  1920
1921  GACCCGCAGA  AGAAGAGCGC  TCTGCAGGAC  GCTGCGCTGT  GTTTGTTGAA  GAGTGACTAT  1980
1981  ACGGTGTTTG  ACAAGGCTCT  TGTCCTGTGC  CAGATGCACA  ACTTCAAGGA  GGGGGTGCTG  2040
2041  TATCTGTACG  AGAAGGGCAA  ACTCTACCAG  CAGATCATGC  ATTACCACAT  GCAGAATGAA  2100
2101  GAGTATGCGA  AGGTGGTGGA  GGCCTGCAAA  CGCTATGGGG  AGCAGGAGGC  CTGCCTGTGG  2160
2161  GAGCAGGCCC  TGGGGTACTT  CGCACGCAAA  GAGGAGGACT  GCAAGACCTA  CATCAGCCAA  2220
2221  GTGCTGCATC  ACATCGACCG  CAATAACCTC  ATGCCTCCGC  TGTTAGTGGT  CCAGACCCTG  2280
2281  GCGCACAACT  CCTCGGCGAC  GCTGTCGGTG  ATCAAGGACT  ACCTCATCAG  CAAGCTGCAG  2340
2341  CGGGAGAGCG  AGCAGATCGA  GGACGACGAG  AGGAAGATCC  GCCAGTACCG  CGAGGACACC  2400
2401  GCGCAGCTGC  GCACGGAGAT  CCAGGAGCTG  AAGAACAGCG  CCAAGATATT  CCAGAAGACG  2460
2461  AAGTGCAGCA  TGTGCAACAG  CCCGCTGGAG  CTGCCCAGCG  TGCACTTCCT  GTGCGGCCAC  2520
2521  TCCTTCCACC  AGCACTGCTT  CGAGAGCTAC  GCCGAGAGCG  AGGCCGAGTG  CCCCACCTGC  2580
2581  ACCCCCGACA  ACCGCAAGGT  GATGGACATG  CTGCGCGCCC  AGGACCAGAA  ACGGGACCTG  2640
2641  CACGAGAACT  TCGCCAGACA  GCTGCGCTGC  TCGAACGACG  GCTTCTCGGT  GGTGGCGGAC  2700
2701  TACTTCGGCC  GGGGGGTGTT  CAACAAGCTG  ACGCTGATCA  CCGACCTGCC  CGGGGGGAAG  2760
2761  CCTGGGGGCA  GCGGCGGCGG  CGGGCTGGAG  GCCGACCTGC  AGCGAGACCT  GCTCATCCAC  2820
2821  ACCAAGAGGA  ACGCCTGA  2838

▼ KEYWORD

ID
Family
Autophagy
Coiled coil
Complete proteome
Cytoplasmic vesicle
Endosome
Lysosome
Membrane
Metal-binding
Protein transport
Reference proteome
Transport
Zinc
Zinc-finger

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Autophagosome
Cellular Component
Clathrin-coated vesicle
Cellular Component
CORVET complex
Cellular Component
Early endosome
Cellular Component
Endosome
Cellular Component
HOPS complex
Cellular Component
Late endosome membrane
Cellular Component
Lysosomal membrane
Molecular Function
Protein binding, bridging
Biological Process
Autophagy
Biological Process
Endosome organization
Biological Process
Intracellular protein transport
Biological Process
Liver development
Biological Process
Lysosome organization
Biological Process
Melanocyte apoptotic process
Biological Process
Melanocyte differentiation
Biological Process
Negative regulation of autophagy
Biological Process
Neural retina development
Biological Process
Notochord cell vacuolation
Biological Process
Regulation of SNARE complex assembly
Biological Process
Retinal pigment epithelium development
Biological Process
Swim bladder development
Biological Process
Vacuole organization
Biological Process
Vesicle docking involved in exocytosis

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Scf-1772Scleropages formosus90.770.01761
LLPS-Icp-2720Ictalurus punctatus88.60.01715
LLPS-Asm-1598Astyanax mexicanus88.190.01736
LLPS-Dar-0551Danio rerio86.770.01696
LLPS-Scm-2945Scophthalmus maximus86.650.01682
LLPS-Orn-2414Oreochromis niloticus86.430.01687
LLPS-Xim-3928Xiphophorus maculatus86.220.01672
LLPS-Gaa-2083Gasterosteus aculeatus86.140.01667
LLPS-Pof-3575Poecilia formosa85.90.01662
LLPS-Tar-0007Takifugu rubripes85.680.01669
LLPS-Anc-2499Anolis carolinensis84.391e-90 292
LLPS-Ten-2684Tetraodon nigroviridis83.730.01613
LLPS-Orl-3149Oryzias latipes82.510.01593
LLPS-Fia-2908Ficedula albicollis78.460.01536
LLPS-Anp-1341Anas platyrhynchos78.410.01449
LLPS-Tag-2224Taeniopygia guttata78.350.01526
LLPS-Pes-2443Pelodiscus sinensis78.210.01446
LLPS-Lac-2844Latimeria chalumnae78.060.01532
LLPS-Meg-2356Meleagris gallopavo77.360.01203
LLPS-Mam-3632Macaca mulatta76.530.01427
LLPS-Pat-1884Pan troglodytes76.30.01425
LLPS-Pap-1816Pan paniscus76.30.01425
LLPS-Nol-4503Nomascus leucogenys76.30.01425
LLPS-Ran-3329Rattus norvegicus76.190.01421
LLPS-Gaga-3899Gallus gallus75.750.01508
LLPS-Mod-3783Monodelphis domestica75.610.01488
LLPS-Orc-2327Oryctolagus cuniculus75.470.01259
LLPS-Sah-3026Sarcophilus harrisii75.40.01481
LLPS-Mup-1430Mustela putorius furo75.240.01491
LLPS-Urm-2653Ursus maritimus75.130.01491
LLPS-Sus-2430Sus scrofa75.130.01494
LLPS-Loa-1140Loxodonta africana75.030.01491
LLPS-Caf-4362Canis familiaris75.030.01491
LLPS-Bot-1348Bos taurus75.030.01491
LLPS-Aim-3924Ailuropoda melanoleuca75.00.01483
LLPS-Fec-4801Felis catus74.920.01486
LLPS-Eqc-3154Equus caballus74.920.01488
LLPS-Cea-2481Cercocebus atys74.920.01491
LLPS-Chs-3258Chlorocebus sabaeus74.920.01491
LLPS-Maf-4690Macaca fascicularis74.920.01491
LLPS-Mum-3904Mus musculus74.920.01490
LLPS-Mal-4065Mandrillus leucophaeus74.920.01491
LLPS-Paa-2475Papio anubis74.920.01491
LLPS-Ict-3926Ictidomys tridecemlineatus74.810.01474
LLPS-Man-4600Macaca nemestrina74.710.01487
LLPS-Hos-3249Homo sapiens74.710.01489
LLPS-Cap-4437Cavia porcellus74.710.01485
LLPS-Poa-4152Pongo abelii74.710.01488
LLPS-Caj-4223Callithrix jacchus74.710.01481
LLPS-Gog-1064Gorilla gorilla74.710.01490
LLPS-Aon-0114Aotus nancymaae74.710.01481
LLPS-Cas-0424Carlito syrichta74.60.01480
LLPS-Otg-1230Otolemur garnettii74.520.01474
LLPS-Dio-4321Dipodomys ordii74.50.01482
LLPS-Fud-2228Fukomys damarensis74.440.01477
LLPS-Mea-3919Mesocricetus auratus74.290.01476
LLPS-Myl-4117Myotis lucifugus74.00.01471
LLPS-Ora-2420Ornithorhynchus anatinus73.544e-163 488
LLPS-Ova-1915Ovis aries73.260.01437
LLPS-Xet-0994Xenopus tropicalis70.340.01358
LLPS-Cis-0681Ciona savignyi50.050.0 895
LLPS-Cii-1628Ciona intestinalis43.186e-90 296
LLPS-Php-1146Physcomitrella patens42.773e-73 266
LLPS-Art-2578Arabidopsis thaliana40.90.0 674
LLPS-Mua-1715Musa acuminata40.880.0 671
LLPS-Bro-1155Brassica oleracea40.660.0 672
LLPS-Brn-1053Brassica napus40.60.0 669
LLPS-Brr-0946Brassica rapa40.50.0 671
LLPS-Coc-0827Corchorus capsularis40.350.0 667
LLPS-Arl-1786Arabidopsis lyrata40.230.0 679
LLPS-Sot-1583Solanum tuberosum40.150.0 669
LLPS-Sol-2387Solanum lycopersicum40.060.0 671
LLPS-Gor-2739Gossypium raimondii39.960.0 662
LLPS-Mae-0213Manihot esculenta39.860.0 652
LLPS-Nia-0019Nicotiana attenuata39.850.0 665
LLPS-Thc-0629Theobroma cacao39.750.0 657
LLPS-Met-0997Medicago truncatula39.690.0 666
LLPS-Glm-2864Glycine max39.670.0 660
LLPS-Via-1536Vigna angularis39.630.0 656
LLPS-Tru-0920Triticum urartu39.620.0 612
LLPS-Zem-2255Zea mays39.550.0 657
LLPS-Amt-0603Amborella trichopoda39.540.0 669
LLPS-Prp-1964Prunus persica39.530.0 650
LLPS-Phv-0719Phaseolus vulgaris39.520.0 652
LLPS-Hea-0213Helianthus annuus39.520.0 619
LLPS-Vir-0252Vigna radiata39.520.0 654
LLPS-Pot-1880Populus trichocarpa39.480.0 653
LLPS-Sei-0783Setaria italica39.420.0 655
LLPS-Sob-0980Sorghum bicolor39.340.0 654
LLPS-Hov-1262Hordeum vulgare39.310.0 627
LLPS-Cus-0852Cucumis sativus39.180.0 659
LLPS-Dac-1137Daucus carota39.10.0 669
LLPS-Orp-0474Oryza punctata39.040.0 652
LLPS-Ors-2085Oryza sativa39.040.0 650
LLPS-Org-0541Oryza glaberrima39.040.0 651
LLPS-Orm-1945Oryza meridionalis39.040.0 651
LLPS-Orr-0677Oryza rufipogon39.040.0 651
LLPS-Orni-1056Oryza nivara39.040.0 651
LLPS-Ori-1386Oryza indica39.040.0 651
LLPS-Orb-0972Oryza barthii39.040.0 651
LLPS-Lep-1421Leersia perrieri39.030.0 651
LLPS-Viv-1155Vitis vinifera39.010.0 644
LLPS-Tra-2963Triticum aestivum39.010.0 644
LLPS-Orgl-0441Oryza glumaepatula38.940.0 649
LLPS-Sem-1586Selaginella moellendorffii38.930.0 646
LLPS-Brd-1097Brachypodium distachyon38.740.0 636
LLPS-Orbr-0434Oryza brachyantha38.720.0 649
LLPS-Crn-0508Cryptococcus neoformans37.644e-119 396
LLPS-Spr-1395Sporisorium reilianum37.065e-79 285
LLPS-Pyt-0893Pyrenophora teres36.931e-111 374
LLPS-Chr-1416Chlamydomonas reinhardtii36.861e-53 207
LLPS-Pytr-1474Pyrenophora triticirepentis36.783e-110 370
LLPS-Zyt-1220Zymoseptoria tritici36.713e-106 359
LLPS-Scs-0909Sclerotinia sclerotiorum36.461e-103 346
LLPS-Mao-0485Magnaporthe oryzae36.294e-104 354
LLPS-Usm-0566Ustilago maydis36.173e-78 283
LLPS-Phn-0439Phaeosphaeria nodorum36.143e-105 357
LLPS-Put-1133Puccinia triticina35.941e-108 367
LLPS-Map-1355Magnaporthe poae35.84e-102 343
LLPS-Lem-0858Leptosphaeria maculans35.783e-105 356
LLPS-Cogr-1307Colletotrichum graminicola35.739e-97 333
LLPS-Cog-0487Colletotrichum gloeosporioides35.695e-92 327
LLPS-Nec-0717Neurospora crassa35.612e-104 355
LLPS-Ved-1327Verticillium dahliae35.523e-103 346
LLPS-Coo-1027Colletotrichum orbiculare35.416e-95 335
LLPS-Pug-0350Puccinia graminis35.386e-102 350
LLPS-Abg-1959Absidia glauca35.180.0 597
LLPS-Fus-1287Fusarium solani35.141e-95 329
LLPS-Dos-0485Dothistroma septosporum34.661e-175 543
LLPS-Beb-0669Beauveria bassiana34.512e-93 323
LLPS-Tum-1310Tuber melanosporum33.931e-159 501
LLPS-Nef-1665Neosartorya fischeri33.773e-160 502
LLPS-Ast-1182Aspergillus terreus33.771e-155 489
LLPS-Asni-1296Aspergillus niger33.737e-155 487
LLPS-Asf-1226Aspergillus flavus33.681e-157 497
LLPS-Aso-0967Aspergillus oryzae33.641e-160 503
LLPS-Asc-1468Aspergillus clavatus33.379e-158 496
LLPS-Asfu-1538Aspergillus fumigatus33.337e-163 509
LLPS-Asn-0788Aspergillus nidulans33.032e-132 440
LLPS-Blg-1249Blumeria graminis32.482e-151 479
LLPS-Gag-1230Gaeumannomyces graminis32.191e-156 494
LLPS-Fuv-1344Fusarium verticillioides31.993e-71 259
LLPS-Fuo-0454Fusarium oxysporum31.647e-70 255
LLPS-Trv-1650Trichoderma virens31.481e-155 491
LLPS-Sac-1244Saccharomyces cerevisiae29.961e-1586.3
LLPS-Trr-1188Trichoderma reesei29.651e-137 442
LLPS-Mel-1382Melampsora laricipopulina29.472e-120 398
LLPS-Cae-0071Caenorhabditis elegans28.744e-108 364
LLPS-Yal-1383Yarrowia lipolytica27.371e-103 353
LLPS-Drm-0912Drosophila melanogaster26.613e-25 116
LLPS-Scj-0504Schizosaccharomyces japonicus24.947e-49 191
LLPS-Asg-1215Ashbya gossypii24.221e-56 216
LLPS-Kop-0840Komagataella pastoris23.852e-76 275
LLPS-Gas-1364Galdieria sulphuraria23.65e-46 183
LLPS-Scp-1579Schizosaccharomyces pombe23.592e-51 199
LLPS-Scc-0799Schizosaccharomyces cryophilus22.926e-54 207
LLPS-Chc-1151Chondrus crispus22.068e-41 167