• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Gaga-3899
VPS11

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Vacuolar protein sorting-associated protein 11 homolog
Gene Name: VPS11
Ensembl Gene: ENSGALG00000029536.2
Ensembl Protein: ENSGALP00000065563.1
Organism: Gallus gallus
Taxa ID: 9031
LLPS Type: LLPS regulator


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Postsynaptic density, OthersPredicted from orthologs(View)

▼ FUNCTION


Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.

▼ SEQUENCE


Protein Sequence (FASTA)
1     MAAYLQWRRF  VFFDREMVKE  PPGPEGAGGK  PFALPPGITV  CDSGRGSLVF  GDMEGRIWFL  60
61    PRSLQLSGFQ  AYKLRVTHLY  QLKQHSILVS  VGEDEEGINP  LVKVWNLEKR  DGGNPLCTRI  120
121   FPAIPGNKPT  VVSCLTVHEN  LNFMAIGFAD  GSVVLTKGDI  TRDRHSKTQI  LHEGSYPVTG  180
181   LAFRQSGKTT  HLFVVTTENI  QSYLLSVKDY  SHLELDTHGC  GLHCSSLSDP  SQDLQFIVAG  240
241   NECVYLYQPD  ERGPCFAFEG  QKLIVHWYRG  YLIIVSKDRK  TSPKSEFAGN  EAQNSDKQVL  300
301   NIYDLCNKFI  AYSSVFDDVV  DVLAEWGSLY  VLTRDGKIHV  LQEKDAQTKL  EMLFRKNLFE  360
361   MAINLAKSHH  LDSDGLSEIF  RQYGDHLYNK  GNHDGAIQQY  IRTIGKLEPS  YVIRKFLDAQ  420
421   RIHNLTAYLQ  TLHLQSLANA  DHTTLLLNCY  TKLKDSTKLE  EFIKASESEV  RFDVETAIKV  480
481   LRQAGYYSHA  VYLAEKHDHH  EWYLKIQLED  IKNYQEALHY  IGKLPFDQAE  SNMKRYGKIL  540
541   MHHVPKETTE  LLKNLCTDYQ  PTGDSEGPGI  LEGKKANSEE  FIPVFANNSR  ELKAFLEHMT  600
601   EVQSDSPQGV  YDTLLELRLQ  NWAHELDEQI  KEKLHDEALT  LLKSGRFKTV  FDKALVLCQM  660
661   HNFKDGVLYL  YEQGKLFQQI  MHYHMQNEQY  KKVIEVCELY  GDQEACLWEQ  ALGYFARKEE  720
721   DCKEYIAAVL  KHIENKNLMP  PLLVVQTLAH  NSTATLSVIK  DYLVNKLQKQ  SCQIEQDGQR  780
781   IQKYREETTR  IRQEIEELKA  SPKIFQKTKC  SICTSALELP  SVHFLCGHSF  HQHCFESYSE  840
841   SDSECPTCMP  ENRKVMDMIR  AQEQKRDLHD  QFQHQWLEYR  ESLMFCKHGI  EASATKAVPF  900
901   MPKLKCSNDG  FSVVADYFGR  GVFNKLTLIT  DLPLGKSATT  IEAGLQRELL  MHTKRST  957
Nucleotide CDS Sequence (FASTA)
1     ATGGCTGCCT  ATCTGCAGTG  GCGCCGCTTC  GTCTTCTTCG  ACAGAGAGAT  GGTGAAGGAG  60
61    CCGCCGGGGC  CGGAGGGGGC  TGGTGGGAAG  CCCTTCGCGT  TGCCTCCGGG  CATCACGGTC  120
121   TGTGACTCGG  GCCGAGGAAG  CCTTGTGTTC  GGAGATATGG  AAGGTCGGAT  CTGGTTTTTG  180
181   CCTCGCTCAC  TTCAACTCAG  TGGTTTCCAA  GCTTACAAGT  TAAGGGTAAC  ACATTTGTAC  240
241   CAGCTGAAGC  AGCACAGTAT  CTTGGTTTCT  GTTGGTGAGG  ATGAAGAGGG  CATTAACCCG  300
301   TTGGTTAAAG  TATGGAATCT  GGAAAAACGA  GATGGTGGCA  ATCCTCTTTG  CACACGAATT  360
361   TTCCCAGCGA  TACCGGGTAA  CAAGCCCACA  GTTGTGTCCT  GTCTAACTGT  CCATGAGAAT  420
421   CTGAATTTCA  TGGCTATTGG  CTTTGCAGAT  GGGAGTGTTG  TGCTTACAAA  AGGAGACATC  480
481   ACTCGAGACC  GGCATAGTAA  GACCCAGATC  CTCCATGAAG  GCAGTTACCC  GGTTACTGGT  540
541   CTTGCTTTTC  GACAGTCTGG  CAAAACAACA  CATCTGTTTG  TGGTGACCAC  AGAGAACATC  600
601   CAGTCTTACC  TGCTTTCTGT  GAAAGACTAT  TCTCATCTGG  AGCTGGACAC  TCATGGCTGT  660
661   GGATTGCACT  GTTCTTCTCT  GAGCGACCCC  TCCCAGGACC  TCCAGTTCAT  TGTAGCAGGA  720
721   AATGAATGTG  TGTACCTTTA  TCAACCAGAT  GAACGAGGCC  CCTGCTTTGC  TTTCGAGGGA  780
781   CAAAAGCTGA  TTGTTCACTG  GTATCGGGGG  TACCTCATCA  TTGTCTCCAA  GGACCGAAAG  840
841   ACTTCTCCAA  AGTCAGAGTT  TGCTGGGAAT  GAAGCACAGA  ATTCAGACAA  GCAAGTTCTA  900
901   AATATCTATG  ATTTGTGCAA  CAAATTCATT  GCATACAGCT  CCGTCTTTGA  TGATGTAGTA  960
961   GATGTCTTAG  CAGAGTGGGG  TTCTTTGTAT  GTTCTGACCA  GAGATGGGAA  GATCCATGTA  1020
1021  CTGCAGGAGA  AGGATGCCCA  AACCAAACTT  GAGATGCTCT  TCAGAAAGAA  CTTATTTGAA  1080
1081  ATGGCCATTA  ATCTAGCCAA  GAGTCACCAC  TTGGACAGTG  ATGGCTTGTC  AGAAATTTTC  1140
1141  CGGCAGTATG  GTGATCATCT  CTATAACAAG  GGGAACCATG  ATGGAGCCAT  CCAGCAGTAT  1200
1201  ATCCGGACTA  TAGGGAAATT  GGAACCATCT  TATGTTATTC  GGAAATTCCT  AGATGCTCAG  1260
1261  CGCATCCACA  ATCTCACTGC  TTATCTGCAG  ACACTCCACC  TGCAATCTCT  CGCCAATGCT  1320
1321  GACCACACTA  CACTTCTGCT  GAACTGCTAT  ACTAAACTCA  AAGACAGCAC  CAAATTGGAG  1380
1381  GAGTTCATTA  AGGCTAGTGA  GAGTGAGGTT  CGCTTCGATG  TAGAAACAGC  AATCAAGGTA  1440
1441  CTTCGTCAAG  CAGGTTACTA  TTCCCATGCA  GTGTACTTGG  CAGAAAAGCA  TGACCATCAT  1500
1501  GAATGGTACC  TCAAAATCCA  GCTAGAAGAC  ATTAAGAACT  ATCAAGAGGC  TTTGCACTAC  1560
1561  ATTGGAAAAC  TGCCTTTTGA  TCAAGCAGAG  AGTAACATGA  AGCGGTATGG  TAAAATCCTG  1620
1621  ATGCACCATG  TCCCTAAAGA  GACAACAGAA  CTATTAAAGA  ACCTTTGCAC  TGATTACCAG  1680
1681  CCAACAGGAG  ACAGTGAAGG  CCCTGGGATT  CTGGAAGGGA  AAAAGGCAAA  TTCTGAGGAG  1740
1741  TTCATTCCAG  TCTTTGCAAA  CAACTCCCGA  GAACTGAAGG  CTTTTCTGGA  GCACATGACT  1800
1801  GAGGTGCAGT  CTGACTCTCC  ACAAGGTGTC  TATGACACTT  TATTGGAACT  TCGCCTCCAG  1860
1861  AATTGGGCAC  ATGAACTAGA  TGAGCAGATC  AAGGAGAAGC  TGCACGATGA  AGCACTCACT  1920
1921  CTCCTGAAGA  GTGGAAGGTT  CAAAACAGTC  TTTGATAAGG  CCTTGGTCTT  ATGTCAGATG  1980
1981  CACAATTTCA  AGGATGGTGT  CCTCTACCTC  TATGAACAGG  GCAAACTTTT  CCAACAGATC  2040
2041  ATGCACTACC  ACATGCAGAA  CGAGCAGTAC  AAGAAAGTGA  TCGAGGTGTG  TGAGTTGTAC  2100
2101  GGGGACCAAG  AGGCTTGTCT  TTGGGAACAG  GCTCTTGGCT  ACTTTGCACG  GAAGGAGGAA  2160
2161  GACTGCAAGG  AGTATATTGC  TGCAGTGCTG  AAACACATAG  AGAACAAGAA  TCTTATGCCT  2220
2221  CCACTTCTTG  TTGTGCAGAC  ACTGGCTCAC  AACTCCACAG  CCACACTGTC  TGTGATTAAG  2280
2281  GATTATCTTG  TCAACAAGCT  GCAGAAGCAG  AGCTGCCAGA  TAGAGCAAGA  TGGGCAGAGA  2340
2341  ATTCAAAAAT  ACCGAGAAGA  AACTACAAGG  ATTCGTCAGG  AGATTGAAGA  GCTAAAAGCA  2400
2401  AGTCCCAAGA  TCTTTCAGAA  GACCAAGTGT  AGCATTTGCA  CGAGTGCCCT  GGAGCTGCCC  2460
2461  TCCGTCCATT  TCCTATGTGG  TCATTCCTTC  CACCAGCATT  GCTTTGAAAG  CTACTCCGAG  2520
2521  AGCGATTCAG  AATGTCCTAC  TTGTATGCCT  GAAAATCGCA  AAGTGATGGA  CATGATCCGA  2580
2581  GCCCAGGAGC  AAAAGAGAGA  TCTGCATGAT  CAGTTTCAGC  ATCAGCTGAA  GTGTTCCAAT  2640
2641  GATGGCTTTT  CCGTCGTCGC  TGACTACTTT  GGTCGAGGCG  TTTTTAATAA  GCTCACCCTC  2700
2701  ATCACAGATT  TGCCTTTGGG  AAAGTCAGCT  ACGACCATTG  AGGCTGGCCT  CCAGAGGGAG  2760
2761  CTGCTGATGC  ACACTAAGCG  CAGTACCTGA  2790

▼ KEYWORD


ID
Family
Autophagy
Coiled coil
Complete proteome
Cytoplasmic vesicle
Endosome
Lysosome
Membrane
Metal-binding
Protein transport
Reference proteome
Transport
Zinc
Zinc-finger

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Autophagosome
Cellular Component
Clathrin-coated vesicle
Cellular Component
CORVET complex
Cellular Component
Early endosome
Cellular Component
Endosome
Cellular Component
HOPS complex
Cellular Component
Late endosome membrane
Cellular Component
Lysosomal membrane
Molecular Function
Protein binding, bridging
Biological Process
Autophagy
Biological Process
Endosome organization
Biological Process
Intracellular protein transport
Biological Process
Lysosome organization
Biological Process
Regulation of SNARE complex assembly
Biological Process
Vacuole organization
Biological Process
Vesicle docking involved in exocytosis

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Meg-2356Meleagris gallopavo97.710.01473
LLPS-Fia-2908Ficedula albicollis92.690.01798
LLPS-Tag-2224Taeniopygia guttata92.060.01782
LLPS-Pes-2443Pelodiscus sinensis91.160.01680
LLPS-Anp-1341Anas platyrhynchos90.850.01701
LLPS-Anc-2499Anolis carolinensis85.162e-100 319
LLPS-Pat-1884Pan troglodytes82.090.01543
LLPS-Pap-1816Pan paniscus82.090.01543
LLPS-Nol-4503Nomascus leucogenys82.090.01544
LLPS-Mam-3632Macaca mulatta81.980.01543
LLPS-Ran-3329Rattus norvegicus81.90.01540
LLPS-Mod-3783Monodelphis domestica81.870.01623
LLPS-Ora-2420Ornithorhynchus anatinus81.850.0 550
LLPS-Sah-3026Sarcophilus harrisii81.70.01610
LLPS-Urm-2653Ursus maritimus80.990.01613
LLPS-Fec-4801Felis catus80.990.01613
LLPS-Eqc-3154Equus caballus80.880.01607
LLPS-Mup-1430Mustela putorius furo80.880.01613
LLPS-Loa-1140Loxodonta africana80.80.01606
LLPS-Hos-3249Homo sapiens80.780.01613
LLPS-Poa-4152Pongo abelii80.780.01610
LLPS-Caf-4362Canis familiaris80.780.01607
LLPS-Gog-1064Gorilla gorilla80.780.01613
LLPS-Bot-1348Bos taurus80.780.01609
LLPS-Aim-3924Ailuropoda melanoleuca80.760.01603
LLPS-Man-4600Macaca nemestrina80.70.01611
LLPS-Cas-0424Carlito syrichta80.680.01610
LLPS-Maf-4690Macaca fascicularis80.680.01612
LLPS-Chs-3258Chlorocebus sabaeus80.680.01612
LLPS-Sus-2430Sus scrofa80.680.01607
LLPS-Cea-2481Cercocebus atys80.680.01610
LLPS-Paa-2475Papio anubis80.680.01612
LLPS-Mal-4065Mandrillus leucophaeus80.680.01612
LLPS-Aon-0114Aotus nancymaae80.60.01601
LLPS-Caj-4223Callithrix jacchus80.580.01602
LLPS-Orc-2327Oryctolagus cuniculus80.460.01355
LLPS-Otg-1230Otolemur garnettii80.390.01595
LLPS-Cap-4437Cavia porcellus80.190.01599
LLPS-Mum-3904Mus musculus80.190.01599
LLPS-Mea-3919Mesocricetus auratus80.160.01600
LLPS-Fud-2228Fukomys damarensis80.120.01591
LLPS-Ict-3926Ictidomys tridecemlineatus79.980.01587
LLPS-Dio-4321Dipodomys ordii79.750.01588
LLPS-Myl-4117Myotis lucifugus79.590.01586
LLPS-Ova-1915Ovis aries78.540.01543
LLPS-Lac-2844Latimeria chalumnae77.820.01519
LLPS-Leo-1958Lepisosteus oculatus75.550.01475
LLPS-Scf-1772Scleropages formosus74.510.01465
LLPS-Xet-0994Xenopus tropicalis74.350.01442
LLPS-Asm-1598Astyanax mexicanus74.090.01463
LLPS-Icp-2720Ictalurus punctatus73.990.01441
LLPS-Scm-2945Scophthalmus maximus73.620.01444
LLPS-Xim-3928Xiphophorus maculatus73.620.01431
LLPS-Gaa-2083Gasterosteus aculeatus73.570.01433
LLPS-Tar-0007Takifugu rubripes73.310.01436
LLPS-Pof-3575Poecilia formosa73.10.01424
LLPS-Orn-2414Oreochromis niloticus73.080.01430
LLPS-Dar-0551Danio rerio72.840.01433
LLPS-Orl-3149Oryzias latipes72.620.01415
LLPS-Ten-2684Tetraodon nigroviridis71.580.01381
LLPS-Scs-0909Sclerotinia sclerotiorum56.716e-47 184
LLPS-Cis-0681Ciona savignyi47.290.0 853
LLPS-Cii-1628Ciona intestinalis43.386e-91 300
LLPS-Php-1146Physcomitrella patens42.554e-147 470
LLPS-Art-2578Arabidopsis thaliana39.90.0 640
LLPS-Mua-1715Musa acuminata39.480.0 644
LLPS-Coc-0827Corchorus capsularis39.380.0 629
LLPS-Gor-2739Gossypium raimondii39.370.0 631
LLPS-Cus-0852Cucumis sativus39.270.0 641
LLPS-Via-1536Vigna angularis39.010.0 634
LLPS-Prp-1964Prunus persica38.980.0 626
LLPS-Crn-0508Cryptococcus neoformans38.986e-123 407
LLPS-Hov-1262Hordeum vulgare38.950.0 595
LLPS-Vir-0252Vigna radiata38.910.0 633
LLPS-Dac-1137Daucus carota38.890.0 642
LLPS-Arl-1786Arabidopsis lyrata38.870.0 642
LLPS-Thc-0629Theobroma cacao38.780.0 628
LLPS-Viv-1155Vitis vinifera38.740.0 625
LLPS-Zem-2255Zea mays38.740.0 630
LLPS-Phv-0719Phaseolus vulgaris38.710.0 628
LLPS-Bro-1155Brassica oleracea38.680.0 647
LLPS-Hea-0213Helianthus annuus38.680.0 592
LLPS-Sem-1586Selaginella moellendorffii38.60.0 633
LLPS-Met-0997Medicago truncatula38.60.0 635
LLPS-Glm-2864Glycine max38.580.0 630
LLPS-Sol-2387Solanum lycopersicum38.570.0 631
LLPS-Sob-0980Sorghum bicolor38.550.0 620
LLPS-Mae-0213Manihot esculenta38.530.0 617
LLPS-Tru-0920Triticum urartu38.520.0 576
LLPS-Sei-0783Setaria italica38.520.0 621
LLPS-Brd-1097Brachypodium distachyon38.520.0 615
LLPS-Tra-2963Triticum aestivum38.480.0 610
LLPS-Orp-0474Oryza punctata38.460.0 620
LLPS-Orm-1945Oryza meridionalis38.460.0 622
LLPS-Sot-1583Solanum tuberosum38.430.0 627
LLPS-Brr-0946Brassica rapa38.420.0 643
LLPS-Brn-1053Brassica napus38.420.0 643
LLPS-Amt-0603Amborella trichopoda38.380.0 640
LLPS-Org-0541Oryza glaberrima38.290.0 619
LLPS-Orr-0677Oryza rufipogon38.290.0 619
LLPS-Orni-1056Oryza nivara38.290.0 619
LLPS-Orb-0972Oryza barthii38.290.0 619
LLPS-Ori-1386Oryza indica38.290.0 619
LLPS-Ors-2085Oryza sativa38.260.0 619
LLPS-Orgl-0441Oryza glumaepatula38.190.0 617
LLPS-Orbr-0434Oryza brachyantha38.180.0 621
LLPS-Pot-1880Populus trichocarpa38.020.0 623
LLPS-Lep-1421Leersia perrieri38.00.0 616
LLPS-Nia-0019Nicotiana attenuata37.720.0 622
LLPS-Ved-1327Verticillium dahliae37.391e-107 358
LLPS-Map-1355Magnaporthe poae37.358e-105 351
LLPS-Nec-0717Neurospora crassa37.172e-109 369
LLPS-Usm-0566Ustilago maydis36.93e-79 286
LLPS-Cogr-1307Colletotrichum graminicola36.813e-99 340
LLPS-Zyt-1220Zymoseptoria tritici36.741e-99 341
LLPS-Mao-0485Magnaporthe oryzae36.381e-105 358
LLPS-Spr-1395Sporisorium reilianum36.345e-78 283
LLPS-Trv-1650Trichoderma virens36.132e-100 343
LLPS-Cog-0487Colletotrichum gloeosporioides36.031e-92 329
LLPS-Abg-1959Absidia glauca35.990.0 609
LLPS-Coo-1027Colletotrichum orbiculare35.983e-95 337
LLPS-Put-1133Puccinia triticina35.279e-113 379
LLPS-Chr-1416Chlamydomonas reinhardtii34.744e-1068.2
LLPS-Pug-0350Puccinia graminis34.492e-107 365
LLPS-Asc-1468Aspergillus clavatus34.473e-157 495
LLPS-Nef-1665Neosartorya fischeri34.02e-160 502
LLPS-Asfu-1538Aspergillus fumigatus32.963e-159 500
LLPS-Ast-1182Aspergillus terreus32.883e-149 473
LLPS-Asn-0788Aspergillus nidulans32.883e-127 426
LLPS-Pyt-0893Pyrenophora teres32.729e-163 510
LLPS-Tum-1310Tuber melanosporum32.651e-147 470
LLPS-Blg-1249Blumeria graminis32.642e-142 456
LLPS-Pytr-1474Pyrenophora triticirepentis32.611e-162 509
LLPS-Asf-1226Aspergillus flavus32.594e-153 485
LLPS-Asni-1296Aspergillus niger32.437e-152 479
LLPS-Aso-0967Aspergillus oryzae32.292e-154 487
LLPS-Gag-1230Gaeumannomyces graminis32.162e-152 483
LLPS-Lem-0858Leptosphaeria maculans31.839e-154 486
LLPS-Phn-0439Phaeosphaeria nodorum31.681e-156 494
LLPS-Dos-0485Dothistroma septosporum31.412e-144 462
LLPS-Beb-0669Beauveria bassiana31.43e-139 448
LLPS-Trr-1188Trichoderma reesei30.443e-135 436
LLPS-Fus-1287Fusarium solani30.364e-123 404
LLPS-Cae-0071Caenorhabditis elegans28.986e-97 334
LLPS-Mel-1382Melampsora laricipopulina28.945e-116 387
LLPS-Fuv-1344Fusarium verticillioides28.421e-111 373
LLPS-Fuo-0454Fusarium oxysporum28.222e-109 367
LLPS-Sac-1244Saccharomyces cerevisiae26.552e-35 149
LLPS-Gas-1364Galdieria sulphuraria26.42e-21 104
LLPS-Yal-1383Yarrowia lipolytica25.723e-90 316
LLPS-Scp-1579Schizosaccharomyces pombe24.625e-49 192
LLPS-Asg-1215Ashbya gossypii24.42e-47 188
LLPS-Kop-0840Komagataella pastoris24.268e-71 258
LLPS-Scj-0504Schizosaccharomyces japonicus24.233e-52 201
LLPS-Drm-0912Drosophila melanogaster24.035e-26 119
LLPS-Chc-1151Chondrus crispus23.878e-26 119
LLPS-Scc-0799Schizosaccharomyces cryophilus23.511e-48 191