• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Caj-4223
VPS11

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Vacuolar protein sorting-associated protein 11 homolog
Gene Name: VPS11
Ensembl Gene: ENSCJAG00000013850.3
Ensembl Protein: ENSCJAP00000051133.1
Organism: Callithrix jacchus
Taxa ID: 9483
LLPS Type: LLPS regulator


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Postsynaptic density, OthersPredicted from orthologs(View)

▼ FUNCTION


Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.

▼ SEQUENCE


Protein Sequence (FASTA)
1     MAAYLQWRRF  VFFDKELVKE  PLGNDGAAPG  AAPASGSAAS  KFLCLPPGIT  VCDSGRGSLV  60
61    FGDMEGQIWF  LPRSLQLTGF  QAYKLRVTHL  YQLKQHNILA  SVGEDEEGIN  PLVKIWNLEK  120
121   RDGGNPLCTR  IFPAIPGTEP  TVVSCLTVHE  NLNFMAIGFT  DGSVTLNKGD  ITRDRHSKTQ  180
181   ILHKGNYPVT  GLAFRQAGKT  THLFVVTTEN  VQSYIVSGKD  YPRVELDTHG  CGLRCSALSD  240
241   PSQDLQFIVA  GDECVYLYQP  DERGPCFAFE  GHKLIAHWFR  GYLVIVSRDR  KVSPKSEFTS  300
301   RDSQSSDKQI  LNIYDLCNKF  IAYSAVFEDV  VDVLAEWGSL  YVLTRDGRVH  ALQEKDTQTK  360
361   LEMLFKKNLF  EMAINLAKSQ  HLDSDGLAQI  FMQYGDHLYS  KGNHDGAVQQ  YIRTIGKLEP  420
421   SYVIRKFLDA  QRIHNLTAYL  QTLHRQSLAN  ADHTTLLLNC  YTKLKDSSKL  EEFIKTKSES  480
481   EVHFDVETAI  KVLRQAGYYS  HALYLAENHA  HHEWYLKIQL  EDIKNYQEAL  RYIGKLPFEQ  540
541   AESNMKRYGK  ILMHHIPEQT  TQLLKGLCTD  YRSSLEGRCD  REAPGCRANS  EEFIPIFANN  600
601   PRELKAFLEH  MSEVQPDSPQ  GIYDTLLELR  LQNWAHEKDP  QVKEKLHAEA  ISLLKSGRFC  660
661   DVFDKALVLC  QMHDFQDGVL  YLYEQGKLFQ  QIMHYHMQHE  QYRQVITVCE  RHGEQDPSLW  720
721   EQALSYFARK  EEDCKEYMAA  VLKHIENKNL  MPPLLVVQTL  AHNSTATLSV  IRDYLVQKLQ  780
781   KQSQQIAQDE  LRVRRYRDET  TRIRQEIQEL  KASPKIFQKT  KCSICNSALE  LPSVHFLCGH  840
841   SFHQHCFESY  SESDADCPTC  LPENRKVMDM  IRAQEQKRDL  HDQFQHQLKC  SNDSFSVIAD  900
901   YFGRGVFNKL  TLLTDPPTTR  LTPSLEAGLQ  RDLLMHSRRG  T  941
Nucleotide CDS Sequence (FASTA)
1     ATGGCAGCCT  ACCTGCAGTG  GCGGCGCTTT  GTCTTTTTCG  ACAAGGAGCT  GGTGAAGGAG  60
61    CCGCTGGGCA  ATGATGGGGC  TGCTCCCGGG  GCCGCACCTG  CTTCTGGATC  CGCTGCTTCC  120
121   AAGTTCCTTT  GCCTCCCTCC  TGGCATCACT  GTCTGCGACT  CAGGTCGAGG  GAGCCTGGTC  180
181   TTTGGAGATA  TGGAAGGCCA  GATCTGGTTC  TTGCCACGTT  CCCTACAGCT  TACAGGCTTC  240
241   CAGGCCTATA  AACTACGGGT  GACACACCTG  TACCAGCTGA  AGCAGCACAA  TATTCTGGCA  300
301   TCTGTTGGAG  AAGATGAAGA  GGGCATCAAC  CCACTGGTTA  AGATCTGGAA  CCTGGAGAAG  360
361   AGAGATGGCG  GCAATCCACT  CTGCACTCGA  ATCTTCCCTG  CTATTCCAGG  AACAGAGCCA  420
421   ACTGTTGTAT  CTTGTTTGAC  CGTCCATGAA  AATCTCAACT  TTATGGCCAT  TGGTTTCACA  480
481   GATGGCAGTG  TCACATTGAA  CAAAGGAGAT  ATCACCCGGG  ACCGGCATAG  CAAGACCCAG  540
541   ATTTTGCACA  AGGGCAACTA  TCCTGTTACT  GGATTGGCCT  TTCGCCAAGC  GGGAAAGACC  600
601   ACTCACTTGT  TTGTTGTGAC  AACAGAGAAT  GTGCAGTCCT  ATATAGTTTC  TGGAAAAGAC  660
661   TACCCTCGCG  TGGAGTTGGA  CACCCATGGT  TGTGGCCTGC  GCTGCTCAGC  CCTAAGTGAC  720
721   CCTTCTCAGG  ACCTGCAGTT  CATTGTGGCC  GGGGATGAGT  GTGTCTACTT  GTACCAGCCT  780
781   GATGAACGTG  GGCCCTGCTT  CGCCTTTGAG  GGCCATAAGC  TTATTGCCCA  CTGGTTTAGA  840
841   GGCTACCTTG  TCATTGTCTC  CCGTGACCGG  AAGGTTTCTC  CCAAGTCAGA  GTTTACCAGC  900
901   AGGGACTCAC  AGAGCTCTGA  TAAGCAGATT  CTAAACATCT  ATGACCTGTG  CAACAAGTTC  960
961   ATAGCCTATA  GCGCTGTCTT  TGAGGATGTA  GTGGATGTGC  TTGCTGAATG  GGGCTCCCTA  1020
1021  TACGTGCTGA  CGCGGGATGG  GCGGGTCCAC  GCACTGCAGG  AGAAGGACAC  ACAGACCAAA  1080
1081  CTGGAGATGC  TGTTTAAGAA  GAACCTATTT  GAGATGGCAA  TTAACCTGGC  CAAGAGCCAA  1140
1141  CATCTGGACA  GTGATGGGCT  GGCCCAGATT  TTCATGCAGT  ATGGAGACCA  TCTCTACAGC  1200
1201  AAGGGCAACC  ACGATGGGGC  TGTCCAGCAG  TATATCCGAA  CCATTGGAAA  GTTGGAGCCA  1260
1261  TCCTATGTGA  TCCGCAAGTT  TCTAGATGCC  CAACGCATTC  ACAACCTGAC  TGCCTATCTG  1320
1321  CAGACCCTGC  ACCGACAATC  CCTGGCCAAT  GCTGACCATA  CCACCCTGCT  CCTCAACTGC  1380
1381  TATACCAAGC  TCAAGGACAG  CTCAAAGCTG  GAGGAGTTCA  TCAAGACAAA  GAGTGAGAGC  1440
1441  GAAGTCCACT  TTGACGTGGA  GACGGCCATC  AAGGTTCTCC  GGCAGGCTGG  CTACTACTCC  1500
1501  CATGCCCTGT  ATCTGGCAGA  GAACCATGCA  CATCATGAGT  GGTACCTGAA  GATCCAGCTA  1560
1561  GAGGACATTA  AGAATTATCA  GGAAGCCCTT  CGGTACATTG  GCAAGCTGCC  TTTTGAGCAG  1620
1621  GCAGAGAGCA  ACATGAAGCG  CTATGGCAAG  ATCCTCATGC  ACCACATACC  AGAGCAGACA  1680
1681  ACTCAGTTGC  TGAAGGGACT  TTGTACTGAT  TATCGGTCCA  GCCTCGAAGG  CCGCTGTGAT  1740
1741  AGGGAGGCCC  CAGGATGCAG  GGCCAACTCT  GAGGAGTTCA  TCCCCATCTT  TGCCAATAAC  1800
1801  CCGCGAGAGC  TGAAAGCCTT  CCTGGAGCAC  ATGAGCGAAG  TGCAGCCAGA  CTCACCCCAG  1860
1861  GGCATCTATG  ACACACTCCT  TGAGCTGCGA  CTGCAGAACT  GGGCCCATGA  GAAGGATCCA  1920
1921  CAGGTCAAAG  AGAAGCTTCA  CGCAGAGGCC  ATTTCCCTGC  TGAAGAGTGG  TCGCTTCTGC  1980
1981  GATGTCTTTG  ACAAGGCCCT  GGTCCTGTGC  CAGATGCACG  ACTTCCAGGA  TGGTGTCCTT  2040
2041  TACCTCTATG  AGCAGGGGAA  GCTGTTCCAG  CAGATCATGC  ACTACCACAT  GCAACACGAG  2100
2101  CAGTACCGGC  AGGTCATCAC  CGTGTGTGAG  CGCCACGGGG  AGCAGGACCC  CTCCTTGTGG  2160
2161  GAGCAGGCCC  TCAGCTACTT  TGCTCGCAAG  GAGGAGGACT  GCAAGGAGTA  CATGGCAGCT  2220
2221  GTCCTCAAGC  ATATCGAGAA  CAAGAACCTT  ATGCCACCTC  TTCTAGTGGT  ACAGACCCTG  2280
2281  GCTCACAACT  CCACAGCCAC  ACTGTCCGTC  ATCAGAGACT  ACCTGGTCCA  AAAACTACAG  2340
2341  AAACAGAGCC  AGCAGATTGC  ACAGGATGAG  CTGCGGGTGC  GGCGGTACCG  AGATGAGACC  2400
2401  ACCCGCATCC  GCCAGGAGAT  ACAGGAACTC  AAGGCCAGTC  CTAAGATTTT  CCAAAAGACC  2460
2461  AAGTGCAGCA  TCTGTAACAG  TGCCTTGGAG  TTGCCCTCAG  TCCACTTCCT  GTGTGGCCAC  2520
2521  TCCTTCCATC  AACACTGCTT  TGAGAGTTAC  TCTGAAAGTG  ATGCTGACTG  CCCCACCTGC  2580
2581  CTCCCTGAAA  ACCGGAAGGT  CATGGATATG  ATCCGGGCCC  AGGAACAGAA  ACGAGATCTC  2640
2641  CATGATCAGT  TCCAGCATCA  GCTCAAGTGC  TCCAATGACA  GCTTCTCTGT  GATTGCTGAC  2700
2701  TACTTCGGCA  GAGGTGTTTT  CAACAAATTG  ACTCTGCTGA  CTGACCCTCC  CACAACCAGA  2760
2761  CTGACCCCCA  GCCTAGAGGC  TGGGCTGCAG  CGTGACCTGC  TCATGCACTC  CAGGAGGGGC  2820
2821  ACTTAA  2826

▼ KEYWORD


ID
Family
Autophagy
Coiled coil
Complete proteome
Cytoplasmic vesicle
Endosome
Lysosome
Membrane
Metal-binding
Protein transport
Reference proteome
Transport
Zinc
Zinc-finger

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Actin filament
Cellular Component
AP-3 adaptor complex
Cellular Component
Autophagosome
Cellular Component
Clathrin-coated vesicle
Cellular Component
CORVET complex
Cellular Component
Early endosome
Cellular Component
HOPS complex
Cellular Component
Late endosome membrane
Cellular Component
Lysosomal membrane
Cellular Component
Presynaptic active zone
Molecular Function
Protein binding, bridging
Biological Process
Autophagy
Biological Process
Endosome organization
Biological Process
Intracellular protein transport
Biological Process
Lysosome organization
Biological Process
Toxin transport
Biological Process
Vesicle docking involved in exocytosis

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Aon-0114Aotus nancymaae99.470.01861
LLPS-Chs-3258Chlorocebus sabaeus99.260.01862
LLPS-Mal-4065Mandrillus leucophaeus99.260.01862
LLPS-Paa-2475Papio anubis99.260.01862
LLPS-Nol-4503Nomascus leucogenys99.20.01760
LLPS-Mam-3632Macaca mulatta99.20.01756
LLPS-Maf-4690Macaca fascicularis99.150.01859
LLPS-Poa-4152Pongo abelii99.040.01860
LLPS-Cea-2481Cercocebus atys99.040.01860
LLPS-Pap-1816Pan paniscus98.970.01756
LLPS-Pat-1884Pan troglodytes98.970.01756
LLPS-Man-4600Macaca nemestrina98.940.01855
LLPS-Hos-3249Homo sapiens98.720.01853
LLPS-Gog-1064Gorilla gorilla98.720.01856
LLPS-Urm-2653Ursus maritimus98.510.01851
LLPS-Fec-4801Felis catus98.510.01841
LLPS-Cas-0424Carlito syrichta98.510.01847
LLPS-Aim-3924Ailuropoda melanoleuca98.310.01843
LLPS-Caf-4362Canis familiaris98.30.01846
LLPS-Eqc-3154Equus caballus98.30.01844
LLPS-Mea-3919Mesocricetus auratus98.30.01837
LLPS-Bot-1348Bos taurus98.30.01844
LLPS-Ran-3329Rattus norvegicus98.180.01743
LLPS-Sus-2430Sus scrofa98.090.01845
LLPS-Otg-1230Otolemur garnettii97.980.01833
LLPS-Mup-1430Mustela putorius furo97.980.01847
LLPS-Orc-2327Oryctolagus cuniculus97.970.01551
LLPS-Mum-3904Mus musculus97.770.01833
LLPS-Dio-4321Dipodomys ordii97.560.01831
LLPS-Loa-1140Loxodonta africana97.340.01824
LLPS-Cap-4437Cavia porcellus97.340.01827
LLPS-Fud-2228Fukomys damarensis97.340.01824
LLPS-Ict-3926Ictidomys tridecemlineatus97.240.01822
LLPS-Myl-4117Myotis lucifugus95.860.01807
LLPS-Ova-1915Ovis aries95.750.01778
LLPS-Mod-3783Monodelphis domestica93.090.01766
LLPS-Sah-3026Sarcophilus harrisii92.670.01771
LLPS-Anc-2499Anolis carolinensis86.712e-94 302
LLPS-Pes-2443Pelodiscus sinensis85.490.01561
LLPS-Ora-2420Ornithorhynchus anatinus84.430.0 573
LLPS-Meg-2356Meleagris gallopavo83.960.01300
LLPS-Tag-2224Taeniopygia guttata83.530.01620
LLPS-Fia-2908Ficedula albicollis83.210.01625
LLPS-Anp-1341Anas platyrhynchos81.740.01537
LLPS-Gaga-3899Gallus gallus80.780.01600
LLPS-Lac-2844Latimeria chalumnae76.50.01477
LLPS-Scf-1772Scleropages formosus74.950.01447
LLPS-Leo-1958Lepisosteus oculatus74.60.01451
LLPS-Xet-0994Xenopus tropicalis74.230.01414
LLPS-Asm-1598Astyanax mexicanus74.210.01438
LLPS-Icp-2720Ictalurus punctatus74.00.01427
LLPS-Scm-2945Scophthalmus maximus73.910.01432
LLPS-Tar-0007Takifugu rubripes73.890.01414
LLPS-Xim-3928Xiphophorus maculatus73.380.01410
LLPS-Dar-0551Danio rerio73.360.01417
LLPS-Pof-3575Poecilia formosa73.280.01402
LLPS-Gaa-2083Gasterosteus aculeatus73.020.01405
LLPS-Orn-2414Oreochromis niloticus72.980.01410
LLPS-Ten-2684Tetraodon nigroviridis72.470.01375
LLPS-Orl-3149Oryzias latipes71.310.01365
LLPS-Cis-0681Ciona savignyi48.020.0 848
LLPS-Php-1146Physcomitrella patens45.66e-65 241
LLPS-Cii-1628Ciona intestinalis42.352e-89 295
LLPS-Abg-1959Absidia glauca41.861e-137 444
LLPS-Coc-0827Corchorus capsularis41.140.0 639
LLPS-Art-2578Arabidopsis thaliana40.020.0 646
LLPS-Mua-1715Musa acuminata39.830.0 644
LLPS-Gor-2739Gossypium raimondii39.750.0 645
LLPS-Dac-1137Daucus carota39.550.0 648
LLPS-Sol-2387Solanum lycopersicum39.550.0 645
LLPS-Bro-1155Brassica oleracea39.490.0 647
LLPS-Thc-0629Theobroma cacao39.470.0 648
LLPS-Sot-1583Solanum tuberosum39.410.0 642
LLPS-Cus-0852Cucumis sativus39.390.0 650
LLPS-Vir-0252Vigna radiata39.330.0 638
LLPS-Via-1536Vigna angularis39.330.0 637
LLPS-Viv-1155Vitis vinifera39.230.0 635
LLPS-Mae-0213Manihot esculenta39.220.0 637
LLPS-Phv-0719Phaseolus vulgaris39.140.0 635
LLPS-Met-0997Medicago truncatula39.140.0 643
LLPS-Sem-1586Selaginella moellendorffii39.110.0 627
LLPS-Hea-0213Helianthus annuus39.090.0 607
LLPS-Prp-1964Prunus persica39.020.0 637
LLPS-Brn-1053Brassica napus39.020.0 641
LLPS-Pot-1880Populus trichocarpa38.960.0 637
LLPS-Glm-2864Glycine max38.880.0 630
LLPS-Hov-1262Hordeum vulgare38.850.0 600
LLPS-Brr-0946Brassica rapa38.820.0 641
LLPS-Tru-0920Triticum urartu38.740.0 582
LLPS-Spr-1395Sporisorium reilianum38.571e-78 284
LLPS-Nia-0019Nicotiana attenuata38.540.0 630
LLPS-Arl-1786Arabidopsis lyrata38.540.0 645
LLPS-Amt-0603Amborella trichopoda38.30.0 643
LLPS-Zem-2255Zea mays38.30.0 619
LLPS-Ors-2085Oryza sativa38.080.0 626
LLPS-Orp-0474Oryza punctata38.080.0 625
LLPS-Org-0541Oryza glaberrima38.080.0 626
LLPS-Orm-1945Oryza meridionalis38.080.0 626
LLPS-Orr-0677Oryza rufipogon38.080.0 626
LLPS-Orni-1056Oryza nivara38.080.0 626
LLPS-Orb-0972Oryza barthii38.080.0 626
LLPS-Ori-1386Oryza indica38.080.0 626
LLPS-Orgl-0441Oryza glumaepatula38.080.0 622
LLPS-Sob-0980Sorghum bicolor38.00.0 611
LLPS-Sei-0783Setaria italica37.970.0 612
LLPS-Tra-2963Triticum aestivum37.930.0 610
LLPS-Usm-0566Ustilago maydis37.928e-79 285
LLPS-Orbr-0434Oryza brachyantha37.860.0 627
LLPS-Lep-1421Leersia perrieri37.760.0 617
LLPS-Crn-0508Cryptococcus neoformans37.699e-121 400
LLPS-Brd-1097Brachypodium distachyon37.150.0 600
LLPS-Pytr-1474Pyrenophora triticirepentis36.716e-108 363
LLPS-Pyt-0893Pyrenophora teres36.73e-108 364
LLPS-Phn-0439Phaeosphaeria nodorum36.53e-102 348
LLPS-Scs-0909Sclerotinia sclerotiorum36.029e-99 333
LLPS-Chr-1416Chlamydomonas reinhardtii35.969e-0963.9
LLPS-Zyt-1220Zymoseptoria tritici35.544e-94 326
LLPS-Asc-1468Aspergillus clavatus35.294e-162 507
LLPS-Pug-0350Puccinia graminis35.161e-97 338
LLPS-Ved-1327Verticillium dahliae35.05e-100 337
LLPS-Mao-0485Magnaporthe oryzae34.921e-96 333
LLPS-Map-1355Magnaporthe poae34.894e-95 325
LLPS-Fus-1287Fusarium solani34.827e-89 310
LLPS-Lem-0858Leptosphaeria maculans34.799e-100 341
LLPS-Nec-0717Neurospora crassa34.517e-103 350
LLPS-Cogr-1307Colletotrichum graminicola34.352e-89 312
LLPS-Cog-0487Colletotrichum gloeosporioides34.153e-87 312
LLPS-Beb-0669Beauveria bassiana33.983e-88 309
LLPS-Trv-1650Trichoderma virens33.454e-94 325
LLPS-Coo-1027Colletotrichum orbiculare33.454e-86 309
LLPS-Nef-1665Neosartorya fischeri33.36e-164 511
LLPS-Fuo-0454Fusarium oxysporum33.024e-45 180
LLPS-Fuv-1344Fusarium verticillioides33.028e-45 179
LLPS-Asf-1226Aspergillus flavus33.013e-157 496
LLPS-Blg-1249Blumeria graminis32.841e-145 464
LLPS-Aso-0967Aspergillus oryzae32.515e-159 499
LLPS-Asfu-1538Aspergillus fumigatus32.475e-164 512
LLPS-Tum-1310Tuber melanosporum32.454e-150 476
LLPS-Ast-1182Aspergillus terreus32.442e-154 486
LLPS-Asni-1296Aspergillus niger32.196e-154 485
LLPS-Asn-0788Aspergillus nidulans31.819e-123 413
LLPS-Gag-1230Gaeumannomyces graminis31.783e-152 483
LLPS-Put-1133Puccinia triticina31.622e-133 434
LLPS-Dos-0485Dothistroma septosporum31.225e-149 474
LLPS-Mel-1382Melampsora laricipopulina30.026e-122 402
LLPS-Trr-1188Trichoderma reesei29.396e-138 443
LLPS-Cae-0071Caenorhabditis elegans27.995e-99 339
LLPS-Yal-1383Yarrowia lipolytica27.193e-98 337
LLPS-Sac-1244Saccharomyces cerevisiae26.28e-1273.6
LLPS-Scj-0504Schizosaccharomyces japonicus25.421e-44 178
LLPS-Scp-1579Schizosaccharomyces pombe24.912e-45 181
LLPS-Drm-0912Drosophila melanogaster24.662e-27 124
LLPS-Kop-0840Komagataella pastoris24.219e-78 278
LLPS-Scc-0799Schizosaccharomyces cryophilus23.963e-49 192
LLPS-Gas-1364Galdieria sulphuraria23.712e-43 176
LLPS-Asg-1215Ashbya gossypii23.358e-48 189
LLPS-Chc-1151Chondrus crispus21.292e-24 115