DrLLPS - Data resource of LLPS

LLPS-Myl-2816
AK4

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Adenylate kinase 4, mitochondrial
Gene Name:	AK4, AK3L1
Ensembl Gene:	ENSMLUG00000009622.2
Ensembl Protein:	ENSMLUP00000008748.2
Organism:	Myotis lucifugus
Taxa ID:	59463
LLPS Type:	Others

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Nucleolus	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Homo sapiens	LLPS-Hos-0472	P27144	Client	Nucleolus	86.94	1e-144	410

▼ FUNCTION

Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSMLUT00000009602.2	ENSMLUP00000008748.2
UniProt		G1PE25, G1PE25_MYOLU
GeneBank	AAPE02019731
RefSeq	XM_006089780.2, XM_014456746.1, XM_014456747.1	XP_006089842.1, XP_014312232.1, XP_014312233.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 MASKLLRAVI LGPPGSGKGT VCQRIAQNFG LQHLSSGHFL RENIKANTEV GDVAKQYIEK 60 61 GRLVPDHVIT RMMLSELENR QDQHWLLDGF PMTLVQAEAL DRICDLDLVI TLNIPFETLR 120 121 DRLSRRWIHP PSGRVYNLDF NPPLVHGVDD VTGERLVQQE DDKPEAVNVR LRQYKEVAKP 180 181 VVKLYKSRGV LHQFSGTDTD KIWPCVYTVF SNKITPIQSR EAC 223
Nucleotide CDS Sequence (FASTA)
1 ATGGCTTCCA AACTCCTGCG CGCGGTCATC CTCGGGCCGC CCGGCTCGGG CAAGGGCACC 60 61 GTGTGCCAGA GGATCGCCCA GAACTTCGGC CTCCAGCATC TCTCCAGCGG CCACTTCTTG 120 121 CGCGAGAACA TCAAAGCCAA CACCGAAGTT GGTGATGTGG CAAAGCAGTA CATAGAGAAA 180 181 GGCCGTTTAG TTCCAGACCA CGTGATCACA CGCATGATGC TGTCGGAGCT GGAGAACCGA 240 241 CAGGATCAGC ACTGGCTGCT AGACGGTTTT CCCATGACAC TAGTTCAGGC TGAAGCCCTA 300 301 GACAGAATCT GTGACCTGGA CCTCGTGATC ACTCTGAACA TTCCATTTGA AACACTCAGA 360 361 GATCGTCTCA GCCGACGCTG GATTCACCCT CCTAGCGGGA GGGTGTATAA CCTGGACTTC 420 421 AATCCACCTC TTGTACATGG GGTTGATGAC GTCACCGGTG AACGGCTGGT CCAGCAGGAG 480 481 GATGATAAGC CGGAAGCCGT CAACGTCAGG CTAAGACAGT ACAAGGAGGT GGCCAAGCCG 540 541 GTGGTTAAAC TCTACAAGTC CCGAGGAGTG CTCCACCAGT TTTCTGGAAC GGACACTGAC 600 601 AAAATCTGGC CCTGTGTTTA CACGGTTTTC TCGAACAAGA TCACACCGAT TCAGTCCAGA 660 661 GAAGCATGCT GA 672

▼ KEYWORD

ID	Family
KW-0067	ATP-binding
KW-0181	Complete proteome
KW-0342	GTP-binding
KW-0418	Kinase
KW-0496	Mitochondrion
KW-0547	Nucleotide-binding
KW-1185	Reference proteome
KW-0808	Transferase

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005759	Cellular Component	Mitochondrial matrix
GO:0004017	Molecular Function	Adenylate kinase activity
GO:0005524	Molecular Function	ATP binding
GO:0005525	Molecular Function	GTP binding
GO:0004550	Molecular Function	Nucleoside diphosphate kinase activity
GO:0046899	Molecular Function	Nucleoside triphosphate adenylate kinase activity
GO:0006172	Biological Process	ADP biosynthetic process
GO:0046033	Biological Process	AMP metabolic process
GO:0046034	Biological Process	ATP metabolic process
GO:0046039	Biological Process	GTP metabolic process
GO:0009142	Biological Process	Nucleoside triphosphate biosynthetic process

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Fec-1356	Felis catus	89.19	3e-148	419
LLPS-Bot-4571	Bos taurus	89.19	2e-147	417
LLPS-Aim-1638	Ailuropoda melanoleuca	88.74	4e-147	416
LLPS-Sus-1111	Sus scrofa	88.29	8e-147	416
LLPS-Mup-3479	Mustela putorius furo	87.84	3e-145	414
LLPS-Poa-1705	Pongo abelii	87.39	3e-145	412
LLPS-Eqc-3941	Equus caballus	87.39	1e-145	412
LLPS-Gog-0063	Gorilla gorilla	87.39	4e-145	411
LLPS-Caj-4416	Callithrix jacchus	87.39	1e-145	412
LLPS-Aon-4187	Aotus nancymaae	87.39	3e-145	412
LLPS-Hos-0472	Homo sapiens	86.94	1e-144	410
LLPS-Pap-4062	Pan paniscus	86.94	1e-144	410
LLPS-Loa-2990	Loxodonta africana	86.94	5e-144	408
LLPS-Maf-2613	Macaca fascicularis	86.94	9e-145	410
LLPS-Cea-0010	Cercocebus atys	86.94	9e-145	410
LLPS-Dio-4026	Dipodomys ordii	86.94	3e-146	414
LLPS-Rhb-1549	Rhinopithecus bieti	86.49	2e-143	407
LLPS-Pat-4413	Pan troglodytes	86.49	5e-144	408
LLPS-Orc-2136	Oryctolagus cuniculus	85.59	5e-143	406
LLPS-Ova-1938	Ovis aries	84.97	2e-106	311
LLPS-Ran-3103	Rattus norvegicus	84.68	5e-141	401
LLPS-Ict-3139	Ictidomys tridecemlineatus	84.23	3e-141	402
LLPS-Mum-4320	Mus musculus	83.78	1e-139	397
LLPS-Cas-0364	Carlito syrichta	83.53	2e-104	306
LLPS-Paa-4699	Papio anubis	83.53	6e-104	305
LLPS-Mal-2663	Mandrillus leucophaeus	83.53	6e-104	305
LLPS-Mea-2216	Mesocricetus auratus	83.41	2e-136	389
LLPS-Otg-4361	Otolemur garnettii	82.86	2e-105	308
LLPS-Nol-1764	Nomascus leucogenys	80.0	2e-97	290
LLPS-Mod-1753	Monodelphis domestica	77.48	4e-126	372
LLPS-Ora-1938	Ornithorhynchus anatinus	77.01	3e-95	283
LLPS-Fud-1349	Fukomys damarensis	76.47	3e-95	282
LLPS-Urm-3251	Ursus maritimus	76.19	3e-110	323
LLPS-Pes-0062	Pelodiscus sinensis	75.37	2e-72	223
LLPS-Cap-3483	Cavia porcellus	74.21	4e-125	360
LLPS-Gaga-0808	Gallus gallus	73.96	2e-92	275
LLPS-Meg-2821	Meleagris gallopavo	73.56	1e-93	279
LLPS-Anc-0951	Anolis carolinensis	73.24	2e-72	224
LLPS-Lac-4046	Latimeria chalumnae	72.27	5e-120	348
LLPS-Xet-2413	Xenopus tropicalis	72.07	3e-119	346
LLPS-Fia-3164	Ficedula albicollis	71.1	1e-89	268
LLPS-Asm-3729	Astyanax mexicanus	67.62	1e-103	306
LLPS-Pof-3272	Poecilia formosa	66.98	2e-107	315
LLPS-Icp-1158	Ictalurus punctatus	66.98	1e-104	308
LLPS-Xim-2350	Xiphophorus maculatus	66.51	2e-106	313
LLPS-Mam-2987	Macaca mulatta	65.9	4e-97	290
LLPS-Man-3977	Macaca nemestrina	65.44	1e-96	288
LLPS-Tar-2785	Takifugu rubripes	64.62	3e-102	303
LLPS-Scf-2780	Scleropages formosus	64.02	2e-103	306
LLPS-Dar-0550	Danio rerio	63.8	5e-105	310
LLPS-Orl-3871	Oryzias latipes	63.68	1e-98	293
LLPS-Gaa-2780	Gasterosteus aculeatus	63.68	1e-103	306
LLPS-Ten-0763	Tetraodon nigroviridis	62.91	3e-97	290
LLPS-Orn-2967	Oreochromis niloticus	62.9	3e-101	300
LLPS-Scm-2939	Scophthalmus maximus	62.44	8e-100	296
LLPS-Tag-1192	Taeniopygia guttata	61.09	9e-92	276
LLPS-Chs-1846	Chlorocebus sabaeus	56.31	1e-89	271
LLPS-Sah-3547	Sarcophilus harrisii	54.91	8e-87	263
LLPS-Leo-3702	Lepisosteus oculatus	54.5	4e-87	264
LLPS-Caf-0197	Canis familiaris	54.05	8e-87	263
LLPS-Cii-1777	Ciona intestinalis	51.87	2e-74	232
LLPS-Ere-0898	Erinaceus europaeus	51.72	2e-63	202
LLPS-Anp-1775	Anas platyrhynchos	51.37	3e-55	181
LLPS-Cis-0940	Ciona savignyi	49.56	4e-70	221
LLPS-Drm-1003	Drosophila melanogaster	48.6	2e-70	221
LLPS-Yal-0201	Yarrowia lipolytica	44.23	5e-57	187
LLPS-Spr-1550	Sporisorium reilianum	43.52	1e-48	167
LLPS-Sac-0959	Saccharomyces cerevisiae	42.08	2e-48	164
LLPS-Viv-1785	Vitis vinifera	41.24	1e-43	153
LLPS-Sei-2131	Setaria italica	40.31	1e-42	151
LLPS-Mae-1823	Manihot esculenta	40.21	2e-44	155
LLPS-Thc-2053	Theobroma cacao	40.21	3e-43	152
LLPS-Sem-1976	Selaginella moellendorffii	40.21	2e-42	150
LLPS-Kop-1236	Komagataella pastoris	40.18	2e-50	170
LLPS-Mel-1114	Melampsora laricipopulina	39.91	1e-44	157
LLPS-Scj-0014	Schizosaccharomyces japonicus	39.81	5e-46	158
LLPS-Phv-1102	Phaseolus vulgaris	39.79	5e-42	149
LLPS-Met-1477	Medicago truncatula	39.79	4e-42	149
LLPS-Gor-2584	Gossypium raimondii	39.69	1e-43	153
LLPS-Orp-1205	Oryza punctata	39.69	3e-42	149
LLPS-Coc-2071	Corchorus capsularis	39.69	1e-41	147
LLPS-Sol-1626	Solanum lycopersicum	39.69	1e-41	147
LLPS-Amt-1607	Amborella trichopoda	39.27	5e-41	146
LLPS-Art-2486	Arabidopsis thaliana	39.27	8e-41	145
LLPS-Nia-1810	Nicotiana attenuata	39.18	8e-42	148
LLPS-Pot-1410	Populus trichocarpa	39.18	5e-41	146
LLPS-Lep-2363	Leersia perrieri	39.18	4e-42	149
LLPS-Crn-0082	Cryptococcus neoformans	38.94	1e-43	155
LLPS-Cym-0813	Cyanidioschyzon merolae	38.89	2e-41	148
LLPS-Orm-1071	Oryza meridionalis	38.78	8e-42	148
LLPS-Ors-0513	Oryza sativa	38.66	6e-41	145
LLPS-Org-0580	Oryza glaberrima	38.66	6e-41	145
LLPS-Orr-0252	Oryza rufipogon	38.66	6e-41	145
LLPS-Prp-1204	Prunus persica	38.66	2e-41	147
LLPS-Orni-1021	Oryza nivara	38.66	6e-41	145
LLPS-Glm-1627	Glycine max	38.66	5e-41	146
LLPS-Orb-0077	Oryza barthii	38.66	6e-41	145
LLPS-Ori-1133	Oryza indica	38.66	6e-41	145
LLPS-Orgl-0879	Oryza glumaepatula	38.66	6e-41	145
LLPS-Asn-0603	Aspergillus nidulans	38.5	8e-48	163
LLPS-Zyt-1373	Zymoseptoria tritici	38.46	9e-50	168
LLPS-Mua-1517	Musa acuminata	38.31	1e-41	147
LLPS-Scp-0879	Schizosaccharomyces pombe	38.25	2e-45	157
LLPS-Ast-0054	Aspergillus terreus	38.03	5e-42	149
LLPS-Nec-0794	Neurospora crassa	38.03	4e-41	147
LLPS-Abg-0576	Absidia glauca	38.03	4e-44	154
LLPS-Asni-0834	Aspergillus niger	37.79	3e-45	157
LLPS-Miv-1051	Microbotryum violaceum	37.38	4e-41	147
LLPS-Phn-0119	Phaeosphaeria nodorum	37.27	4e-44	155
LLPS-Put-0435	Puccinia triticina	37.27	4e-48	166
LLPS-Pyt-0219	Pyrenophora teres	37.27	3e-43	153
LLPS-Asf-1519	Aspergillus flavus	37.16	2e-46	160
LLPS-Aso-0797	Aspergillus oryzae	37.16	2e-46	160
LLPS-Scs-0397	Sclerotinia sclerotiorum	37.12	6e-43	152
LLPS-Dos-0898	Dothistroma septosporum	37.09	9e-43	151
LLPS-Asfu-1253	Aspergillus fumigatus	37.09	6e-41	146
LLPS-Map-0357	Magnaporthe poae	37.09	1e-42	151
LLPS-Gag-1143	Gaeumannomyces graminis	37.09	9e-41	146
LLPS-Trr-1570	Trichoderma reesei	37.05	8e-41	146
LLPS-Trv-0307	Trichoderma virens	36.65	7e-41	146
LLPS-Asc-1349	Aspergillus clavatus	36.62	7e-42	149
LLPS-Cogr-0943	Colletotrichum graminicola	36.57	3e-41	147
LLPS-Pug-1384	Puccinia graminis	36.55	2e-47	165
LLPS-Lem-1164	Leptosphaeria maculans	36.36	4e-43	152
LLPS-Tum-0311	Tuber melanosporum	36.32	1e-44	155
LLPS-Cog-0477	Colletotrichum gloeosporioides	36.2	3e-42	150
LLPS-Usm-1146	Ustilago maydis	36.07	7e-46	160
LLPS-Ved-0811	Verticillium dahliae	35.87	6e-43	152
LLPS-Beb-1240	Beauveria bassiana	35.75	1e-41	148
LLPS-Fus-0783	Fusarium solani	35.29	3e-41	147
LLPS-Nef-1364	Neosartorya fischeri	35.22	1e-43	153
LLPS-Pytr-1490	Pyrenophora triticirepentis	34.24	5e-47	162
LLPS-Mao-0776	Magnaporthe oryzae	33.46	8e-44	154
LLPS-Blg-1451	Blumeria graminis	33.33	3e-42	150
LLPS-Fuo-1080	Fusarium oxysporum	31.94	2e-42	150
LLPS-Fuv-1567	Fusarium verticillioides	31.94	2e-42	150

LLPS-Myl-2816AK4

Protein Sequence

Nucleotide Sequence

LLPS-Myl-2816
AK4