DrLLPS - Data resource of LLPS

LLPS-Dio-4026
Ak4

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Adenylate kinase 4, mitochondrial
Gene Name:	Ak4, AK3L1, AK4
Ensembl Gene:	ENSDORG00000023966.1
Ensembl Protein:	ENSDORP00000024041.1
Organism:	Dipodomys ordii
Taxa ID:	10020
LLPS Type:	Others

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Nucleolus	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Homo sapiens	LLPS-Hos-0472	P27144	Client	Nucleolus	93.27	2e-157	442

▼ FUNCTION

Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSDORT00000026258.1	ENSDORP00000024041.1
UniProt		A0A1S3FJ71, A0A1S3FJ71_DIPOR
RefSeq	, XM_013020630.1	, XP_012876084.1, XP_012876084.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 MASKLLRAVI LGPPGSGKGT VCQRIAQNFG LQHLSSGHFL RENLKANTEV GDMAKQYLEK 60 61 GLLVPDHVIT RLMMSELENR SGQHWLLDGF PRTLVQAEAL DRICDLDLVI SLNIPFETLK 120 121 DRLSRRWIHP PSGRVYNLDF NPPHVHGIDD ITGEPLVQQE DDKPEAVAAR LRRYKDAAKP 180 181 VIELYKSRGV LHQFSGTETN KIWPYVYSLF SNKITPIQSK QAY 223
Nucleotide CDS Sequence (FASTA)
1 ATGGCTTCCA AACTCCTGCG CGCGGTCATC CTCGGGCCGC CCGGCTCGGG GAAAGGCACG 60 61 GTGTGCCAGA GGATCGCCCA GAACTTTGGC CTCCAGCATC TGTCCAGCGG TCACTTCTTA 120 121 CGGGAGAACC TCAAGGCCAA CACGGAAGTT GGTGACATGG CAAAGCAGTA CTTGGAGAAA 180 181 GGTCTTTTGG TTCCAGATCA TGTGATCACA CGCCTAATGA TGTCAGAGCT GGAGAACAGG 240 241 AGCGGCCAAC ACTGGCTGCT AGATGGTTTT CCGAGGACAT TAGTACAGGC TGAAGCCCTG 300 301 GACAGAATCT GTGACCTGGA TTTAGTGATC AGTTTGAACA TTCCATTTGA AACACTTAAA 360 361 GATCGACTTA GCCGACGTTG GATTCATCCT CCTAGTGGAC GAGTGTATAA CCTGGATTTC 420 421 AACCCACCTC ATGTACATGG GATTGATGAT ATCACTGGGG AACCACTAGT CCAACAGGAG 480 481 GATGATAAAC CTGAAGCCGT TGCTGCTAGG CTAAGACGGT ACAAAGATGC AGCAAAACCA 540 541 GTCATCGAAC TATACAAGAG CAGAGGAGTT CTCCACCAGT TTTCCGGGAC CGAGACTAAC 600 601 AAGATCTGGC CTTACGTTTA CTCACTTTTC TCCAACAAGA TCACACCTAT TCAGTCCAAA 660 661 CAAGCATACT GA 672

▼ KEYWORD

ID	Family
KW-0067	ATP-binding
KW-0181	Complete proteome
KW-0342	GTP-binding
KW-0418	Kinase
KW-0496	Mitochondrion
KW-0547	Nucleotide-binding
KW-1185	Reference proteome
KW-0808	Transferase

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005759	Cellular Component	Mitochondrial matrix
GO:0004017	Molecular Function	Adenylate kinase activity
GO:0005524	Molecular Function	ATP binding
GO:0005525	Molecular Function	GTP binding
GO:0004550	Molecular Function	Nucleoside diphosphate kinase activity
GO:0046899	Molecular Function	Nucleoside triphosphate adenylate kinase activity
GO:0006172	Biological Process	ADP biosynthetic process
GO:0046033	Biological Process	AMP metabolic process
GO:0046034	Biological Process	ATP metabolic process
GO:0046039	Biological Process	GTP metabolic process
GO:0009142	Biological Process	Nucleoside triphosphate biosynthetic process

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Fec-1356	Felis catus	95.52	1e-160	451
LLPS-Ict-3139	Ictidomys tridecemlineatus	95.07	7e-159	446
LLPS-Orc-2136	Oryctolagus cuniculus	94.17	3e-158	444
LLPS-Poa-1705	Pongo abelii	93.72	4e-158	444
LLPS-Gog-0063	Gorilla gorilla	93.72	8e-158	443
LLPS-Caj-4416	Callithrix jacchus	93.72	3e-158	444
LLPS-Aon-4187	Aotus nancymaae	93.72	4e-158	444
LLPS-Sus-1111	Sus scrofa	93.72	3e-158	444
LLPS-Cas-0364	Carlito syrichta	93.57	9e-119	342
LLPS-Pap-4062	Pan paniscus	93.27	2e-157	442
LLPS-Hos-0472	Homo sapiens	93.27	2e-157	442
LLPS-Ran-3103	Rattus norvegicus	93.27	7e-156	438
LLPS-Mup-3479	Mustela putorius furo	93.27	6e-157	443
LLPS-Aim-1638	Ailuropoda melanoleuca	93.27	6e-158	444
LLPS-Bot-4571	Bos taurus	93.27	2e-158	445
LLPS-Maf-2613	Macaca fascicularis	93.27	1e-157	443
LLPS-Mum-4320	Mus musculus	93.27	9e-155	436
LLPS-Cea-0010	Cercocebus atys	93.27	1e-157	443
LLPS-Mea-2216	Mesocricetus auratus	93.09	2e-150	424
LLPS-Rhb-1549	Rhinopithecus bieti	92.83	2e-156	440
LLPS-Pat-4413	Pan troglodytes	92.83	1e-156	441
LLPS-Eqc-3941	Equus caballus	92.79	4e-156	439
LLPS-Mal-2663	Mandrillus leucophaeus	92.4	4e-117	338
LLPS-Paa-4699	Papio anubis	92.4	4e-117	338
LLPS-Loa-2990	Loxodonta africana	91.93	6e-155	436
LLPS-Ova-1938	Ovis aries	90.8	6e-117	338
LLPS-Otg-4361	Otolemur garnettii	90.34	1e-117	340
LLPS-Nol-1764	Nomascus leucogenys	88.3	4e-110	322
LLPS-Fud-1349	Fukomys damarensis	88.24	2e-110	321
LLPS-Pes-0062	Pelodiscus sinensis	87.31	2e-84	253
LLPS-Myl-2816	Myotis lucifugus	86.94	3e-146	414
LLPS-Cap-3483	Cavia porcellus	83.18	3e-137	391
LLPS-Gaga-0808	Gallus gallus	82.46	4e-105	308
LLPS-Anc-0951	Anolis carolinensis	82.14	5e-82	248
LLPS-Urm-3251	Ursus maritimus	81.99	1e-122	354
LLPS-Mod-1753	Monodelphis domestica	81.98	1e-133	391
LLPS-Meg-2821	Meleagris gallopavo	81.82	1e-106	312
LLPS-Ora-1938	Ornithorhynchus anatinus	81.03	5e-102	300
LLPS-Xet-2413	Xenopus tropicalis	79.26	4e-129	371
LLPS-Fia-3164	Ficedula albicollis	78.29	4e-101	298
LLPS-Lac-4046	Latimeria chalumnae	77.38	4e-130	373
LLPS-Mam-2987	Macaca mulatta	74.31	4e-112	328
LLPS-Man-3977	Macaca nemestrina	73.85	8e-112	327
LLPS-Asm-3729	Astyanax mexicanus	70.48	9e-111	324
LLPS-Icp-1158	Ictalurus punctatus	70.28	4e-111	325
LLPS-Orn-2967	Oreochromis niloticus	69.81	3e-109	320
LLPS-Xim-2350	Xiphophorus maculatus	69.81	6e-111	325
LLPS-Pof-3272	Poecilia formosa	69.34	5e-109	320
LLPS-Tag-1192	Taeniopygia guttata	68.2	1e-101	301
LLPS-Orl-3871	Oryzias latipes	67.45	3e-105	310
LLPS-Scf-2780	Scleropages formosus	67.29	6e-111	325
LLPS-Tar-2785	Takifugu rubripes	66.51	1e-107	316
LLPS-Dar-0550	Danio rerio	66.36	3e-108	318
LLPS-Scm-2939	Scophthalmus maximus	66.04	4e-105	310
LLPS-Gaa-2780	Gasterosteus aculeatus	66.04	6e-108	317
LLPS-Ten-0763	Tetraodon nigroviridis	64.32	8e-102	301
LLPS-Anp-1775	Anas platyrhynchos	61.2	2e-68	214
LLPS-Chs-1846	Chlorocebus sabaeus	60.18	1e-97	291
LLPS-Sah-3547	Sarcophilus harrisii	58.3	1e-92	278
LLPS-Caf-0197	Canis familiaris	57.47	2e-93	280
LLPS-Leo-3702	Lepisosteus oculatus	56.87	2e-91	275
LLPS-Ere-0898	Erinaceus europaeus	55.49	1e-69	218
LLPS-Cii-1777	Ciona intestinalis	50.47	3e-76	236
LLPS-Cis-0940	Ciona savignyi	49.55	2e-71	224
LLPS-Drm-1003	Drosophila melanogaster	47.2	8e-72	224
LLPS-Yal-0201	Yarrowia lipolytica	43.32	3e-60	195
LLPS-Sac-0959	Saccharomyces cerevisiae	42.57	1e-49	168
LLPS-Sot-0077	Solanum tuberosum	42.33	1e-44	155
LLPS-Viv-1785	Vitis vinifera	42.27	6e-48	164
LLPS-Cym-0813	Cyanidioschyzon merolae	42.08	6e-46	159
LLPS-Nia-1810	Nicotiana attenuata	41.88	8e-46	158
LLPS-Sei-2131	Setaria italica	41.88	6e-47	162
LLPS-Thc-2053	Theobroma cacao	41.88	3e-47	162
LLPS-Mae-0067	Manihot esculenta	41.75	2e-47	162
LLPS-Bro-1971	Brassica oleracea	41.36	1e-44	155
LLPS-Brr-1705	Brassica rapa	41.36	1e-44	155
LLPS-Orp-1205	Oryza punctata	41.36	3e-46	159
LLPS-Sol-1626	Solanum lycopersicum	41.36	2e-45	157
LLPS-Brn-2977	Brassica napus	41.36	1e-44	155
LLPS-Coc-2071	Corchorus capsularis	41.24	2e-46	160
LLPS-Gor-2584	Gossypium raimondii	41.24	9e-48	164
LLPS-Lep-2363	Leersia perrieri	41.24	2e-46	160
LLPS-Kop-1236	Komagataella pastoris	41.1	5e-52	174
LLPS-Chr-1589	Chlamydomonas reinhardtii	41.05	1e-44	155
LLPS-Orbr-2188	Oryza brachyantha	40.84	2e-45	158
LLPS-Amt-1607	Amborella trichopoda	40.84	4e-45	156
LLPS-Phv-1102	Phaseolus vulgaris	40.84	5e-46	159
LLPS-Art-2486	Arabidopsis thaliana	40.84	2e-44	155
LLPS-Met-1477	Medicago truncatula	40.84	4e-46	159
LLPS-Arl-1016	Arabidopsis lyrata	40.84	3e-44	155
LLPS-Org-0580	Oryza glaberrima	40.31	6e-45	156
LLPS-Orr-0252	Oryza rufipogon	40.31	6e-45	156
LLPS-Ors-0513	Oryza sativa	40.31	6e-45	156
LLPS-Orgl-0879	Oryza glumaepatula	40.31	6e-45	156
LLPS-Orni-1021	Oryza nivara	40.31	6e-45	156
LLPS-Ori-1133	Oryza indica	40.31	6e-45	156
LLPS-Orb-0077	Oryza barthii	40.31	6e-45	156
LLPS-Mua-1517	Musa acuminata	40.3	5e-46	159
LLPS-Pot-1410	Populus trichocarpa	40.21	8e-45	156
LLPS-Glm-1627	Glycine max	39.69	3e-45	157
LLPS-Orm-1071	Oryza meridionalis	39.3	8e-46	159
LLPS-Mel-1114	Melampsora laricipopulina	39.29	2e-46	162
LLPS-Sem-1976	Selaginella moellendorffii	39.15	2e-47	162
LLPS-Crn-1273	Cryptococcus neoformans	39.07	1e-44	156
LLPS-Ast-0054	Aspergillus terreus	38.97	6e-45	157
LLPS-Zyt-1373	Zymoseptoria tritici	38.91	1e-50	170
LLPS-Asn-0756	Aspergillus nidulans	38.89	6e-46	159
LLPS-Prp-1204	Prunus persica	38.81	6e-45	156
LLPS-Cus-0610	Cucumis sativus	38.31	8e-45	156
LLPS-Usm-1146	Ustilago maydis	38.11	4e-51	173
LLPS-Asni-0834	Aspergillus niger	38.07	4e-48	164
LLPS-Aso-1040	Aspergillus oryzae	38.03	7e-44	152
LLPS-Asf-1519	Aspergillus flavus	37.9	5e-49	167
LLPS-Scp-0879	Schizosaccharomyces pombe	37.85	8e-48	163
LLPS-Put-0435	Puccinia triticina	37.73	8e-49	168
LLPS-Tum-0311	Tuber melanosporum	37.61	5e-48	164
LLPS-Asfu-1253	Aspergillus fumigatus	37.56	4e-44	154
LLPS-Dos-0898	Dothistroma septosporum	37.56	6e-45	157
LLPS-Scj-0014	Schizosaccharomyces japonicus	37.56	1e-47	162
LLPS-Abg-0576	Absidia glauca	37.56	6e-46	159
LLPS-Asc-1349	Aspergillus clavatus	37.56	3e-45	157
LLPS-Spr-1550	Sporisorium reilianum	37.55	2e-52	177
LLPS-Scs-0397	Sclerotinia sclerotiorum	37.17	3e-44	155
LLPS-Cog-0477	Colletotrichum gloeosporioides	37.1	1e-44	156
LLPS-Map-0357	Magnaporthe poae	37.09	7e-45	157
LLPS-Pyt-0219	Pyrenophora teres	36.82	2e-44	156
LLPS-Pug-1384	Puccinia graminis	36.64	9e-48	165
LLPS-Phn-0119	Phaeosphaeria nodorum	36.36	2e-44	156
LLPS-Ved-0811	Verticillium dahliae	35.87	2e-44	156
LLPS-Pytr-1490	Pyrenophora triticirepentis	35.55	2e-50	171
LLPS-Trr-1267	Trichoderma reesei	35.2	4e-50	170
LLPS-Nef-1364	Neosartorya fischeri	35.06	9e-46	158
LLPS-Mao-0776	Magnaporthe oryzae	33.46	8e-47	162
LLPS-Trv-0881	Trichoderma virens	33.33	2e-47	163
LLPS-Beb-1195	Beauveria bassiana	32.57	3e-45	158

LLPS-Dio-4026Ak4

Protein Sequence

Nucleotide Sequence

LLPS-Dio-4026
Ak4