LLPS-Myl-2743
CHML
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Rab proteins geranylgeranyltransferase component A |
| Gene Name: | CHML |
| Ensembl Gene: | ENSMLUG00000000699.2 |
| Ensembl Protein: | ENSMLUP00000000633.2 |
| Organism: | Myotis lucifugus |
| Taxa ID: | 59463 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMLUT00000000695.2 | ENSMLUP00000000633.2 |
| UniProt | G1NTW4, G1NTW4_MYOLU | |
| GeneBank | AAPE02045557 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MADSLPTEFD VIIIGTGLPE SILAAACSRS GQRVLHVDSR SYYGGNWASF TFSGLLSWLK 60 61 ECEQDSEAGD KSTVAWQNLI QDTEEAIALR RKDDSIQHVE VFCYASKDTG DSAEEIDVLQ 120 121 KNPSLVASST LTKPLDSACL SEETHSDSTS PEMPAKDTPQ HDGEILPEVT DREETQVKET 180 181 DCGEKTCIHT VSDGAKDENK PVVEDNSGQP KRNRITYSQI VKEGRRFNID LVSKLLYSQG 240 241 SLIDLLIKSN VSRYAEFKNV TRILAFREGK VEQVPCSRAD VFNSKELTMV EKRMLMKFLT 300 301 FCLDYEQHPG EYQDFTQRPF SEYLKTQKLT PNLQHFILHS IAMTEPSCLT VDGLKATKHF 360 361 LQCLGRYGNT PFLFPLYGQG EIPQCFCRMC AVFGGIYCLR HRVQCLVVDK ESGRCEAVID 420 421 HFGQRISAKF FIVEDSYLSE DTCAGVQYGQ ISRAVLITDQ SVLKADSDQQ ISMLTVPPAE 480 481 PGARAVRVAE LCSSTMTCMK DTYLVHLTCS SASTAREDLE PVVQKLFTPY AETEIDEGDP 540 541 PKPRLLWALY FNMRDSSGVS RSSYHGLPSN VYVCSGPDCG LGNEHAVKLA ETLFQQIFPG 600 601 EDFCPPPPNP EDIIFDGDDK QPEAPGTNTL IVAKLEASEG SQNLDSPGQH LQ 652 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCGGACA GTCTCCCTAC AGAGTTTGAT GTAATTATCA TAGGGACAGG TTTGCCTGAA 60 61 TCCATCCTTG CGGCTGCATG TTCAAGAAGT GGGCAGAGAG TGCTACATGT TGATTCGAGA 120 121 AGTTACTATG GAGGAAACTG GGCTAGTTTC ACCTTTTCGG GATTGCTCTC CTGGTTGAAG 180 181 GAGTGTGAGC AAGACAGTGA GGCTGGGGAC AAAAGCACTG TTGCCTGGCA AAACCTGATC 240 241 CAGGACACAG AAGAAGCCAT CGCTCTGCGT CGGAAGGATG ACAGCATTCA ACACGTAGAA 300 301 GTGTTCTGTT ACGCCAGCAA GGACACCGGT GACAGTGCTG AAGAGATTGA TGTTTTGCAG 360 361 AAAAATCCTT CCTTGGTAGC ATCTAGTACC CTCACCAAAC CTCTGGATTC TGCATGCCTG 420 421 TCCGAAGAAA CACACTCAGA CAGCACTAGC CCCGAAATGC CTGCCAAAGA CACTCCACAA 480 481 CACGATGGAG AAATTTTACC AGAAGTAACC GATAGAGAGG AAACTCAGGT GAAAGAAACG 540 541 GATTGTGGAG AGAAAACTTG TATACACACA GTTTCAGATG GAGCTAAGGA TGAAAATAAA 600 601 CCTGTCGTAG AAGACAACTC GGGTCAACCA AAGAGAAATC GGATTACTTA CTCTCAGATA 660 661 GTTAAAGAAG GCAGGAGGTT TAATATCGAC TTGGTCTCAA AGCTGCTGTA TTCTCAAGGC 720 721 TCGCTGATCG ATCTCTTGAT CAAATCCAAT GTTAGTCGCT ACGCTGAATT TAAAAACGTC 780 781 ACCAGGATCC TCGCATTTCG AGAGGGGAAA GTAGAACAGG TGCCTTGTTC CCGAGCAGAT 840 841 GTCTTTAACA GCAAAGAGCT CACCATGGTA GAAAAGAGGA TGCTGATGAA GTTTCTGACA 900 901 TTTTGCTTAG ACTATGAGCA GCATCCTGGG GAATACCAGG ACTTCACACA GCGCCCCTTT 960 961 TCCGAGTACT TAAAGACTCA AAAGTTAACC CCCAACCTCC AGCACTTTAT ACTACACTCG 1020 1021 ATCGCAATGA CAGAGCCATC CTGCTTGACC GTCGACGGCC TTAAAGCAAC AAAGCACTTC 1080 1081 CTTCAGTGTC TTGGCCGGTA CGGCAACACT CCCTTCTTAT TCCCCTTGTA CGGCCAAGGG 1140 1141 GAAATTCCCC AGTGTTTCTG CAGGATGTGT GCTGTTTTTG GTGGAATCTA TTGTCTTCGC 1200 1201 CACAGAGTGC AGTGCCTCGT GGTTGACAAG GAATCTGGAA GGTGTGAAGC AGTGATAGAT 1260 1261 CATTTTGGCC AGAGAATCAG TGCGAAGTTT TTCATAGTGG AGGACAGCTA CCTTTCCGAG 1320 1321 GACACCTGCG CAGGCGTGCA GTATGGGCAG ATCTCCAGGG CCGTGCTCAT CACAGACCAG 1380 1381 TCCGTGCTCA AGGCAGATTC CGACCAGCAG ATCTCCATGT TGACGGTCCC TCCGGCGGAA 1440 1441 CCAGGCGCGC GTGCCGTTCG GGTCGCTGAG TTATGTTCTT CAACCATGAC GTGCATGAAA 1500 1501 GACACCTACC TGGTGCATCT GACCTGCTCA TCGGCTAGCA CAGCAAGAGA AGACTTAGAA 1560 1561 CCAGTGGTGC AGAAGTTATT CACCCCCTAC GCGGAGACAG AAATAGACGA GGGAGACCCT 1620 1621 CCGAAGCCAC GGCTCTTGTG GGCTCTTTAT TTTAACATGA GGGATTCCTC AGGGGTCAGC 1680 1681 AGAAGCTCTT ACCATGGCTT ACCTTCCAAC GTGTATGTCT GCTCTGGGCC TGACTGTGGA 1740 1741 CTAGGAAACG AGCACGCAGT CAAGCTCGCC GAAACCCTGT TCCAGCAGAT CTTCCCAGGA 1800 1801 GAAGACTTCT GCCCCCCACC GCCCAATCCA GAAGACATTA TCTTCGATGG GGATGACAAG 1860 1861 CAACCAGAGG CTCCTGGGAC CAATACTCTC ATCGTGGCCA AACTAGAAGC CTCCGAAGGC 1920 1921 AGCCAAAACC TAGACAGCCC AGGACAGCAT CTTCAA 1956 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Nucleoplasm | |
Cellular Component | Rab-protein geranylgeranyltransferase complex | |
Molecular Function | GDP-dissociation inhibitor activity | |
Molecular Function | GTPase activator activity | |
Molecular Function | Rab GTPase binding | |
Biological Process | Intracellular protein transport | |
Biological Process | Protein geranylgeranylation | |
Biological Process | Small GTPase mediated signal transduction |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Fud-1197 | Fukomys damarensis | 80.87 | 1e-167 | 488 |
| LLPS-Hos-2890 | Homo sapiens | 79.54 | 0.0 | 1083 |
| LLPS-Mal-1288 | Mandrillus leucophaeus | 79.12 | 0.0 | 1058 |
| LLPS-Bot-3776 | Bos taurus | 79.05 | 0.0 | 1067 |
| LLPS-Gog-4187 | Gorilla gorilla | 78.93 | 0.0 | 1072 |
| LLPS-Mam-3011 | Macaca mulatta | 78.81 | 0.0 | 1077 |
| LLPS-Ova-2649 | Ovis aries | 77.86 | 0.0 | 1048 |
| LLPS-Dio-0950 | Dipodomys ordii | 76.79 | 0.0 | 1034 |
| LLPS-Mea-1681 | Mesocricetus auratus | 76.61 | 0.0 | 992 |
| LLPS-Sus-3089 | Sus scrofa | 75.5 | 0.0 | 1008 |
| LLPS-Mum-4754 | Mus musculus | 74.19 | 0.0 | 951 |
| LLPS-Ora-2224 | Ornithorhynchus anatinus | 70.27 | 8e-29 | 116 |
| LLPS-Gaga-3138 | Gallus gallus | 56.82 | 1e-06 | 55.8 |
| LLPS-Dar-3725 | Danio rerio | 56.82 | 7e-07 | 56.2 |
| LLPS-Otg-3982 | Otolemur garnettii | 54.55 | 2e-06 | 55.1 |
| LLPS-Crn-0355 | Cryptococcus neoformans | 52.08 | 9e-07 | 55.8 |
| LLPS-Fuo-1254 | Fusarium oxysporum | 44.44 | 3e-06 | 54.3 |
| LLPS-Fuv-1062 | Fusarium verticillioides | 44.44 | 3e-06 | 54.3 |
| LLPS-Beb-0425 | Beauveria bassiana | 42.59 | 3e-06 | 54.3 |
| LLPS-Mao-1135 | Magnaporthe oryzae | 42.59 | 4e-06 | 53.9 |
| LLPS-Sac-1052 | Saccharomyces cerevisiae | 42.37 | 3e-07 | 57.8 |
| LLPS-Php-1495 | Physcomitrella patens | 31.56 | 6e-27 | 118 |
| LLPS-Coc-0364 | Corchorus capsularis | 29.87 | 5e-07 | 54.3 |
| LLPS-Pug-1494 | Puccinia graminis | 29.51 | 1e-32 | 135 |
| LLPS-Art-2658 | Arabidopsis thaliana | 28.93 | 3e-28 | 122 |
| LLPS-Put-0321 | Puccinia triticina | 28.8 | 3e-31 | 132 |
| LLPS-Chc-0583 | Chondrus crispus | 28.63 | 9e-25 | 112 |
| LLPS-Arl-1404 | Arabidopsis lyrata | 28.57 | 4e-28 | 122 |
| LLPS-Mel-0503 | Melampsora laricipopulina | 28.44 | 2e-30 | 128 |
| LLPS-Abg-0449 | Absidia glauca | 27.93 | 2e-29 | 125 |
| LLPS-Nia-2093 | Nicotiana attenuata | 27.91 | 3e-30 | 127 |
| LLPS-Usm-0648 | Ustilago maydis | 27.67 | 1e-34 | 140 |
| LLPS-Orm-0991 | Oryza meridionalis | 27.48 | 6e-29 | 124 |
| LLPS-Ori-1899 | Oryza indica | 27.48 | 6e-29 | 124 |
| LLPS-Scf-2261 | Scleropages formosus | 27.41 | 1e-29 | 126 |
| LLPS-Gor-1527 | Gossypium raimondii | 27.3 | 7e-28 | 121 |
| LLPS-Xet-1442 | Xenopus tropicalis | 27.25 | 1e-29 | 126 |
| LLPS-Hov-1619 | Hordeum vulgare | 27.25 | 7e-29 | 124 |
| LLPS-Mae-0680 | Manihot esculenta | 27.11 | 3e-30 | 128 |
| LLPS-Orbr-1532 | Oryza brachyantha | 27.03 | 8e-29 | 124 |
| LLPS-Lem-1088 | Leptosphaeria maculans | 27.02 | 4e-23 | 107 |
| LLPS-Org-0622 | Oryza glaberrima | 26.9 | 2e-28 | 123 |
| LLPS-Ors-0897 | Oryza sativa | 26.9 | 1e-28 | 123 |
| LLPS-Urm-2274 | Ursus maritimus | 26.85 | 4e-31 | 130 |
| LLPS-Spr-1306 | Sporisorium reilianum | 26.76 | 1e-32 | 135 |
| LLPS-Vir-1267 | Vigna radiata | 26.72 | 1e-19 | 95.5 |
| LLPS-Bro-0614 | Brassica oleracea | 26.6 | 2e-29 | 125 |
| LLPS-Brn-2636 | Brassica napus | 26.6 | 2e-29 | 127 |
| LLPS-Fia-3131 | Ficedula albicollis | 26.59 | 4e-30 | 127 |
| LLPS-Tag-3033 | Taeniopygia guttata | 26.28 | 1e-29 | 126 |
| LLPS-Brr-2513 | Brassica rapa | 26.28 | 4e-29 | 127 |
| LLPS-Meg-2440 | Meleagris gallopavo | 26.28 | 9e-30 | 127 |
| LLPS-Chr-1249 | Chlamydomonas reinhardtii | 26.28 | 8e-25 | 112 |
| LLPS-Hea-1662 | Helianthus annuus | 26.28 | 3e-28 | 122 |
| LLPS-Trv-0876 | Trichoderma virens | 25.94 | 2e-24 | 111 |
| LLPS-Anp-3373 | Anas platyrhynchos | 25.94 | 8e-24 | 107 |
| LLPS-Mua-2403 | Musa acuminata | 25.8 | 3e-28 | 122 |
| LLPS-Anc-3514 | Anolis carolinensis | 25.68 | 6e-27 | 118 |
| LLPS-Lep-0400 | Leersia perrieri | 25.45 | 2e-25 | 113 |