• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Anp-3373
GDI2

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Rab GDP dissociation inhibitor
Gene Name: GDI2
Ensembl Gene: ENSAPLG00000007527.1
Ensembl Protein: ENSAPLP00000007195.1
Organism: Anas platyrhynchos
Taxa ID: 8839
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole body, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSAPLT00000007851.1ENSAPLP00000007195.1
UniProtU3IIX3, U3IIX3_ANAPL
GeneBankADON01037674, ADON01037673

▼ SEQUENCE

Protein Sequence (FASTA)
1     TGQLVKMLLY  TEVTRYLDFK  VIEGSFVYKG  GKIYKVPSTE  AEALASSLMG  LFEKRRFRKF  60
61    LVYVANFDEN  DPRTFEGVDP  KKTTMRDVYK  KFDLGQDVID  FTGHALALYR  TDDYLDQPCQ  120
121   ETINRIKLYS  ESLARYGKSP  YLYPLYGLGE  LPQGFARLSA  IYGGTYMLNK  PIEEIVIENG  180
181   KVVGVKSEGE  VARCKQLICD  PSYVSDRVTK  VGQVIRVICI  LSHPIKNTND  ANSCQIIIPQ  240
241   NQVNRKSDIY  VCMISSAHNV  AAQGKYIAIA  STTVETADPE  KEIKPALDLL  EPISSRFVSI  300
301   SDLFAPTDLG  TESQIFISRT  YDATTHFETT  CDDIKDIYKR  MMGSEFDFEE  MKRKKNDIYG  360
361   EEEQQ  365
Nucleotide CDS Sequence (FASTA)
1     ACAGGTCAGT  TGGTAAAGAT  GCTGCTCTAC  ACAGAAGTCA  CTCGCTACTT  AGACTTCAAG  60
61    GTGATCGAGG  GGAGCTTTGT  CTACAAGGGA  GGGAAGATCT  ACAAAGTTCC  TTCCACTGAG  120
121   GCAGAAGCCT  TGGCATCCAG  CTTGATGGGC  TTGTTCGAGA  AACGCCGCTT  CAGGAAATTC  180
181   CTCGTGTACG  TGGCCAACTT  CGACGAGAAC  GATCCCCGAA  CTTTTGAGGG  CGTCGATCCC  240
241   AAGAAGACCA  CCATGCGTGA  CGTGTACAAG  AAGTTCGACC  TGGGGCAGGA  TGTTATCGAC  300
301   TTCACGGGCC  ATGCCCTCGC  GCTCTACAGG  ACTGACGACT  ATCTAGATCA  ACCATGCCAA  360
361   GAAACAATCA  ACAGGATCAA  GCTCTACAGC  GAGTCGCTGG  CTAGGTACGG  TAAAAGCCCC  420
421   TACCTGTACC  CCCTCTATGG  CCTCGGAGAG  CTGCCACAGG  GATTTGCAAG  GCTAAGTGCT  480
481   ATATACGGAG  GCACCTACAT  GCTGAACAAG  CCCATTGAAG  AAATTGTGAT  AGAAAACGGC  540
541   AAAGTGGTTG  GCGTCAAATC  TGAAGGGGAG  GTGGCTCGCT  GCAAACAGCT  CATCTGCGAC  600
601   CCCAGCTACG  TCTCGGACCG  GGTGACGAAG  GTTGGCCAGG  TGATTCGGGT  CATCTGCATC  660
661   CTGAGCCACC  CCATCAAGAA  CACGAACGAC  GCCAACTCGT  GCCAGATCAT  CATTCCACAG  720
721   AACCAGGTCA  ACCGGAAATC  AGATATCTAC  GTCTGCATGA  TCTCCTCTGC  ACACAACGTG  780
781   GCGGCGCAGG  GGAAGTACAT  CGCCATCGCC  AGCACCACCG  TGGAAACCGC  GGACCCAGAG  840
841   AAAGAGATCA  AGCCGGCCTT  GGACCTCCTG  GAGCCCATTT  CTTCCAGGTT  CGTTAGCATC  900
901   AGCGACCTGT  TTGCACCGAC  TGACCTGGGA  ACCGAGAGCC  AGATTTTCAT  TTCTCGCACC  960
961   TACGACGCGA  CCACTCACTT  CGAGACGACG  TGCGATGACA  TCAAGGATAT  TTATAAGAGG  1020
1021  ATGATGGGAT  CAGAGTTTGA  CTTTGAAGAG  ATGAAACGCA  AGAAGAACGA  TATCTACGGG  1080
1081  GAGGAGGAGC  AGCAG  1095

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
GTPase activation
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Golgi apparatus
Molecular Function
GTPase activator activity
Molecular Function
Rab GDP-dissociation inhibitor activity
Biological Process
Protein transport
Biological Process
Small GTPase mediated signal transduction

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Gaga-3138Gallus gallus99.180.0 672
LLPS-Meg-2440Meleagris gallopavo98.90.0 669
LLPS-Tag-3033Taeniopygia guttata98.360.0 664
LLPS-Fia-3131Ficedula albicollis98.080.0 664
LLPS-Pes-2829Pelodiscus sinensis96.70.0 655
LLPS-Ora-3151Ornithorhynchus anatinus96.160.0 655
LLPS-Anc-3514Anolis carolinensis93.70.0 635
LLPS-Bot-0810Bos taurus93.370.0 632
LLPS-Loa-3491Loxodonta africana93.090.0 630
LLPS-Ova-2397Ovis aries93.090.0 631
LLPS-Ict-3259Ictidomys tridecemlineatus92.820.0 625
LLPS-Orc-3162Oryctolagus cuniculus92.820.0 624
LLPS-Myl-0069Myotis lucifugus92.820.0 629
LLPS-Sah-0846Sarcophilus harrisii92.80.0 625
LLPS-Poa-1434Pongo abelii92.540.0 626
LLPS-Caf-1422Canis familiaris92.540.0 625
LLPS-Nol-3953Nomascus leucogenys92.540.0 625
LLPS-Cas-2617Carlito syrichta92.540.0 625
LLPS-Hos-1171Homo sapiens92.540.0 626
LLPS-Urm-2274Ursus maritimus92.540.0 625
LLPS-Mup-4570Mustela putorius furo92.540.0 624
LLPS-Sus-4627Sus scrofa92.540.0 625
LLPS-Eqc-3658Equus caballus92.270.0 624
LLPS-Pat-4326Pan troglodytes92.270.0 625
LLPS-Pap-1661Pan paniscus92.270.0 625
LLPS-Fec-1725Felis catus92.270.0 623
LLPS-Dio-1106Dipodomys ordii92.270.0 625
LLPS-Ran-4541Rattus norvegicus92.270.0 624
LLPS-Mum-4780Mus musculus92.270.0 624
LLPS-Gog-2708Gorilla gorilla92.270.0 624
LLPS-Aim-1876Ailuropoda melanoleuca92.240.0 619
LLPS-Mam-3226Macaca mulatta91.990.0 623
LLPS-Man-4059Macaca nemestrina91.990.0 623
LLPS-Mod-1059Monodelphis domestica91.990.0 625
LLPS-Rhb-1914Rhinopithecus bieti91.990.0 622
LLPS-Mal-2221Mandrillus leucophaeus91.990.0 622
LLPS-Paa-3301Papio anubis91.990.0 623
LLPS-Cea-2374Cercocebus atys91.990.0 623
LLPS-Maf-4183Macaca fascicularis91.990.0 623
LLPS-Mea-1806Mesocricetus auratus91.990.0 622
LLPS-Fud-1798Fukomys damarensis91.990.0 621
LLPS-Caj-2693Callithrix jacchus91.990.0 624
LLPS-Aon-4622Aotus nancymaae91.710.0 622
LLPS-Chs-1768Chlorocebus sabaeus91.710.0 620
LLPS-Xet-1442Xenopus tropicalis90.630.0 609
LLPS-Dar-3725Danio rerio89.320.0 609
LLPS-Scf-2261Scleropages formosus88.740.0 606
LLPS-Asm-3769Astyanax mexicanus87.910.0 598
LLPS-Otg-3982Otolemur garnettii86.540.0 578
LLPS-Cap-2519Cavia porcellus85.910.0 568
LLPS-Lac-2400Latimeria chalumnae84.133e-167 480
LLPS-Icp-3295Ictalurus punctatus83.230.0 515
LLPS-Leo-3243Lepisosteus oculatus79.058e-96 297
LLPS-Tar-2140Takifugu rubripes63.921e-55 189
LLPS-Cae-0396Caenorhabditis elegans61.711e-138 410
LLPS-Coc-0364Corchorus capsularis57.955e-30 117
LLPS-Mua-2403Musa acuminata57.435e-119 359
LLPS-Brr-2513Brassica rapa57.314e-120 367
LLPS-Art-3091Arabidopsis thaliana57.311e-122 368
LLPS-Arl-2783Arabidopsis lyrata57.143e-121 365
LLPS-Bro-0614Brassica oleracea56.452e-122 368
LLPS-Brn-2636Brassica napus56.452e-120 368
LLPS-Glm-2346Glycine max56.297e-120 361
LLPS-Crn-0355Cryptococcus neoformans55.873e-116 352
LLPS-Prp-1540Prunus persica55.712e-116 352
LLPS-Orbr-1444Oryza brachyantha55.717e-119 358
LLPS-Tra-2721Triticum aestivum55.431e-117 355
LLPS-Hea-1662Helianthus annuus55.013e-121 365
LLPS-Abg-0449Absidia glauca54.956e-120 361
LLPS-Mae-0680Manihot esculenta54.863e-115 349
LLPS-Lep-0400Leersia perrieri54.862e-114 347
LLPS-Spr-1306Sporisorium reilianum54.734e-110 336
LLPS-Orm-0991Oryza meridionalis54.736e-111 338
LLPS-Orr-0790Oryza rufipogon54.734e-110 337
LLPS-Ori-1899Oryza indica54.736e-111 338
LLPS-Gor-1527Gossypium raimondii54.572e-114 347
LLPS-Nia-2093Nicotiana attenuata54.571e-112 343
LLPS-Sol-2510Solanum lycopersicum54.572e-116 356
LLPS-Orp-0688Oryza punctata54.445e-110 336
LLPS-Sei-2244Setaria italica54.153e-110 337
LLPS-Dac-1188Daucus carota54.154e-115 349
LLPS-Ors-0897Oryza sativa53.872e-109 334
LLPS-Orgl-1535Oryza glumaepatula53.872e-109 335
LLPS-Orni-2195Oryza nivara53.872e-109 334
LLPS-Chr-1249Chlamydomonas reinhardtii53.717e-114 346
LLPS-Org-0622Oryza glaberrima53.584e-109 333
LLPS-Sob-0354Sorghum bicolor53.582e-108 332
LLPS-Orb-2057Oryza barthii53.584e-109 333
LLPS-Pot-2549Populus trichocarpa53.492e-108 332
LLPS-Zem-0936Zea mays53.32e-106 327
LLPS-Php-1495Physcomitrella patens53.146e-106 325
LLPS-Tru-0549Triticum urartu53.011e-105 328
LLPS-Mao-1135Magnaporthe oryzae52.992e-108 332
LLPS-Mel-0503Melampsora laricipopulina52.912e-113 345
LLPS-Sac-1052Saccharomyces cerevisiae52.895e-113 343
LLPS-Vir-1267Vigna radiata52.662e-97 302
LLPS-Put-0321Puccinia triticina52.354e-112 345
LLPS-Fuo-1254Fusarium oxysporum52.321e-104 322
LLPS-Chc-0583Chondrus crispus52.34e-106 326
LLPS-Pug-1494Puccinia graminis52.084e-112 341
LLPS-Beb-0425Beauveria bassiana52.041e-103 320
LLPS-Usm-0648Ustilago maydis51.881e-107 330
LLPS-Brd-0643Brachypodium distachyon51.865e-106 325
LLPS-Fuv-1062Fusarium verticillioides51.771e-103 320
LLPS-Trv-0876Trichoderma virens50.941e-100 312
LLPS-Hov-1619Hordeum vulgare49.141e-109 335
LLPS-Viv-0233Vitis vinifera46.093e-33 126
LLPS-Phv-2050Phaseolus vulgaris39.054e-34 131