• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Scf-2261
Z043_108103

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Rab GDP dissociation inhibitor
Gene Name: Z043_108103
Ensembl Gene: ENSSFOG00015011655.1
Ensembl Protein: ENSSFOP00015018178.1
Organism: Scleropages formosus
Taxa ID: 113540
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MDEEYDVIVL  GTGLTECILS  GIMSVNGKKV  LHMDRNPYYG  GESSSITPLE  ELYKRFGLPD  60
61    GPPESMGRGR  DWNVDLIPKF  LMANGQLVKM  LLYTEVTRYL  DFKVVEGSFV  YKGGKIYKVP  120
121   STESEALASN  LMGMFEKRRF  RKFLVFVANF  DENDSKTFEG  VDPKVTTMRD  VYKKFDLGQD  180
181   VIDFTGHALA  LYRTDDYLDQ  PCLETISRIK  LYSESLARYG  KSPYLYPLYG  LGELPQGFAR  240
241   LSAIYGGTYM  LNKPVEEIVM  ENGRVVGVKS  EGEVARCKQL  ICDPSYIPER  VRKTGQVIRV  300
301   ICILSHPIKN  TNDANSCQII  IPQNQVNRKS  DIYVCMISYA  HNVAAQGKYI  AIASTTVETS  360
361   DPEAEIEPAL  ELLEPIDQKF  VAISDLYEPT  DDGTESQIFA  SRAYDATTHF  ETTCNDIKDI  420
421   YKRMTGSDFD  FENMKRKQND  VFGEDEQ  447
Nucleotide CDS Sequence (FASTA)
1     ATGGATGAGG  AATATGATGT  GATCGTTTTG  GGCACTGGAC  TCACAGAATG  CATCTTGTCG  60
61    GGGATCATGT  CTGTCAATGG  GAAGAAGGTT  CTGCACATGG  ACAGAAACCC  GTATTATGGA  120
121   GGCGAGAGCT  CATCTATCAC  TCCCTTGGAG  GAGCTCTACA  AGCGATTTGG  CCTCCCCGAT  180
181   GGCCCTCCTG  AATCTATGGG  TCGTGGCCGG  GACTGGAATG  TTGACCTCAT  TCCAAAATTT  240
241   CTCATGGCCA  ATGACCTAAT  GGGGATGTTT  GAGAAAAGAA  GGTTCCGGAA  ATTCTTGGTA  300
301   TTTGTGGCAA  ACTTTGATGA  GAATGATTCC  AAAACATTTG  AGGGTGTTGA  CCCCAAAGTC  360
361   ACCACAATGA  GAGATGTCTA  CAAGAAGTTT  GATCTGGGGC  AGGACGTCAT  CGACTTCACT  420
421   GGTCATGCCC  TGGCGCTCTA  CAGAACAGAT  GATTACCTGG  ACCAACCCTG  TCTGGAGACC  480
481   ATCAGTCGCA  TAAAGCTGTA  CAGCGAGTCC  CTGGCTCGCT  ATGGAAAGAG  TCCCTACCTG  540
541   TACCCACTGT  ATGGCCTGGG  GGAGCTGCCT  CAGGGTTTTG  CAAGGTTAAG  TGCCATTTAT  600
601   GGGGGGACAT  ATATGCTGAA  CAAACCAGTG  GAGGAGATTG  TGATGGAGAA  TGGACGTGTG  660
661   GTTGGAGTGA  AGTCTGAAGG  AGAGGTGGCA  CGTTGCAAAC  AGCTCATTTG  TGACCCCAGC  720
721   TACATTCCGG  AGCGGGTTCG  TAAGACCGGC  CAGGTCATCC  GCGTGATATG  CATACTCAGC  780
781   CACCCAATCA  AGAACACAAA  TGATGCCAAC  TCCTGTCAGA  TCATTATCCC  CCAGAACCAA  840
841   GTCAACCGCA  AGTCAGATAT  CTATGTGTGC  ATGATCTCTT  ACGCCCACAA  TGTGGCAGCC  900
901   CAGGGGAAGT  ACATAGCGAT  TGCCAGCACC  ACTGTAGAGA  CTAGTGACCC  CGAGGCTGAG  960
961   ATTGAACCTG  CACTGGAGCT  ACTGGAACCT  ATTGACCAGA  AGTTTGTGGC  CATCAGTGAT  1020
1021  CTCTATGAGC  CCACGGATGA  TGGCACTGAG  AGCCAGATAT  TTGCATCCCG  GGCATACGAC  1080
1081  GCTACTACCC  ACTTTGAGAC  CACCTGCAAT  GACATAAAGG  ACATCTACAA  GCGCATGACA  1140
1141  GGCAGCGACT  TCGACTTTGA  AAACATGAAG  CGCAAACAAA  ACGATGTGTT  TGGGGAGGAT  1200
1201  GAGCAGTGA  1209

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
GTPase activation
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Molecular Function
GTPase activator activity
Molecular Function
Rab GDP-dissociation inhibitor activity
Biological Process
Protein transport
Biological Process
Small GTPase mediated signal transduction

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Asm-3168Astyanax mexicanus94.360.0 783
LLPS-Mod-2400Monodelphis domestica93.740.0 798
LLPS-Mam-1672Macaca mulatta93.290.0 791
LLPS-Hos-2773Homo sapiens93.060.0 791
LLPS-Orc-1608Oryctolagus cuniculus93.060.0 792
LLPS-Gog-3686Gorilla gorilla93.060.0 791
LLPS-Mea-2717Mesocricetus auratus92.840.0 791
LLPS-Fud-3705Fukomys damarensis92.840.0 791
LLPS-Bot-3233Bos taurus92.840.0 790
LLPS-Mum-3942Mus musculus92.620.0 788
LLPS-Dio-3794Dipodomys ordii92.620.0 790
LLPS-Ova-3376Ovis aries92.590.0 761
LLPS-Myl-3992Myotis lucifugus92.40.0 762
LLPS-Mal-2620Mandrillus leucophaeus90.240.0 757
LLPS-Gaga-3138Gallus gallus89.930.0 768
LLPS-Fia-3131Ficedula albicollis89.860.0 741
LLPS-Tag-3033Taeniopygia guttata89.40.0 738
LLPS-Anp-3373Anas platyrhynchos88.740.0 599
LLPS-Pap-1661Pan paniscus88.540.0 753
LLPS-Pat-4326Pan troglodytes88.540.0 753
LLPS-Loa-3491Loxodonta africana88.540.0 755
LLPS-Sah-0846Sarcophilus harrisii88.540.0 748
LLPS-Ict-3259Ictidomys tridecemlineatus88.310.0 748
LLPS-Fec-1725Felis catus88.090.0 748
LLPS-Poa-1434Pongo abelii88.090.0 751
LLPS-Meg-2440Meleagris gallopavo88.040.0 741
LLPS-Man-4059Macaca nemestrina87.870.0 749
LLPS-Maf-4183Macaca fascicularis87.870.0 749
LLPS-Chs-1768Chlorocebus sabaeus87.870.0 751
LLPS-Sus-4627Sus scrofa87.870.0 748
LLPS-Cea-2374Cercocebus atys87.870.0 749
LLPS-Ran-4541Rattus norvegicus87.870.0 750
LLPS-Paa-3301Papio anubis87.870.0 749
LLPS-Pes-2829Pelodiscus sinensis87.730.0 723
LLPS-Mup-4570Mustela putorius furo87.710.0 708
LLPS-Rhb-1914Rhinopithecus bieti87.670.0 722
LLPS-Caf-1422Canis familiaris87.670.0 719
LLPS-Eqc-3658Equus caballus87.640.0 746
LLPS-Urm-2274Ursus maritimus87.470.0 704
LLPS-Aon-4622Aotus nancymaae87.420.0 744
LLPS-Aim-1876Ailuropoda melanoleuca87.420.0 741
LLPS-Cas-2617Carlito syrichta87.210.0 714
LLPS-Dar-3725Danio rerio87.160.0 743
LLPS-Ora-3151Ornithorhynchus anatinus86.880.0 733
LLPS-Nol-3953Nomascus leucogenys86.850.0 733
LLPS-Anc-3514Anolis carolinensis86.520.0 728
LLPS-Xet-1442Xenopus tropicalis85.680.0 726
LLPS-Caj-2693Callithrix jacchus85.520.0 726
LLPS-Icp-3295Ictalurus punctatus84.560.0 687
LLPS-Cap-2519Cavia porcellus83.60.0 696
LLPS-Otg-3982Otolemur garnettii83.00.0 690
LLPS-Tru-0549Triticum urartu80.02e-0654.7
LLPS-Lac-2400Latimeria chalumnae76.650.0 548
LLPS-Tar-2140Takifugu rubripes66.538e-104 316
LLPS-Cae-0396Caenorhabditis elegans64.440.0 540
LLPS-Art-3091Arabidopsis thaliana59.822e-163 476
LLPS-Bro-0614Brassica oleracea59.829e-162 471
LLPS-Brn-2636Brassica napus59.822e-159 472
LLPS-Leo-3243Lepisosteus oculatus59.43e-128 383
LLPS-Brr-2513Brassica rapa59.356e-159 470
LLPS-Arl-2783Arabidopsis lyrata59.354e-163 475
LLPS-Prp-1540Prunus persica58.662e-163 476
LLPS-Mua-2403Musa acuminata58.664e-163 475
LLPS-Hea-1662Helianthus annuus58.433e-168 488
LLPS-Orm-0991Oryza meridionalis57.973e-160 468
LLPS-Orr-0790Oryza rufipogon57.973e-159 467
LLPS-Ori-1899Oryza indica57.973e-160 468
LLPS-Crn-0355Cryptococcus neoformans57.827e-151 444
LLPS-Orp-0688Oryza punctata57.742e-159 465
LLPS-Mae-0680Manihot esculenta57.741e-160 468
LLPS-Nia-2093Nicotiana attenuata57.744e-159 465
LLPS-Glm-2346Glycine max57.744e-160 467
LLPS-Orbr-1532Oryza brachyantha57.511e-157 461
LLPS-Sei-2244Setaria italica57.516e-159 464
LLPS-Abg-0449Absidia glauca57.51e-160 469
LLPS-Orni-2195Oryza nivara57.276e-159 464
LLPS-Ors-0897Oryza sativa57.041e-158 464
LLPS-Sob-0354Sorghum bicolor57.045e-158 462
LLPS-Dac-1188Daucus carota57.043e-159 465
LLPS-Orgl-1535Oryza glumaepatula57.044e-159 464
LLPS-Pot-2549Populus trichocarpa57.013e-155 455
LLPS-Gor-1527Gossypium raimondii56.812e-157 460
LLPS-Org-0622Oryza glaberrima56.812e-158 463
LLPS-Orb-2057Oryza barthii56.812e-158 463
LLPS-Php-1495Physcomitrella patens56.813e-154 452
LLPS-Tra-2721Triticum aestivum56.812e-160 468
LLPS-Sac-1052Saccharomyces cerevisiae56.585e-150 442
LLPS-Chr-1249Chlamydomonas reinhardtii56.128e-158 461
LLPS-Sol-2510Solanum lycopersicum55.484e-144 431
LLPS-Zem-0936Zea mays55.332e-152 448
LLPS-Brd-0643Brachypodium distachyon55.27e-154 451
LLPS-Mel-0503Melampsora laricipopulina54.832e-149 440
LLPS-Usm-0648Ustilago maydis54.737e-141 418
LLPS-Spr-1306Sporisorium reilianum54.631e-141 420
LLPS-Lep-0400Leersia perrieri54.56e-157 459
LLPS-Pug-1494Puccinia graminis54.389e-150 441
LLPS-Put-0321Puccinia triticina54.281e-147 439
LLPS-Hov-1619Hordeum vulgare53.461e-155 456
LLPS-Coc-0364Corchorus capsularis53.225e-54 183
LLPS-Mao-1135Magnaporthe oryzae53.192e-142 423
LLPS-Fuo-1254Fusarium oxysporum53.074e-140 417
LLPS-Fuv-1062Fusarium verticillioides52.852e-139 415
LLPS-Vir-1267Vigna radiata52.667e-133 396
LLPS-Chc-0583Chondrus crispus52.319e-136 405
LLPS-Beb-0425Beauveria bassiana52.091e-137 410
LLPS-Trv-0876Trichoderma virens51.652e-135 405
LLPS-Viv-0233Vitis vinifera49.221e-28 114
LLPS-Phv-2050Phaseolus vulgaris39.137e-33 129
LLPS-Lem-1088Leptosphaeria maculans26.065e-0859.3