LLPS-Mum-3199
Lsm1

▼ OVERVIEW

Status: Unreviewed
Protein Name: U6 snRNA-associated Sm-like protein LSm1
Gene Name: Lsm1
Ensembl Gene: ENSMUSG00000037296.7
Ensembl Protein: ENSMUSP00000147832.1
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
P-body, Stress granulePredicted from orthologs(View)

▼ FUNCTION

Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (By similarity). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MNYMPGTASL  IEDIDKKHLV  LLRDGRTLIG  FLRSIDQFAN  LVLHQTVERI  HVGKKYGDIP  60
61    RGIFVVRGEN  VVLLGEIDLE  KESDTPLQQV  SIEEILEEQR  VQQQTRLEAE  KLKVQTLKDR  120
121   GLSIPRADTL  DEY  133
Nucleotide CDS Sequence (FASTA)
1     ATGAACTATA  TGCCCGGCAC  CGCCAGCCTC  ATCGAGGACA  TCGACAAAAA  GCACTTGGTC  60
61    CTACTTCGAG  ATGGAAGAAC  ACTTATAGGT  TTTTTAAGAA  GCATTGATCA  ATTTGCTAAC  120
121   TTAGTGCTCC  ATCAGACTGT  GGAGCGAATT  CATGTGGGCA  AAAAGTACGG  TGATATTCCT  180
181   CGAGGGATTT  TCGTGGTCAG  AGGAGAGAAT  GTGGTCCTAC  TAGGAGAAAT  AGACCTGGAG  240
241   AAGGAGAGTG  ACACGCCCCT  TCAGCAAGTG  TCTATTGAAG  AGATCCTAGA  GGAACAGAGG  300
301   GTGCAACAGC  AGACCAGACT  GGAGGCAGAG  AAGCTGAAGG  TCCAGACCCT  TAAAGATCGG  360
361   GGCCTTTCCA  TTCCTCGCGC  AGACACTCTG  GACGAGTACT  GA  402

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
mRNA processing
mRNA splicing
Phosphoprotein
Reference proteome
Ribonucleoprotein
RNA-binding

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Axon
Cellular Component
Cytoplasm
Cellular Component
Dendrite
Cellular Component
Lsm1-7-Pat1 complex
Cellular Component
Messenger ribonucleoprotein complex
Cellular Component
Neuronal cell body
Cellular Component
Nucleus
Cellular Component
P-body
Molecular Function
MRNA binding
Molecular Function
Pre-mRNA binding
Molecular Function
RNA binding
Molecular Function
RNA cap binding
Biological Process
Deadenylation-dependent decapping of nuclear-transcribed mRNA
Biological Process
Histone mRNA catabolic process
Biological Process
MRNA processing
Biological Process
Negative regulation of neuron differentiation
Biological Process
RNA metabolic process
Biological Process
RNA splicing
Biological Process
Stem cell population maintenance

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ict-1483Ictidomys tridecemlineatus100.03e-49 159
LLPS-Tut-1594Tursiops truncatus97.747e-89 261
LLPS-Dio-0030Dipodomys ordii97.747e-89 261
LLPS-Paa-1027Papio anubis97.747e-89 261
LLPS-Mal-1107Mandrillus leucophaeus97.747e-89 261
LLPS-Aim-0875Ailuropoda melanoleuca97.747e-89 261
LLPS-Ova-0040Ovis aries97.747e-89 261
LLPS-Maf-1355Macaca fascicularis97.747e-89 261
LLPS-Chs-1943Chlorocebus sabaeus97.747e-89 261
LLPS-Sus-2572Sus scrofa97.741e-88 261
LLPS-Cea-0018Cercocebus atys97.747e-89 261
LLPS-Aon-2361Aotus nancymaae97.747e-89 261
LLPS-Gog-1891Gorilla gorilla97.747e-89 261
LLPS-Fud-0635Fukomys damarensis97.747e-89 261
LLPS-Poa-2737Pongo abelii97.747e-89 261
LLPS-Caf-0769Canis familiaris97.747e-89 261
LLPS-Cap-0167Cavia porcellus97.747e-89 261
LLPS-Eqc-3245Equus caballus97.746e-89 261
LLPS-Cas-0238Carlito syrichta97.747e-89 261
LLPS-Nol-0100Nomascus leucogenys97.747e-89 261
LLPS-Hos-0291Homo sapiens97.747e-89 261
LLPS-Pat-1612Pan troglodytes97.747e-89 261
LLPS-Urm-1462Ursus maritimus97.747e-89 261
LLPS-Pap-1406Pan paniscus97.747e-89 261
LLPS-Fec-1663Felis catus97.747e-89 261
LLPS-Loa-0012Loxodonta africana97.747e-89 261
LLPS-Otg-1601Otolemur garnettii97.747e-89 261
LLPS-Orc-0306Oryctolagus cuniculus97.747e-89 261
LLPS-Rhb-0060Rhinopithecus bieti97.747e-89 261
LLPS-Mam-3349Macaca mulatta97.442e-1981.6
LLPS-Man-3166Macaca nemestrina97.442e-1981.6
LLPS-Bot-1262Bos taurus96.993e-88 259
LLPS-Ran-2587Rattus norvegicus96.992e-88 260
LLPS-Mup-1062Mustela putorius furo96.995e-88 259
LLPS-Myl-3288Myotis lucifugus96.995e-88 259
LLPS-Caj-2288Callithrix jacchus96.993e-88 259
LLPS-Sah-1994Sarcophilus harrisii95.498e-87 256
LLPS-Mod-1732Monodelphis domestica95.498e-87 256
LLPS-Ora-1014Ornithorhynchus anatinus94.742e-86 255
LLPS-Leo-0534Lepisosteus oculatus92.482e-73 222
LLPS-Tag-0051Taeniopygia guttata92.486e-85 251
LLPS-Fia-1356Ficedula albicollis92.371e-72 219
LLPS-Scf-2706Scleropages formosus90.986e-82 243
LLPS-Gaga-0302Gallus gallus90.982e-82 244
LLPS-Meg-1340Meleagris gallopavo90.981e-81 243
LLPS-Xet-0133Xenopus tropicalis90.513e-82 244
LLPS-Lac-2562Latimeria chalumnae88.141e-68 209
LLPS-Pes-0131Pelodiscus sinensis86.922e-73 222
LLPS-Tar-2363Takifugu rubripes85.594e-62 194
LLPS-Orl-0368Oryzias latipes84.961e-77 233
LLPS-Asm-1087Astyanax mexicanus84.213e-76 229
LLPS-Ten-3174Tetraodon nigroviridis84.212e-76 230
LLPS-Scm-1083Scophthalmus maximus84.214e-77 231
LLPS-Orn-2110Oreochromis niloticus84.213e-77 232
LLPS-Gaa-1715Gasterosteus aculeatus83.468e-77 231
LLPS-Dar-0293Danio rerio83.463e-76 229
LLPS-Pof-2024Poecilia formosa83.461e-76 230
LLPS-Xim-0643Xiphophorus maculatus82.713e-76 229
LLPS-Icp-2370Ictalurus punctatus82.716e-76 228
LLPS-Mea-4086Mesocricetus auratus75.943e-55 175
LLPS-Ere-0055Erinaceus europaeus69.174e-51 164
LLPS-Cii-1671Ciona intestinalis65.912e-51 166
LLPS-Drm-0601Drosophila melanogaster62.92e-47 155
LLPS-Coc-0647Corchorus capsularis58.897e-25 101
LLPS-Cogr-0826Colletotrichum graminicola58.542e-2087.0
LLPS-Cae-1457Caenorhabditis elegans58.069e-26 100
LLPS-Nec-1084Neurospora crassa58.026e-1983.6
LLPS-Coo-0716Colletotrichum orbiculare57.321e-1985.1
LLPS-Fuo-0031Fusarium oxysporum57.324e-1983.6
LLPS-Met-1714Medicago truncatula56.678e-26 100
LLPS-Chc-0229Chondrus crispus56.381e-27 107
LLPS-Cus-0267Cucumis sativus56.02e-28 106
LLPS-Abg-0863Absidia glauca55.862e-37 130
LLPS-Viv-0304Vitis vinifera55.562e-27 104
LLPS-Glm-0137Glycine max55.051e-26 102
LLPS-Dac-1176Daucus carota55.058e-27 102
LLPS-Phv-0404Phaseolus vulgaris55.051e-26 102
LLPS-Trr-0377Trichoderma reesei54.958e-2496.3
LLPS-Gag-0579Gaeumannomyces graminis54.882e-1984.7
LLPS-Map-0895Magnaporthe poae54.883e-1984.7
LLPS-Cog-0263Colletotrichum gloeosporioides54.881e-1882.4
LLPS-Via-1044Vigna angularis54.842e-2189.4
LLPS-Sem-0588Selaginella moellendorffii54.559e-27 102
LLPS-Asni-0298Aspergillus niger54.314e-32 117
LLPS-Hea-1492Helianthus annuus54.02e-27 104
LLPS-Thc-0645Theobroma cacao54.02e-27 104
LLPS-Gor-0366Gossypium raimondii54.07e-28 105
LLPS-Mae-1279Manihot esculenta54.07e-28 105
LLPS-Trv-1320Trichoderma virens53.852e-2292.8
LLPS-Arl-0904Arabidopsis lyrata53.44e-27 103
LLPS-Brn-0131Brassica napus53.43e-27 103
LLPS-Bro-0266Brassica oleracea53.43e-27 103
LLPS-Prp-0821Prunus persica53.02e-27 104
LLPS-Brr-0563Brassica rapa53.02e-26 102
LLPS-Art-2649Arabidopsis thaliana53.01e-26 102
LLPS-Pot-1543Populus trichocarpa53.08e-26 100
LLPS-Scs-0047Sclerotinia sclerotiorum52.693e-2189.7
LLPS-Php-0176Physcomitrella patens52.485e-27 103
LLPS-Mua-0262Musa acuminata52.345e-27 103
LLPS-Tru-0931Triticum urartu52.274e-2392.4
LLPS-Sot-0682Solanum tuberosum52.02e-26 101
LLPS-Miv-0151Microbotryum violaceum51.828e-2496.7
LLPS-Pug-0665Puccinia graminis51.81e-28 107
LLPS-Asfu-1099Aspergillus fumigatus51.691e-31 116
LLPS-Ast-0785Aspergillus terreus51.691e-32 119
LLPS-Nef-0665Neosartorya fischeri51.691e-31 116
LLPS-Sol-1874Solanum lycopersicum51.08e-26 100
LLPS-Nia-1770Nicotiana attenuata51.01e-2599.8
LLPS-Gas-0597Galdieria sulphuraria50.961e-26 102
LLPS-Asc-1161Aspergillus clavatus50.859e-31 114
LLPS-Amt-0547Amborella trichopoda50.54e-2598.2
LLPS-Scc-0072Schizosaccharomyces cryophilus50.455e-28 106
LLPS-Dos-0670Dothistroma septosporum49.511e-2292.8
LLPS-Chr-0523Chlamydomonas reinhardtii49.53e-2598.6
LLPS-Sei-0886Setaria italica49.52e-2496.3
LLPS-Orb-0414Oryza barthii49.57e-2495.1
LLPS-Ori-0575Oryza indica49.57e-2495.1
LLPS-Orr-0078Oryza rufipogon49.57e-2495.1
LLPS-Orm-0978Oryza meridionalis49.55e-2496.3
LLPS-Ors-1697Oryza sativa49.57e-2495.1
LLPS-Orp-1768Oryza punctata49.56e-2495.1
LLPS-Sob-0709Sorghum bicolor49.52e-2496.7
LLPS-Cym-0531Cyanidioschyzon merolae49.457e-2084.3
LLPS-Mel-0204Melampsora laricipopulina49.291e-31 115
LLPS-Asf-0439Aspergillus flavus49.152e-29 110
LLPS-Usm-0789Ustilago maydis49.152e-33 120
LLPS-Hov-1731Hordeum vulgare49.07e-2290.1
LLPS-Tra-1117Triticum aestivum48.65e-2495.5
LLPS-Brd-1004Brachypodium distachyon48.69e-2495.1
LLPS-Zem-1269Zea mays48.61e-2394.7
LLPS-Crn-1182Cryptococcus neoformans48.281e-27 105
LLPS-Blg-0023Blumeria graminis48.03e-26 102
LLPS-Asg-0665Ashbya gossypii47.112e-28 107
LLPS-Kop-0784Komagataella pastoris46.885e-2599.0
LLPS-Scp-0048Schizosaccharomyces pombe46.673e-29 109
LLPS-Spr-1250Sporisorium reilianum46.273e-34 122
LLPS-Orbr-1069Oryza brachyantha46.023e-2188.6
LLPS-Osl-0053Ostreococcus lucimarinus45.459e-27 102
LLPS-Scj-0711Schizosaccharomyces japonicus45.382e-27 105
LLPS-Mao-0298Magnaporthe oryzae45.35e-2189.0
LLPS-Zyt-1376Zymoseptoria tritici44.763e-2290.9
LLPS-Fuv-0350Fusarium verticillioides44.72e-1984.7
LLPS-Sac-0224Saccharomyces cerevisiae42.152e-2498.2
LLPS-Fus-0894Fusarium solani41.675e-1983.2
LLPS-Yal-0828Yarrowia lipolytica38.283e-1675.5
LLPS-Tum-1151Tuber melanosporum36.893e-0955.5
LLPS-Beb-0378Beauveria bassiana36.052e-1882.0
LLPS-Pyt-0274Pyrenophora teres35.613e-1367.8
LLPS-Orgl-1858Oryza glumaepatula34.292e-1058.9
LLPS-Orni-1215Oryza nivara34.292e-1058.9
LLPS-Phn-0279Phaeosphaeria nodorum33.834e-1367.4
LLPS-Lem-0188Leptosphaeria maculans33.336e-1264.3
LLPS-Anp-2833Anas platyrhynchos32.987e-0954.3