LLPS-Mum-1459
Xrn2

▼ OVERVIEW

Status: Reviewed
Protein Name: 5'-3' exoribonuclease 2; Protein Dhm1
Gene Name: Xrn2, Dhm1
Ensembl Gene: ENSMUSG00000027433.5
Ensembl Protein: ENSMUSP00000028921.5
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
P-body, Stress granulePredicted from orthologsN/A(View)

▼ FUNCTION

Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGVPAFFRWL  SRKYPSIIVN  CVEEKPKECN  GVKIPVDASK  PNPNDVEFDN  LYLDMNGIIH  60
61    PCTHPEDKPA  PKNEDEMMVA  IFEYIDRLFN  IVRPRRLLYM  AIDGVAPRAK  MNQQRSRRFR  120
121   ASKEGMEAAV  EKQRVREEIL  AKGGFLPPEE  IKERFDSNCI  TPGTEFMDNL  AKCLRYYIAD  180
181   RLNNDPGWKN  LTVILSDASA  PGEGEHKIMD  YIRRQRAQPN  HDPNTHHCLC  GADADLIMLG  240
241   LATHEPNFTI  IREEFKPNKP  KPCALCNQFG  HEVKDCEGLP  REKKGKHDEL  ADSLPCAEGE  300
301   FIFLRLNVLR  EYLERELTMA  SLPFPFDVER  SIDDWVFMCF  FVGNDFLPHL  PSLEIREGAI  360
361   DRLVNIYKNV  VHKTGGYLTE  SGYVNLQRVQ  MIMLAVGEVE  DSIFKKRKDD  EDSFRRRQKE  420
421   KRKRMKRDQP  AFTPSGILTP  HALGSRNSPG  CQVASNPRQA  AYEMRMQRNS  SPSISPNTSF  480
481   ASDGSPSPLG  GIKRKAEDSD  SEPEPEDNVR  LWEAGWKQRY  YKNKFDVDAA  DEKFRRKVVQ  540
541   SYVEGLCWVL  RYYYQGCASW  KWYYPFHYAP  FASDFEGIAD  MSSEFEKGTK  PFKPLEQLMG  600
601   VFPAASGNFL  PPTWRKLMSD  PDSSIIDFYP  EDFAIDLNGK  KYAWQGVALL  PFVDERRLRA  660
661   ALEEVYPDLT  PEENRRNSLG  GDVLFVGKLH  PLRDFILELY  QTGSTEPVDV  PPELCHGIQG  720
721   TFSLDEEAIL  PDQTVCSPVP  MLRDLTQNTA  VSINFKDPQF  AEDYVFKAAM  LPGARKPATV  780
781   LKPGDWEKSS  NGRQWKPQLG  FNRDRRPVHL  DQAAFRTLGH  VTPRGSGTSV  YTNTALPPAN  840
841   YQGNNYRPLL  RGQAQIPKLM  SNMRPQDSWR  GPPPLFQQHR  FERSVGAEPL  LPWNRMIQNQ  900
901   NAAFQPNQYQ  MLGGPGGYPP  RRDDHRGGRQ  GYPREGRKYP  LPPPSGRYSW  N  951
Nucleotide CDS Sequence (FASTA)
1     ATGGGAGTCC  CGGCGTTCTT  CCGCTGGCTC  AGCCGCAAGT  ACCCGTCCAT  CATTGTCAAC  60
61    TGCGTGGAGG  AGAAGCCAAA  AGAATGCAAC  GGTGTAAAGA  TTCCAGTTGA  TGCCAGTAAA  120
121   CCTAATCCAA  ATGATGTGGA  GTTTGATAAT  CTGTATTTGG  ATATGAATGG  GATCATCCAC  180
181   CCCTGCACTC  ATCCTGAAGA  CAAACCAGCA  CCAAAAAATG  AAGATGAAAT  GATGGTTGCA  240
241   ATTTTTGAGT  ACATTGACAG  ACTTTTCAAT  ATTGTAAGAC  CAAGAAGACT  TCTCTACATG  300
301   GCAATAGATG  GGGTGGCACC  ACGTGCAAAA  ATGAATCAGC  AGCGTTCAAG  GAGGTTCAGA  360
361   GCATCAAAGG  AAGGAATGGA  AGCAGCAGTT  GAGAAGCAGC  GAGTCAGAGA  GGAAATACTT  420
421   GCAAAAGGTG  GCTTTCTTCC  TCCAGAAGAA  ATAAAAGAAA  GATTTGACAG  CAACTGTATT  480
481   ACCCCAGGAA  CTGAGTTCAT  GGACAATCTT  GCTAAATGCC  TTCGCTATTA  CATAGCTGAT  540
541   CGTTTAAATA  ATGACCCTGG  GTGGAAAAAT  TTGACAGTTA  TATTATCTGA  TGCTAGTGCA  600
601   CCTGGTGAAG  GAGAACACAA  AATCATGGAT  TACATTAGAA  GACAAAGAGC  CCAGCCTAAC  660
661   CATGACCCAA  ATACTCATCA  TTGTTTGTGT  GGAGCTGATG  CTGATCTAAT  TATGCTTGGT  720
721   CTTGCTACAC  ATGAACCTAA  CTTCACCATA  ATCAGAGAAG  AATTCAAACC  AAATAAACCT  780
781   AAACCATGTG  CTCTTTGTAA  TCAGTTTGGA  CACGAGGTCA  AGGATTGTGA  AGGTTTGCCA  840
841   AGAGAAAAGA  AGGGAAAGCA  TGATGAACTT  GCAGATAGTC  TTCCTTGTGC  AGAAGGGGAG  900
901   TTTATCTTCC  TTCGGCTGAA  TGTCCTTCGA  GAGTATCTGG  AAAGAGAACT  CACCATGGCC  960
961   AGCTTACCAT  TCCCATTTGA  TGTGGAGAGG  AGCATTGATG  ACTGGGTGTT  CATGTGCTTC  1020
1021  TTTGTGGGGA  ATGATTTCCT  TCCTCACTTG  CCATCACTAG  AGATTAGGGA  AGGTGCAATT  1080
1081  GATCGTTTGG  TTAACATATA  CAAAAACGTG  GTACACAAAA  CTGGGGGTTA  CCTTACAGAA  1140
1141  AGTGGTTATG  TCAATCTGCA  AAGAGTACAG  ATGATCATGT  TAGCAGTTGG  TGAAGTTGAG  1200
1201  GATAGCATTT  TTAAAAAGAG  AAAAGATGAT  GAGGACAGTT  TTAGAAGACG  ACAGAAAGAA  1260
1261  AAAAGAAAGA  GGATGAAGAG  AGATCAACCA  GCTTTTACTC  CTAGTGGAAT  ATTAACACCT  1320
1321  CATGCCTTGG  GTTCAAGAAA  TTCACCAGGT  TGTCAAGTAG  CCAGTAATCC  AAGACAAGCA  1380
1381  GCCTATGAAA  TGAGGATGCA  GAGAAACTCT  AGTCCTTCAA  TATCTCCTAA  TACAAGTTTT  1440
1441  GCATCTGATG  GCTCCCCATC  TCCACTAGGA  GGAATTAAGA  GAAAAGCAGA  AGACAGTGAC  1500
1501  AGTGAGCCAG  AGCCAGAGGA  TAACGTCAGG  TTATGGGAAG  CTGGTTGGAA  GCAACGATAC  1560
1561  TACAAGAACA  AATTTGATGT  AGATGCAGCT  GATGAGAAAT  TCCGACGTAA  GGTTGTTCAG  1620
1621  TCCTACGTTG  AAGGACTGTG  CTGGGTTCTT  CGCTATTATT  ACCAGGGCTG  TGCTTCCTGG  1680
1681  AAGTGGTATT  ATCCATTCCA  TTATGCACCA  TTTGCCTCAG  ACTTTGAAGG  TATTGCAGAC  1740
1741  ATGTCCTCTG  AATTTGAAAA  GGGCACAAAA  CCGTTTAAGC  CACTGGAACA  ACTAATGGGG  1800
1801  GTTTTCCCAG  CTGCAAGTGG  TAACTTTCTA  CCTCCAACAT  GGCGGAAGCT  CATGAGTGAC  1860
1861  CCTGATTCCA  GTATAATTGA  CTTCTATCCT  GAAGATTTTG  CTATTGATTT  GAATGGGAAG  1920
1921  AAATATGCAT  GGCAAGGTGT  TGCTCTATTG  CCATTTGTGG  ATGAGCGAAG  GCTGCGAGCG  1980
1981  GCTCTAGAAG  AGGTGTACCC  AGACCTCACT  CCAGAAGAGA  ACAGGAGAAA  TAGTCTTGGA  2040
2041  GGTGATGTTT  TGTTTGTGGG  AAAACTTCAT  CCACTACGCG  ACTTCATTTT  AGAGCTGTAT  2100
2101  CAGACGGGTT  CCACAGAGCC  AGTTGATGTG  CCACCTGAAT  TGTGTCACGG  GATTCAAGGG  2160
2161  ACGTTTTCTT  TGGATGAAGA  AGCCATTCTT  CCAGACCAAA  CAGTATGTTC  CCCTGTGCCC  2220
2221  ATGTTGCGGG  ACCTGACACA  GAACACTGCA  GTCAGTATTA  ATTTTAAAGA  TCCACAGTTT  2280
2281  GCTGAAGATT  ATGTTTTTAA  AGCTGCAATG  CTTCCAGGAG  CAAGAAAGCC  AGCAACAGTT  2340
2341  CTGAAACCTG  GTGACTGGGA  AAAATCCAGC  AATGGGCGGC  AATGGAAACC  TCAGCTTGGC  2400
2401  TTTAACCGGG  ACCGGCGGCC  TGTTCACCTG  GACCAGGCAG  CCTTTAGAAC  TTTAGGCCAT  2460
2461  GTTACACCAA  GAGGCTCGGG  GACGAGTGTT  TATACGAACA  CTGCACTACC  ACCTGCCAAT  2520
2521  TACCAGGGGA  ACAATTACAG  GCCACTGCTG  AGAGGTCAAG  CTCAGATCCC  AAAACTTATG  2580
2581  TCAAATATGA  GGCCCCAAGA  TTCCTGGCGA  GGCCCTCCTC  CTCTTTTCCA  GCAGCATAGA  2640
2641  TTTGAGAGAA  GTGTTGGAGC  TGAACCTCTA  CTGCCATGGA  ACCGGATGAT  CCAAAACCAA  2700
2701  AATGCAGCCT  TTCAGCCAAA  TCAGTACCAG  ATGCTAGGAG  GACCTGGAGG  CTATCCACCC  2760
2761  AGACGTGACG  ATCACCGAGG  AGGGAGACAG  GGATATCCCA  GAGAAGGACG  GAAATACCCT  2820
2821  TTGCCACCAC  CCTCGGGAAG  ATACAGTTGG  AATTAG  2856

▼ KEYWORD

ID
Family
Acetylation
Alternative splicing
Complete proteome
DNA-binding
Exonuclease
Hydrolase
Metal-binding
Methylation
mRNA processing
Nuclease
Nucleus
Phosphoprotein
Reference proteome
Transcription
Transcription regulation
Transcription termination
Zinc
Zinc-finger

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Aggresome
Cellular Component
Nucleolus
Cellular Component
Nucleus
Molecular Function
3'-5'-exoribonuclease activity
Molecular Function
5'-3' exonuclease activity
Molecular Function
5'-3' exoribonuclease activity
Molecular Function
Metal ion binding
Molecular Function
Transcription termination site sequence-specific DNA binding
Biological Process
DNA catabolic process, exonucleolytic
Biological Process
DNA recombination
Biological Process
DNA repair
Biological Process
DNA-templated transcription, termination
Biological Process
Hippocampus development
Biological Process
Microtubule-based process
Biological Process
MRNA processing
Biological Process
Neuron differentiation
Biological Process
Retina development in camera-type eye
Biological Process
RNA metabolic process
Biological Process
Spermatogenesis

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-1278Rattus norvegicus97.690.01804
LLPS-Rhb-0991Rhinopithecus bieti97.310.01594
LLPS-Paa-1097Papio anubis96.270.01771
LLPS-Mea-1960Mesocricetus auratus96.210.01806
LLPS-Orc-0297Oryctolagus cuniculus95.480.01796
LLPS-Pap-0290Pan paniscus95.480.01797
LLPS-Pat-0967Pan troglodytes95.480.01797
LLPS-Gog-2258Gorilla gorilla95.480.01797
LLPS-Nol-0076Nomascus leucogenys95.370.01796
LLPS-Mam-0738Macaca mulatta95.370.01796
LLPS-Chs-0124Chlorocebus sabaeus95.370.01796
LLPS-Maf-1826Macaca fascicularis95.370.01796
LLPS-Cea-1282Cercocebus atys95.370.01796
LLPS-Cap-0449Cavia porcellus95.270.01798
LLPS-Hos-0105Homo sapiens95.270.01793
LLPS-Man-0165Macaca nemestrina95.270.01796
LLPS-Ict-1693Ictidomys tridecemlineatus95.060.01795
LLPS-Caf-1749Canis familiaris94.950.01789
LLPS-Poa-0647Pongo abelii94.950.01785
LLPS-Aim-0452Ailuropoda melanoleuca94.950.01785
LLPS-Fud-1565Fukomys damarensis94.950.01793
LLPS-Fec-2832Felis catus94.740.01787
LLPS-Caj-0137Callithrix jacchus94.740.01785
LLPS-Urm-1966Ursus maritimus94.710.01732
LLPS-Myl-0799Myotis lucifugus94.640.01783
LLPS-Aon-3127Aotus nancymaae94.640.01785
LLPS-Eqc-3488Equus caballus94.620.01776
LLPS-Otg-1278Otolemur garnettii94.540.01780
LLPS-Cas-1851Carlito syrichta94.220.01781
LLPS-Loa-1408Loxodonta africana93.690.01769
LLPS-Mup-1457Mustela putorius furo93.180.01780
LLPS-Mal-1665Mandrillus leucophaeus93.170.01747
LLPS-Sus-1479Sus scrofa93.060.01736
LLPS-Bot-1821Bos taurus92.750.01754
LLPS-Dio-0262Dipodomys ordii92.740.01736
LLPS-Ova-1478Ovis aries92.660.01702
LLPS-Ora-1406Ornithorhynchus anatinus89.40.01693
LLPS-Mod-0212Monodelphis domestica89.170.01684
LLPS-Pes-0002Pelodiscus sinensis87.110.01358
LLPS-Fia-1750Ficedula albicollis83.790.01543
LLPS-Meg-0402Meleagris gallopavo83.220.01520
LLPS-Anp-0686Anas platyrhynchos83.060.01501
LLPS-Gaga-0456Gallus gallus82.370.01550
LLPS-Tag-1688Taeniopygia guttata82.330.01498
LLPS-Anc-1795Anolis carolinensis79.60.01489
LLPS-Lac-1188Latimeria chalumnae74.810.01320
LLPS-Gaa-0902Gasterosteus aculeatus74.640.01276
LLPS-Xet-0285Xenopus tropicalis73.510.01395
LLPS-Scm-2179Scophthalmus maximus73.360.01301
LLPS-Asm-2211Astyanax mexicanus73.040.01322
LLPS-Orn-3066Oreochromis niloticus72.450.01317
LLPS-Orl-0269Oryzias latipes72.140.01306
LLPS-Leo-2675Lepisosteus oculatus71.910.01345
LLPS-Ten-1284Tetraodon nigroviridis71.90.01332
LLPS-Scf-0771Scleropages formosus71.310.01334
LLPS-Dar-2002Danio rerio69.950.01332
LLPS-Icp-2235Ictalurus punctatus69.550.01315
LLPS-Xim-1329Xiphophorus maculatus68.520.01291
LLPS-Pof-2316Poecilia formosa68.450.01296
LLPS-Tar-3110Takifugu rubripes67.50.01305
LLPS-Nia-1324Nicotiana attenuata60.051e-156 497
LLPS-Usm-0261Ustilago maydis59.811e-151 488
LLPS-Orbr-1275Oryza brachyantha59.81e-142 459
LLPS-Cii-0076Ciona intestinalis59.670.0 980
LLPS-Spr-0847Sporisorium reilianum59.322e-149 482
LLPS-Org-0802Oryza glaberrima58.823e-139 450
LLPS-Orr-0087Oryza rufipogon58.823e-139 450
LLPS-Orm-0043Oryza meridionalis58.823e-139 450
LLPS-Ors-0535Oryza sativa58.822e-139 450
LLPS-Orp-1087Oryza punctata58.823e-139 450
LLPS-Orgl-0145Oryza glumaepatula58.822e-139 451
LLPS-Orni-0923Oryza nivara58.822e-139 451
LLPS-Ori-0344Oryza indica58.822e-139 451
LLPS-Orb-0518Oryza barthii58.823e-139 450
LLPS-Hov-0040Hordeum vulgare58.093e-135 439
LLPS-Sol-1096Solanum lycopersicum58.097e-143 461
LLPS-Dac-2380Daucus carota57.952e-147 471
LLPS-Gor-1559Gossypium raimondii57.467e-147 468
LLPS-Sot-0181Solanum tuberosum57.352e-141 457
LLPS-Asfu-0929Aspergillus fumigatus57.284e-161 508
LLPS-Asc-0672Aspergillus clavatus57.283e-162 510
LLPS-Blg-1118Blumeria graminis57.256e-158 498
LLPS-Gas-0233Galdieria sulphuraria57.143e-1894.0
LLPS-Nef-0198Neosartorya fischeri56.85e-160 505
LLPS-Art-1044Arabidopsis thaliana56.721e-141 453
LLPS-Arl-0747Arabidopsis lyrata56.724e-142 457
LLPS-Mae-2408Manihot esculenta56.492e-147 469
LLPS-Asf-0292Aspergillus flavus56.351e-159 503
LLPS-Aso-0088Aspergillus oryzae56.351e-159 503
LLPS-Thc-1863Theobroma cacao56.351e-143 459
LLPS-Scc-0543Schizosaccharomyces cryophilus56.282e-139 449
LLPS-Asn-0397Aspergillus nidulans56.224e-159 502
LLPS-Ved-0446Verticillium dahliae56.191e-158 500
LLPS-Brr-2673Brassica rapa56.138e-138 443
LLPS-Vir-1221Vigna radiata56.133e-139 446
LLPS-Via-2370Vigna angularis56.137e-139 446
LLPS-Brn-0355Brassica napus56.139e-138 443
LLPS-Sac-1194Saccharomyces cerevisiae56.111e-57 219
LLPS-Lep-1457Leersia perrieri55.994e-135 437
LLPS-Cis-1147Ciona savignyi55.990.0 956
LLPS-Drm-0592Drosophila melanogaster55.880.0 882
LLPS-Ast-1113Aspergillus terreus55.851e-158 500
LLPS-Scp-0200Schizosaccharomyces pombe55.827e-138 444
LLPS-Prp-1358Prunus persica55.756e-143 457
LLPS-Chr-1612Chlamydomonas reinhardtii55.752e-138 452
LLPS-Sei-0315Setaria italica55.752e-135 438
LLPS-Mua-0481Musa acuminata55.646e-140 449
LLPS-Met-0962Medicago truncatula55.617e-140 449
LLPS-Put-0790Puccinia triticina55.582e-148 476
LLPS-Amt-0283Amborella trichopoda55.583e-142 454
LLPS-Pytr-1362Pyrenophora triticirepentis55.565e-144 464
LLPS-Pyt-1204Pyrenophora teres55.561e-146 464
LLPS-Coc-0269Corchorus capsularis55.536e-144 459
LLPS-Zem-0949Zea mays55.55e-135 437
LLPS-Sob-2175Sorghum bicolor55.52e-134 436
LLPS-Bro-0513Brassica oleracea55.391e-134 435
LLPS-Pot-1545Populus trichocarpa55.376e-142 454
LLPS-Cae-0124Caenorhabditis elegans55.260.0 916
LLPS-Abg-0390Absidia glauca55.226e-147 471
LLPS-Hea-0209Helianthus annuus55.184e-139 446
LLPS-Trr-0786Trichoderma reesei55.111e-152 484
LLPS-Miv-1362Microbotryum violaceum54.851e-137 449
LLPS-Tra-0358Triticum aestivum54.812e-132 431
LLPS-Mel-1180Melampsora laricipopulina54.731e-97 319
LLPS-Tru-0596Triticum urartu54.336e-128 426
LLPS-Glm-1782Glycine max54.242e-136 440
LLPS-Phv-1486Phaseolus vulgaris54.033e-137 441
LLPS-Phn-0798Phaeosphaeria nodorum54.015e-140 451
LLPS-Cus-0737Cucumis sativus53.923e-127 414
LLPS-Pug-0272Puccinia graminis53.99e-148 476
LLPS-Crn-0446Cryptococcus neoformans53.791e-141 458
LLPS-Lem-0475Leptosphaeria maculans53.431e-139 452
LLPS-Brd-0142Brachypodium distachyon53.124e-137 442
LLPS-Scj-1171Schizosaccharomyces japonicus52.724e-131 426
LLPS-Kop-0812Komagataella pastoris51.463e-133 432
LLPS-Php-0609Physcomitrella patens49.10.0 708
LLPS-Osl-0556Ostreococcus lucimarinus48.974e-38 154
LLPS-Tum-0484Tuber melanosporum48.178e-120 394
LLPS-Fuo-0878Fusarium oxysporum47.730.0 548
LLPS-Asg-0110Ashbya gossypii47.71e-141 453
LLPS-Viv-0516Vitis vinifera46.640.0 701
LLPS-Yal-0893Yarrowia lipolytica46.545e-115 384
LLPS-Cogr-0647Colletotrichum graminicola46.280.0 681
LLPS-Mao-1232Magnaporthe oryzae46.240.0 719
LLPS-Coo-0596Colletotrichum orbiculare45.90.0 663
LLPS-Asni-0109Aspergillus niger45.870.0 748
LLPS-Beb-0321Beauveria bassiana45.760.0 697
LLPS-Cog-0753Colletotrichum gloeosporioides45.660.0 700
LLPS-Fuv-0515Fusarium verticillioides45.510.0 680
LLPS-Gag-0989Gaeumannomyces graminis45.450.0 705
LLPS-Map-0267Magnaporthe poae45.040.0 707
LLPS-Nec-0239Neurospora crassa43.980.0 681
LLPS-Scs-0291Sclerotinia sclerotiorum40.520.0 624
LLPS-Cym-0451Cyanidioschyzon merolae37.645e-128 429