• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Beb-0321
RAT1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: 5'-3' exoribonuclease
Gene Name: RAT1, BM221_000891
Ensembl Gene: BB8028_0008g02550
Ensembl Protein: BB8028_0008g02550.1
Organism: Beauveria bassiana
Taxa ID: 176275
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nuclear speckle, Nucleolus, P-body, Stress granulePredicted from orthologs(View)

▼ FUNCTION

Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGIPAAFRWL  SNKYPKIISP  VVEDRPIVMD  DGTEIPVDIT  RANPNGEELD  NLYLDMNGIV  60
61    HPCAHPEDKP  APKDEEEMML  EIFKYTDRVV  NMVRPRKILM  IAVDGVAPRA  KMNQQRSRRF  120
121   RSAQEAKEKE  NDKQELIKLL  KQQNGGSLTA  ESTESVTKKA  FDNNSITPGT  PFMDILASSL  180
181   RYWCQYKLNT  DPGWAKLKVI  ISDATVPGEG  EHKIMNFVRS  QRASPDYDPN  TRHVIYGLDA  240
241   DLIMLGLATH  EPHFRVLRED  VFFQDSKARA  CKLCGQKGHD  AQNCKGETKE  PTEEFDAKDN  300
301   ALTLKPFIWL  HVSVLREYLA  AELAIPELPF  RFDLERVIDD  WIFMCCFVGN  DFLPHLPALE  360
361   IREHGIDTLT  TIWKRNLPAL  GGYITKDGHI  DLERAQCILD  GLAGQEDMIF  KKRREQEDRR  420
421   EASAKRRRLQ  NNGATGRDNR  SDGKGLKSGH  EDPSRGLALH  PIGSMPIAPL  RAITHDMTVN  480
481   RTGAADANVA  NKSAASVLKE  RLKAGRGALS  PEANSKDTKD  PPSHSVPVKR  KLSAVEAFAE  540
541   STSNDAQGTN  TPGDKPEIPA  DPVRLWEDGY  ADRYYQLKFH  RDPGDISFRT  HVAHAYVEGL  600
601   AWVLQYYFQG  CPSWEWYYPY  HYAPFAADFK  DISQANVTFE  KGTVSRPFEQ  LMSVLPAASR  660
661   DNLPEVFHSL  MTDQDSLIID  FYPEEFEVDL  NGKKMAWQGV  ALLPFIEMDR  LLAAVQKRYP  720
721   LLSDEDRKRN  GVGRDVLLLS  DSHESIYDEI  LTNFYSKKQG  STQFRLNPKT  SDGLSGYVEK  780
781   QEGYVPHGTL  HYPLERKSMP  DLDYDRSMSV  NYDMPKMTHD  HKSMLLRGVK  MPSPALTRSD  840
841   IEVLRGKASR  GGYSGGNRGG  RYDPGGQHHF  RQNGRGRGQD  FGHGRPQSNY  HRREDPRPLP  900
901   HQHFRGQGGW  QPPHPGSSGF  GRGVPPPPPP  AHEQGWSSQS  FDASVYSYGP  SQGHHLPRGG  960
961   YHSRGRWN  968
Nucleotide CDS Sequence (FASTA)
1     ATGGGTATTC  CAGCTGCCTT  TCGATGGCTT  TCGAACAAGT  ATCCGAAGAT  CATATCTCCT  60
61    GTGGTCGAGG  ATCGGCCCAT  CGTCATGGAC  GATGGCACCG  AGATACCAGT  CGACATTACT  120
121   CGTGCAAATC  CAAACGGCGA  AGAGCTGGAC  AATCTCTATC  TCGACATGAA  TGGCATTGTT  180
181   CATCCCTGTG  CACATCCGGA  AGACAAGCCA  GCCCCTAAAG  ATGAAGAAGA  AATGATGCTT  240
241   GAAATCTTTA  AGTACACGGA  CAGAGTGGTT  AACATGGTTC  GACCACGAAA  GATTCTCATG  300
301   ATAGCAGTCG  ATGGCGTTGC  GCCCCGTGCC  AAGATGAATC  AACAACGATC  GAGACGATTT  360
361   CGATCGGCAC  AGGAAGCCAA  AGAAAAAGAA  AATGACAAGC  AAGAGCTGAT  CAAGCTGCTC  420
421   AAACAGCAAA  ATGGGGGCAG  TCTTACTGCT  GAGAGCACTG  AATCTGTAAC  GAAGAAAGCA  480
481   TTCGACAACA  ATTCGATCAC  GCCTGGCACA  CCTTTTATGG  ATATACTGGC  AAGCAGCCTT  540
541   CGCTATTGGT  GCCAGTATAA  ACTGAATACG  GATCCTGGTT  GGGCGAAACT  GAAGGTCATT  600
601   ATCTCAGACG  CTACCGTACC  AGGCGAGGGC  GAACATAAGA  TCATGAATTT  TGTTAGATCC  660
661   CAGCGCGCTA  GCCCCGATTA  TGACCCTAAC  ACTCGGCATG  TCATCTACGG  TCTGGACGCT  720
721   GATCTGATTA  TGCTAGGACT  TGCAACTCAC  GAGCCGCATT  TTCGCGTCCT  GCGCGAAGAT  780
781   GTCTTCTTTC  AGGACAGCAA  AGCTCGGGCC  TGTAAGCTTT  GCGGTCAGAA  AGGGCACGAT  840
841   GCGCAAAATT  GCAAAGGTGA  AACAAAAGAG  CCAACTGAAG  AGTTTGACGC  AAAGGACAAT  900
901   GCATTGACAC  TTAAGCCTTT  CATTTGGCTG  CATGTCTCCG  TGCTAAGAGA  ATACCTGGCC  960
961   GCTGAACTCG  CAATTCCTGA  GCTCCCTTTC  CGTTTCGATC  TCGAGCGCGT  CATCGATGAC  1020
1021  TGGATCTTCA  TGTGCTGCTT  TGTAGGAAAT  GACTTTCTTC  CACACTTACC  GGCTTTGGAA  1080
1081  ATACGTGAAC  ACGGCATTGA  CACCCTTACA  ACCATCTGGA  AACGCAATCT  ACCCGCACTC  1140
1141  GGTGGTTACA  TCACAAAAGA  TGGTCACATT  GACTTGGAAC  GAGCTCAGTG  TATTTTGGAC  1200
1201  GGACTTGCTG  GGCAGGAAGA  TATGATTTTC  AAGAAGAGAA  GAGAACAGGA  AGACCGCCGT  1260
1261  GAAGCGAGTG  CAAAACGTCG  CCGACTGCAG  AATAATGGCG  CGACCGGACG  GGATAACCGC  1320
1321  AGTGATGGTA  AAGGTCTCAA  AAGCGGACAC  GAAGACCCTT  CACGTGGGCT  TGCTCTGCAT  1380
1381  CCCATCGGAT  CAATGCCAAT  CGCACCGTTG  AGAGCCATCA  CTCATGACAT  GACTGTCAAT  1440
1441  CGCACGGGTG  CGGCCGACGC  GAATGTTGCC  AACAAAAGTG  CTGCGAGTGT  ACTCAAAGAG  1500
1501  CGCTTGAAGG  CAGGTAGAGG  AGCTTTAAGC  CCCGAAGCAA  ATTCGAAAGA  CACAAAAGAT  1560
1561  CCTCCATCAC  ACTCAGTACC  GGTCAAAAGG  AAACTCTCAG  CTGTCGAGGC  ATTTGCGGAG  1620
1621  TCGACTTCAA  ACGATGCGCA  AGGCACGAAC  ACTCCGGGTG  ATAAACCTGA  GATCCCAGCG  1680
1681  GACCCGGTTA  GGCTATGGGA  AGATGGATAT  GCTGATCGCT  ACTACCAGCT  CAAATTCCAC  1740
1741  AGAGACCCTG  GCGACATATC  CTTTCGCACA  CATGTTGCCC  ATGCATATGT  TGAAGGATTG  1800
1801  GCGTGGGTTT  TGCAGTATTA  TTTTCAAGGC  TGCCCGTCCT  GGGAATGGTA  TTATCCATAC  1860
1861  CATTACGCAC  CATTCGCAGC  CGATTTCAAA  GACATATCGC  AGGCCAATGT  TACGTTCGAA  1920
1921  AAAGGCACCG  TCTCTCGACC  GTTCGAACAG  CTCATGAGTG  TCCTGCCAGC  TGCTTCGCGT  1980
1981  GATAATTTGC  CGGAAGTGTT  TCATAGTTTG  ATGACTGACC  AGGACAGTCT  CATCATTGAT  2040
2041  TTTTATCCAG  AAGAGTTCGA  AGTTGACTTA  AATGGAAAAA  AGATGGCGTG  GCAAGGAGTT  2100
2101  GCACTGCTGC  CTTTCATTGA  AATGGACCGC  CTTCTGGCAG  CTGTGCAGAA  GAGATACCCA  2160
2161  CTACTTAGTG  ACGAAGACAG  GAAGCGCAAC  GGTGTCGGAA  GAGATGTCTT  GCTCTTGTCA  2220
2221  GATAGCCATG  AGAGCATCTA  CGACGAGATC  CTGACAAATT  TCTACTCCAA  AAAGCAGGGC  2280
2281  TCTACTCAGT  TCAGACTCAA  CCCCAAGACA  AGCGACGGAC  TCTCTGGCTA  CGTTGAGAAG  2340
2341  CAAGAAGGGT  ATGTGCCACA  TGGAACGCTA  CATTATCCCC  TTGAACGCAA  GTCTATGCCA  2400
2401  GACCTAGACT  ATGACCGCTC  CATGAGCGTT  AATTATGACA  TGCCGAAAAT  GACCCATGAT  2460
2461  CATAAGTCGA  TGCTCCTGCG  TGGAGTCAAA  ATGCCAAGCC  CCGCACTCAC  GCGAAGTGAT  2520
2521  ATAGAGGTTT  TGCGAGGGAA  GGCATCGAGA  GGTGGATACA  GCGGCGGCAA  CCGCGGAGGA  2580
2581  CGCTATGACC  CTGGTGGACA  ACACCACTTC  AGGCAGAATG  GAAGGGGTAG  GGGACAAGAT  2640
2641  TTTGGTCATG  GCCGCCCGCA  GTCAAATTAC  CACAGGCGCG  AGGATCCGCG  CCCTCTTCCC  2700
2701  CATCAGCACT  TTCGTGGACA  GGGTGGTTGG  CAGCCTCCAC  ATCCTGGCTC  TTCCGGCTTT  2760
2761  GGAAGAGGTG  TTCCACCACC  ACCTCCTCCG  GCACATGAAC  AAGGCTGGAG  TTCCCAAAGC  2820
2821  TTTGACGCTA  GTGTTTACAG  CTACGGTCCT  AGTCAAGGCC  ATCATCTCCC  GAGAGGTGGT  2880
2881  TACCATTCTC  GTGGTCGATG  GAATTGA  2907

▼ KEYWORD

ID
Family
Coiled coil
Complete proteome
Exonuclease
Hydrolase
Metal-binding
mRNA processing
Nuclease
Reference proteome
Zinc
Zinc-finger

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nucleus
Molecular Function
5'-3' exoribonuclease activity
Molecular Function
Nucleic acid binding
Molecular Function
Zinc ion binding
Biological Process
MRNA processing

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Trv-0098Trichoderma virens82.543e-96 308
LLPS-Fuo-0878Fusarium oxysporum74.030.0 880
LLPS-Fuv-0515Fusarium verticillioides73.390.01189
LLPS-Cogr-0647Colletotrichum graminicola70.330.01197
LLPS-Cog-0753Colletotrichum gloeosporioides70.310.01209
LLPS-Gag-0989Gaeumannomyces graminis70.050.01186
LLPS-Trr-0786Trichoderma reesei69.740.01214
LLPS-Ved-0446Verticillium dahliae69.560.01193
LLPS-Coo-0596Colletotrichum orbiculare68.410.01101
LLPS-Map-0267Magnaporthe poae67.440.01200
LLPS-Nec-0239Neurospora crassa67.280.01136
LLPS-Mao-1232Magnaporthe oryzae66.130.01158
LLPS-Put-0790Puccinia triticina63.176e-172 540
LLPS-Mel-1180Melampsora laricipopulina63.122e-117 372
LLPS-Pug-0272Puccinia graminis62.995e-175 549
LLPS-Usm-0261Ustilago maydis62.735e-163 518
LLPS-Ast-1113Aspergillus terreus61.630.01044
LLPS-Spr-0847Sporisorium reilianum61.422e-162 517
LLPS-Crn-0446Cryptococcus neoformans61.42e-169 532
LLPS-Blg-1118Blumeria graminis61.090.01018
LLPS-Asn-0397Aspergillus nidulans60.820.01028
LLPS-Asc-0672Aspergillus clavatus60.570.01038
LLPS-Miv-1362Microbotryum violaceum60.542e-159 507
LLPS-Scs-0291Sclerotinia sclerotiorum60.070.0 970
LLPS-Scj-1171Schizosaccharomyces japonicus59.351e-152 483
LLPS-Sac-1194Saccharomyces cerevisiae57.997e-161 506
LLPS-Asni-0109Aspergillus niger57.520.01045
LLPS-Tum-0484Tuber melanosporum57.144e-158 495
LLPS-Nef-0198Neosartorya fischeri56.630.01051
LLPS-Asfu-0929Aspergillus fumigatus56.580.01054
LLPS-Asf-0292Aspergillus flavus56.230.01045
LLPS-Aso-0088Aspergillus oryzae56.230.01045
LLPS-Leo-2675Lepisosteus oculatus55.953e-142 455
LLPS-Xet-0285Xenopus tropicalis55.717e-142 455
LLPS-Loa-1408Loxodonta africana55.487e-142 454
LLPS-Ran-1278Rattus norvegicus55.482e-141 453
LLPS-Dio-0262Dipodomys ordii55.481e-141 454
LLPS-Fud-1565Fukomys damarensis55.481e-141 454
LLPS-Mea-1960Mesocricetus auratus55.481e-141 454
LLPS-Cap-0449Cavia porcellus55.241e-141 454
LLPS-Ten-1284Tetraodon nigroviridis55.242e-143 459
LLPS-Mod-0212Monodelphis domestica55.247e-142 454
LLPS-Myl-0799Myotis lucifugus55.242e-141 453
LLPS-Caj-0137Callithrix jacchus55.247e-141 452
LLPS-Aon-3127Aotus nancymaae55.249e-141 452
LLPS-Pes-0002Pelodiscus sinensis54.792e-118 387
LLPS-Pof-2316Poecilia formosa54.762e-141 454
LLPS-Scf-0771Scleropages formosus54.764e-140 450
LLPS-Xim-1329Xiphophorus maculatus54.762e-141 454
LLPS-Gaga-0456Gallus gallus54.298e-140 449
LLPS-Anp-0686Anas platyrhynchos54.18e-130 422
LLPS-Gaa-0902Gasterosteus aculeatus54.012e-139 444
LLPS-Meg-0402Meleagris gallopavo53.94e-137 442
LLPS-Fia-1750Ficedula albicollis53.815e-140 449
LLPS-Php-0609Physcomitrella patens52.212e-131 428
LLPS-Abg-0390Absidia glauca52.181e-132 434
LLPS-Tag-1688Taeniopygia guttata52.131e-127 417
LLPS-Pytr-1362Pyrenophora triticirepentis51.470.0 815
LLPS-Lem-0475Leptosphaeria maculans51.080.0 799
LLPS-Art-1044Arabidopsis thaliana51.047e-130 422
LLPS-Drm-0592Drosophila melanogaster50.91e-131 426
LLPS-Pyt-1204Pyrenophora teres50.510.0 812
LLPS-Coc-0269Corchorus capsularis50.362e-129 421
LLPS-Vir-1221Vigna radiata50.242e-123 404
LLPS-Sol-1096Solanum lycopersicum50.233e-120 400
LLPS-Lep-1457Leersia perrieri50.06e-122 402
LLPS-Thc-1863Theobroma cacao50.07e-128 418
LLPS-Glm-1782Glycine max49.881e-123 406
LLPS-Brr-2673Brassica rapa49.774e-126 412
LLPS-Brn-0355Brassica napus49.775e-126 412
LLPS-Orbr-1275Oryza brachyantha49.654e-122 405
LLPS-Bro-0513Brassica oleracea49.541e-125 411
LLPS-Phv-1486Phaseolus vulgaris49.526e-122 401
LLPS-Nia-1279Nicotiana attenuata49.43e-120 393
LLPS-Met-0962Medicago truncatula49.075e-127 415
LLPS-Via-2370Vigna angularis49.071e-123 406
LLPS-Brd-1195Brachypodium distachyon48.965e-121 403
LLPS-Tra-0358Triticum aestivum48.744e-122 403
LLPS-Sei-0315Setaria italica48.747e-123 405
LLPS-Pot-1545Populus trichocarpa48.733e-123 405
LLPS-Mua-0481Musa acuminata48.617e-119 394
LLPS-Amt-0283Amborella trichopoda48.512e-123 405
LLPS-Org-0802Oryza glaberrima48.492e-120 400
LLPS-Orr-0087Oryza rufipogon48.492e-120 400
LLPS-Orm-0043Oryza meridionalis48.492e-120 400
LLPS-Orp-1087Oryza punctata48.492e-120 400
LLPS-Ors-0535Oryza sativa48.492e-120 400
LLPS-Orgl-0145Oryza glumaepatula48.492e-120 400
LLPS-Orni-0923Oryza nivara48.492e-120 400
LLPS-Ori-0344Oryza indica48.492e-120 400
LLPS-Orb-0518Oryza barthii48.492e-120 400
LLPS-Tru-0596Triticum urartu48.288e-118 399
LLPS-Sob-2175Sorghum bicolor48.282e-122 404
LLPS-Prp-1358Prunus persica48.152e-121 400
LLPS-Mae-2408Manihot esculenta47.92e-121 400
LLPS-Hea-0209Helianthus annuus47.99e-117 387
LLPS-Arl-0747Arabidopsis lyrata47.879e-119 395
LLPS-Phn-0798Phaeosphaeria nodorum47.770.0 716
LLPS-Hov-0914Hordeum vulgare47.754e-96 333
LLPS-Chr-1612Chlamydomonas reinhardtii47.429e-120 402
LLPS-Zem-0949Zea mays47.383e-121 400
LLPS-Scc-0543Schizosaccharomyces cryophilus47.350.0 756
LLPS-Gor-1559Gossypium raimondii47.292e-125 411
LLPS-Ict-2387Ictidomys tridecemlineatus47.28e-41 168
LLPS-Cas-1098Carlito syrichta47.22e-40 166
LLPS-Mam-0955Macaca mulatta47.22e-40 166
LLPS-Eqc-2291Equus caballus47.22e-40 167
LLPS-Hos-0264Homo sapiens47.23e-40 166
LLPS-Pap-1673Pan paniscus47.23e-40 166
LLPS-Urm-0260Ursus maritimus47.22e-40 167
LLPS-Pat-0457Pan troglodytes47.23e-40 166
LLPS-Mup-0056Mustela putorius furo47.22e-40 167
LLPS-Paa-0132Papio anubis47.22e-40 166
LLPS-Cea-1205Cercocebus atys47.23e-40 166
LLPS-Chs-2975Chlorocebus sabaeus47.22e-40 166
LLPS-Maf-1611Macaca fascicularis47.22e-40 166
LLPS-Kop-0812Komagataella pastoris47.120.0 709
LLPS-Dac-2380Daucus carota46.992e-116 389
LLPS-Rhb-1246Rhinopithecus bieti46.583e-40 166
LLPS-Icp-1109Ictalurus punctatus46.582e-39 163
LLPS-Bot-1821Bos taurus46.310.0 680
LLPS-Orl-0269Oryzias latipes46.130.0 674
LLPS-Cus-0737Cucumis sativus46.061e-113 378
LLPS-Aim-0452Ailuropoda melanoleuca46.00.0 677
LLPS-Otg-1278Otolemur garnettii45.950.0 672
LLPS-Mum-1459Mus musculus45.880.0 673
LLPS-Caf-1749Canis familiaris45.760.0 674
LLPS-Fec-2832Felis catus45.760.0 674
LLPS-Ova-1478Ovis aries45.690.0 647
LLPS-Ora-1406Ornithorhynchus anatinus45.470.0 660
LLPS-Asg-0110Ashbya gossypii45.420.0 695
LLPS-Orc-0297Oryctolagus cuniculus45.290.0 666
LLPS-Anc-1795Anolis carolinensis45.210.0 657
LLPS-Poa-0647Pongo abelii45.180.0 665
LLPS-Man-0165Macaca nemestrina45.180.0 665
LLPS-Scm-2179Scophthalmus maximus45.170.0 662
LLPS-Scp-0200Schizosaccharomyces pombe45.170.0 749
LLPS-Lac-1188Latimeria chalumnae45.10.0 634
LLPS-Nol-0076Nomascus leucogenys45.060.0 664
LLPS-Gog-2258Gorilla gorilla45.060.0 663
LLPS-Cae-1322Caenorhabditis elegans44.675e-33 143
LLPS-Orn-3066Oreochromis niloticus44.610.0 654
LLPS-Sus-1479Sus scrofa44.290.0 639
LLPS-Mal-1665Mandrillus leucophaeus43.830.0 634
LLPS-Dar-2002Danio rerio43.780.0 646
LLPS-Osl-0556Ostreococcus lucimarinus43.72e-87 296
LLPS-Tar-3110Takifugu rubripes43.270.0 672
LLPS-Yal-0893Yarrowia lipolytica43.20.0 639
LLPS-Cis-0037Ciona savignyi42.754e-86 306
LLPS-Asm-2211Astyanax mexicanus41.950.0 671
LLPS-Cii-0076Ciona intestinalis41.360.0 605
LLPS-Viv-0516Vitis vinifera41.010.0 609
LLPS-Sot-0181Solanum tuberosum39.750.0 583
LLPS-Gas-0233Galdieria sulphuraria39.78e-142 445