• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Icp-2235
xrn2

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: 5'-3' exoribonuclease
Gene Name: xrn2
Ensembl Gene: ENSIPUG00000006639.1
Ensembl Protein: ENSIPUP00000009687.1
Organism: Ictalurus punctatus
Taxa ID: 7998
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nuclear speckle, Nucleolus, P-body, Stress granulePredicted from orthologs(View)

▼ FUNCTION

Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGVPAFFRWL  SRKYPSIIVH  CVEEKSKECN  GVRIPVDTTK  PNPNEVEFDN  LYLDMNGIIH  60
61    PCTHPEDKPA  PKNEDEMMVA  IFEYIDRLFN  IVRPRRVLYM  AIDGVAPRAK  MNQQRSRRFR  120
121   ASKEGVELAE  EKKKMREEVF  QRGGYLPPDE  IKERFDSNCI  TPGTEFMDNL  AKCLRYYIAD  180
181   RLSNDPGWRN  VTVFLSDASV  PGEGEHKIMD  FIRRQRGQPN  HDPNTHHCLC  GADADLIMLG  240
241   LATHEPNFTI  IREEFKPNKP  RPCALCGQIG  HEIKECQGVA  REKKGEHDEF  ADTVPVSEQE  300
301   FIFIRLCVLR  EYLERELTMA  SLPFPFNFER  SVDDWVFMCF  FVGNDFLPHL  PSLEIREGAI  360
361   DRLVGIYKDV  VHKTGGYLTE  HGFVNLERVE  LIMQAVGVAE  DNIFKKRKED  EENFKRRSKE  420
421   KKKRMKAERG  PAFVTGGQFA  PRALGGRDRP  MPVHNARHTA  YDMRMQGSNY  QQNKDAASSL  480
481   KAMLRNGGKD  PAGPSDSTDL  HGLKRKAEDS  DSEPEPEDNV  RLWEAGWKQR  YYKTKFDVDE  540
541   TDDEFRKKVV  KAYVEGLCWV  LRYYYQGCAS  WKWYFPFHYA  PFASDFKDIK  DMFTDFEKGT  600
601   KPFKPLEQLM  GVFPAASGNF  LPPTWRELMS  DPDSPIIDFY  PEDFAIDLNG  KKFAWQGVAL  660
661   LPFVDERRLR  AALEKVYPDL  TADEVRRNSL  GSDVVFVSKS  HPLCDFIKEL  YRSESYEGTG  720
721   IPPELCFGIQ  GALSLEEDPI  LPDKPVESPI  PMLRDIPCSS  AVLIKFKDPQ  YEDNYVFKAV  780
781   ILPGAKIPQK  VLKPGDWERS  NRQPWRPQLG  FNHNRQQMHL  DQSAFRTLGH  HVSSPQQGGQ  840
841   HGPRPPRVAP  TMGGQYSNAP  PPSTYHQGNY  RPPLRDHQHS  RQQGFPRNIP  PSHPPQYPQL  900
901   VHGAHGWDRA  MQTQVSAYQQ  NIQRGRGGAG  GFQQHVQRPD  DRRPQEGYNS  RSYGLPPPAR  960
961   RYNWN  965
Nucleotide CDS Sequence (FASTA)
1     ATGGGTGTCC  CTGCTTTTTT  CCGTTGGCTG  AGTCGGAAGT  ATCCGTCTAT  AATTGTACAC  60
61    TGCGTGGAGG  AGAAGTCTAA  AGAGTGCAAT  GGTGTCCGGA  TACCTGTTGA  TACAACTAAA  120
121   CCCAACCCAA  ACGAGGTGGA  GTTTGATAAC  CTGTATTTGG  ACATGAATGG  AATTATCCAC  180
181   CCTTGCACAC  ACCCCGAGGA  CAAGCCTGCA  CCCAAGAATG  AGGATGAAAT  GATGGTTGCA  240
241   ATTTTTGAGT  ACATTGACCG  GCTCTTCAAC  ATCGTTCGTC  CAAGAAGAGT  TCTTTACATG  300
301   GCAATCGATG  GTGTTGCTCC  TCGTGCCAAA  ATGAACCAGC  AGCGATCCAG  ACGATTCCGT  360
361   GCCTCCAAAG  AAGGAGTGGA  GCTCGCTGAA  GAGAAAAAGA  AAATGAGGGA  GGAAGTTTTT  420
421   CAGAGAGGTG  GTTACCTGCC  CCCTGATGAA  ATAAAAGAGA  GGTTTGACAG  CAACTGCATC  480
481   ACTCCGGGCA  CAGAGTTCAT  GGACAACTTG  GCCAAATGTT  TGCGCTACTA  CATTGCAGAC  540
541   AGACTGAGCA  ATGATCCTGG  ATGGCGGAAT  GTCACAGTCT  TTCTCTCTGA  TGCTAGTGTT  600
601   CCTGGAGAAG  GTGAACATAA  GATCATGGAT  TTCATCAGGA  GACAGCGAGG  TCAGCCCAAT  660
661   CATGACCCTA  ATACACACCA  CTGTCTCTGT  GGTGCTGATG  CTGATCTTAT  TATGTTGGGT  720
721   CTGGCAACAC  ACGAGCCCAA  CTTCACCATC  ATCCGAGAAG  AATTCAAGCC  TAACAAACCC  780
781   AGACCATGTG  CACTGTGTGG  ACAGATTGGA  CATGAAATTA  AAGAGTGCCA  GGGTGTGGCC  840
841   AGGGAGAAGA  AAGGAGAGCA  TGATGAGTTT  GCTGACACAG  TGCCAGTATC  CGAGCAGGAG  900
901   TTTATCTTCA  TTCGTTTGTG  CGTACTACGT  GAGTATCTGG  AGCGAGAGTT  AACCATGGCC  960
961   AGCCTGCCTT  TCCCCTTTAA  CTTCGAGAGG  AGTGTTGATG  ACTGGGTTTT  CATGTGCTTC  1020
1021  TTTGTGGGAA  ATGACTTTCT  GCCCCATTTG  CCCTCTCTAG  AAATCAGAGA  GGGCGCCATC  1080
1081  GACCGGCTTG  TGGGTATTTA  CAAAGATGTT  GTGCACAAGA  CTGGGGGATA  CCTCACAGAA  1140
1141  CATGGTTTTG  TCAACCTGGA  GCGAGTGGAG  CTTATCATGC  AGGCTGTGGG  GGTTGCTGAG  1200
1201  GACAACATAT  TCAAGAAGCG  CAAAGAGGAT  GAGGAAAATT  TCAAAAGGAG  ATCAAAGGAA  1260
1261  AAGAAGAAAC  GAATGAAGGC  AGAACGGGGT  CCGGCATTTG  TCACAGGAGG  TCAGTTTGCC  1320
1321  CCTCGTGCAT  TGGGAGGACG  AGACCGACCG  ATGCCTGTAC  ACAACGCTCG  CCATACGGCC  1380
1381  TATGATATGA  GGATGCAGGG  CAGTAACTAC  CAGCAGAACA  AAGATGCTGC  CAGTTCTTTA  1440
1441  AAAGCCATGT  TGAGAAATGG  TGGAAAGGAT  CCTGCAGGGC  CAAGCGATAG  TACGGACCTG  1500
1501  CACGGTTTAA  AGAGGAAAGC  AGAAGACAGC  GACAGCGAGC  CAGAGCCTGA  AGATAACGTC  1560
1561  AGGTTGTGGG  AGGCAGGATG  GAAGCAGCGG  TATTACAAAA  CCAAATTTGA  CGTGGATGAG  1620
1621  ACTGACGATG  AATTTCGTAA  AAAGGTGGTC  AAGGCTTATG  TGGAGGGCCT  TTGCTGGGTT  1680
1681  CTTAGATACT  ACTACCAGGG  CTGTGCGTCC  TGGAAGTGGT  ACTTTCCGTT  CCACTATGCA  1740
1741  CCATTTGCAT  CCGACTTCAA  AGACATCAAG  GACATGTTCA  CAGATTTCGA  AAAAGGCACC  1800
1801  AAGCCATTCA  AACCTCTAGA  GCAGCTGATG  GGAGTGTTTC  CTGCTGCCAG  TGGGAACTTC  1860
1861  CTGCCTCCGA  CATGGCGGGA  ACTGATGTCA  GACCCGGACT  CCCCCATCAT  CGACTTCTAT  1920
1921  CCTGAAGACT  TTGCGATTGA  TTTGAATGGA  AAGAAGTTCG  CCTGGCAGGG  TGTTGCTTTG  1980
1981  TTGCCGTTTG  TTGATGAGCG  CAGGCTGCGG  GCAGCCTTGG  AAAAGGTCTA  TCCTGACTTA  2040
2041  ACAGCAGATG  AAGTCAGAAG  GAATAGTCTG  GGCAGCGATG  TGGTTTTTGT  CTCGAAATCC  2100
2101  CACCCTCTGT  GTGACTTCAT  CAAGGAACTC  TATAGATCAG  AATCTTACGA  GGGAACTGGG  2160
2161  ATTCCTCCAG  AGCTGTGCTT  TGGGATCCAA  GGTGCATTAT  CACTTGAAGA  AGATCCTATT  2220
2221  CTACCAGATA  AACCTGTAGA  ATCTCCGATC  CCTATGCTGA  GGGATATTCC  ATGCAGCAGT  2280
2281  GCAGTTCTAA  TTAAGTTCAA  GGATCCACAG  TATGAAGACA  ATTATGTGTT  CAAAGCAGTC  2340
2341  ATCCTTCCTG  GGGCAAAGAT  TCCCCAAAAA  GTGTTGAAGC  CTGGTGACTG  GGAGAGGTCT  2400
2401  AATAGACAAC  CATGGAGACC  CCAACTGGGC  TTTAATCACA  ACCGCCAGCA  AATGCACCTG  2460
2461  GACCAGTCTG  CCTTCAGGAC  GCTGGGCCAT  CATGTCAGCA  GTCCTCAACA  AGGTGGTCAA  2520
2521  CATGGCCCCA  GGCCCCCTCG  AGTCGCGCCG  ACCATGGGTG  GGCAATACAG  CAATGCCCCG  2580
2581  CCCCCCAGTA  CATATCACCA  AGGGAACTAT  CGTCCACCTC  TTCGAGACCA  CCAGCATTCC  2640
2641  AGGCAGCAGG  GATTTCCAAG  AAATATACCA  CCATCTCATC  CACCGCAGTA  CCCACAACTT  2700
2701  GTGCACGGTG  CTCATGGATG  GGATCGTGCG  ATGCAGACTC  AAGTCTCTGC  ATATCAGCAG  2760
2761  AACATTCAGA  GAGGTCGTGG  AGGAGCAGGT  GGCTTTCAGC  AGCACGTGCA  ACGCCCGGAT  2820
2821  GATCGCCGAC  CACAGGAGGG  TTATAATTCG  AGGAGTTACG  GCCTGCCTCC  ACCTGCAAGG  2880
2881  CGCTACAACT  GGAACTGA  2898

▼ KEYWORD

ID
Family
Complete proteome
Exonuclease
Hydrolase
mRNA processing
Nuclease
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nucleus
Molecular Function
5'-3' exoribonuclease activity
Molecular Function
Nucleic acid binding
Biological Process
MRNA processing

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Asm-2211Astyanax mexicanus86.030.01590
LLPS-Dar-2002Danio rerio81.630.01524
LLPS-Gaa-0902Gasterosteus aculeatus80.310.01350
LLPS-Scm-2179Scophthalmus maximus79.960.01438
LLPS-Scf-0771Scleropages formosus77.530.01471
LLPS-Orl-0269Oryzias latipes77.370.01461
LLPS-Pes-0002Pelodiscus sinensis76.480.01191
LLPS-Xim-1329Xiphophorus maculatus75.870.01447
LLPS-Rhb-0991Rhinopithecus bieti75.810.01258
LLPS-Orn-3066Oreochromis niloticus75.50.01466
LLPS-Pof-2316Poecilia formosa75.030.01446
LLPS-Tar-3110Takifugu rubripes74.730.01434
LLPS-Leo-2675Lepisosteus oculatus73.80.01357
LLPS-Tag-1688Taeniopygia guttata72.710.01268
LLPS-Ten-1284Tetraodon nigroviridis72.10.01377
LLPS-Paa-1097Papio anubis71.030.01279
LLPS-Meg-0402Meleagris gallopavo70.990.01292
LLPS-Xet-0285Xenopus tropicalis70.530.01319
LLPS-Ran-1278Rattus norvegicus70.130.01300
LLPS-Mea-1960Mesocricetus auratus69.830.01303
LLPS-Gaga-0456Gallus gallus69.820.01322
LLPS-Mum-1459Mus musculus69.680.01295
LLPS-Anp-0686Anas platyrhynchos69.580.01263
LLPS-Otg-1278Otolemur garnettii69.580.01304
LLPS-Fia-1750Ficedula albicollis69.530.01315
LLPS-Cap-0449Cavia porcellus69.520.01302
LLPS-Orc-0297Oryctolagus cuniculus69.420.01299
LLPS-Lac-1188Latimeria chalumnae69.330.01242
LLPS-Hos-0105Homo sapiens69.320.01295
LLPS-Pap-0290Pan paniscus69.320.01295
LLPS-Pat-0967Pan troglodytes69.320.01295
LLPS-Caf-1749Canis familiaris69.320.01298
LLPS-Mam-0738Macaca mulatta69.320.01295
LLPS-Nol-0076Nomascus leucogenys69.320.01295
LLPS-Ict-1693Ictidomys tridecemlineatus69.320.01299
LLPS-Chs-0124Chlorocebus sabaeus69.320.01295
LLPS-Maf-1826Macaca fascicularis69.320.01295
LLPS-Cea-1282Cercocebus atys69.320.01295
LLPS-Gog-2258Gorilla gorilla69.320.01295
LLPS-Eqc-3488Equus caballus69.290.01297
LLPS-Myl-0799Myotis lucifugus69.290.01299
LLPS-Man-0165Macaca nemestrina69.220.01295
LLPS-Aon-3127Aotus nancymaae69.220.01293
LLPS-Fud-1565Fukomys damarensis69.220.01297
LLPS-Aim-0452Ailuropoda melanoleuca69.220.01298
LLPS-Mod-0212Monodelphis domestica69.110.01301
LLPS-Caj-0137Callithrix jacchus69.110.01293
LLPS-Fec-2832Felis catus69.010.01295
LLPS-Loa-1408Loxodonta africana69.010.01296
LLPS-Poa-0647Pongo abelii69.010.01289
LLPS-Ora-1406Ornithorhynchus anatinus68.840.01299
LLPS-Cas-1851Carlito syrichta68.710.01286
LLPS-Bot-1821Bos taurus68.50.01285
LLPS-Urm-1966Ursus maritimus68.480.01247
LLPS-Anc-1795Anolis carolinensis68.460.01286
LLPS-Dio-0262Dipodomys ordii68.20.01263
LLPS-Sus-1479Sus scrofa67.990.01259
LLPS-Mup-1457Mustela putorius furo67.940.01289
LLPS-Ova-1478Ovis aries67.850.01234
LLPS-Mal-1665Mandrillus leucophaeus67.410.01251
LLPS-Cii-0076Ciona intestinalis59.270.0 986
LLPS-Cis-1147Ciona savignyi59.030.0 968
LLPS-Usm-0261Ustilago maydis58.61e-149 483
LLPS-Spr-0847Sporisorium reilianum58.64e-149 481
LLPS-Gas-0233Galdieria sulphuraria58.571e-1895.5
LLPS-Nec-0239Neurospora crassa58.272e-160 507
LLPS-Asfu-0929Aspergillus fumigatus57.934e-160 506
LLPS-Sol-1096Solanum lycopersicum57.841e-143 463
LLPS-Php-0128Physcomitrella patens57.849e-151 483
LLPS-Gor-1559Gossypium raimondii57.77e-148 471
LLPS-Nef-0198Neosartorya fischeri57.696e-160 505
LLPS-Mae-2408Manihot esculenta57.212e-145 464
LLPS-Scp-0200Schizosaccharomyces pombe56.879e-139 447
LLPS-Sot-0181Solanum tuberosum56.868e-142 458
LLPS-Coc-0269Corchorus capsularis56.834e-146 466
LLPS-Miv-1362Microbotryum violaceum56.811e-134 441
LLPS-Ast-1113Aspergillus terreus56.734e-159 502
LLPS-Art-1044Arabidopsis thaliana56.729e-143 457
LLPS-Orp-2319Oryza punctata56.723e-140 451
LLPS-Asn-0397Aspergillus nidulans56.632e-158 500
LLPS-Thc-1863Theobroma cacao56.591e-143 460
LLPS-Ors-0413Oryza sativa56.487e-140 450
LLPS-Orbr-2246Oryza brachyantha56.487e-136 439
LLPS-Orr-0768Oryza rufipogon56.484e-139 451
LLPS-Ori-1637Oryza indica56.484e-140 451
LLPS-Orb-1209Oryza barthii56.482e-139 451
LLPS-Orni-2203Oryza nivara56.485e-140 451
LLPS-Orgl-2258Oryza glumaepatula56.488e-140 450
LLPS-Amt-0283Amborella trichopoda56.284e-143 457
LLPS-Prp-1358Prunus persica56.232e-144 462
LLPS-Brr-2673Brassica rapa56.132e-139 447
LLPS-Brn-0355Brassica napus56.132e-139 447
LLPS-Lep-1457Leersia perrieri55.994e-137 443
LLPS-Blg-1118Blumeria graminis55.962e-154 489
LLPS-Mua-0481Musa acuminata55.881e-140 452
LLPS-Via-2370Vigna angularis55.886e-138 444
LLPS-Vir-1221Vigna radiata55.882e-138 444
LLPS-Met-0962Medicago truncatula55.836e-140 449
LLPS-Dac-2380Daucus carota55.753e-144 464
LLPS-Tra-0358Triticum aestivum55.752e-134 436
LLPS-Chr-1612Chlamydomonas reinhardtii55.751e-135 446
LLPS-Bro-0513Brassica oleracea55.641e-136 440
LLPS-Hea-0209Helianthus annuus55.645e-141 452
LLPS-Scc-0543Schizosaccharomyces cryophilus55.586e-137 442
LLPS-Pot-1545Populus trichocarpa55.52e-139 448
LLPS-Trr-0786Trichoderma reesei55.55e-151 481
LLPS-Ved-0446Verticillium dahliae55.46e-154 488
LLPS-Put-0790Puccinia triticina55.349e-149 478
LLPS-Sob-2175Sorghum bicolor55.265e-137 442
LLPS-Tru-0596Triticum urartu55.263e-130 433
LLPS-Zem-0949Zea mays55.268e-138 445
LLPS-Sei-0315Setaria italica55.262e-137 444
LLPS-Hov-0914Hordeum vulgare55.137e-105 358
LLPS-Pug-0272Puccinia graminis55.16e-147 474
LLPS-Brd-0142Brachypodium distachyon55.011e-139 450
LLPS-Arl-0747Arabidopsis lyrata54.993e-140 452
LLPS-Drm-0592Drosophila melanogaster54.830.0 869
LLPS-Cae-0124Caenorhabditis elegans54.530.0 900
LLPS-Pyt-1204Pyrenophora teres54.521e-142 454
LLPS-Glm-1782Glycine max54.249e-135 436
LLPS-Mel-1180Melampsora laricipopulina54.054e-96 316
LLPS-Cus-0737Cucumis sativus53.921e-126 413
LLPS-Phn-0798Phaeosphaeria nodorum53.812e-137 444
LLPS-Viv-0995Vitis vinifera53.728e-95 323
LLPS-Abg-0390Absidia glauca53.57e-141 456
LLPS-Lem-0475Leptosphaeria maculans53.335e-136 442
LLPS-Phv-1486Phaseolus vulgaris53.33e-135 436
LLPS-Sac-1194Saccharomyces cerevisiae53.35e-57 217
LLPS-Crn-0446Cryptococcus neoformans52.862e-140 455
LLPS-Asg-0110Ashbya gossypii52.064e-136 439
LLPS-Nia-1279Nicotiana attenuata51.932e-132 426
LLPS-Scj-1171Schizosaccharomyces japonicus51.785e-128 418
LLPS-Cog-0753Colletotrichum gloeosporioides49.80.0 699
LLPS-Asni-0180Aspergillus niger49.123e-42 172
LLPS-Coo-0596Colletotrichum orbiculare48.870.0 674
LLPS-Fuo-0878Fusarium oxysporum48.550.0 551
LLPS-Tum-0484Tuber melanosporum48.057e-119 391
LLPS-Asc-0364Aspergillus clavatus47.951e-41 170
LLPS-Mao-1232Magnaporthe oryzae47.510.0 719
LLPS-Orm-0043Oryza meridionalis46.630.0 662
LLPS-Org-0802Oryza glaberrima46.620.0 663
LLPS-Aso-0088Aspergillus oryzae46.380.0 743
LLPS-Asf-0292Aspergillus flavus46.380.0 743
LLPS-Fuv-0515Fusarium verticillioides46.340.0 692
LLPS-Beb-0621Beauveria bassiana46.24e-40 165
LLPS-Cogr-0647Colletotrichum graminicola46.050.0 689
LLPS-Gag-0989Gaeumannomyces graminis46.050.0 706
LLPS-Map-0267Magnaporthe poae45.690.0 704
LLPS-Osl-0382Ostreococcus lucimarinus44.310.0 629
LLPS-Scs-0291Sclerotinia sclerotiorum43.980.0 658
LLPS-Pytr-1362Pyrenophora triticirepentis43.540.0 674
LLPS-Kop-0812Komagataella pastoris43.210.0 610
LLPS-Yal-0893Yarrowia lipolytica40.295e-175 543