• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Mea-2275
Tubb4a

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Tubulin beta chain
Gene Name: Tubb4a
Ensembl Gene: ENSMAUG00000017901.1
Ensembl Protein: ENSMAUP00000019661.1
Organism: Mesocricetus auratus
Taxa ID: 10036
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MREIVHLQAG  QCGNQIGAKF  WEVISDEHGI  DPTGTYHGDS  DLQLERINVY  YNEATGGNYV  60
61    PRAVLVDLEP  GTMDSVRSGP  FGQIFRPDNF  VFGQSGAGNN  WAKGHYTEGA  ELVDAVLDVV  120
121   RKEAESCDCL  QGFQLTHSLG  GGTGSGMGTL  LISKIREEFP  DRIMNTFSVV  PSPKVSDTVV  180
181   EPYNATLSVH  QLVENTDETY  CIDNEALYDI  CFRTLKLTTP  TYGDLNHLVS  ATMSGVTTCL  240
241   RFPGQLNADL  RKLAVNMVPF  PRLHFFMPGF  APLTSRGSQQ  YRALTVPELT  QQMFDAKNMM  300
301   AACDPRHGRY  LTVAAVFRGR  MSMKEVDEQM  LSVQSKNSSY  FVEWIPNNVK  TAVCDIPPRG  360
361   LKMAATFIGN  STAIQELFKR  ISEQFTAMFR  RKAFLHWYTG  EGMDEMEFTE  AESNMNDLVS  420
421   EYQQYQDATA  EEGEFEEEAE  EEVA  444
Nucleotide CDS Sequence (FASTA)
1     ATGCGGGAAA  TCGTGCACCT  GCAAGCCGGG  CAATGCGGCA  ACCAGATCGG  GGCCAAGTTC  60
61    TGGGAAGTTA  TCAGTGATGA  ACACGGCATC  GACCCCACCG  GGACCTATCA  CGGGGATAGT  120
121   GACCTCCAGT  TGGAAAGAAT  CAATGTCTAC  TACAATGAGG  CCACAGGTGG  AAATTATGTT  180
181   CCCAGAGCCG  TGCTGGTTGA  CCTGGAACCT  GGCACCATGG  ACTCCGTCCG  CTCCGGCCCT  240
241   TTTGGCCAGA  TCTTCAGGCC  AGACAACTTT  GTGTTCGGTC  AATCCGGAGC  CGGCAACAAC  300
301   TGGGCCAAGG  GTCACTACAC  GGAGGGCGCG  GAGTTAGTGG  ACGCGGTCCT  GGACGTGGTG  360
361   CGGAAGGAGG  CGGAAAGCTG  TGACTGTCTG  CAGGGCTTCC  AGCTCACACA  CTCGCTGGGC  420
421   GGCGGCACCG  GCTCCGGCAT  GGGGACCCTG  CTCATCAGCA  AGATCCGGGA  GGAGTTCCCG  480
481   GACAGGATCA  TGAACACCTT  CAGCGTGGTG  CCGTCGCCCA  AGGTGTCCGA  CACGGTGGTG  540
541   GAGCCCTACA  ACGCCACGCT  GTCGGTGCAC  CAGCTGGTGG  AGAACACCGA  CGAGACCTAC  600
601   TGCATCGACA  ACGAGGCCCT  GTACGACATC  TGCTTCCGCA  CGCTCAAGCT  CACCACGCCC  660
661   ACCTACGGGG  ACCTCAACCA  CCTGGTGTCA  GCCACCATGA  GCGGGGTGAC  CACCTGCCTG  720
721   CGCTTCCCAG  GCCAGCTCAA  CGCGGATCTT  CGGAAGCTGG  CGGTGAACAT  GGTGCCCTTC  780
781   CCTCGCCTGC  ATTTCTTCAT  GCCGGGATTC  GCGCCCCTGA  CCAGCCGGGG  CAGCCAGCAG  840
841   TACCGGGCCC  TCACCGTGCC  CGAGCTCACC  CAGCAGATGT  TCGACGCCAA  GAACATGATG  900
901   GCCGCGTGCG  ACCCGAGGCA  CGGCCGCTAC  CTGACGGTGG  CTGCCGTCTT  CCGGGGGCGC  960
961   ATGTCCATGA  AGGAGGTGGA  CGAGCAGATG  CTGAGCGTGC  AGAGTAAGAA  CAGCAGCTAC  1020
1021  TTCGTGGAGT  GGATCCCCAA  CAACGTCAAG  ACGGCCGTGT  GTGACATCCC  CCCTCGGGGC  1080
1081  CTGAAGATGG  CAGCCACCTT  CATCGGCAAC  AGCACCGCCA  TCCAGGAGCT  CTTCAAGCGC  1140
1141  ATCTCGGAGC  AGTTCACCGC  CATGTTCCGG  CGCAAGGCCT  TCCTGCACTG  GTACACGGGC  1200
1201  GAGGGCATGG  ACGAGATGGA  GTTTACGGAA  GCAGAGAGCA  ACATGAACGA  CCTGGTGTCC  1260
1261  GAGTACCAGC  AGTACCAGGA  TGCCACGGCC  GAGGAGGGCG  AGTTCGAGGA  GGAGGCCGAA  1320
1321  GAGGAGGTGG  CCTAA  1335

▼ KEYWORD

ID
Family
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
GTP-binding
Microtubule
Nucleotide-binding
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Axoneme
Cellular Component
Internode region of axon
Cellular Component
Microtubule
Cellular Component
Myelin sheath
Cellular Component
Neuronal cell body
Molecular Function
Calcium ion binding
Molecular Function
GTP binding
Molecular Function
GTPase activity
Molecular Function
Structural constituent of cytoskeleton
Biological Process
Microtubule-based process
Biological Process
Negative regulation of microtubule polymerization

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ict-2215Ictidomys tridecemlineatus100.00.0 855
LLPS-Eqc-3902Equus caballus100.00.0 849
LLPS-Cap-1337Cavia porcellus100.00.0 855
LLPS-Caf-4115Canis familiaris100.00.0 855
LLPS-Mam-3561Macaca mulatta100.00.0 855
LLPS-Otg-1654Otolemur garnettii100.00.0 855
LLPS-Orc-3339Oryctolagus cuniculus100.00.0 855
LLPS-Fec-3605Felis catus100.00.0 855
LLPS-Pap-1145Pan paniscus100.00.0 855
LLPS-Pat-0017Pan troglodytes100.00.0 855
LLPS-Hos-0109Homo sapiens100.00.0 855
LLPS-Man-2213Macaca nemestrina100.00.0 855
LLPS-Ran-2428Rattus norvegicus100.00.0 855
LLPS-Myl-2541Myotis lucifugus100.00.0 855
LLPS-Bot-0249Bos taurus100.00.0 855
LLPS-Chs-4682Chlorocebus sabaeus100.00.0 855
LLPS-Mum-4314Mus musculus100.00.0 855
LLPS-Aon-3799Aotus nancymaae100.00.0 855
LLPS-Cea-0463Cercocebus atys100.00.0 855
LLPS-Sus-1819Sus scrofa100.00.0 855
LLPS-Paa-0932Papio anubis99.770.0 852
LLPS-Urm-2586Ursus maritimus99.750.0 801
LLPS-Mup-3527Mustela putorius furo99.530.0 853
LLPS-Rhb-2745Rhinopithecus bieti99.30.0 850
LLPS-Xet-1448Xenopus tropicalis98.590.0 847
LLPS-Gaga-0553Gallus gallus98.590.0 847
LLPS-Anc-3698Anolis carolinensis98.590.0 846
LLPS-Lac-4047Latimeria chalumnae98.590.0 846
LLPS-Mod-3852Monodelphis domestica98.590.0 846
LLPS-Dar-4256Danio rerio98.590.0 847
LLPS-Scf-3711Scleropages formosus98.590.0 847
LLPS-Caj-2185Callithrix jacchus98.590.0 846
LLPS-Fud-3138Fukomys damarensis98.590.0 847
LLPS-Maf-3352Macaca fascicularis98.590.0 846
LLPS-Sah-3322Sarcophilus harrisii98.590.0 846
LLPS-Orn-2508Oreochromis niloticus98.360.0 845
LLPS-Scm-0259Scophthalmus maximus98.360.0 846
LLPS-Asm-3759Astyanax mexicanus98.360.0 846
LLPS-Cii-2095Ciona intestinalis98.360.0 845
LLPS-Cis-0796Ciona savignyi98.360.0 845
LLPS-Leo-2361Lepisosteus oculatus98.360.0 845
LLPS-Icp-0893Ictalurus punctatus98.130.0 846
LLPS-Gaa-1346Gasterosteus aculeatus97.650.0 839
LLPS-Cas-0144Carlito syrichta97.420.0 840
LLPS-Nol-3585Nomascus leucogenys97.420.0 840
LLPS-Poa-2450Pongo abelii97.420.0 840
LLPS-Pof-3559Poecilia formosa97.420.0 838
LLPS-Ova-2492Ovis aries97.420.0 840
LLPS-Mal-0435Mandrillus leucophaeus97.420.0 840
LLPS-Xim-1769Xiphophorus maculatus97.420.0 842
LLPS-Dio-3081Dipodomys ordii97.420.0 840
LLPS-Gog-0740Gorilla gorilla97.420.0 840
LLPS-Ten-2857Tetraodon nigroviridis97.190.0 838
LLPS-Orl-3812Oryzias latipes97.190.0 838
LLPS-Tar-2601Takifugu rubripes96.960.0 839
LLPS-Fia-0318Ficedula albicollis96.720.0 839
LLPS-Aim-3912Ailuropoda melanoleuca96.720.0 839
LLPS-Tut-2274Tursiops truncatus96.720.0 839
LLPS-Pes-0306Pelodiscus sinensis96.490.0 837
LLPS-Drm-0325Drosophila melanogaster96.320.0 792
LLPS-Tag-2634Taeniopygia guttata96.250.0 835
LLPS-Ere-0293Erinaceus europaeus96.250.0 830
LLPS-Ora-3257Ornithorhynchus anatinus96.250.0 834
LLPS-Anp-3174Anas platyrhynchos95.750.0 773
LLPS-Cae-1271Caenorhabditis elegans95.080.0 822
LLPS-Loa-2963Loxodonta africana94.150.0 812
LLPS-Chr-0860Chlamydomonas reinhardtii89.460.0 788
LLPS-Php-1447Physcomitrella patens89.460.0 790
LLPS-Orbr-1685Oryza brachyantha88.290.0 773
LLPS-Sem-1389Selaginella moellendorffii88.060.0 781