LLPS-Mam-3561
TUBB4A
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Tubulin beta chain |
| Gene Name: | TUBB4A |
| Ensembl Gene: | ENSMMUG00000014216.3 |
| Ensembl Protein: | ENSMMUP00000057010.1 |
| Organism: | Macaca mulatta |
| Taxa ID: | 9544 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, Centrosome/Spindle pole body, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSMMUT00000077705.1 | ENSMMUP00000057010.1 |
| Ensembl | ENSMMUT00000065542.1 | ENSMMUP00000050954.1 |
| Ensembl | ENSMMUT00000073836.1 | ENSMMUP00000049977.1 |
| Ensembl | ENSMMUT00000064113.1 | ENSMMUP00000046339.1 |
| Ensembl | ENSMMUT00000058000.1 | ENSMMUP00000055724.1 |
| Ensembl | ENSMMUT00000065873.1 | ENSMMUP00000052103.1 |
| UniProt | A0A1D5QPK0, A0A1D5QPK0_MACMU | |
| GeneBank | JSUE03020487, JSUE03020491, JSUE03020489, JSUE03020488, JSUE03020492, JSUE03020490 | |
| RefSeq | XM_015122634.1 | XP_014978120.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MREIVHLQAG QCGNQIGAKF WEVISDEHGI DPTGTYHGDS DLQLERINVY YNEATGGNYV 60 61 PRAVLVDLEP GTMDSVRSGP FGQIFRPDNF VFGQSGAGNN WAKGHYTEGA ELVDAVLDVV 120 121 RKEAESCDCL QGFQLTHSLG GGTGSGMGTL LISKIREEFP DRIMNTFSVV PSPKVSDTVV 180 181 EPYNATLSVH QLVENTDETY CIDNEALYDI CFRTLKLTTP TYGDLNHLVS ATMSGVTTCL 240 241 RFPGQLNADL RKLAVNMVPF PRLHFFMPGF APLTSRGSQQ YRALTVPELT QQMFDAKNMM 300 301 AACDPRHGRY LTVAAVFRGR MSMKEVDEQM LSVQSKNSSY FVEWIPNNVK TAVCDIPPRG 360 361 LKMAATFIGN STAIQELFKR ISEQFTAMFR RKAFLHWYTG EGMDEMEFTE AESNMNDLVS 420 421 EYQQYQDATA EEGEFEEEAE EEVA 444 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCGGGAGA TCGTGCACCT GCAGGCCGGC CAGTGCGGCA ACCAGATCGG GGCCAAGTTT 60 61 TGGGAGGTTA TCAGTGACGA ACATGGCATC GACCCCACAG GCACATACCA TGGGGACAGT 120 121 GACCTGCAAC TGGAGAGGAT CAACGTGTAC TACAACGAGG CCACAGGGAA TTATGTCCCC 180 181 AGAGCGGTGC TGGTGGACCT GGAACCCGGC ACCATGGACT CTGTCCGTTC CGGCCCCTTC 240 241 GGTCAGATCT TTCGGCCCGA CAACTTTGTG TTTGGGCAAT CCGGAGCCGG CAACAACTGG 300 301 GCAAAAGGGC ACTACACGGA GGGCGCGGAG CTGGTGGACG CCGTCCTGGA TGTAGTCCGG 360 361 AAGGAGGCCG AGAGCTGCGA CTGCCTTCAG GGCTTCCAGC TGACCCACTC GCTGGGAGGT 420 421 GGCACGGGGT CTGGGATGGG CACGCTGCTC ATTAGTAAGA TCCGCGAGGA GTTCCCGGAC 480 481 CGCATCATGA ACACCTTCAG CGTGGTGCCC TCGCCCAAAG TGTCGGATAC GGTGGTGGAG 540 541 CCCTACAATG CCACGCTGTC CGTGCACCAG CTGGTGGAGA ATACGGATGA GACCTACTGC 600 601 ATCGACAACG AGGCGCTCTA CGACATCTGC TTCCGCACCC TCAAGCTGAC CACCCCCACC 660 661 TACGGGGACC TCAACCACCT GGTGTCGGCC ACCATGAGCG GGGTCACCAC CTGCCTGCGC 720 721 TTCCCGGGCC AGCTGAACGC CGACCTGCGC AAGCTGGCAG TCAACATGGT CCCCTTTCCT 780 781 CGCCTGCACT TCTTCATGCC TGGCTTCGCG CCCCTGACCA GCCGGGGCAG CCAGCAGTAC 840 841 CGGGCCCTGA CGGTGCCTGA GCTCACCCAG CAGATGTTCG ACGCCAAGAA CATGATGGCC 900 901 GCGTGCGACC CGCGCCACGG CCGCTACCTG ACCGTGGCCG CCGTGTTCCG GGGCCGCATG 960 961 TCCATGAAGG AGGTGGACGA GCAGATGCTG AGCGTGCAGA GCAAGAACAG CAGCTACTTC 1020 1021 GTGGAGTGGA TCCCCAACAA CGTGAAGACG GCCGTGTGCG ACATCCCGCC CCGCGGCCTG 1080 1081 AAGATGGCTG CAACCTTCAT CGGCAACAGC ACGGCCATCC AGGAGCTGTT CAAGCGCCTT 1140 1141 CCTGCACTGG TACACGGGCG AGGGCATGGA CGAGATGGAG TTCACCGAGG CCGAGAGCAA 1200 1201 CATGAATGA 1209 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Axoneme | |
Cellular Component | Cytoplasm | |
Cellular Component | Microtubule | |
Molecular Function | Calcium ion binding | |
Molecular Function | GTP binding | |
Molecular Function | GTPase activity | |
Molecular Function | Structural constituent of cytoskeleton | |
Biological Process | Microtubule cytoskeleton organization | |
Biological Process | Microtubule-based process | |
Biological Process | Mitotic cell cycle | |
Biological Process | Negative regulation of microtubule polymerization |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ran-2428 | Rattus norvegicus | 100.0 | 0.0 | 855 |
| LLPS-Myl-2541 | Myotis lucifugus | 100.0 | 0.0 | 855 |
| LLPS-Bot-0249 | Bos taurus | 100.0 | 0.0 | 855 |
| LLPS-Chs-4682 | Chlorocebus sabaeus | 100.0 | 0.0 | 855 |
| LLPS-Mea-2275 | Mesocricetus auratus | 100.0 | 0.0 | 855 |
| LLPS-Mum-4314 | Mus musculus | 100.0 | 0.0 | 855 |
| LLPS-Cea-0463 | Cercocebus atys | 100.0 | 0.0 | 855 |
| LLPS-Aon-3799 | Aotus nancymaae | 100.0 | 0.0 | 855 |
| LLPS-Sus-1819 | Sus scrofa | 100.0 | 0.0 | 855 |
| LLPS-Ict-2215 | Ictidomys tridecemlineatus | 100.0 | 0.0 | 855 |
| LLPS-Eqc-3902 | Equus caballus | 100.0 | 0.0 | 849 |
| LLPS-Cap-1337 | Cavia porcellus | 100.0 | 0.0 | 855 |
| LLPS-Caf-4115 | Canis familiaris | 100.0 | 0.0 | 855 |
| LLPS-Otg-1654 | Otolemur garnettii | 100.0 | 0.0 | 855 |
| LLPS-Orc-3339 | Oryctolagus cuniculus | 100.0 | 0.0 | 855 |
| LLPS-Fec-3605 | Felis catus | 100.0 | 0.0 | 855 |
| LLPS-Pat-0017 | Pan troglodytes | 100.0 | 0.0 | 855 |
| LLPS-Pap-1145 | Pan paniscus | 100.0 | 0.0 | 855 |
| LLPS-Hos-0109 | Homo sapiens | 100.0 | 0.0 | 855 |
| LLPS-Man-2213 | Macaca nemestrina | 100.0 | 0.0 | 855 |
| LLPS-Paa-0932 | Papio anubis | 99.77 | 0.0 | 852 |
| LLPS-Urm-2586 | Ursus maritimus | 99.75 | 0.0 | 801 |
| LLPS-Mup-3527 | Mustela putorius furo | 99.53 | 0.0 | 853 |
| LLPS-Rhb-2745 | Rhinopithecus bieti | 99.3 | 0.0 | 850 |
| LLPS-Scf-3711 | Scleropages formosus | 98.59 | 0.0 | 847 |
| LLPS-Caj-2185 | Callithrix jacchus | 98.59 | 0.0 | 846 |
| LLPS-Fud-3138 | Fukomys damarensis | 98.59 | 0.0 | 847 |
| LLPS-Maf-3352 | Macaca fascicularis | 98.59 | 0.0 | 846 |
| LLPS-Sah-3322 | Sarcophilus harrisii | 98.59 | 0.0 | 846 |
| LLPS-Gaga-0553 | Gallus gallus | 98.59 | 0.0 | 847 |
| LLPS-Xet-1448 | Xenopus tropicalis | 98.59 | 0.0 | 847 |
| LLPS-Anc-3698 | Anolis carolinensis | 98.59 | 0.0 | 846 |
| LLPS-Lac-4047 | Latimeria chalumnae | 98.59 | 0.0 | 846 |
| LLPS-Mod-3852 | Monodelphis domestica | 98.59 | 0.0 | 846 |
| LLPS-Dar-4256 | Danio rerio | 98.59 | 0.0 | 847 |
| LLPS-Asm-3759 | Astyanax mexicanus | 98.36 | 0.0 | 846 |
| LLPS-Cii-2095 | Ciona intestinalis | 98.36 | 0.0 | 845 |
| LLPS-Cis-0796 | Ciona savignyi | 98.36 | 0.0 | 845 |
| LLPS-Leo-2361 | Lepisosteus oculatus | 98.36 | 0.0 | 845 |
| LLPS-Orn-2508 | Oreochromis niloticus | 98.36 | 0.0 | 845 |
| LLPS-Scm-0259 | Scophthalmus maximus | 98.36 | 0.0 | 846 |
| LLPS-Icp-0893 | Ictalurus punctatus | 98.13 | 0.0 | 846 |
| LLPS-Gaa-1346 | Gasterosteus aculeatus | 97.65 | 0.0 | 839 |
| LLPS-Ova-2492 | Ovis aries | 97.42 | 0.0 | 840 |
| LLPS-Mal-0435 | Mandrillus leucophaeus | 97.42 | 0.0 | 840 |
| LLPS-Xim-1769 | Xiphophorus maculatus | 97.42 | 0.0 | 842 |
| LLPS-Dio-3081 | Dipodomys ordii | 97.42 | 0.0 | 840 |
| LLPS-Gog-0740 | Gorilla gorilla | 97.42 | 0.0 | 840 |
| LLPS-Cas-0144 | Carlito syrichta | 97.42 | 0.0 | 840 |
| LLPS-Nol-3585 | Nomascus leucogenys | 97.42 | 0.0 | 840 |
| LLPS-Poa-2450 | Pongo abelii | 97.42 | 0.0 | 840 |
| LLPS-Pof-3559 | Poecilia formosa | 97.42 | 0.0 | 838 |
| LLPS-Orl-3812 | Oryzias latipes | 97.19 | 0.0 | 838 |
| LLPS-Ten-2857 | Tetraodon nigroviridis | 97.19 | 0.0 | 838 |
| LLPS-Tar-2601 | Takifugu rubripes | 96.96 | 0.0 | 839 |
| LLPS-Aim-3912 | Ailuropoda melanoleuca | 96.72 | 0.0 | 839 |
| LLPS-Tut-2274 | Tursiops truncatus | 96.72 | 0.0 | 839 |
| LLPS-Fia-0318 | Ficedula albicollis | 96.72 | 0.0 | 839 |
| LLPS-Pes-0306 | Pelodiscus sinensis | 96.49 | 0.0 | 837 |
| LLPS-Drm-0325 | Drosophila melanogaster | 96.32 | 0.0 | 792 |
| LLPS-Ere-0293 | Erinaceus europaeus | 96.25 | 0.0 | 830 |
| LLPS-Ora-3257 | Ornithorhynchus anatinus | 96.25 | 0.0 | 834 |
| LLPS-Tag-2634 | Taeniopygia guttata | 96.25 | 0.0 | 835 |
| LLPS-Anp-3174 | Anas platyrhynchos | 95.75 | 0.0 | 773 |
| LLPS-Cae-1271 | Caenorhabditis elegans | 95.08 | 0.0 | 822 |
| LLPS-Loa-2963 | Loxodonta africana | 94.15 | 0.0 | 812 |
| LLPS-Chr-0860 | Chlamydomonas reinhardtii | 89.46 | 0.0 | 788 |
| LLPS-Php-1447 | Physcomitrella patens | 89.46 | 0.0 | 790 |
| LLPS-Orbr-1685 | Oryza brachyantha | 88.29 | 0.0 | 773 |
| LLPS-Sem-1389 | Selaginella moellendorffii | 88.06 | 0.0 | 781 |