• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Gog-0740
TUBB

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Tubulin beta chain
Gene Name: TUBB
Ensembl Gene: ENSGGOG00000022655.2
Ensembl Protein: ENSGGOP00000025350.1
Organism: Gorilla gorilla
Taxa ID: 9595
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Centrosome/Spindle pole body, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MREIVHIQAG  QCGNQIGAKF  WEVISDEHGI  DPTGTYHGDS  DLQLDRISVY  YNEATGGKYV  60
61    PRAILVDLEP  GTMDSVRSGP  FGQIFRPDNF  VFGQSGAGNN  WAKGHYTEGA  ELVDSVLDVV  120
121   RKEAESCDCL  QGFQLTHSLG  GGTGSGMGTL  LISKIREEYP  DRIMNTFSVV  PSPKVSDTVV  180
181   EPYNATLSVH  QLVENTDETY  CIDNEALYDI  CFRTLKLTTP  TYGDLNHLVS  ATMSGVTTCL  240
241   RFPGQLNADL  RKLAVNMVPF  PRLHFFMPGF  APLTSRGSQQ  YRALTVPELT  QQVFDAKNMM  300
301   AACDPRHGRY  LTVAAVFRGR  MSMKEVDEQM  LNVQNKNSSY  FVEWIPNNVK  TAVCDIPPRG  360
361   LKMAVTFIGN  STAIQELFKR  ISEQFTAMFR  RKAFLHWYTG  EGMDEMEFTE  AESNMNDLVS  420
421   EYQQYQDATA  EEEEDFGEEA  EEEA  444
Nucleotide CDS Sequence (FASTA)
1     ATGAGGGAAA  TCGTGCACAT  CCAGGCTGGT  CAGTGTGGCA  ACCAGATCGG  TGCCAAGTTC  60
61    TGGGAGGTGA  TCAGTGATGA  ACATGGCATC  GACCCCACCG  GCACCTACCA  CGGGGACAGC  120
121   GACCTGCAGC  TGGACCGCAT  CTCTGTGTAC  TACAATGAAG  CCACAGGTGG  CAAATATGTT  180
181   CCTCGTGCCA  TCCTGGTGGA  TCTAGAACCT  GGGACCATGG  ACTCTGTTCG  CTCAGGTCCT  240
241   TTTGGCCAGA  TCTTTAGACC  AGACAACTTT  GTATTTGGTC  AGTCTGGGGC  AGGTAACAAC  300
301   TGGGCCAAAG  GCCACTACAC  AGAGGGCGCC  GAGCTGGTTG  ATTCTGTCCT  GGATGTGGTA  360
361   CGGAAGGAGG  CAGAGAGCTG  TGACTGCCTG  CAGGGCTTCC  AGCTGACCCA  CTCACTGGGC  420
421   GGGGGCACAG  GCTCTGGAAT  GGGCACTCTC  CTTATCAGCA  AGATCCGAGA  AGAATATCCT  480
481   GATCGCATCA  TGAATACCTT  CAGTGTGGTG  CCTTCACCCA  AAGTATCTGA  CACCGTGGTC  540
541   GAGCCCTACA  ATGCCACCCT  CTCCGTCCAT  CAGTTGGTAG  AGAATACTGA  TGAGACCTAT  600
601   TGCATTGACA  ACGAGGCCCT  CTATGATATC  TGCTTCCGCA  CTCTGAAGCT  GACCACACCA  660
661   ACCTACGGGG  ATCTGAACCA  CCTTGTCTCA  GCCACCATGA  GTGGTGTCAC  CACCTGCCTC  720
721   CGTTTCCCTG  GCCAGCTCAA  TGCTGACCTC  CGCAAGTTGG  CAGTCAACAT  GGTCCCCTTC  780
781   CCACGTCTCC  ATTTCTTTAT  GCCTGGCTTT  GCCCCTCTCA  CCAGCCGTGG  AAGCCAGCAG  840
841   TATCGAGCTC  TCACAGTGCC  GGAACTCACC  CAGCAGGTCT  TCGATGCCAA  GAACATGATG  900
901   GCTGCCTGTG  ACCCCCGCCA  CGGCCGATAC  CTCACCGTGG  CTGCTGTCTT  CCGTGGTCGG  960
961   ATGTCCATGA  AGGAGGTCGA  TGAGCAGATG  CTTAACGTGC  AGAACAAGAA  CAGCAGCTAC  1020
1021  TTTGTGGAAT  GGATCCCCAA  CAATGTCAAG  ACAGCCGTCT  GTGACATCCC  ACCTCGTGGC  1080
1081  CTCAAGATGG  CAGTCACCTT  CATTGGCAAC  AGCACAGCCA  TCCAGGAGCT  CTTCAAGCGC  1140
1141  ATCTCGGAGC  AGTTCACTGC  CATGTTCCGC  CGGAAGGCCT  TCCTCCACTG  GTACACAGGC  1200
1201  GAGGGCATGG  ACGAGATGGA  GTTCACCGAG  GCTGAGAGCA  ACATGAACGA  CCTCGTCTCT  1260
1261  GAGTATCAGC  AGTACCAGGA  TGCCACCGCA  GAAGAGGAGG  AGGATTTCGG  TGAGGAGGCC  1320
1321  GAAGAGGAGG  CCTAA  1335

▼ KEYWORD

ID
Family
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
GTP-binding
Microtubule
Nucleotide-binding
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cell body
Cellular Component
Cytoplasm
Cellular Component
Cytoplasmic ribonucleoprotein granule
Cellular Component
Microtubule
Cellular Component
Nuclear envelope lumen
Molecular Function
GTP binding
Molecular Function
GTPase activity
Molecular Function
MHC class I protein binding
Molecular Function
Structural constituent of cytoskeleton
Molecular Function
Ubiquitin protein ligase binding
Biological Process
Microtubule cytoskeleton organization
Biological Process
Microtubule-based process
Biological Process
Mitotic cell cycle
Biological Process
Regulation of synapse organization
Biological Process
Spindle assembly

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Dio-3081Dipodomys ordii100.00.0 856
LLPS-Bot-1827Bos taurus100.00.0 856
LLPS-Mal-0435Mandrillus leucophaeus100.00.0 856
LLPS-Paa-2063Papio anubis100.00.0 815
LLPS-Ova-2492Ovis aries100.00.0 856
LLPS-Ran-0387Rattus norvegicus100.00.0 856
LLPS-Aon-0745Aotus nancymaae100.00.0 856
LLPS-Sah-2303Sarcophilus harrisii100.00.0 856
LLPS-Cea-2760Cercocebus atys100.00.0 856
LLPS-Maf-1203Macaca fascicularis100.00.0 856
LLPS-Mum-2220Mus musculus100.00.0 856
LLPS-Mea-0977Mesocricetus auratus100.00.0 856
LLPS-Chs-2404Chlorocebus sabaeus100.00.0 856
LLPS-Caj-4022Callithrix jacchus100.00.0 856
LLPS-Mam-1384Macaca mulatta100.00.0 856
LLPS-Poa-2450Pongo abelii100.00.0 856
LLPS-Caf-1898Canis familiaris100.00.0 856
LLPS-Cap-2266Cavia porcellus100.00.0 856
LLPS-Nol-3585Nomascus leucogenys100.00.0 856
LLPS-Ict-0371Ictidomys tridecemlineatus100.00.0 856
LLPS-Xet-2638Xenopus tropicalis100.00.0 856
LLPS-Gaga-0956Gallus gallus100.00.0 856
LLPS-Cas-0144Carlito syrichta100.00.0 856
LLPS-Man-2333Macaca nemestrina100.00.0 856
LLPS-Hos-2586Homo sapiens100.00.0 856
LLPS-Pat-3341Pan troglodytes100.00.0 856
LLPS-Urm-3705Ursus maritimus100.00.0 856
LLPS-Mod-1514Monodelphis domestica100.00.0 856
LLPS-Fec-0714Felis catus100.00.0 856
LLPS-Rhb-0035Rhinopithecus bieti100.00.0 856
LLPS-Gaa-1416Gasterosteus aculeatus99.770.0 854
LLPS-Scf-1527Scleropages formosus99.770.0 854
LLPS-Xim-3736Xiphophorus maculatus99.770.0 853
LLPS-Orl-3812Oryzias latipes99.770.0 854
LLPS-Icp-3812Ictalurus punctatus99.770.0 854
LLPS-Ten-2857Tetraodon nigroviridis99.770.0 854
LLPS-Dar-0751Danio rerio99.770.0 854
LLPS-Pof-2149Poecilia formosa99.770.0 854
LLPS-Scm-0346Scophthalmus maximus99.770.0 854
LLPS-Orn-1311Oreochromis niloticus99.770.0 854
LLPS-Mup-3390Mustela putorius furo99.530.0 851
LLPS-Lac-1301Latimeria chalumnae99.530.0 853
LLPS-Orc-2133Oryctolagus cuniculus99.530.0 851
LLPS-Eqc-1937Equus caballus99.510.0 813
LLPS-Fud-1632Fukomys damarensis99.30.0 850
LLPS-Anc-3698Anolis carolinensis98.360.0 845
LLPS-Tar-2601Takifugu rubripes98.130.0 847
LLPS-Leo-2361Lepisosteus oculatus98.130.0 845
LLPS-Cis-0796Ciona savignyi98.130.0 846
LLPS-Cii-1237Ciona intestinalis98.130.0 845
LLPS-Asm-3759Astyanax mexicanus98.130.0 846
LLPS-Anp-3174Anas platyrhynchos98.00.0 784
LLPS-Sus-0286Sus scrofa97.820.0 803
LLPS-Tut-2274Tursiops truncatus97.420.0 842
LLPS-Aim-3912Ailuropoda melanoleuca97.420.0 842
LLPS-Myl-2541Myotis lucifugus97.420.0 839
LLPS-Pap-1145Pan paniscus97.420.0 839
LLPS-Fia-0318Ficedula albicollis97.420.0 842
LLPS-Otg-1654Otolemur garnettii97.420.0 839
LLPS-Pes-0306Pelodiscus sinensis97.190.0 840
LLPS-Ere-0293Erinaceus europaeus96.960.0 833
LLPS-Ora-3257Ornithorhynchus anatinus96.960.0 837
LLPS-Tag-2634Taeniopygia guttata96.960.0 838
LLPS-Drm-0325Drosophila melanogaster96.320.0 793
LLPS-Cae-1271Caenorhabditis elegans95.320.0 825
LLPS-Loa-2963Loxodonta africana94.850.0 815
LLPS-Chr-0860Chlamydomonas reinhardtii89.930.0 790
LLPS-Php-1447Physcomitrella patens89.460.0 791
LLPS-Orbr-1685Oryza brachyantha88.290.0 773
LLPS-Sem-1389Selaginella moellendorffii88.060.0 782