• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Mam-0022
DDX39B

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Spliceosome RNA helicase DDX39B; 56 kDa U2AF65-associated protein; DEAD box protein UAP56
Gene Name: DDX39B, BAT1, UAP56
Ensembl Gene: ENSMMUG00000008839.3
Ensembl Protein: ENSMMUP00000050210.1
Organism: Macaca mulatta
Taxa ID: 9544
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nuclear speckle, Nucleolus, P-body, Stress granulePredicted from orthologs(View)

▼ FUNCTION

Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC and CHTOP onto mRNA. Also associates with pre-mRNA independent of ALYREF/THOC4 and the THO complex. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAENDVDNEL  LDYEDDEVET  AAGGDGAEAP  AKKDVKGSYV  SIHSSGFRDF  LLKPELLRAI  60
61    VDCGFEHPSE  VQHECIPQAI  LGMDVLCQAK  SGMGKTAVFV  LATLQQLEPV  TGQVSVLVMC  120
121   HTRELAFQIS  KEYERFSKYM  PNVKVAVFFG  GLSIKKDEEV  LKKNCPHIVV  GTPGRILALA  180
181   RNKSLNLKHI  KHFILDECDK  MLEQLDMRRD  VQEIFRMTPH  EKQVMMFSAT  LSKEIRPVCR  240
241   KFMQDPMEIF  VDDETKLTLH  GLQQYYVKLK  DNEKNRKLFD  LLDVLEFNQV  VIFVKSVQRC  300
301   IALAQLLVEQ  NFPAIAIHRG  MPQEERLSRY  QQFKDFQRRI  LVATNLFGRG  MDIERVNIAF  360
361   NYDMPEDSDT  YLHRVARAGR  FGTKGLAITF  VSDENDAKIL  NDVQDRFEVN  ISELPDEIDI  420
421   SSYIEQTR  428
Nucleotide CDS Sequence (FASTA)
1     ATGTGGACAA  TGAGCTCTTG  GACTATGAAG  ATGATGAGGT  GGAGACAGCA  GCTGGGGGAG  60
61    ATGGGGCTGA  GGCCCCTGCC  AAGAAGGATG  TCAAGGGCTC  CTATGTCTCC  ATCCACAGCT  120
121   CTGGCTTTCG  TGACTTCCTG  CTCAAGCCAG  AAAGGTAAAT  TTTCTCTTGG  GCATCATGAG  180
181   TGCATCCCTC  AGGCCATTCT  GGGAATGGAT  GTCCTGTGCC  AGGCCAAGTC  GGGCATGGGA  240
241   AAGACAGCAG  TGTTTGTGTT  GGCCACACTG  CAACAGCTGG  AGCCAGTTAC  TGGGCAGGTG  300
301   TCTGTGCTGG  TGATGTGTCA  CACTCGGGAG  TTGGCTTTTC  AGATCAGCAA  GGAATATGAG  360
361   CGCTTCTCTA  AATACATGCC  CAATGTCAAG  GTTGCTGTTT  TTTTTGGTGG  TCTGTCTATC  420
421   AAGAAGGATG  AAGAGGTGCT  GAAGAAGAAC  TGCCCGCATA  TCGTCGTGGG  GACTCCAGGC  480
481   CGTATCCTAG  CCCTGGCTCG  AAATAAGAGC  CTCAACCTCA  AACACATTAA  ACACTTTATT  540
541   TTGGATGAAT  GTGATAAGAT  GCTTGAACAG  CTCGACATGC  GTCGGGATGT  CCAGGAAATT  600
601   TTTCGCATGA  CCCCCCACGA  GAAGCAGGTC  ATGATGTTCA  GTGCTACCTT  GAGCAAAGAG  660
661   ATCCGTCCAG  TCTGCCGCAA  GTTCATGCAA  GATCCAATGG  AGATCTTCGT  GGATGATGAG  720
721   ACGAAGTTGA  CGCTGCATGG  GTTGCAGCAG  TACTACGTGA  AACTGAAGGA  CAACGAGAAG  780
781   AACCGGAAGC  TCTTTGACCT  TCTGGATGTC  CTTGAGTTCA  ACCAGGTGGT  GATCTTTGTG  840
841   AAGTCTGTGC  AGCGGTGCAT  TGCCTTGGCC  CAGCTACTGG  TGGAGCAGAA  CTTTCCAGCC  900
901   ATTGCCATCC  ACCGTGGGAT  GCCCCAGGAG  GAGAGGCTTT  CTCGGTATCA  GCAGTTTAAA  960
961   GATTTTCAAC  GACGAATTCT  TGTGGCTACC  AACCTATTTG  GCCGAGGCAT  GGACATCGAG  1020
1021  CGGGTGAACA  TTGCTTTTAA  TTATGACATG  CCTGAGGATT  CTGACACCTA  CCTACATCGG  1080
1081  GTGGCCAGAG  CAGGCCGGTT  TGGCACCAAG  GGCTTGGCTA  TCACATTTGT  GTCCGATGAG  1140
1141  AATGATGCCA  AGATCCTCAA  TGATGTGCAG  GATCGCTTTG  AGGTCAATAT  TAGTGAGCTG  1200
1201  CCTGATGAGA  TAGACATCTC  CTCCTACATT  GAACAGACAC  GGTAG  1245

▼ KEYWORD

ID
Family
Acetylation
ATP-binding
Complete proteome
Cytoplasm
Helicase
Hydrolase
Isopeptide bond
mRNA processing
mRNA splicing
mRNA transport
Nucleotide-binding
Nucleus
Phosphoprotein
Reference proteome
RNA-binding
Spliceosome
Transport
Ubl conjugation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Nuclear speck
Cellular Component
Spliceosomal complex
Cellular Component
Transcription export complex
Cellular Component
U4 snRNP
Cellular Component
U6 snRNP
Molecular Function
ATP binding
Molecular Function
ATP-dependent protein binding
Molecular Function
ATP-dependent RNA helicase activity
Molecular Function
Identical protein binding
Molecular Function
U4 snRNA binding
Molecular Function
U6 snRNA binding
Biological Process
MRNA export from nucleus
Biological Process
Negative regulation of DNA damage checkpoint
Biological Process
Positive regulation of DNA-templated transcription, elongation
Biological Process
RNA secondary structure unwinding
Biological Process
Spliceosomal complex assembly
Biological Process
Viral mRNA export from host cell nucleus

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Cas-0082Carlito syrichta100.00.0 884
LLPS-Poa-0394Pongo abelii100.00.0 884
LLPS-Eqc-0932Equus caballus100.00.0 884
LLPS-Man-1842Macaca nemestrina100.00.0 884
LLPS-Pat-2506Pan troglodytes100.00.0 884
LLPS-Pap-1115Pan paniscus100.00.0 884
LLPS-Hos-1151Homo sapiens100.00.0 884
LLPS-Mal-1710Mandrillus leucophaeus100.00.0 884
LLPS-Paa-0582Papio anubis100.00.0 884
LLPS-Caj-1164Callithrix jacchus100.00.0 884
LLPS-Gog-1901Gorilla gorilla100.00.0 884
LLPS-Sah-0920Sarcophilus harrisii100.00.0 884
LLPS-Aon-0264Aotus nancymaae100.00.0 884
LLPS-Sus-3161Sus scrofa100.00.0 882
LLPS-Maf-1409Macaca fascicularis100.00.0 884
LLPS-Cap-1732Cavia porcellus99.770.0 882
LLPS-Loa-1828Loxodonta africana99.770.0 877
LLPS-Fec-0254Felis catus99.770.0 882
LLPS-Mup-1159Mustela putorius furo99.770.0 882
LLPS-Ova-0989Ovis aries99.770.0 881
LLPS-Bot-0629Bos taurus99.770.0 882
LLPS-Fud-2623Fukomys damarensis99.770.0 882
LLPS-Chs-1287Chlorocebus sabaeus99.760.0 875
LLPS-Mod-1745Monodelphis domestica99.730.0 780
LLPS-Ict-0534Ictidomys tridecemlineatus99.530.0 880
LLPS-Caf-2108Canis familiaris99.530.0 881
LLPS-Ran-1696Rattus norvegicus99.530.0 880
LLPS-Mum-0441Mus musculus99.530.0 880
LLPS-Mea-1861Mesocricetus auratus99.30.0 880
LLPS-Otg-0511Otolemur garnettii98.60.0 869
LLPS-Anc-0778Anolis carolinensis97.20.0 859
LLPS-Orc-3048Oryctolagus cuniculus96.160.0 865
LLPS-Aim-2974Ailuropoda melanoleuca96.140.0 863
LLPS-Pes-0107Pelodiscus sinensis93.230.0 610
LLPS-Lac-0197Latimeria chalumnae92.540.0 815
LLPS-Cea-4433Cercocebus atys92.510.0 686
LLPS-Asm-0430Astyanax mexicanus92.430.0 828
LLPS-Dar-3636Danio rerio92.180.0 823
LLPS-Orn-1514Oreochromis niloticus91.90.0 809
LLPS-Urm-0782Ursus maritimus91.360.0 797
LLPS-Tut-1177Tursiops truncatus91.120.0 795
LLPS-Myl-2700Myotis lucifugus90.890.0 794
LLPS-Scf-2713Scleropages formosus90.890.0 790
LLPS-Dio-0943Dipodomys ordii90.420.0 791
LLPS-Tar-1251Takifugu rubripes90.310.0 774
LLPS-Rhb-1744Rhinopithecus bieti89.950.0 800
LLPS-Gaa-0899Gasterosteus aculeatus89.720.0 782
LLPS-Xim-2261Xiphophorus maculatus89.720.0 800
LLPS-Orl-0063Oryzias latipes89.720.0 806
LLPS-Leo-2952Lepisosteus oculatus89.720.0 785
LLPS-Pof-1644Poecilia formosa89.490.0 800
LLPS-Icp-3149Ictalurus punctatus89.490.0 779
LLPS-Cii-1985Ciona intestinalis89.460.0 736
LLPS-Scm-1971Scophthalmus maximus89.020.0 795
LLPS-Xet-0761Xenopus tropicalis88.790.0 792
LLPS-Ere-0235Erinaceus europaeus86.760.0 768
LLPS-Cis-0376Ciona savignyi86.760.0 733
LLPS-Drm-1565Drosophila melanogaster84.510.0 731
LLPS-Ora-0010Ornithorhynchus anatinus78.350.0 704
LLPS-Art-2405Arabidopsis thaliana77.837e-122 370
LLPS-Viv-0576Vitis vinifera76.730.0 640
LLPS-Nia-0050Nicotiana attenuata76.350.0 636
LLPS-Cae-0090Caenorhabditis elegans76.240.0 684
LLPS-Hea-2219Helianthus annuus76.230.0 628
LLPS-Mae-0162Manihot esculenta76.090.0 633
LLPS-Sol-1369Solanum lycopersicum76.090.0 637
LLPS-Pot-0334Populus trichocarpa75.90.0 632
LLPS-Php-1383Physcomitrella patens75.640.0 635
LLPS-Amt-0824Amborella trichopoda75.630.0 640
LLPS-Nol-2576Nomascus leucogenys75.470.0 606
LLPS-Arl-0084Arabidopsis lyrata75.380.0 630
LLPS-Orni-0439Oryza nivara75.380.0 542
LLPS-Sot-0103Solanum tuberosum75.320.0 632
LLPS-Phv-1859Phaseolus vulgaris75.190.0 630
LLPS-Via-2025Vigna angularis75.190.0 631
LLPS-Cus-1569Cucumis sativus74.940.0 634
LLPS-Prp-0740Prunus persica74.870.0 634
LLPS-Lep-0009Leersia perrieri74.860.0 569
LLPS-Sob-0925Sorghum bicolor74.810.0 639
LLPS-Gor-0914Gossypium raimondii74.750.0 639
LLPS-Met-1832Medicago truncatula74.680.0 632
LLPS-Glm-2062Glycine max74.680.0 631
LLPS-Bro-0372Brassica oleracea74.620.0 625
LLPS-Mua-0822Musa acuminata74.580.0 568
LLPS-Sei-0848Setaria italica74.560.0 636
LLPS-Thc-0040Theobroma cacao74.50.0 626
LLPS-Sem-0136Selaginella moellendorffii74.370.0 630
LLPS-Brr-1478Brassica rapa74.360.0 621
LLPS-Ori-0285Oryza indica73.980.0 544
LLPS-Org-1102Oryza glaberrima73.972e-114 345
LLPS-Tra-0539Triticum aestivum73.440.0 645
LLPS-Brd-1708Brachypodium distachyon73.350.0 646
LLPS-Ors-1272Oryza sativa73.090.0 642
LLPS-Orb-1740Oryza barthii72.843e-177 507
LLPS-Brn-2147Brassica napus72.460.0 617
LLPS-Dac-1343Daucus carota72.430.0 534
LLPS-Hov-1775Hordeum vulgare72.10.0 637
LLPS-Orbr-0424Oryza brachyantha71.990.0 647
LLPS-Zem-0338Zea mays71.64e-28 119
LLPS-Osl-1014Ostreococcus lucimarinus70.620.0 525
LLPS-Orp-1708Oryza punctata70.180.0 616
LLPS-Usm-1069Ustilago maydis70.050.0 602
LLPS-Spr-0256Sporisorium reilianum69.740.0 596
LLPS-Miv-0346Microbotryum violaceum69.690.0 623
LLPS-Abg-0136Absidia glauca69.520.0 622
LLPS-Tru-0411Triticum urartu69.10.0 596
LLPS-Scp-0216Schizosaccharomyces pombe69.010.0 618
LLPS-Scj-0723Schizosaccharomyces japonicus68.780.0 620
LLPS-Coc-1980Corchorus capsularis68.650.0 587
LLPS-Scc-1132Schizosaccharomyces cryophilus67.840.0 607
LLPS-Crn-0251Cryptococcus neoformans67.610.0 606
LLPS-Pug-0321Puccinia graminis67.440.0 607
LLPS-Chc-0073Chondrus crispus67.30.0 599
LLPS-Gas-0611Galdieria sulphuraria67.060.0 608
LLPS-Put-0252Puccinia triticina66.590.0 592
LLPS-Tum-0048Tuber melanosporum66.210.0 602
LLPS-Mel-0141Melampsora laricipopulina66.130.0 601
LLPS-Cogr-0751Colletotrichum graminicola65.970.0 597
LLPS-Ved-0868Verticillium dahliae65.623e-171 497
LLPS-Cog-0783Colletotrichum gloeosporioides65.580.0 587
LLPS-Coo-0756Colletotrichum orbiculare65.580.0 587
LLPS-Vir-2196Vigna radiata65.510.0 603
LLPS-Nec-0713Neurospora crassa65.350.0 590
LLPS-Orr-0452Oryza rufipogon64.880.0 544
LLPS-Gag-0060Gaeumannomyces graminis64.843e-100 305
LLPS-Trv-1456Trichoderma virens64.720.0 585
LLPS-Beb-0959Beauveria bassiana64.640.0 588
LLPS-Mao-1401Magnaporthe oryzae64.580.0 585
LLPS-Ast-0122Aspergillus terreus64.530.0 585
LLPS-Asf-0894Aspergillus flavus64.530.0 588
LLPS-Aso-0779Aspergillus oryzae64.530.0 588
LLPS-Asni-1268Aspergillus niger64.450.0 588
LLPS-Blg-1317Blumeria graminis64.370.0 590
LLPS-Trr-0666Trichoderma reesei64.250.0 587
LLPS-Nef-0688Neosartorya fischeri64.070.0 585
LLPS-Asc-0213Aspergillus clavatus64.070.0 587
LLPS-Yal-0874Yarrowia lipolytica64.060.0 585
LLPS-Fus-0302Fusarium solani63.870.0 582
LLPS-Map-1206Magnaporthe poae63.820.0 582
LLPS-Asg-0055Ashbya gossypii63.570.0 578
LLPS-Chr-1532Chlamydomonas reinhardtii63.430.0 538
LLPS-Kop-0264Komagataella pastoris63.430.0 581
LLPS-Dos-1338Dothistroma septosporum63.220.0 558
LLPS-Sac-1034Saccharomyces cerevisiae62.870.0 579
LLPS-Asfu-0803Aspergillus fumigatus62.840.0 576
LLPS-Fuo-0492Fusarium oxysporum62.70.0 576
LLPS-Fuv-1014Fusarium verticillioides62.70.0 576
LLPS-Scs-0442Sclerotinia sclerotiorum61.930.0 565
LLPS-Phn-0347Phaeosphaeria nodorum61.820.0 556
LLPS-Asn-1245Aspergillus nidulans61.582e-151 442
LLPS-Pyt-0918Pyrenophora teres61.520.0 561
LLPS-Zyt-0469Zymoseptoria tritici61.140.0 560
LLPS-Cym-0744Cyanidioschyzon merolae60.630.0 548
LLPS-Pytr-0891Pyrenophora triticirepentis57.050.0 540
LLPS-Lem-0302Leptosphaeria maculans55.120.0 531