LLPS-Cae-0090
hel-1

▼ OVERVIEW

Status: Reviewed
Protein Name: Spliceosome RNA helicase DDX39B homolog; DEAD box protein UAP56
Gene Name: hel-1, C26D10.2
Ensembl Gene: WBGene00001840
Ensembl Protein: C26D10.2a
Organism: Caenorhabditis elegans
Taxa ID: 6239
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
P-body
"...Here we describe a systematic RNAi screen in C. elegans that identified 224 genes with diverse cellular functions whose inactivations result in a dramatic increase in the number of P bodies."
Caenorhabditis elegans22180091
Nuclear speckle, NucleolusPredicted from orthologsN/A(View)

▼ FUNCTION

Required for mRNA export out of the nucleus. May play a role in spliceosome assembly.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblC26D10.2aC26D10.2a
UniProtQ18212, DX39B_CAEEL, Q17323
GeneBankZ54327, U08102AAB65852.1, CAA91120.1
RefSeqNM_001026814.3NP_001021985.1
Entrez174333

▼ SEQUENCE

Protein Sequence (FASTA)
1     MEEEQLLDYE  EEQEEIQDKQ  PEVGGGDARK  TKGTYASIHS  SGFRDFLLKP  EILRAIGDCG  60
61    FEHPSEVQHE  CIPQAILGMD  VVCQAKSGMG  KTAVFVITTL  QQLEPVDGEV  SVVCMCHTRE  120
121   LAFQISKEYE  RFSKYLPGVK  VAVFFGGMAI  KKDEERLAND  CPHIVVGTPG  RMLALARSGK  180
181   LKLDKVKYFV  LDECDKMIGD  ADMRRDVQEI  VKMTPQQKQV  MMFSATLPKE  LRTVCKRFMQ  240
241   DPMEVYVDDE  AKLTLHGLQQ  HYVKLKEAEK  NRRLLNLLDA  LEFNQVVIFV  KAVKRCEALH  300
301   QLLTEQNFPS  IAIHRQMAQE  ERLSRYQAFK  DFQKRILVAT  DLFGRGMDIE  RVNIVFNYDM  360
361   PEDSDSYLHR  VARAGRFGTK  GLAITFVSDE  NDAKTLNSVQ  DRFDISITEL  PEKIDVSTYI  420
421   EGRTN  425
Nucleotide CDS Sequence (FASTA)
1     Sequence u  navailable  20

▼ KEYWORD

ID
Family
ATP-binding
Complete proteome
Helicase
Hydrolase
mRNA processing
mRNA splicing
Nucleotide-binding
Nucleus
Reference proteome
RNA-binding
Spliceosome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nucleus
Cellular Component
Spliceosomal complex
Cellular Component
Transcription factor complex
Molecular Function
ATP binding
Molecular Function
Helicase activity
Molecular Function
RNA binding
Molecular Function
Transcription factor binding
Biological Process
Determination of adult lifespan
Biological Process
MRNA processing
Biological Process
Positive regulation of gene expression
Biological Process
RNA splicing

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Drm-1565Drosophila melanogaster81.060.0 663
LLPS-Org-1102Oryza glaberrima80.563e-1167.8
LLPS-Cii-1985Ciona intestinalis80.560.0 678
LLPS-Cap-0199Cavia porcellus80.150.0 677
LLPS-Mup-0850Mustela putorius furo80.150.0 676
LLPS-Ran-1696Rattus norvegicus80.150.0 677
LLPS-Gaa-0899Gasterosteus aculeatus80.150.0 675
LLPS-Scf-2713Scleropages formosus80.150.0 676
LLPS-Fud-3375Fukomys damarensis80.150.0 678
LLPS-Mum-0441Mus musculus80.150.0 677
LLPS-Anc-0778Anolis carolinensis79.950.0 672
LLPS-Caf-3518Canis familiaris79.90.0 676
LLPS-Otg-0338Otolemur garnettii79.90.0 676
LLPS-Urm-0782Ursus maritimus79.90.0 677
LLPS-Dar-1467Danio rerio79.90.0 672
LLPS-Lac-0197Latimeria chalumnae79.90.0 674
LLPS-Fec-1153Felis catus79.90.0 676
LLPS-Aim-2827Ailuropoda melanoleuca79.90.0 677
LLPS-Myl-2700Myotis lucifugus79.90.0 676
LLPS-Asm-1879Astyanax mexicanus79.90.0 676
LLPS-Orn-1514Oreochromis niloticus79.850.0 667
LLPS-Ict-2441Ictidomys tridecemlineatus79.80.0 673
LLPS-Cas-1264Carlito syrichta79.640.0 675
LLPS-Eqc-2817Equus caballus79.640.0 674
LLPS-Loa-2103Loxodonta africana79.640.0 672
LLPS-Mod-0138Monodelphis domestica79.640.0 675
LLPS-Tut-1177Tursiops truncatus79.640.0 676
LLPS-Icp-1056Ictalurus punctatus79.640.0 672
LLPS-Sah-0561Sarcophilus harrisii79.640.0 674
LLPS-Pes-0107Pelodiscus sinensis79.480.0 522
LLPS-Ova-0188Ovis aries79.390.0 677
LLPS-Dio-0943Dipodomys ordii79.390.0 671
LLPS-Bot-4298Bos taurus79.390.0 675
LLPS-Leo-2952Lepisosteus oculatus79.390.0 674
LLPS-Mea-2402Mesocricetus auratus79.390.0 674
LLPS-Xet-0761Xenopus tropicalis79.240.0 668
LLPS-Mam-2248Macaca mulatta79.130.0 672
LLPS-Poa-1022Pongo abelii79.130.0 672
LLPS-Rhb-1744Rhinopithecus bieti79.130.0 672
LLPS-Pat-4576Pan troglodytes79.130.0 672
LLPS-Pof-1644Poecilia formosa79.130.0 669
LLPS-Pap-1546Pan paniscus79.130.0 672
LLPS-Hos-2018Homo sapiens79.130.0 672
LLPS-Gog-0959Gorilla gorilla79.130.0 672
LLPS-Orl-3058Oryzias latipes79.130.0 671
LLPS-Chs-2750Chlorocebus sabaeus79.130.0 672
LLPS-Man-0999Macaca nemestrina79.030.0 667
LLPS-Paa-2009Papio anubis78.880.0 669
LLPS-Mal-1902Mandrillus leucophaeus78.880.0 669
LLPS-Xim-2261Xiphophorus maculatus78.880.0 669
LLPS-Cea-0941Cercocebus atys78.880.0 669
LLPS-Maf-1504Macaca fascicularis78.880.0 669
LLPS-Caj-1164Callithrix jacchus78.710.0 678
LLPS-Aon-0264Aotus nancymaae78.710.0 678
LLPS-Sus-3161Sus scrofa78.710.0 675
LLPS-Scm-1971Scophthalmus maximus78.540.0 671
LLPS-Tar-1251Takifugu rubripes78.430.0 665
LLPS-Nol-2576Nomascus leucogenys77.663e-162 468
LLPS-Ere-0235Erinaceus europaeus77.490.0 650
LLPS-Lep-0009Leersia perrieri77.426e-0755.8
LLPS-Cis-0376Ciona savignyi77.260.0 660
LLPS-Orc-3048Oryctolagus cuniculus75.660.0 661
LLPS-Zem-0338Zea mays74.074e-30 125
LLPS-Ved-0868Verticillium dahliae73.812e-1375.9
LLPS-Ors-0877Oryza sativa73.330.0 609
LLPS-Sol-1224Solanum lycopersicum73.060.0 601
LLPS-Orni-0439Oryza nivara72.972e-178 518
LLPS-Hea-2219Helianthus annuus72.540.0 595
LLPS-Hov-1775Hordeum vulgare72.470.0 600
LLPS-Prp-0030Prunus persica72.240.0 596
LLPS-Cus-1569Cucumis sativus72.240.0 597
LLPS-Tra-1746Triticum aestivum72.240.0 601
LLPS-Ora-0010Ornithorhynchus anatinus72.240.0 608
LLPS-Sob-0287Sorghum bicolor72.220.0 607
LLPS-Viv-1527Vitis vinifera72.050.0 598
LLPS-Brd-1708Brachypodium distachyon72.050.0 603
LLPS-Sei-0513Setaria italica71.970.0 607
LLPS-Sot-0538Solanum tuberosum71.860.0 603
LLPS-Orbr-0424Oryza brachyantha71.790.0 607
LLPS-Mua-0822Musa acuminata71.750.0 540
LLPS-Gor-2120Gossypium raimondii71.720.0 594
LLPS-Glm-2062Glycine max71.720.0 595
LLPS-Ori-0285Oryza indica71.640.0 520
LLPS-Bro-0372Brassica oleracea71.460.0 592
LLPS-Mae-0162Manihot esculenta71.360.0 600
LLPS-Sem-0022Selaginella moellendorffii71.320.0 602
LLPS-Nia-0050Nicotiana attenuata71.280.0 601
LLPS-Via-2025Vigna angularis71.250.0 597
LLPS-Met-1832Medicago truncatula71.210.0 592
LLPS-Orp-1708Oryza punctata71.140.0 586
LLPS-Pot-0334Populus trichocarpa71.070.0 595
LLPS-Php-0408Physcomitrella patens71.070.0 600
LLPS-Abg-0964Absidia glauca71.030.0 591
LLPS-Phv-1859Phaseolus vulgaris70.990.0 592
LLPS-Brr-1478Brassica rapa70.960.0 589
LLPS-Amt-0824Amborella trichopoda70.890.0 600
LLPS-Thc-0040Theobroma cacao70.850.0 589
LLPS-Art-1161Arabidopsis thaliana70.810.0 595
LLPS-Arl-0084Arabidopsis lyrata70.810.0 594
LLPS-Brn-2147Brassica napus70.680.0 584
LLPS-Orb-1740Oryza barthii70.689e-169 485
LLPS-Osl-1014Ostreococcus lucimarinus69.498e-180 513
LLPS-Dac-1343Daucus carota68.622e-175 501
LLPS-Scj-0723Schizosaccharomyces japonicus68.450.0 578
LLPS-Scp-0216Schizosaccharomyces pombe67.750.0 581
LLPS-Tru-0411Triticum urartu67.680.0 553
LLPS-Crn-0251Cryptococcus neoformans67.520.0 566
LLPS-Miv-0346Microbotryum violaceum67.330.0 579
LLPS-Gas-0611Galdieria sulphuraria67.330.0 574
LLPS-Pug-0321Puccinia graminis67.090.0 574
LLPS-Put-0252Puccinia triticina67.010.0 563
LLPS-Asf-0894Aspergillus flavus66.830.0 557
LLPS-Aso-0779Aspergillus oryzae66.830.0 557
LLPS-Coc-1980Corchorus capsularis66.590.0 553
LLPS-Asni-1268Aspergillus niger66.580.0 556
LLPS-Scc-1132Schizosaccharomyces cryophilus66.50.0 577
LLPS-Nef-0688Neosartorya fischeri66.330.0 555
LLPS-Mel-0141Melampsora laricipopulina66.330.0 573
LLPS-Asc-0213Aspergillus clavatus66.330.0 556
LLPS-Chc-0073Chondrus crispus66.250.0 565
LLPS-Ast-0122Aspergillus terreus66.080.0 551
LLPS-Spr-0256Sporisorium reilianum66.070.0 568
LLPS-Coo-0756Colletotrichum orbiculare66.070.0 560
LLPS-Tum-0048Tuber melanosporum66.00.0 564
LLPS-Asn-1245Aspergillus nidulans65.819e-141 414
LLPS-Map-1206Magnaporthe poae65.750.0 556
LLPS-Cog-0783Colletotrichum gloeosporioides65.560.0 557
LLPS-Blg-1317Blumeria graminis65.340.0 557
LLPS-Usm-1069Ustilago maydis65.330.0 569
LLPS-Asfu-0803Aspergillus fumigatus65.20.0 547
LLPS-Mao-1401Magnaporthe oryzae65.090.0 555
LLPS-Nec-0713Neurospora crassa65.050.0 549
LLPS-Cogr-0751Colletotrichum graminicola65.00.0 561
LLPS-Cym-0744Cyanidioschyzon merolae64.630.0 540
LLPS-Beb-0959Beauveria bassiana64.540.0 553
LLPS-Orr-0452Oryza rufipogon64.367e-173 512
LLPS-Trr-0666Trichoderma reesei64.290.0 549
LLPS-Sac-1034Saccharomyces cerevisiae64.030.0 540
LLPS-Scs-0442Sclerotinia sclerotiorum63.50.0 542
LLPS-Vir-2196Vigna radiata63.470.0 561
LLPS-Kop-0264Komagataella pastoris63.410.0 548
LLPS-Yal-0874Yarrowia lipolytica63.270.0 535
LLPS-Trv-1456Trichoderma virens63.250.0 548
LLPS-Asg-0055Ashbya gossypii63.160.0 540
LLPS-Gag-0060Gaeumannomyces graminis63.011e-96 295
LLPS-Fus-0302Fusarium solani62.590.0 545
LLPS-Phn-0347Phaeosphaeria nodorum62.370.0 522
LLPS-Fuo-0492Fusarium oxysporum62.340.0 543
LLPS-Fuv-1014Fusarium verticillioides62.340.0 543
LLPS-Chr-1532Chlamydomonas reinhardtii62.010.0 526
LLPS-Zyt-0469Zymoseptoria tritici61.580.0 526
LLPS-Dos-1338Dothistroma septosporum61.20.0 530
LLPS-Pyt-0918Pyrenophora teres60.740.0 529
LLPS-Pytr-0891Pyrenophora triticirepentis56.165e-176 508
LLPS-Lem-0302Leptosphaeria maculans54.974e-174 503