• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Leo-0191

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Telomeric repeat-binding factor
Ensembl Gene: ENSLOCG00000003784.1
Ensembl Protein: ENSLOCP00000004537.1
Organism: Lepisosteus oculatus
Taxa ID: 7918
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
PML nuclear bodyPredicted from orthologs(View)

▼ FUNCTION

Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MEERESRSEV  SAEFSEVEHV  AKSWMLDFVI  GSLCHHFRHD  KYKEFNQSLS  VLEALIPGFG  60
61    QFKSYQKKMI  NICFVLSRIV  NGKKTSLQYE  EDARITPLMS  ASHIWNVIEQ  EIEQKTLYED  120
121   IKRLLFVQSV  AVCLQSGQHQ  KASWVLERLT  ETTEVPQNLR  MKLSMIVNKK  DAYHQFLLNF  180
181   SFDVLLEKIK  ILLDSFQKDY  LSDFLLKAAS  KVVEASKEKG  VEEETTEIQE  SGTAAPNEAQ  240
241   LQSDGPFQQE  GVDAGPKITD  VNYSNGNVFS  LTPSASLLAK  KTFRPRRKLF  SVQNIEHWKP  300
301   KSSRKSFLVC  RRNYSIRGTR  LSFDFTKRKT  SELKKKRVKR  HWTFEENQAL  KAGVRRYGEG  360
361   NWAKILKHFE  FNNRTGVMLK  DRWRTMKKLY  LVSENNSSED  400
Nucleotide CDS Sequence (FASTA)
1     CAAGAAGGCA  AGATGGAGGA  GCGGGAGTCC  CGCTCGGAAG  TGTCTGCGGA  GTTTTCAGAA  60
61    GTTGAACATG  TCGCTAAAAG  TTGGATGCTG  GACTTTGTAA  TTGGTTCTTT  GTGTCATCAT  120
121   TTCAGACACG  ACAAGTACAA  GGAATTCAAC  CAGTCGCTGA  GTGTTTTAGA  AGCTTTGATT  180
181   CCGGGATTTG  GTCAGTTCAA  GTCTTATCAG  AAGAAGATGA  TTAACATCTG  TTTTGTCCTG  240
241   TCCAGGATTG  TGAATGGGAA  AAAAACAAGT  CTCCAGTACG  AAGAAGATGC  ACGAATTACA  300
301   CCTTTAATGT  CTGCTTCCCA  CATTTGGAAT  GTAATAGAAC  AAGAGATTGA  GCAAAAGACA  360
361   CTATATGAAG  ATATCAAAAG  GTTACTGTTT  GTTCAGTCTG  TAGCAGTTTG  TTTGCAAAGT  420
421   GGACAACATC  AAAAGGCATC  ATGGGTTCTT  GAGAGGCTGA  CAGAAACCAC  TGAAGTGCCG  480
481   CAGAACCTAA  GAATGAAACT  TTCCATGATT  GTGAACAAGA  AGGATGCATA  TCATCAATTT  540
541   CTCTTGAACT  TCAGTTTTGA  CGTTTTGTTG  GAGAAAATCA  AGATATTACT  TGATTCCTTT  600
601   CAAAAAGACT  ATCTGTCTGA  TTTCCTACTA  AAGGCAGCAT  CAAAGGTTGT  AGAGGCCAGC  660
661   AAGGAAAAAG  GAGTGGAAGA  GGAAACGAGC  CCAGAAGGAA  ACTCTTTTCT  GTGCAAAACA  720
721   TCGAACATTG  GAAGCCGAAA  AGTTCCAGAA  AATCTTTTCT  CGTCTGTCGG  AGAAATTACA  780
781   GCATCAGAGA  CCATTACAAG  GTCCCTCACA  TCACGGAGCC  TTTCGCTCGT  GGATTCCAGG  840
841   GCTCGACGAG  CTTCACCCAC  ATGCTCATCC  CTTTCGAGGA  GTAGTGGGAG  GCCCTCGACC  900
901   CGGTTCAAAA  AGGGCGCTGC  CTCTAAAAGA  TATAACTCAG  GAACACGGTT  ATCCTTTGAT  960
961   TTTACAAAAA  GGAAAACCTC  AGAATTAAAA  AAGAAAAGAG  TAAAGAGGCA  CTGGACCTTT  1020
1021  GAGGAAAACC  AGGCGCTAAA  AGCAGGGGTG  AGACGTTATG  GAGAAGGAAA  TTGGGCTAAA  1080
1081  ATACTGAAGC  ATTTCGAGTT  TAATAATCGT  ACTGGTGTCA  TGTTAAAGGA  CAGGTGGAGA  1140
1141  ACCATGAAGA  AATTGTATCT  GGTCTCTGAA  AACAATTCTT  CTGAAGACTG  A  1191

▼ KEYWORD

ID
Family
Cell cycle
Chromosome
Complete proteome
DNA-binding
Nucleus
Reference proteome
Telomere

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nuclear chromosome, telomeric region
Molecular Function
Double-stranded telomeric DNA binding
Molecular Function
Protein homodimerization activity
Biological Process
Cell cycle
Biological Process
Telomere maintenance

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Orc-0515Oryctolagus cuniculus66.01e-1479.7
LLPS-Scm-1891Scophthalmus maximus64.716e-1477.8
LLPS-Fec-2845Felis catus64.153e-1581.6
LLPS-Ict-3331Ictidomys tridecemlineatus64.155e-1580.9
LLPS-Caf-4256Canis familiaris64.153e-1581.6
LLPS-Fud-3158Fukomys damarensis64.152e-1581.6
LLPS-Sah-2088Sarcophilus harrisii64.152e-1582.0
LLPS-Mum-2953Mus musculus64.158e-1580.1
LLPS-Dio-2997Dipodomys ordii64.154e-1581.3
LLPS-Aon-1120Aotus nancymaae63.831e-1273.6
LLPS-Paa-2691Papio anubis63.831e-1273.6
LLPS-Mod-3482Monodelphis domestica62.962e-1581.6
LLPS-Anc-0835Anolis carolinensis62.752e-1479.0
LLPS-Rhb-3777Rhinopithecus bieti62.266e-1580.1
LLPS-Otg-0292Otolemur garnettii62.269e-1579.7
LLPS-Man-3524Macaca nemestrina62.267e-1580.1
LLPS-Pat-1768Pan troglodytes62.267e-1580.1
LLPS-Pap-1524Pan paniscus62.265e-1580.9
LLPS-Urm-2433Ursus maritimus62.264e-1580.9
LLPS-Hos-2125Homo sapiens62.267e-1580.1
LLPS-Nol-1345Nomascus leucogenys62.267e-1580.1
LLPS-Mam-1653Macaca mulatta62.267e-1580.1
LLPS-Eqc-2415Equus caballus62.266e-1580.5
LLPS-Cap-2187Cavia porcellus62.261e-1479.3
LLPS-Caj-1412Callithrix jacchus62.267e-1580.1
LLPS-Gog-0601Gorilla gorilla62.268e-1580.1
LLPS-Cea-1787Cercocebus atys62.267e-1580.5
LLPS-Sus-2357Sus scrofa62.268e-1580.1
LLPS-Chs-1601Chlorocebus sabaeus62.267e-1580.1
LLPS-Mea-2149Mesocricetus auratus62.261e-1479.3
LLPS-Maf-2728Macaca fascicularis62.267e-1580.1
LLPS-Aim-0697Ailuropoda melanoleuca62.261e-1479.7
LLPS-Mup-3531Mustela putorius furo62.263e-1580.9
LLPS-Ova-4190Ovis aries62.266e-1580.5
LLPS-Mal-4264Mandrillus leucophaeus62.268e-1580.1
LLPS-Ran-2845Rattus norvegicus62.268e-1477.0
LLPS-Bot-1012Bos taurus62.268e-1580.1
LLPS-Tut-1305Tursiops truncatus62.267e-1580.1
LLPS-Scf-0867Scleropages formosus62.071e-1580.5
LLPS-Xet-1615Xenopus tropicalis61.41e-1582.4
LLPS-Poa-2571Pongo abelii60.382e-1478.6
LLPS-Ora-0747Ornithorhynchus anatinus60.387e-1476.6
LLPS-Myl-0584Myotis lucifugus60.382e-1479.0
LLPS-Orn-3340Oreochromis niloticus58.824e-1272.0
LLPS-Pes-3155Pelodiscus sinensis58.491e-1376.6
LLPS-Tar-1491Takifugu rubripes57.455e-1165.5
LLPS-Orl-1567Oryzias latipes57.413e-1375.5
LLPS-Anp-1253Anas platyrhynchos55.561e-1376.6
LLPS-Fia-1087Ficedula albicollis53.73e-1272.4
LLPS-Tag-0551Taeniopygia guttata53.72e-1272.8
LLPS-Asm-1327Astyanax mexicanus53.73e-1066.2
LLPS-Xim-2156Xiphophorus maculatus53.73e-1169.3
LLPS-Meg-1370Meleagris gallopavo52.085e-0962.0
LLPS-Gaga-0102Gallus gallus51.854e-1168.9
LLPS-Dar-0854Danio rerio51.721e-1067.0
LLPS-Pof-2341Poecilia formosa50.01e-1067.4
LLPS-Icp-2675Ictalurus punctatus49.213e-1066.2
LLPS-Sem-0878Selaginella moellendorffii45.163e-0653.5
LLPS-Gaa-0255Gasterosteus aculeatus43.062e-1169.7
LLPS-Cii-1470Ciona intestinalis40.212e-1065.9
LLPS-Cis-1702Ciona savignyi39.674e-1268.6
LLPS-Loa-3164Loxodonta africana37.287e-70 233
LLPS-Lac-1115Latimeria chalumnae36.814e-51 181
LLPS-Cas-0181Carlito syrichta35.893e-58 201