LLPS-Orc-0515
TERF2
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Telomeric repeat-binding factor |
| Gene Name: | TERF2 |
| Ensembl Gene: | ENSOCUG00000017662.3 |
| Ensembl Protein: | ENSOCUP00000022061.1 |
| Organism: | Oryctolagus cuniculus |
| Taxa ID: | 9986 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Chromatin, PML nuclear body | Predicted from orthologs | (View) |
▼ FUNCTION
| Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSOCUT00000026558.1 | ENSOCUP00000022061.1 |
| Ensembl | ENSOCUT00000017662.3 | ENSOCUP00000015167.2 |
| UniProt | G1TE57, G1TE57_RABIT | |
| GeneBank | AAGW02055507 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAAGAGTAGP ASGPGVVRDP AASQPRKRPS RGGGEGARRS DAMAGGGGSS DGSGRAGRRA 60 61 SRSGGRARRG RHEPGLGGPG DRGAGEARLE EAVNRWVLKF YFHEALRAFR GSRYGDFRQI 120 121 RDIMQALLVR PLGKEHTVSR LLRVMQCLSR IEEGENLDCS FDMEAELTPL ESAINVLEMI 180 181 KTEFTLTEAV IESSRKLVKE AAVIICIKNK EFEKASKILK KHMSKDPTTQ KMKNDLLNII 240 241 REKNVAHPVI QNFSYETFQQ KMLRFLESHL DDTEPYLLTM AKKALKSQSA ASSTVKEDKQ 300 301 PAPEPVAKPP REPGRQLQNT PTTIGITTLK AAFKALSGAQ DSDAAFSKLD QKDLVLPNQV 360 361 TPPSPALKNK RPRKDENESS APAEGEGSSE LQPKSKRMTI SRLILEEDSQ STEPSTGLTS 420 421 SQEAVPASPP KPTALNQPRP REISLRVPKS KWNSSNGVEE KETWVEEDDL FQVQGEPWNR 480 481 LGASLILLQK WTVEESEWVK AGVQKYGEGN WAAISKNYPF VNRTAVMIKD RWRTMKKLGM 540 541 N 541 |
| Nucleotide CDS Sequence (FASTA) |
1 TTCCCGGCCG ACCTGAGCGG CACGGACTGC AAGTCCCAGC AGGCCTTGCG GCCAGCGGAC 60 61 CGGGAACTAC GGAGGCCGAG ACGGAGGCTG GGCCCTCCGG TCCTTTCCCT CCCAGAAGCC 120 121 CGCGGGCGGC TAGAAGCACG GCTGGAAGAA GCGGTCAACC GCTGGGTGCT CAAGTTCTAC 180 181 TTCCACGAGG CGCTGCGGGC CTTTCGGGGT AGCCGGTACG GGGACTTCAG GCAGATCCGG 240 241 GACATTATGC AGGCTCTGCT TGTCAGGCCC CTGGGGAAGG AGCACACGGT GTCCCGGTTG 300 301 CTGCGGGTTA TGCAGTGTCT GTCGCGCATT GAAGAAGGGG AGAATTTAGA CTGCTCCTTT 360 361 GATATGGAAG CTGAGCTTAC ACCCCTGGAG TCAGCCATCA ATGTGCTGGA GATGATTAAA 420 421 ACCGAGTTTA CGTTGACAGA AGCGGTGATC GAATCCAGCA GAAAGCTGGT CAAGGAGGCT 480 481 GCTGTCATTA TTTGTATCAA GAACAAAGAA TTTGAAAAGG CTTCAAAAAT TTTGAAAAAA 540 541 CATATGTCTA AGGACCCCAC AACTCAGAAG ATGAAAAATG ATCTCCTGAA CATTATTCGA 600 601 GAAAAGAACG TGGCCCACCC TGTAATCCAG AACTTTTCCT ATGAGACCTT CCAACAGAAG 660 661 ATGCTGCGCT TCCTGGAGAG CCACCTGGAC GACACAGAGC CCTACCTCCT CACGATGGCC 720 721 AAAAAGGCTT TGAAATCTCA GTCTGCTGCC TCGAGTACAG TGAAGGAAGA CAAACAGCCA 780 781 GCACCAGAGC CTGTGGCAAA GCCCCCAAGA GAACCAGCAA GGCAGCTACA GAACACACCA 840 841 ACCACCATTG GAATCACAAC TCTGAAGGCA GCTTTCAAGG CTCTGTCTGG TGCACAGGAT 900 901 TCTGATGCCG CCTTCTCAAA ATTGGACCAG AAAGATTTGG TACTTCCAAA TCAAGTGACC 960 961 CCACCATCAC CAGCCCTCAA AAACAAGAGA CCAAGAAAAG ATGAAAATGA AAGTTCAGCC 1020 1021 CCTGCTGAGG GCGAGGGCAG CTCAGAACTG CAGCCCAAGA GCAAGCGCAT GACGATAAGC 1080 1081 AGATTGATTT TGGAAGAGGA CAGCCAGAGT ACTGAGCCGA GCACAGGCCT CACCTCCTCC 1140 1141 CAGGAGGCTG TTCCTGCATC ACCACCCAAG CCCACGGCTC TCAACCAACC CCGCCCCAGG 1200 1201 GAGAAGAATT CCAAAGTGCC CAAGAGCAAG TGGAACAGCT CTAACGGGGT GGAAGAAAAA 1260 1261 GAGACCTGGG TGGAAGAGGA CGACTTGTTT CAAGTTCAGG CAGCACCAGA TGAAGACAGT 1320 1321 GCCAGCATGA TAGCAAGAAA GCAGAAGTGG ACTGTAGAAG AAAGCGAGTG GGTCAAGGCT 1380 1381 GGTGTGCAGA AGTATGGGGA AGGAAACTGG GCTGCCATTT CTAAAAATTA CCCATTTGTT 1440 1441 AATCGAACAG CTGTGATGAT TAAGGATCGC TGGCGGACCA TGAAAAAACT TGGCATGAAC 1500 1501 TGA 1503 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nuclear chromosome, telomeric region | |
Molecular Function | Double-stranded telomeric DNA binding | |
Molecular Function | Protein homodimerization activity | |
Biological Process | Cell cycle | |
Biological Process | Protection from non-homologous end joining at telomere |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Aim-0697 | Ailuropoda melanoleuca | 97.38 | 6e-125 | 389 |
| LLPS-Urm-2433 | Ursus maritimus | 88.56 | 0.0 | 743 |
| LLPS-Caj-1412 | Callithrix jacchus | 88.24 | 0.0 | 776 |
| LLPS-Pap-1524 | Pan paniscus | 88.14 | 0.0 | 757 |
| LLPS-Mal-4264 | Mandrillus leucophaeus | 88.08 | 0.0 | 764 |
| LLPS-Tut-1305 | Tursiops truncatus | 88.08 | 0.0 | 775 |
| LLPS-Caf-4256 | Canis familiaris | 87.75 | 0.0 | 762 |
| LLPS-Mup-3531 | Mustela putorius furo | 87.74 | 0.0 | 692 |
| LLPS-Chs-1601 | Chlorocebus sabaeus | 87.64 | 0.0 | 763 |
| LLPS-Ict-3331 | Ictidomys tridecemlineatus | 87.1 | 0.0 | 799 |
| LLPS-Eqc-2415 | Equus caballus | 86.72 | 0.0 | 786 |
| LLPS-Pat-1768 | Pan troglodytes | 86.72 | 0.0 | 784 |
| LLPS-Fec-2845 | Felis catus | 86.53 | 0.0 | 790 |
| LLPS-Hos-2125 | Homo sapiens | 86.53 | 0.0 | 781 |
| LLPS-Cea-1787 | Cercocebus atys | 86.53 | 0.0 | 781 |
| LLPS-Aon-1120 | Aotus nancymaae | 86.51 | 0.0 | 744 |
| LLPS-Mam-1653 | Macaca mulatta | 86.34 | 0.0 | 779 |
| LLPS-Gog-0601 | Gorilla gorilla | 86.34 | 0.0 | 783 |
| LLPS-Maf-2728 | Macaca fascicularis | 86.34 | 0.0 | 779 |
| LLPS-Fud-3158 | Fukomys damarensis | 86.26 | 0.0 | 719 |
| LLPS-Man-3524 | Macaca nemestrina | 86.15 | 0.0 | 779 |
| LLPS-Sus-2357 | Sus scrofa | 85.77 | 0.0 | 785 |
| LLPS-Bot-1012 | Bos taurus | 85.04 | 0.0 | 757 |
| LLPS-Dio-2997 | Dipodomys ordii | 84.77 | 0.0 | 746 |
| LLPS-Otg-0292 | Otolemur garnettii | 84.1 | 0.0 | 726 |
| LLPS-Poa-2571 | Pongo abelii | 82.56 | 0.0 | 700 |
| LLPS-Cap-2187 | Cavia porcellus | 81.54 | 0.0 | 740 |
| LLPS-Mea-2149 | Mesocricetus auratus | 81.17 | 0.0 | 556 |
| LLPS-Nol-1345 | Nomascus leucogenys | 80.68 | 0.0 | 754 |
| LLPS-Paa-2691 | Papio anubis | 80.46 | 0.0 | 687 |
| LLPS-Ran-2845 | Rattus norvegicus | 80.35 | 0.0 | 684 |
| LLPS-Myl-0584 | Myotis lucifugus | 80.27 | 0.0 | 750 |
| LLPS-Mum-2953 | Mus musculus | 77.02 | 0.0 | 686 |
| LLPS-Ova-4190 | Ovis aries | 76.77 | 0.0 | 749 |
| LLPS-Mod-3482 | Monodelphis domestica | 73.86 | 0.0 | 646 |
| LLPS-Loa-1666 | Loxodonta africana | 71.9 | 3e-42 | 153 |
| LLPS-Ora-0747 | Ornithorhynchus anatinus | 71.61 | 4e-169 | 492 |
| LLPS-Rhb-3777 | Rhinopithecus bieti | 69.69 | 1e-177 | 514 |
| LLPS-Sah-2088 | Sarcophilus harrisii | 69.52 | 0.0 | 549 |
| LLPS-Pes-3155 | Pelodiscus sinensis | 66.89 | 2e-60 | 217 |
| LLPS-Leo-0191 | Lepisosteus oculatus | 66.0 | 1e-14 | 79.7 |
| LLPS-Gaga-0102 | Gallus gallus | 62.3 | 4e-76 | 261 |
| LLPS-Xet-0739 | Xenopus tropicalis | 61.54 | 1e-12 | 73.6 |
| LLPS-Tag-0551 | Taeniopygia guttata | 60.22 | 9e-73 | 251 |
| LLPS-Cas-0181 | Carlito syrichta | 59.62 | 2e-12 | 72.8 |
| LLPS-Fia-1087 | Ficedula albicollis | 58.06 | 7e-72 | 247 |
| LLPS-Asm-0940 | Astyanax mexicanus | 57.69 | 8e-12 | 70.9 |
| LLPS-Icp-3373 | Ictalurus punctatus | 57.45 | 4e-11 | 68.9 |
| LLPS-Lac-1115 | Latimeria chalumnae | 56.86 | 2e-11 | 70.1 |
| LLPS-Scf-0867 | Scleropages formosus | 56.86 | 2e-11 | 68.9 |
| LLPS-Tar-1491 | Takifugu rubripes | 56.41 | 4e-07 | 54.3 |
| LLPS-Anc-1375 | Anolis carolinensis | 55.77 | 1e-10 | 67.4 |
| LLPS-Meg-1994 | Meleagris gallopavo | 54.0 | 6e-09 | 62.0 |
| LLPS-Anp-1253 | Anas platyrhynchos | 50.87 | 4e-47 | 177 |
| LLPS-Sob-1393 | Sorghum bicolor | 49.06 | 4e-08 | 59.7 |
| LLPS-Glm-2452 | Glycine max | 48.98 | 3e-06 | 53.9 |
| LLPS-Dar-3327 | Danio rerio | 48.08 | 8e-08 | 58.5 |
| LLPS-Prp-1784 | Prunus persica | 47.37 | 3e-07 | 56.6 |
| LLPS-Scm-2908 | Scophthalmus maximus | 46.94 | 2e-07 | 57.4 |
| LLPS-Cis-1702 | Ciona savignyi | 44.9 | 4e-07 | 54.3 |
| LLPS-Orl-1818 | Oryzias latipes | 44.9 | 4e-07 | 56.6 |
| LLPS-Orn-3340 | Oreochromis niloticus | 43.9 | 8e-13 | 75.1 |
| LLPS-Xim-2156 | Xiphophorus maculatus | 43.02 | 5e-11 | 69.3 |
| LLPS-Gaa-1980 | Gasterosteus aculeatus | 42.86 | 3e-07 | 54.7 |
| LLPS-Pof-2341 | Poecilia formosa | 38.81 | 2e-13 | 77.0 |