• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Fud-3158
H920_18660

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Telomeric repeat-binding factor
Gene Name: H920_18660
Ensembl Gene: ENSFDAG00000004766.1
Ensembl Protein: ENSFDAP00000016316.1
Organism: Fukomys damarensis
Taxa ID: 885580
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Chromatin, PML nuclear bodyPredicted from orthologs(View)

▼ FUNCTION

Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAAGAGTAGS  ASGPGLKFYF  YEALRAFQSS  RYADFRQIRD  IMQALLVRPL  GKEHTVSRLL  60
61    RVMQCLSRIE  EGENLDCSFD  MEAELTPLES  AMNVLEMIKT  EFTLTEAVVE  SSRKLVKEAA  120
121   VIICIKNKEF  EKASKILKKH  MSKDPSTQKL  RSDLLNIIRE  KNLAHPVIQN  FSYETFQQKM  180
181   LRFLESHLDD  TEPYLLTMAK  KALKSESAAS  STVKEDKQPA  PEPVEKPLRE  PARPLQNTPT  240
241   TIGIRTLKAA  FKALSGAQDS  EAAFLKLDQK  DLVLPNQASL  SSPALKTKRP  RKDENENSAP  300
301   AEGEGSSELQ  PKNKRMTISR  LILEEDSQST  EPNTGLSSSP  EVASKSSALN  QPHPGEKNPK  360
361   VSKGKWNSSN  GVEEKETWME  EDELFKVQAT  GEDSTASVTR  KQKWTVEESE  WVKAGVQKYG  420
421   EGNWAAISKN  YPFVNRTAVM  IKDRWRTMKK  LGMN  454
Nucleotide CDS Sequence (FASTA)
1     ATGGCCGCGG  GAGCCGGCAC  GGCGGGCTCC  GCTTCCGGCC  CGGGCCTCAA  GTTCTACTTC  60
61    TATGAGGCGC  TGCGGGCCTT  TCAGAGTAGC  CGGTACGCGG  ACTTCAGGCA  GATCCGGGAC  120
121   ATCATGCAGG  CTTTGCTTGT  CAGGCCCTTG  GGGAAGGAGC  ATACGGTGTC  CCGGTTGCTG  180
181   CGAGTTATGC  AGTGTCTGTC  GCGCATTGAA  GAAGGGGAAA  ATCTAGACTG  TTCCTTTGAT  240
241   ATGGAGGCTG  AGCTCACACC  ATTGGAATCA  GCTATGAATG  TGCTGGAGAT  GATTAAAACA  300
301   GAATTTACAC  TGACAGAAGC  AGTGGTTGAA  TCCAGTAGAA  AACTGGTCAA  GGAAGCTGCT  360
361   GTCATTATTT  GTATCAAAAA  CAAAGAATTT  GAAAAGGCTT  CAAAAATTTT  GAAAAAGCAT  420
421   ATGTCCAAGG  ACCCTTCAAC  TCAGAAGCTG  AGAAGTGATC  TCCTGAACAT  CATCCGAGAA  480
481   AAGAACTTGG  CCCACCCTGT  TATCCAGAAC  TTCTCCTATG  AGACCTTCCA  GCAGAAGATG  540
541   CTGCGCTTCT  TGGAGAGCCA  CCTGGACGAC  ACAGAGCCCT  ACCTCCTCAC  GATGGCCAAA  600
601   AAGGCTTTGA  AATCTGAGTC  TGCGGCCTCA  AGTACAGTAA  AGGAAGATAA  GCAGCCAGCA  660
661   CCGGAGCCTG  TGGAGAAGCC  ACTCAGAGAG  CCTGCAAGGC  CACTACAGAA  TACTCCAACT  720
721   ACCATTGGAA  TTAGGACTCT  GAAGGCAGCT  TTCAAGGCTC  TCTCCGGTGC  CCAGGATTCC  780
781   GAGGCGGCCT  TCTTAAAACT  GGACCAGAAA  GATCTGGTAC  TTCCTAATCA  AGCGTCCCTA  840
841   TCATCACCAG  CCCTCAAAAC  CAAGAGACCC  AGAAAAGATG  AAAATGAAAA  TTCAGCCCCT  900
901   GCTGAGGGTG  AGGGCAGCTC  AGAACTGCAG  CCCAAGAACA  AGCGCATGAC  AATAAGCAGA  960
961   TTGATTTTGG  AGGAGGACAG  CCAGAGTACT  GAGCCCAACA  CAGGCCTCAG  CTCCTCCCCG  1020
1021  GAGGTTGCAT  CCAAGTCCAG  TGCTCTCAAC  CAACCCCACC  CAGGGGAGAA  GAATCCCAAA  1080
1081  GTATCCAAAG  GCAAGTGGAA  CAGCTCTAAT  GGGGTTGAAG  AAAAAGAGAC  TTGGATGGAA  1140
1141  GAGGACGAAC  TGTTTAAAGT  TCAGGCAACA  GGTGAAGACA  GTACAGCCAG  TGTAACAAGG  1200
1201  AAGCAGAAAT  GGACTGTAGA  AGAAAGTGAA  TGGGTCAAAG  CCGGAGTGCA  GAAATATGGG  1260
1261  GAAGGAAACT  GGGCTGCCAT  TTCTAAAAAT  TACCCATTTG  TTAACCGAAC  AGCTGTGATG  1320
1321  ATCAAGGATC  GTTGGCGGAC  CATGAAAAAA  CTTGGCATGA  ACTGA  1365

▼ KEYWORD

ID
Family
Cell cycle
Chromosome
Complete proteome
DNA-binding
Nucleus
Reference proteome
Telomere

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nuclear chromosome, telomeric region
Molecular Function
Double-stranded telomeric DNA binding
Molecular Function
Protein homodimerization activity
Biological Process
Cell cycle
Biological Process
Protection from non-homologous end joining at telomere

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Aim-0697Ailuropoda melanoleuca95.61e-115 362
LLPS-Cap-2187Cavia porcellus92.790.0 786
LLPS-Ict-3331Ictidomys tridecemlineatus89.190.0 770
LLPS-Urm-2433Ursus maritimus89.020.0 753
LLPS-Fec-2845Felis catus88.740.0 771
LLPS-Mup-3531Mustela putorius furo88.460.0 705
LLPS-Pap-1524Pan paniscus88.290.0 757
LLPS-Pat-1768Pan troglodytes88.290.0 758
LLPS-Hos-2125Homo sapiens88.290.0 758
LLPS-Mam-1653Macaca mulatta88.060.0 755
LLPS-Eqc-2415Equus caballus88.060.0 758
LLPS-Cea-1787Cercocebus atys88.060.0 755
LLPS-Sus-2357Sus scrofa88.060.0 761
LLPS-Maf-2728Macaca fascicularis88.060.0 755
LLPS-Caj-1412Callithrix jacchus88.060.0 752
LLPS-Gog-0601Gorilla gorilla88.060.0 754
LLPS-Mal-4264Mandrillus leucophaeus88.060.0 753
LLPS-Aon-1120Aotus nancymaae87.870.0 718
LLPS-Man-3524Macaca nemestrina87.840.0 754
LLPS-Chs-1601Chlorocebus sabaeus87.840.0 753
LLPS-Nol-1345Nomascus leucogenys87.420.0 742
LLPS-Tut-1305Tursiops truncatus87.390.0 759
LLPS-Caf-4256Canis familiaris86.830.0 754
LLPS-Myl-0584Myotis lucifugus86.520.0 744
LLPS-Dio-2997Dipodomys ordii86.490.0 736
LLPS-Orc-0515Oryctolagus cuniculus86.260.0 738
LLPS-Bot-1012Bos taurus85.840.0 728
LLPS-Ova-4190Ovis aries85.390.0 721
LLPS-Mea-2149Mesocricetus auratus85.370.0 605
LLPS-Otg-0292Otolemur garnettii84.440.0 720
LLPS-Mum-2953Mus musculus84.390.0 720
LLPS-Poa-2571Pongo abelii82.170.0 689
LLPS-Ran-2845Rattus norvegicus82.170.0 712
LLPS-Paa-2691Papio anubis81.320.0 665
LLPS-Loa-1666Loxodonta africana74.793e-41 149
LLPS-Mod-3482Monodelphis domestica73.330.0 623
LLPS-Sah-2088Sarcophilus harrisii72.210.0 574
LLPS-Rhb-3777Rhinopithecus bieti71.260.0 531
LLPS-Ora-0747Ornithorhynchus anatinus70.593e-173 499
LLPS-Pes-3155Pelodiscus sinensis68.212e-62 220
LLPS-Leo-0191Lepisosteus oculatus64.153e-1581.3
LLPS-Tag-0551Taeniopygia guttata60.111e-69 240
LLPS-Gaga-0102Gallus gallus59.566e-70 241
LLPS-Asm-0940Astyanax mexicanus58.492e-1272.4
LLPS-Fia-1087Ficedula albicollis58.431e-68 236
LLPS-Xet-0739Xenopus tropicalis58.332e-1479.0
LLPS-Cas-0181Carlito syrichta57.416e-1374.3
LLPS-Scf-0867Scleropages formosus56.869e-1269.7
LLPS-Tar-1491Takifugu rubripes56.413e-0754.3
LLPS-Anc-1375Anolis carolinensis55.365e-1271.2
LLPS-Meg-1994Meleagris gallopavo54.04e-0962.4
LLPS-Anp-1253Anas platyrhynchos52.338e-49 181
LLPS-Glm-2452Glycine max50.982e-0757.4
LLPS-Lac-1115Latimeria chalumnae50.01e-1170.1
LLPS-Icp-3373Ictalurus punctatus50.09e-1270.5
LLPS-Via-1043Vigna angularis49.022e-0757.4
LLPS-Prp-1784Prunus persica48.285e-0858.5
LLPS-Scm-1891Scophthalmus maximus48.192e-1376.3
LLPS-Orl-1818Oryzias latipes46.31e-0757.8
LLPS-Dar-0854Danio rerio46.156e-1787.4
LLPS-Orn-3340Oreochromis niloticus45.687e-1374.7
LLPS-Sei-1941Setaria italica45.283e-0653.5
LLPS-Cis-1702Ciona savignyi44.235e-0856.6
LLPS-Gaa-1980Gasterosteus aculeatus43.149e-0855.8
LLPS-Xim-1508Xiphophorus maculatus41.676e-0858.5
LLPS-Orp-0875Oryza punctata40.07e-0652.4
LLPS-Sob-1393Sorghum bicolor32.385e-0962.4
LLPS-Pof-2341Poecilia formosa32.035e-27 118