• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Loa-3164
TERF1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Telomeric repeat-binding factor
Gene Name: TERF1
Ensembl Gene: ENSLAFG00000004308.3
Ensembl Protein: ENSLAFP00000003592.3
Organism: Loxodonta africana
Taxa ID: 9785
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
PML nuclear bodyPredicted from orthologs(View)

▼ FUNCTION

Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSLAFT00000004308.3ENSLAFP00000003592.3
UniProtG3SU07, G3SU07_LOXAF

▼ SEQUENCE

Protein Sequence (FASTA)
1     HGGACSSAAL  SPRGCADGED  ANATEERVAE  TARDDQEQFE  CQELLECQVQ  MGNPEEEEED  60
61    ADVVAEAETV  AAGWMLDFLC  VSLCRAFRDG  RSEDFHQTRD  SAEAIIHGLS  SLTAYQLRTV  120
121   YICQFLTRIA  AGKTLDAQFE  SDERITPLES  ALIIWDSIEK  EHDKLHEEIQ  NLIKIQAIAV  180
181   CMESGNFKEA  EEVFERIFDD  PNSYTPLKRK  LLTIISQKDA  FHSIFQHFSY  SHMMEKIKRY  240
241   VNYVLKEKSS  TFLMKAATKV  VESKRARTSS  QDKPNNNDSE  METPANLDVG  ESVSDKQSAE  300
301   TESSEGTVSL  LRSHKNLFLS  KFNHGCQLQD  PGETEERIET  LQNCDICGRK  NDDCRRSSKR  360
361   KTRDVLNNQP  ATSEKHRSRK  KQQKAWLWEE  DKNLRCGVRK  YGEGNWTKIL  LHYKFNNRTS  420
421   VMLKDRWRTM  KKLKLIC  437
Nucleotide CDS Sequence (FASTA)
1     CATGGCGGCG  CCTGCAGCTC  GGCGGCTCTG  AGTCCGCGGG  GCTGTGCGGA  CGGGGAGGAT  60
61    GCCAACGCTA  CAGAGGAGCG  GGTGGCGGAA  ACGGCAAGAG  ACGACCAGGA  GCAGTTCGAG  120
121   TGTCAGGAGC  TGCTGGAGTG  CCAGGTGCAG  ATGGGGAACC  CCGAGGAGGA  GGAGGAGGAC  180
181   GCGGACGTGG  TGGCCGAGGC  CGAGACCGTG  GCTGCCGGCT  GGATGCTCGA  CTTCCTCTGT  240
241   GTCTCTCTTT  GCCGGGCCTT  CCGCGACGGC  CGCTCCGAGG  ACTTCCACCA  GACCCGCGAC  300
301   AGCGCCGAGG  CTATTATTCA  TGGACTGTCC  AGCCTAACAG  CTTACCAATT  GAGAACTGTA  360
361   TACATATGTC  AGTTTTTGAC  AAGAATTGCA  GCTGGAAAAA  CCCTTGATGC  ACAGTTTGAA  420
421   AGTGATGAAC  GAATTACACC  CTTGGAATCA  GCCCTGATAA  TTTGGGATTC  AATTGAAAAG  480
481   GAGCATGACA  AACTTCATGA  AGAAATACAG  AATTTAATTA  AAATTCAGGC  TATAGCTGTT  540
541   TGTATGGAAA  GTGGCAATTT  TAAGGAAGCT  GAAGAAGTCT  TTGAAAGAAT  ATTTGATGAC  600
601   CCAAATTCTT  ATACGCCTTT  AAAAAGAAAA  TTGCTTACAA  TAATCTCTCA  GAAAGATGCA  660
661   TTCCATTCCA  TTTTTCAACA  CTTCAGCTAC  AGCCACATGA  TGGAGAAAAT  TAAGAGATAT  720
721   GTGAATTATG  TGCTAAAAGA  AAAATCATCG  ACTTTTCTAA  TGAAGGCAGC  AACAAAAGTA  780
781   GTGGAAAGTA  AAAGAGCAAG  AACAAGTTCT  CAAGATAAAC  CTAATAATAA  TGATAGTGAA  840
841   ATGGAAACTC  CGGCTAATTT  GGATGTAGGA  GAAAGTGTTA  GTGACAAACA  GTCTGCGGAA  900
901   ACTGAATCCT  CAGAGGGTAC  AGTATCCTTA  TTGAGGTCTC  ACAAGAATCT  CTTCTTATCT  960
961   AAGTTTAACC  ATGGATGCCA  ACTACAAGAT  CCTGGTGAGA  CAGAGGAAAG  AATAGAAACT  1020
1021  CTTCAAAACT  GTGATATTTG  TGGAAGAAAG  AACGATGACT  GTAGAAGATC  CAGTAAACGC  1080
1081  AAGACAAGAG  ATGTTTTAAA  CAATCAGCCA  GCAACTTCTG  AAAAACATCG  ATCTCGGAAA  1140
1141  AAACAGCAAA  AGGCATGGCT  TTGGGAAGAA  GACAAGAATC  TGAGATGTGG  CGTAAGGAAA  1200
1201  TATGGAGAGG  GAAACTGGAC  TAAAATACTA  TTACATTATA  AGTTCAACAA  CCGAACAAGC  1260
1261  GTCATGTTAA  AAGACAGATG  GAGGACCATG  AAGAAACTAA  AACTGATTTG  C  1311

▼ KEYWORD

ID
Family
Cell cycle
Chromosome
Complete proteome
DNA-binding
Nucleus
Reference proteome
Telomere

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Fibrillar center
Cellular Component
Nuclear body
Cellular Component
Shelterin complex
Molecular Function
Ankyrin repeat binding
Molecular Function
DNA binding, bending
Molecular Function
Double-stranded telomeric DNA binding
Molecular Function
G-rich strand telomeric DNA binding
Molecular Function
Protein homodimerization activity
Molecular Function
Telomerase activity
Biological Process
Meiotic telomere clustering
Biological Process
Negative regulation of DNA replication
Biological Process
Negative regulation of establishment of protein localization to telomere
Biological Process
Negative regulation of establishment of RNA localization to telomere
Biological Process
Negative regulation of exonuclease activity
Biological Process
Negative regulation of telomerase activity
Biological Process
Negative regulation of telomere maintenance via telomerase
Biological Process
Negative regulation of telomeric D-loop disassembly
Biological Process
Positive regulation of shelterin complex assembly
Biological Process
Telomere maintenance via telomerase
Biological Process
Telomeric D-loop disassembly

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Sus-3280Sus scrofa79.630.0 639
LLPS-Eqc-1377Equus caballus79.580.0 643
LLPS-Cea-2335Cercocebus atys79.540.0 636
LLPS-Mam-3907Macaca mulatta79.360.0 632
LLPS-Man-0341Macaca nemestrina79.360.0 632
LLPS-Mal-1035Mandrillus leucophaeus79.360.0 632
LLPS-Maf-0913Macaca fascicularis79.360.0 632
LLPS-Poa-0194Pongo abelii79.030.0 624
LLPS-Caj-0864Callithrix jacchus79.030.0 625
LLPS-Paa-2013Papio anubis78.90.0 630
LLPS-Chs-1524Chlorocebus sabaeus78.770.0 626
LLPS-Aon-4108Aotus nancymaae78.570.0 638
LLPS-Hos-2224Homo sapiens77.980.0 619
LLPS-Fec-3274Felis catus77.960.0 628
LLPS-Pat-1334Pan troglodytes77.80.0 625
LLPS-Ova-2556Ovis aries77.710.0 532
LLPS-Pap-3265Pan paniscus77.570.0 622
LLPS-Gog-2124Gorilla gorilla77.190.0 626
LLPS-Bot-2441Bos taurus76.910.0 625
LLPS-Cas-0181Carlito syrichta76.420.0 534
LLPS-Caf-2735Canis familiaris75.80.0 616
LLPS-Orc-3824Oryctolagus cuniculus75.580.0 560
LLPS-Aim-0831Ailuropoda melanoleuca74.130.0 588
LLPS-Myl-3646Myotis lucifugus73.640.0 591
LLPS-Nol-2971Nomascus leucogenys72.940.0 557
LLPS-Tut-0812Tursiops truncatus72.070.0 536
LLPS-Mea-2661Mesocricetus auratus70.962e-168 487
LLPS-Rhb-0704Rhinopithecus bieti70.68e-178 510
LLPS-Mup-3116Mustela putorius furo70.510.0 548
LLPS-Mum-0500Mus musculus69.048e-172 496
LLPS-Fud-3086Fukomys damarensis68.433e-175 504
LLPS-Urm-2238Ursus maritimus68.421e-128 379
LLPS-Otg-2298Otolemur garnettii67.660.0 522
LLPS-Ran-0345Rattus norvegicus66.285e-177 509
LLPS-Cap-2836Cavia porcellus65.596e-166 480
LLPS-Dio-1132Dipodomys ordii64.611e-161 469
LLPS-Lac-0283Latimeria chalumnae62.54e-1168.6
LLPS-Cii-1470Ciona intestinalis61.222e-1169.7
LLPS-Xet-1615Xenopus tropicalis60.712e-1272.8
LLPS-Ict-3331Ictidomys tridecemlineatus60.02e-1272.8
LLPS-Ora-0747Ornithorhynchus anatinus60.05e-1271.2
LLPS-Anc-0835Anolis carolinensis59.266e-1374.7
LLPS-Scf-2015Scleropages formosus59.266e-1271.6
LLPS-Scm-1891Scophthalmus maximus58.492e-1273.2
LLPS-Met-2045Medicago truncatula57.784e-0859.3
LLPS-Tar-1491Takifugu rubripes57.452e-1167.0
LLPS-Meg-1370Meleagris gallopavo57.148e-1064.7
LLPS-Pes-3155Pelodiscus sinensis57.143e-1169.3
LLPS-Gaga-0102Gallus gallus56.362e-1067.0
LLPS-Tag-0551Taeniopygia guttata55.931e-1274.3
LLPS-Orn-3340Oreochromis niloticus54.96e-1168.6
LLPS-Anp-1253Anas platyrhynchos54.398e-1271.2
LLPS-Zem-2593Zea mays52.02e-0757.4
LLPS-Mod-0023Monodelphis domestica51.851e-114 350
LLPS-Orl-1818Oryzias latipes50.01e-0860.8
LLPS-Sah-1002Sarcophilus harrisii49.465e-111 339
LLPS-Dac-1409Daucus carota49.259e-0961.2
LLPS-Asm-1327Astyanax mexicanus49.231e-0964.7
LLPS-Bro-1005Brassica oleracea48.212e-0654.7
LLPS-Brn-1191Brassica napus48.212e-0654.3
LLPS-Gaa-0255Gasterosteus aculeatus48.151e-1067.4
LLPS-Hea-0113Helianthus annuus46.433e-0756.6
LLPS-Dar-0854Danio rerio45.768e-0961.6
LLPS-Cis-1702Ciona savignyi45.686e-1268.6
LLPS-Prp-1301Prunus persica45.02e-0757.4
LLPS-Xim-2156Xiphophorus maculatus44.442e-1170.1
LLPS-Icp-2675Ictalurus punctatus43.641e-0758.5
LLPS-Sob-1393Sorghum bicolor42.621e-0654.7
LLPS-Fia-1087Ficedula albicollis42.348e-1477.4
LLPS-Leo-1296Lepisosteus oculatus41.418e-1477.8
LLPS-Via-1043Vigna angularis40.582e-0757.0
LLPS-Glm-2452Glycine max40.585e-0755.8
LLPS-Pof-2341Poecilia formosa30.673e-1169.3