LLPS-Asc-0364
ACLA_002030
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | 5'-3' exoribonuclease 1 |
| Gene Name: | ACLA_002030 |
| Ensembl Gene: | ACLA_002030 |
| Ensembl Protein: | EAW14792 |
| Organism: | Aspergillus clavatus |
| Taxa ID: | 344612 |
| LLPS Type: | LLPS regulator |
▼ PROPERTY
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, P-body, Stress granule, TAM body, Others | Predicted from orthologs | (View) |
▼ FUNCTION
| Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | EAW14792 | EAW14792 |
| UniProt | A1C524, A1C524_ASPCL | |
| GeneBank | DS027004 | EAW14792.1 |
| RefSeq | XM_001276217.1 | XP_001276218.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MGVPKFFRWL SERYPTISML IAENRIPEFD ALYLDMNGII HNCTHKDSDS PTFRMTEDKM 60 61 FIAIFNYIEH LYGKIKPKKL FFMAIDGVAP RAKMNQQRAR RFRTALDAEV AKEKAIAQGI 120 121 EMPKEDAFDS NCITPGTEFM AKLTQQLKYF ISKKISEDKD WQGVEIVLSG HEVPGEGEHK 180 181 IMEYIRHAKA QPDYDSNIRH CLYGLDADLI MLGLLSHDPH FCLLREEVTF GRQVQKKPKE 240 241 LEHQNFFLLH LCMVREYLEL EFQELEQEGV LDFPFDMERV IDDFILMAFF VGNDFLPNLP 300 301 NLHINEGALA LMFKIYKEVL PKMGGYVNEG GVINLKRLGM LVEALSDVEF RFFEVEYSDA 360 361 KWITAKRKAI ENDFEPPEKQ RGLTVTPAQK ELFKEVKKYV LNRPEKETGS KPLDLPSALP 420 421 ARDRKFVEQL ANDLHVPWTT VADEHGDRFI RLQLPTNDDD DSEEEEDEEA SMAVRRVIRR 480 481 YENAKVQEIS PEEAQKAAEQ KYEEKFQEWK DKYYMSKFGW GLDNHEEMRK LTENYVQGLQ 540 541 WVLYYYYRGI ASWPWFFKYH YAPMISDVTK GLKADMNFQL GQPFKPYEQL MGVLPDRSKK 600 601 IVPAAYRDLM TSPDSPIIDF YPRDFELDMN GKKMEWEAVV KIPFIEERRL LDALATKSHL 660 661 LTPEEKVRND FGVSLKFTYS PDANYSYPSS LPGVFPDIPN CHCIENVFDL PTMDGLEPYI 720 721 GLVDGVQLGA AALAGFPSLK TLPHVGQLGF HGVCVFQQES RNESMVITIL DPGSRSSVEL 780 781 AKSKLGKRVF VGYPFLQEAL VVRVSDELFD YIIPDGEEHP VPIPHTEAQI DQWRKKADKI 840 841 EGTYSRRLGT VIGPVDSMVH VQLLKGLIKT DEGATIKEFA DILGQETDYA LQLVVDEVIN 900 901 PDERFIERDA LPIEKEFPEG SRAFFLGDYN YGRPVHVTGH DDGKVNGLIA SIPGREPEFG 960 961 KERAREAEKL CPYMPSFAIA RSLRLNPLVL AKITSSFSVD VEGQRVNLGL NLKFEARKQK 1020 1021 VLGYSRRGDS GWEFSQRTVD LLQQYMIKFP EFIAGIQRNP QRDRYNPADF YPEDVALQKI 1080 1081 QEIKDWLKSI EAKNFERVPL EAEQLDSEVV KLIEQDADRL MQSQPQMQAK KVRGVPRSAL 1140 1141 LRPSDVEQRL QNQSFKLGDR VVYAQDSGKV PIATRGTVVG LTRTSRAMLL DVVFDVSFMS 1200 1201 GTTLGDRCSP FRGQTVLASS VLNVSYRQLL ASTRAAASQQ SQSQPSPLTV AGYGAPLGPN 1260 1261 GQGQLREAAA PPPLSGSYRG AVSGVSNGRG NGRGRGGRGA SNGGSNPTSL PFRPHPNGSE 1320 1321 NRGGRGRGGM YRTRGGYVSV DNSNPDAGII KNNPNFRPQN YSQVPPPKGL DRGSGRGGRG 1380 1381 GFRGSDKGNG SRGRGGQRGR GAATTNNN 1408 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasmic stress granule | |
Cellular Component | P-body | |
Molecular Function | 5'-3' exoribonuclease activity | |
Molecular Function | Magnesium ion binding | |
Molecular Function | RNA binding | |
Biological Process | Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Nef-0717 | Neosartorya fischeri | 89.74 | 0.0 | 2362 |
| LLPS-Asfu-0533 | Aspergillus fumigatus | 89.45 | 0.0 | 2360 |
| LLPS-Ast-1037 | Aspergillus terreus | 84.92 | 0.0 | 2256 |
| LLPS-Asf-0306 | Aspergillus flavus | 83.86 | 0.0 | 2248 |
| LLPS-Aso-0507 | Aspergillus oryzae | 83.79 | 0.0 | 2245 |
| LLPS-Asni-0180 | Aspergillus niger | 83.25 | 0.0 | 2219 |
| LLPS-Asn-0366 | Aspergillus nidulans | 82.28 | 0.0 | 2195 |
| LLPS-Trv-0305 | Trichoderma virens | 81.33 | 2e-82 | 296 |
| LLPS-Mel-0705 | Melampsora laricipopulina | 70.79 | 2e-98 | 319 |
| LLPS-Lem-0321 | Leptosphaeria maculans | 66.95 | 0.0 | 1677 |
| LLPS-Pytr-0724 | Pyrenophora triticirepentis | 65.01 | 0.0 | 1582 |
| LLPS-Phn-0081 | Phaeosphaeria nodorum | 64.77 | 0.0 | 1667 |
| LLPS-Nec-0395 | Neurospora crassa | 63.4 | 0.0 | 1575 |
| LLPS-Pyt-0354 | Pyrenophora teres | 63.05 | 0.0 | 1662 |
| LLPS-Map-0189 | Magnaporthe poae | 62.67 | 0.0 | 1526 |
| LLPS-Gag-0445 | Gaeumannomyces graminis | 62.47 | 0.0 | 1534 |
| LLPS-Mao-0268 | Magnaporthe oryzae | 62.17 | 0.0 | 1562 |
| LLPS-Cogr-0715 | Colletotrichum graminicola | 60.0 | 0.0 | 1505 |
| LLPS-Spr-0374 | Sporisorium reilianum | 59.95 | 3e-160 | 529 |
| LLPS-Blg-0521 | Blumeria graminis | 59.78 | 0.0 | 1534 |
| LLPS-Cog-0237 | Colletotrichum gloeosporioides | 59.77 | 0.0 | 1518 |
| LLPS-Lac-0084 | Latimeria chalumnae | 59.67 | 7e-132 | 453 |
| LLPS-Fuv-0080 | Fusarium verticillioides | 59.43 | 0.0 | 1499 |
| LLPS-Coo-0228 | Colletotrichum orbiculare | 59.32 | 0.0 | 1494 |
| LLPS-Ved-0340 | Verticillium dahliae | 58.88 | 0.0 | 1519 |
| LLPS-Beb-0621 | Beauveria bassiana | 58.81 | 0.0 | 1457 |
| LLPS-Mod-1553 | Monodelphis domestica | 58.74 | 2e-129 | 446 |
| LLPS-Sah-0013 | Sarcophilus harrisii | 58.65 | 5e-117 | 409 |
| LLPS-Paa-0132 | Papio anubis | 58.47 | 6e-129 | 444 |
| LLPS-Mal-3242 | Mandrillus leucophaeus | 58.47 | 9e-139 | 440 |
| LLPS-Ova-2996 | Ovis aries | 58.47 | 5e-129 | 445 |
| LLPS-Bot-0650 | Bos taurus | 58.47 | 4e-129 | 445 |
| LLPS-Gog-0511 | Gorilla gorilla | 58.47 | 4e-129 | 445 |
| LLPS-Caj-0375 | Callithrix jacchus | 58.47 | 1e-128 | 443 |
| LLPS-Maf-1611 | Macaca fascicularis | 58.47 | 5e-129 | 445 |
| LLPS-Chs-2975 | Chlorocebus sabaeus | 58.47 | 7e-129 | 444 |
| LLPS-Cea-1205 | Cercocebus atys | 58.47 | 5e-129 | 444 |
| LLPS-Aon-0820 | Aotus nancymaae | 58.47 | 6e-129 | 444 |
| LLPS-Ict-2387 | Ictidomys tridecemlineatus | 58.47 | 3e-129 | 446 |
| LLPS-Nol-1689 | Nomascus leucogenys | 58.47 | 5e-129 | 445 |
| LLPS-Poa-0322 | Pongo abelii | 58.47 | 7e-129 | 444 |
| LLPS-Caf-0252 | Canis familiaris | 58.47 | 8e-129 | 444 |
| LLPS-Eqc-2291 | Equus caballus | 58.47 | 1e-128 | 444 |
| LLPS-Mam-0955 | Macaca mulatta | 58.47 | 5e-129 | 445 |
| LLPS-Otg-0833 | Otolemur garnettii | 58.47 | 3e-129 | 446 |
| LLPS-Orc-0053 | Oryctolagus cuniculus | 58.47 | 2e-129 | 446 |
| LLPS-Rhb-1246 | Rhinopithecus bieti | 58.47 | 4e-129 | 445 |
| LLPS-Hos-0264 | Homo sapiens | 58.47 | 6e-129 | 444 |
| LLPS-Man-1598 | Macaca nemestrina | 58.47 | 6e-129 | 444 |
| LLPS-Loa-2626 | Loxodonta africana | 58.47 | 2e-132 | 442 |
| LLPS-Icp-1109 | Ictalurus punctatus | 58.31 | 7e-129 | 444 |
| LLPS-Ran-0697 | Rattus norvegicus | 58.2 | 7e-129 | 444 |
| LLPS-Mup-0056 | Mustela putorius furo | 58.2 | 1e-128 | 444 |
| LLPS-Myl-1069 | Myotis lucifugus | 58.2 | 1e-128 | 444 |
| LLPS-Dio-0049 | Dipodomys ordii | 58.2 | 5e-126 | 436 |
| LLPS-Fud-0057 | Fukomys damarensis | 58.2 | 5e-128 | 442 |
| LLPS-Mum-1547 | Mus musculus | 58.2 | 6e-129 | 445 |
| LLPS-Cas-1098 | Carlito syrichta | 58.2 | 1e-128 | 443 |
| LLPS-Pat-0457 | Pan troglodytes | 58.2 | 5e-129 | 444 |
| LLPS-Urm-0260 | Ursus maritimus | 58.2 | 1e-128 | 444 |
| LLPS-Pap-1673 | Pan paniscus | 58.2 | 6e-129 | 444 |
| LLPS-Leo-0035 | Lepisosteus oculatus | 58.04 | 2e-128 | 443 |
| LLPS-Orn-0593 | Oreochromis niloticus | 57.77 | 5e-126 | 436 |
| LLPS-Anp-0616 | Anas platyrhynchos | 57.77 | 8e-117 | 409 |
| LLPS-Fia-1489 | Ficedula albicollis | 57.65 | 6e-130 | 448 |
| LLPS-Xim-1777 | Xiphophorus maculatus | 57.49 | 5e-126 | 434 |
| LLPS-Scf-1476 | Scleropages formosus | 57.49 | 2e-126 | 436 |
| LLPS-Orl-0763 | Oryzias latipes | 57.49 | 8e-127 | 439 |
| LLPS-Pes-0180 | Pelodiscus sinensis | 57.49 | 6e-127 | 439 |
| LLPS-Pof-1376 | Poecilia formosa | 57.49 | 2e-125 | 432 |
| LLPS-Dar-0942 | Danio rerio | 57.49 | 1e-127 | 441 |
| LLPS-Aim-0659 | Ailuropoda melanoleuca | 57.38 | 7e-124 | 430 |
| LLPS-Gaga-1171 | Gallus gallus | 57.38 | 3e-129 | 446 |
| LLPS-Anc-1708 | Anolis carolinensis | 57.38 | 6e-129 | 445 |
| LLPS-Tag-0733 | Taeniopygia guttata | 57.38 | 4e-129 | 445 |
| LLPS-Tar-0389 | Takifugu rubripes | 57.22 | 6e-125 | 431 |
| LLPS-Cis-0037 | Ciona savignyi | 56.91 | 6e-136 | 457 |
| LLPS-Osl-0556 | Ostreococcus lucimarinus | 56.89 | 2e-117 | 384 |
| LLPS-Gaa-1710 | Gasterosteus aculeatus | 56.68 | 9e-123 | 426 |
| LLPS-Ten-0372 | Tetraodon nigroviridis | 56.52 | 2e-122 | 425 |
| LLPS-Scm-2006 | Scophthalmus maximus | 56.4 | 3e-123 | 427 |
| LLPS-Ora-0176 | Ornithorhynchus anatinus | 55.41 | 1e-67 | 256 |
| LLPS-Cae-1322 | Caenorhabditis elegans | 55.05 | 9e-121 | 419 |
| LLPS-Zyt-0678 | Zymoseptoria tritici | 54.93 | 2e-108 | 352 |
| LLPS-Drm-0046 | Drosophila melanogaster | 54.42 | 8e-119 | 414 |
| LLPS-Asm-0887 | Astyanax mexicanus | 54.35 | 8e-116 | 405 |
| LLPS-Cii-1507 | Ciona intestinalis | 53.93 | 4e-87 | 298 |
| LLPS-Php-0128 | Physcomitrella patens | 52.73 | 1e-45 | 184 |
| LLPS-Fuo-0908 | Fusarium oxysporum | 51.15 | 0.0 | 627 |
| LLPS-Pug-0272 | Puccinia graminis | 50.59 | 3e-48 | 192 |
| LLPS-Fec-3138 | Felis catus | 50.27 | 2e-104 | 370 |
| LLPS-Chr-0879 | Chlamydomonas reinhardtii | 50.13 | 2e-107 | 381 |
| LLPS-Scj-1171 | Schizosaccharomyces japonicus | 49.7 | 1e-44 | 181 |
| LLPS-Xet-0285 | Xenopus tropicalis | 49.7 | 3e-41 | 169 |
| LLPS-Put-0790 | Puccinia triticina | 49.41 | 8e-47 | 188 |
| LLPS-Miv-0213 | Microbotryum violaceum | 49.24 | 0.0 | 1173 |
| LLPS-Gas-0045 | Galdieria sulphuraria | 49.17 | 4e-90 | 325 |
| LLPS-Nia-1279 | Nicotiana attenuata | 49.14 | 9e-48 | 189 |
| LLPS-Usm-0088 | Ustilago maydis | 48.93 | 0.0 | 1169 |
| LLPS-Via-0406 | Vigna angularis | 48.85 | 3e-44 | 179 |
| LLPS-Tum-0484 | Tuber melanosporum | 48.82 | 1e-43 | 177 |
| LLPS-Scp-0200 | Schizosaccharomyces pombe | 48.52 | 7e-44 | 178 |
| LLPS-Zem-0949 | Zea mays | 48.17 | 2e-42 | 173 |
| LLPS-Asg-0110 | Ashbya gossypii | 48.15 | 2e-40 | 167 |
| LLPS-Abg-0390 | Absidia glauca | 48.09 | 3e-49 | 196 |
| LLPS-Sol-0134 | Solanum lycopersicum | 47.98 | 3e-43 | 176 |
| LLPS-Mea-1960 | Mesocricetus auratus | 47.95 | 4e-42 | 172 |
| LLPS-Meg-0402 | Meleagris gallopavo | 47.95 | 8e-42 | 171 |
| LLPS-Scc-0543 | Schizosaccharomyces cryophilus | 47.93 | 3e-44 | 179 |
| LLPS-Mae-2408 | Manihot esculenta | 47.67 | 4e-42 | 172 |
| LLPS-Sei-0315 | Setaria italica | 47.56 | 1e-41 | 171 |
| LLPS-Glm-1507 | Glycine max | 47.42 | 3e-46 | 186 |
| LLPS-Crn-0446 | Cryptococcus neoformans | 47.34 | 4e-43 | 176 |
| LLPS-Dac-2380 | Daucus carota | 46.96 | 1e-26 | 122 |
| LLPS-Brd-0142 | Brachypodium distachyon | 46.95 | 2e-41 | 170 |
| LLPS-Sob-2175 | Sorghum bicolor | 46.95 | 2e-41 | 170 |
| LLPS-Tra-0358 | Triticum aestivum | 46.34 | 3e-41 | 169 |
| LLPS-Orgl-2258 | Oryza glumaepatula | 46.34 | 1e-40 | 167 |
| LLPS-Orni-2203 | Oryza nivara | 46.34 | 1e-40 | 167 |
| LLPS-Orb-1209 | Oryza barthii | 46.34 | 2e-40 | 167 |
| LLPS-Ori-1637 | Oryza indica | 46.34 | 1e-40 | 167 |
| LLPS-Orr-0768 | Oryza rufipogon | 46.34 | 2e-40 | 167 |
| LLPS-Ors-0413 | Oryza sativa | 46.34 | 1e-40 | 167 |
| LLPS-Orp-2319 | Oryza punctata | 46.34 | 1e-40 | 168 |
| LLPS-Met-0962 | Medicago truncatula | 46.2 | 6e-42 | 171 |
| LLPS-Cus-1183 | Cucumis sativus | 46.02 | 5e-43 | 176 |
| LLPS-Chc-0376 | Chondrus crispus | 46.0 | 7e-99 | 338 |
| LLPS-Phv-1486 | Phaseolus vulgaris | 45.98 | 2e-43 | 176 |
| LLPS-Yal-0399 | Yarrowia lipolytica | 45.92 | 0.0 | 1038 |
| LLPS-Trr-0786 | Trichoderma reesei | 45.73 | 2e-40 | 167 |
| LLPS-Prp-1857 | Prunus persica | 45.2 | 9e-35 | 149 |
| LLPS-Gor-1559 | Gossypium raimondii | 45.14 | 1e-41 | 171 |
| LLPS-Cym-0545 | Cyanidioschyzon merolae | 45.05 | 7e-92 | 322 |
| LLPS-Kop-0812 | Komagataella pastoris | 44.85 | 8e-37 | 155 |
| LLPS-Coc-0269 | Corchorus capsularis | 44.57 | 2e-40 | 167 |
| LLPS-Sac-1194 | Saccharomyces cerevisiae | 44.38 | 2e-41 | 170 |
| LLPS-Hea-0209 | Helianthus annuus | 44.19 | 8e-40 | 165 |
| LLPS-Cap-0449 | Cavia porcellus | 44.02 | 5e-42 | 172 |
| LLPS-Mua-0481 | Musa acuminata | 43.91 | 3e-82 | 296 |
| LLPS-Lep-1457 | Leersia perrieri | 43.41 | 2e-82 | 297 |
| LLPS-Orbr-2246 | Oryza brachyantha | 43.17 | 2e-82 | 297 |
| LLPS-Sus-1479 | Sus scrofa | 37.77 | 6e-136 | 449 |
| LLPS-Pot-1019 | Populus trichocarpa | 37.47 | 6e-133 | 445 |
| LLPS-Brr-0599 | Brassica rapa | 37.37 | 2e-128 | 431 |
| LLPS-Art-0269 | Arabidopsis thaliana | 36.08 | 4e-115 | 393 |