• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Gaa-1567

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: DNA repair protein RAD51 homolog
Ensembl Gene: ENSGACG00000012241.1
Ensembl Protein: ENSGACP00000016197.1
Organism: Gasterosteus aculeatus
Taxa ID: 69293
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
DNA damage foci, PML nuclear bodyPredicted from orthologs(View)

▼ FUNCTION

Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSGACT00000016228.1ENSGACP00000016197.1
UniProtG3PF23, G3PF23_GASAC

▼ SEQUENCE

Protein Sequence (FASTA)
1     PTMAMRSEAR  VETEVEEEES  FGPQPLSRLE  QCGVSASDIK  KLGESGFHTI  EAVAYAPKKE  60
61    LLNIKGISEA  KADKILAEAA  KLVPMGFTTA  TEFHQRRAEI  IQISTGSKEL  DKLLQGGIET  120
121   GSITEMFGEF  RTGKTQLCHT  LAVTCQLPID  QGGGEGKAMY  IDTEGTFRPE  RLLAVAERYG  180
181   LVGSDVLDNV  AYARAFNTDH  QTQLLYQASA  MMAESRYALL  IVDSATALYR  TDYSGRGELS  240
241   ARQGHLGRFL  RMLLRLADEF  GVAVVISNQV  VAQVDGAAMF  SADPKKPIGG  NILAHASTTR  300
301   LYLRKGRGET  RICKIYDSPC  LPEAEAMFAI  NPDGVGDAKD  340
Nucleotide CDS Sequence (FASTA)
1     CCGACCATGG  CGATGCGGAG  CGAGGCCAGG  GTGGAGACGG  AGGTGGAGGA  GGAGGAAAGC  60
61    TTCGGGCCGC  AGCCTCTGAG  CAGGCTGGAG  CAATGTGGCG  TCAGCGCCAG  CGACATCAAA  120
121   AAGCTGGGGG  AGTCTGGTTT  CCACACCATC  GAGGCAGTGG  CCTACGCACC  CAAGAAGGAG  180
181   CTGCTCAACA  TCAAAGGCAT  CAGTGAGGCC  AAGGCCGACA  AAATTCTAGC  GGAAGCTGCC  240
241   AAACTTGTGC  CGATGGGTTT  CACCACGGCT  ACCGAGTTCC  ACCAGAGGAG  AGCGGAGATC  300
301   ATCCAGATCT  CCACCGGCTC  CAAAGAGCTC  GACAAACTGC  TGCAGGGCGG  GATCGAGACC  360
361   GGCTCCATCA  CGGAGATGTT  TGGGGAGTTT  CGGACGGGGA  AGACCCAGCT  GTGCCACACG  420
421   CTCGCTGTTA  CCTGTCAGCT  GCCCATTGAT  CAGGGGGGAG  GAGAAGGCAA  AGCCATGTAC  480
481   ATTGACACAG  AGGGAACCTT  CAGACCAGAG  AGACTCCTCG  CAGTGGCTGA  GAGGTACGGG  540
541   CTGGTAGGCA  GTGACGTTCT  GGACAACGTG  GCTTACGCCC  GAGCCTTCAA  CACGGACCAT  600
601   CAGACCCAGC  TGCTGTACCA  AGCCTCCGCC  ATGATGGCCG  AGTCCAGGTA  CGCCCTGCTG  660
661   ATAGTGGACA  GCGCGACAGC  TCTGTACAGA  ACGGACTACT  CGGGCAGAGG  CGAGCTGTCG  720
721   GCGCGACAGG  GCCACCTGGG  TCGCTTCCTC  CGCATGCTGC  TCCGGCTGGC  GGACGAGTTT  780
781   GGCGTTGCCG  TGGTGATATC  CAACCAGGTG  GTGGCGCAGG  TGGACGGGGC  AGCCATGTTT  840
841   TCCGCGGATC  CCAAGAAACC  GATTGGAGGC  AACATTCTGG  CTCACGCCTC  CACCACGCGT  900
901   CTGTATCTGA  GGAAAGGCCG  AGGAGAGACG  AGGATTTGCA  AAATCTACGA  CTCGCCCTGC  960
961   CTGCCGGAGG  CTGAAGCCAT  GTTTGCTATT  AACCCCGATG  GCGTGGGCGA  TGCCAAGGAC  1020
1021  TGA  1023

▼ KEYWORD

ID
Family
ATP-binding
Complete proteome
DNA damage
DNA recombination
DNA repair
DNA-binding
Nucleotide-binding
Nucleus
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nucleus
Molecular Function
ATP binding
Molecular Function
DNA-dependent ATPase activity
Molecular Function
Double-stranded DNA binding
Molecular Function
Recombinase activity
Molecular Function
Single-stranded DNA binding
Biological Process
Double-strand break repair via homologous recombination
Biological Process
Hematopoietic stem cell proliferation
Biological Process
Mitotic recombination-dependent replication fork processing
Biological Process
Response to cadmium ion
Biological Process
Response to methylmercury

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Xim-1742Xiphophorus maculatus97.190.0 643
LLPS-Scf-2691Scleropages formosus97.190.0 642
LLPS-Orl-1751Oryzias latipes97.190.0 643
LLPS-Asm-1642Astyanax mexicanus97.190.0 644
LLPS-Orn-0144Oreochromis niloticus97.190.0 642
LLPS-Pof-0747Poecilia formosa96.880.0 641
LLPS-Scm-3837Scophthalmus maximus96.560.0 643
LLPS-Leo-3073Lepisosteus oculatus96.260.0 635
LLPS-Icp-0931Ictalurus punctatus96.250.0 640
LLPS-Tar-0893Takifugu rubripes96.150.0 644
LLPS-Dar-1797Danio rerio95.940.0 637
LLPS-Anp-0940Anas platyrhynchos95.450.0 523
LLPS-Aim-1407Ailuropoda melanoleuca95.060.0 521
LLPS-Sah-0299Sarcophilus harrisii95.055e-123 358
LLPS-Ten-2068Tetraodon nigroviridis94.690.0 635
LLPS-Pes-0183Pelodiscus sinensis94.060.0 629
LLPS-Anc-1588Anolis carolinensis93.750.0 627
LLPS-Xet-1829Xenopus tropicalis93.460.0 623
LLPS-Chs-1202Chlorocebus sabaeus93.440.0 629
LLPS-Aon-1692Aotus nancymaae93.440.0 629
LLPS-Caj-1810Callithrix jacchus93.440.0 629
LLPS-Poa-0639Pongo abelii93.440.0 629
LLPS-Mam-1537Macaca mulatta93.440.0 629
LLPS-Tag-0126Taeniopygia guttata93.440.0 625
LLPS-Nol-0176Nomascus leucogenys93.440.0 629
LLPS-Dio-2170Dipodomys ordii93.120.0 627
LLPS-Fud-2126Fukomys damarensis93.120.0 627
LLPS-Cap-1639Cavia porcellus93.120.0 627
LLPS-Fec-2852Felis catus93.120.0 627
LLPS-Loa-1315Loxodonta africana93.120.0 627
LLPS-Bot-1331Bos taurus92.810.0 625
LLPS-Ran-1257Rattus norvegicus92.810.0 625
LLPS-Ova-0042Ovis aries92.810.0 625
LLPS-Sus-2233Sus scrofa92.810.0 627
LLPS-Eqc-0952Equus caballus92.810.0 625
LLPS-Urm-2536Ursus maritimus92.810.0 625
LLPS-Mum-2256Mus musculus92.50.0 624
LLPS-Caf-0869Canis familiaris92.50.0 623
LLPS-Orc-0101Oryctolagus cuniculus92.50.0 624
LLPS-Gaga-2504Gallus gallus92.190.0 621
LLPS-Meg-1764Meleagris gallopavo91.250.0 612
LLPS-Mod-0210Monodelphis domestica90.940.0 615
LLPS-Rhb-3015Rhinopithecus bieti88.00.0 550
LLPS-Lac-3436Latimeria chalumnae87.50.0 580
LLPS-Otg-1308Otolemur garnettii86.250.0 576
LLPS-Mup-0160Mustela putorius furo85.670.0 567
LLPS-Maf-1412Macaca fascicularis83.490.0 545
LLPS-Mal-0702Mandrillus leucophaeus83.180.0 543
LLPS-Paa-0451Papio anubis82.920.0 542
LLPS-Gog-2953Gorilla gorilla82.870.0 543
LLPS-Hos-0179Homo sapiens82.870.0 543
LLPS-Pat-3187Pan troglodytes82.870.0 543
LLPS-Pap-2883Pan paniscus82.870.0 543
LLPS-Myl-2666Myotis lucifugus80.970.0 535
LLPS-Cas-0856Carlito syrichta80.00.0 544
LLPS-Cis-1251Ciona savignyi77.430.0 518
LLPS-Spr-0661Sporisorium reilianum76.970.0 516
LLPS-Scp-0055Schizosaccharomyces pombe76.490.0 520
LLPS-Usm-0658Ustilago maydis75.940.0 516
LLPS-Scj-0347Schizosaccharomyces japonicus75.550.0 517
LLPS-Ved-0295Verticillium dahliae74.843e-173 493
LLPS-Gas-0290Galdieria sulphuraria74.690.0 514
LLPS-Cea-1224Cercocebus atys74.699e-166 472
LLPS-Ast-1271Aspergillus terreus74.538e-176 499
LLPS-Aso-0730Aspergillus oryzae73.92e-174 495
LLPS-Asf-1520Aspergillus flavus73.92e-174 495
LLPS-Asn-0406Aspergillus nidulans73.95e-175 497
LLPS-Asfu-0380Aspergillus fumigatus73.97e-175 497
LLPS-Nef-0743Neosartorya fischeri73.96e-175 497
LLPS-Asc-1540Aspergillus clavatus73.582e-174 495
LLPS-Mao-0993Magnaporthe oryzae73.581e-171 488
LLPS-Blg-0137Blumeria graminis73.271e-172 491
LLPS-Nec-0357Neurospora crassa73.271e-171 489
LLPS-Coo-0828Colletotrichum orbiculare73.274e-172 490
LLPS-Crn-0871Cryptococcus neoformans73.127e-167 476
LLPS-Beb-0886Beauveria bassiana72.964e-169 482
LLPS-Cog-1113Colletotrichum gloeosporioides72.963e-171 488
LLPS-Man-0009Macaca nemestrina72.841e-156 449
LLPS-Scc-0715Schizosaccharomyces cryophilus72.733e-171 488
LLPS-Cogr-1167Colletotrichum graminicola72.642e-170 486
LLPS-Lem-0187Leptosphaeria maculans72.599e-174 494
LLPS-Map-0007Magnaporthe poae72.333e-169 483
LLPS-Pyt-1474Pyrenophora teres72.272e-173 493
LLPS-Pytr-1374Pyrenophora triticirepentis72.272e-173 493
LLPS-Thc-0045Theobroma cacao71.752e-167 478
LLPS-Gag-0894Gaeumannomyces graminis71.71e-168 481
LLPS-Fuv-0487Fusarium verticillioides71.71e-167 478
LLPS-Fuo-0637Fusarium oxysporum71.71e-167 478
LLPS-Kop-1215Komagataella pastoris71.565e-175 498
LLPS-Yal-0630Yarrowia lipolytica71.472e-169 482
LLPS-Hea-1054Helianthus annuus71.471e-171 488
LLPS-Nia-1356Nicotiana attenuata71.163e-172 489
LLPS-Trv-0441Trichoderma virens70.863e-167 478
LLPS-Tra-1763Triticum aestivum70.852e-173 493
LLPS-Prp-0255Prunus persica70.855e-173 492
LLPS-Gor-0244Gossypium raimondii70.853e-171 487
LLPS-Asg-1051Ashbya gossypii70.572e-157 453
LLPS-Hov-0673Hordeum vulgare70.534e-171 488
LLPS-Sei-0805Setaria italica70.532e-172 490
LLPS-Chc-0721Chondrus crispus70.535e-168 479
LLPS-Ori-0868Oryza indica70.533e-171 487
LLPS-Coc-1076Corchorus capsularis70.531e-170 486
LLPS-Ors-0561Oryza sativa70.536e-171 486
LLPS-Mae-1281Manihot esculenta70.532e-170 485
LLPS-Abg-0004Absidia glauca70.311e-164 470
LLPS-Org-0387Oryza glaberrima70.317e-170 484
LLPS-Brd-2104Brachypodium distachyon70.222e-172 490
LLPS-Met-1439Medicago truncatula70.225e-169 481
LLPS-Cus-0879Cucumis sativus70.223e-170 485
LLPS-Zem-1050Zea mays70.221e-171 488
LLPS-Phv-1803Phaseolus vulgaris70.222e-171 488
LLPS-Amt-0464Amborella trichopoda70.222e-171 488
LLPS-Orgl-1378Oryza glumaepatula69.912e-167 477
LLPS-Orb-0968Oryza barthii69.912e-167 477
LLPS-Orni-0346Oryza nivara69.912e-167 477
LLPS-Orm-1476Oryza meridionalis69.912e-167 477
LLPS-Orr-0589Oryza rufipogon69.912e-167 477
LLPS-Art-2234Arabidopsis thaliana69.912e-169 483
LLPS-Viv-1113Vitis vinifera69.911e-169 483
LLPS-Sob-0629Sorghum bicolor69.911e-171 488
LLPS-Orbr-1581Oryza brachyantha69.919e-172 488
LLPS-Bro-1544Brassica oleracea69.592e-169 483
LLPS-Brr-0279Brassica rapa69.592e-169 483
LLPS-Vir-0647Vigna radiata69.332e-121 370
LLPS-Via-1323Vigna angularis69.283e-170 485
LLPS-Cym-0733Cyanidioschyzon merolae69.167e-155 452
LLPS-Drm-0946Drosophila melanogaster69.063e-159 456
LLPS-Sac-1028Saccharomyces cerevisiae68.674e-153 443
LLPS-Lep-0045Leersia perrieri68.341e-161 462
LLPS-Php-0500Physcomitrella patens68.342e-166 475
LLPS-Orp-1774Oryza punctata68.038e-163 465
LLPS-Mua-0989Musa acuminata67.711e-156 450
LLPS-Miv-1138Microbotryum violaceum67.34e-155 446
LLPS-Chr-0041Chlamydomonas reinhardtii66.251e-142 415
LLPS-Dac-0824Daucus carota66.184e-163 467
LLPS-Pot-0303Populus trichocarpa64.671e-154 445
LLPS-Put-0279Puccinia triticina64.382e-149 434
LLPS-Brn-0477Brassica napus64.269e-152 437
LLPS-Pug-0396Puccinia graminis64.064e-149 431
LLPS-Sol-2208Solanum lycopersicum63.111e-155 448
LLPS-Osl-0652Ostreococcus lucimarinus61.394e-141 410
LLPS-Cae-1748Caenorhabditis elegans60.448e-137 402
LLPS-Fia-1219Ficedula albicollis53.617e-112 336
LLPS-Tut-0459Tursiops truncatus52.984e-111 334
LLPS-Ict-4253Ictidomys tridecemlineatus52.665e-111 334
LLPS-Tum-1144Tuber melanosporum52.536e-102 308
LLPS-Sot-0776Solanum tuberosum51.91e-100 307