LLPS-Drm-2063
SdhB
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur subunit of complex II; Ip |
| Gene Name: | SdhB, SDH, CG3283 |
| Ensembl Gene: | FBgn0014028 |
| Ensembl Protein: | FBpp0085489 |
| Organism: | Drosophila melanogaster |
| Taxa ID: | 7227 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | FBtr0086156 | FBpp0085489 |
| UniProt | P21914, SDHB_DROME, Q9V9A0 | |
| GeneBank | AY118923, AE013599, L27705 | AAA61925.1, AAM50783.1, AAF57396.1 |
| RefSeq | NM_057753.5 | NP_477101.1 |
| Entrez | 35590 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MLATEARQIL SRVGSLVARN QMRAISNGTA QLEQQAQPKE AQEPQIKKFE IYRWNPDNAG 60 61 EKPYMQTYEV DLRECGPMVL DALIKIKNEM DPTLTFRRSC REGICGSCAM NIGGTNTLAC 120 121 ISKIDINTSK SLKVYPLPHM YVVRDLVPDM NNFYEQYRNI QPWLQRKNEA GEKKGKAQYL 180 181 QSVEDRSKLD GLYECILCAC CSTSCPSYWW NAEKYLGPAV LMQAYRWIID SRDENSAERL 240 241 NKLKDPFSVY RCHTIMNCTR TCPKGLNPGR AIAEIKKLLS GLASKPAPKL ETAALHK 297 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTTGGCGA CCGAGGCGAG ACAGATCCTG AGCCGCGTGG GATCCCTGGT GGCCAGGAAC 60 61 CAGATGCGCG CCATCAGCAA TGGCACCGCC CAGCTGGAGC AGCAGGCGCA GCCCAAGGAG 120 121 GCCCAGGAGC CGCAGATCAA GAAGTTCGAG ATCTACCGCT GGAACCCGGA CAACGCCGGC 180 181 GAGAAGCCGT ACATGCAGAC CTACGAGGTG GACCTGCGCG AGTGCGGCCC CATGGTGCTG 240 241 GACGCGCTGA TCAAGATCAA GAACGAGATG GACCCCACGC TCACCTTTAG GCGCTCCTGT 300 301 CGCGAGGGCA TCTGCGGCTC CTGCGCCATG AACATCGGCG GCACCAACAC GCTGGCCTGC 360 361 ATCAGCAAGA TCGACATCAA CACCTCCAAG TCGCTGAAGG TGTACCCGCT GCCCCATATG 420 421 TACGTGGTGC GCGACCTGGT CCCGGACATG AACAACTTCT ACGAGCAGTA CCGCAACATC 480 481 CAGCCCTGGC TGCAGCGCAA GAACGAAGCG GGCGAGAAGA AGGGCAAGGC CCAGTACCTG 540 541 CAGTCCGTCG AGGATCGCTC CAAGTTGGAC GGCCTGTACG AGTGCATCCT GTGCGCCTGC 600 601 TGCTCCACCT CGTGCCCCTC GTACTGGTGG AACGCCGAGA AGTACCTGGG CCCCGCCGTG 660 661 CTGATGCAGG CCTACCGCTG GATCATCGAC TCGCGTGACG AGAACTCCGC CGAGCGTCTG 720 721 AACAAGTTGA AGGACCCCTT CAGCGTCTAC CGGTGCCACA CGATCATGAA CTGCACGCGC 780 781 ACCTGCCCCA AGGGGCTCAA TCCCGGCCGT GCCATCGCCG AGATCAAGAA GCTGCTCTCG 840 841 GGCCTGGCCT CCAAGCCGGC TCCGAAGCTG GAGACGGCGG CGCTGCACAA G 891 |
▼ KEYWORD
ID | Family |
2Fe-2S | |
3Fe-4S | |
4Fe-4S | |
Complete proteome | |
Electron transport | |
Iron | |
Iron-sulfur | |
Membrane | |
Metal-binding | |
Mitochondrion | |
Mitochondrion inner membrane | |
Oxidoreductase | |
Reference proteome | |
Transit peptide | |
Transport | |
Tricarboxylic acid cycle
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Mitochondrial inner membrane | |
Cellular Component | Mitochondrial membrane | |
Cellular Component | Mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) | |
Molecular Function | 2 iron, 2 sulfur cluster binding | |
Molecular Function | 3 iron, 4 sulfur cluster binding | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | Electron transfer activity | |
Molecular Function | Metal ion binding | |
Molecular Function | Succinate dehydrogenase (ubiquinone) activity | |
Molecular Function | Ubiquinone binding | |
Biological Process | Aerobic respiration | |
Biological Process | Mitochondrial electron transport, succinate to ubiquinone | |
Biological Process | Respiratory electron transport chain | |
Biological Process | Tricarboxylic acid cycle |
▼ ANNOTATION
| PTM | ||||
| PTMcode | ||||
| Physicochemical | ||||
| AAindex | ||||
| Localization | ||||
| COMPARTMENTS | ||||
| Expression | ||||
| ArrayExpress | ||||
| Element | ||||
| RAID | microRNA.org | |||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Tag-3068 | Taeniopygia guttata | 78.97 | 2e-114 | 337 |
| LLPS-Orl-1451 | Oryzias latipes | 78.3 | 1e-141 | 408 |
| LLPS-Tar-0081 | Takifugu rubripes | 77.69 | 2e-145 | 417 |
| LLPS-Asm-0858 | Astyanax mexicanus | 77.69 | 1e-143 | 413 |
| LLPS-Dar-1970 | Danio rerio | 77.69 | 3e-144 | 414 |
| LLPS-Xim-0518 | Xiphophorus maculatus | 77.27 | 4e-143 | 412 |
| LLPS-Xet-0091 | Xenopus tropicalis | 77.27 | 1e-141 | 408 |
| LLPS-Ten-3726 | Tetraodon nigroviridis | 76.86 | 2e-143 | 412 |
| LLPS-Pof-1808 | Poecilia formosa | 76.86 | 5e-143 | 411 |
| LLPS-Orn-2350 | Oreochromis niloticus | 76.86 | 6e-144 | 414 |
| LLPS-Scf-0122 | Scleropages formosus | 76.67 | 4e-143 | 412 |
| LLPS-Cap-1024 | Cavia porcellus | 76.45 | 1e-141 | 408 |
| LLPS-Scm-0542 | Scophthalmus maximus | 76.45 | 2e-140 | 405 |
| LLPS-Lac-2928 | Latimeria chalumnae | 76.35 | 1e-141 | 408 |
| LLPS-Mod-0969 | Monodelphis domestica | 76.25 | 3e-140 | 404 |
| LLPS-Nol-2522 | Nomascus leucogenys | 76.03 | 4e-139 | 401 |
| LLPS-Gaga-1046 | Gallus gallus | 76.03 | 3e-141 | 407 |
| LLPS-Meg-0423 | Meleagris gallopavo | 76.03 | 2e-140 | 405 |
| LLPS-Paa-1141 | Papio anubis | 75.62 | 1e-140 | 405 |
| LLPS-Mup-3790 | Mustela putorius furo | 75.62 | 9e-141 | 405 |
| LLPS-Aim-0276 | Ailuropoda melanoleuca | 75.62 | 6e-141 | 406 |
| LLPS-Sah-3090 | Sarcophilus harrisii | 75.62 | 2e-139 | 402 |
| LLPS-Aon-4672 | Aotus nancymaae | 75.62 | 1e-140 | 405 |
| LLPS-Mum-4111 | Mus musculus | 75.62 | 1e-139 | 403 |
| LLPS-Fud-3211 | Fukomys damarensis | 75.62 | 2e-140 | 404 |
| LLPS-Caj-4489 | Callithrix jacchus | 75.62 | 2e-140 | 405 |
| LLPS-Gog-0719 | Gorilla gorilla | 75.62 | 8e-141 | 406 |
| LLPS-Poa-1078 | Pongo abelii | 75.62 | 8e-141 | 406 |
| LLPS-Caf-1900 | Canis familiaris | 75.62 | 3e-141 | 407 |
| LLPS-Cas-0522 | Carlito syrichta | 75.62 | 2e-140 | 404 |
| LLPS-Loa-4073 | Loxodonta africana | 75.62 | 2e-140 | 405 |
| LLPS-Hos-0318 | Homo sapiens | 75.62 | 8e-141 | 406 |
| LLPS-Pat-3270 | Pan troglodytes | 75.62 | 8e-141 | 406 |
| LLPS-Pap-0528 | Pan paniscus | 75.62 | 8e-141 | 406 |
| LLPS-Fec-1174 | Felis catus | 75.62 | 2e-140 | 405 |
| LLPS-Otg-1032 | Otolemur garnettii | 75.62 | 5e-140 | 404 |
| LLPS-Anc-3959 | Anolis carolinensis | 75.57 | 1e-99 | 299 |
| LLPS-Mal-1444 | Mandrillus leucophaeus | 75.21 | 3e-140 | 404 |
| LLPS-Maf-3260 | Macaca fascicularis | 75.21 | 3e-140 | 404 |
| LLPS-Mea-2085 | Mesocricetus auratus | 75.21 | 7e-139 | 401 |
| LLPS-Chs-3312 | Chlorocebus sabaeus | 75.21 | 3e-140 | 404 |
| LLPS-Icp-2911 | Ictalurus punctatus | 75.21 | 2e-141 | 407 |
| LLPS-Mam-1433 | Macaca mulatta | 75.21 | 3e-140 | 404 |
| LLPS-Ict-1903 | Ictidomys tridecemlineatus | 75.21 | 3e-140 | 404 |
| LLPS-Anp-2808 | Anas platyrhynchos | 75.21 | 5e-139 | 401 |
| LLPS-Urm-3289 | Ursus maritimus | 75.21 | 5e-140 | 404 |
| LLPS-Bot-1823 | Bos taurus | 74.79 | 1e-139 | 403 |
| LLPS-Ran-3814 | Rattus norvegicus | 74.79 | 2e-138 | 400 |
| LLPS-Sus-4602 | Sus scrofa | 74.38 | 2e-138 | 400 |
| LLPS-Eqc-4232 | Equus caballus | 74.38 | 2e-139 | 402 |
| LLPS-Asni-0946 | Aspergillus niger | 74.26 | 9e-52 | 172 |
| LLPS-Dio-1852 | Dipodomys ordii | 73.97 | 4e-136 | 394 |
| LLPS-Cii-1324 | Ciona intestinalis | 73.53 | 2e-132 | 385 |
| LLPS-Myl-3007 | Myotis lucifugus | 73.14 | 5e-136 | 394 |
| LLPS-Cea-1029 | Cercocebus atys | 72.97 | 1e-100 | 301 |
| LLPS-Asg-0373 | Ashbya gossypii | 72.65 | 1e-128 | 374 |
| LLPS-Sac-1110 | Saccharomyces cerevisiae | 71.91 | 1e-127 | 372 |
| LLPS-Cae-1541 | Caenorhabditis elegans | 71.9 | 8e-133 | 386 |
| LLPS-Cis-1319 | Ciona savignyi | 71.85 | 2e-127 | 372 |
| LLPS-Kop-1486 | Komagataella pastoris | 71.49 | 7e-127 | 370 |
| LLPS-Abg-1934 | Absidia glauca | 71.37 | 5e-123 | 359 |
| LLPS-Crn-0670 | Cryptococcus neoformans | 71.12 | 7e-97 | 294 |
| LLPS-Ora-1572 | Ornithorhynchus anatinus | 70.77 | 7e-99 | 300 |
| LLPS-Gaa-0709 | Gasterosteus aculeatus | 70.71 | 1e-144 | 415 |
| LLPS-Pes-1955 | Pelodiscus sinensis | 70.42 | 3e-130 | 379 |
| LLPS-Rhb-4064 | Rhinopithecus bieti | 70.25 | 3e-124 | 363 |
| LLPS-Ova-1380 | Ovis aries | 69.83 | 2e-124 | 364 |
| LLPS-Man-4032 | Macaca nemestrina | 69.83 | 6e-124 | 362 |
| LLPS-Yal-0430 | Yarrowia lipolytica | 69.79 | 3e-122 | 358 |
| LLPS-Cogr-0881 | Colletotrichum graminicola | 69.36 | 2e-122 | 358 |
| LLPS-Amt-1117 | Amborella trichopoda | 69.15 | 1e-100 | 301 |
| LLPS-Scp-0546 | Schizosaccharomyces pombe | 68.94 | 4e-120 | 353 |
| LLPS-Scc-1641 | Schizosaccharomyces cryophilus | 68.94 | 1e-117 | 347 |
| LLPS-Blg-1266 | Blumeria graminis | 68.8 | 1e-121 | 356 |
| LLPS-Asfu-0708 | Aspergillus fumigatus | 68.78 | 5e-122 | 358 |
| LLPS-Gag-0758 | Gaeumannomyces graminis | 68.51 | 3e-123 | 361 |
| LLPS-Phn-1012 | Phaeosphaeria nodorum | 68.51 | 3e-122 | 359 |
| LLPS-Cog-1046 | Colletotrichum gloeosporioides | 68.51 | 2e-121 | 356 |
| LLPS-Trr-1473 | Trichoderma reesei | 68.51 | 6e-124 | 363 |
| LLPS-Nef-0315 | Neosartorya fischeri | 68.49 | 1e-122 | 360 |
| LLPS-Pyt-0215 | Pyrenophora teres | 68.38 | 4e-121 | 357 |
| LLPS-Lem-1386 | Leptosphaeria maculans | 68.38 | 6e-121 | 356 |
| LLPS-Pytr-0573 | Pyrenophora triticirepentis | 68.38 | 3e-121 | 357 |
| LLPS-Pot-0673 | Populus trichocarpa | 68.24 | 7e-115 | 340 |
| LLPS-Aso-1105 | Aspergillus oryzae | 68.09 | 5e-123 | 360 |
| LLPS-Asf-0585 | Aspergillus flavus | 68.09 | 5e-123 | 360 |
| LLPS-Nec-1162 | Neurospora crassa | 68.09 | 2e-121 | 356 |
| LLPS-Asc-0234 | Aspergillus clavatus | 68.09 | 2e-122 | 360 |
| LLPS-Map-0289 | Magnaporthe poae | 68.09 | 2e-122 | 359 |
| LLPS-Coo-0213 | Colletotrichum orbiculare | 68.09 | 2e-121 | 356 |
| LLPS-Trv-0433 | Trichoderma virens | 68.09 | 8e-124 | 362 |
| LLPS-Bro-2200 | Brassica oleracea | 67.81 | 2e-115 | 341 |
| LLPS-Fia-2597 | Ficedula albicollis | 67.77 | 8e-118 | 347 |
| LLPS-Mao-1450 | Magnaporthe oryzae | 67.66 | 3e-121 | 356 |
| LLPS-Ved-0366 | Verticillium dahliae | 67.66 | 6e-119 | 350 |
| LLPS-Zyt-0254 | Zymoseptoria tritici | 67.52 | 2e-119 | 352 |
| LLPS-Mel-0173 | Melampsora laricipopulina | 67.52 | 3e-123 | 361 |
| LLPS-Viv-1033 | Vitis vinifera | 67.4 | 8e-81 | 256 |
| LLPS-Ast-1189 | Aspergillus terreus | 67.37 | 3e-121 | 356 |
| LLPS-Mae-1736 | Manihot esculenta | 67.36 | 1e-114 | 339 |
| LLPS-Asn-0847 | Aspergillus nidulans | 67.23 | 5e-122 | 358 |
| LLPS-Fuo-1290 | Fusarium oxysporum | 67.23 | 3e-122 | 358 |
| LLPS-Usm-0325 | Ustilago maydis | 67.08 | 3e-120 | 354 |
| LLPS-Via-0154 | Vigna angularis | 67.04 | 2e-83 | 258 |
| LLPS-Dac-1628 | Daucus carota | 66.95 | 5e-115 | 340 |
| LLPS-Gor-0644 | Gossypium raimondii | 66.95 | 6e-114 | 337 |
| LLPS-Fuv-0690 | Fusarium verticillioides | 66.81 | 9e-122 | 357 |
| LLPS-Php-0752 | Physcomitrella patens | 66.81 | 1e-115 | 342 |
| LLPS-Beb-1227 | Beauveria bassiana | 66.81 | 8e-121 | 355 |
| LLPS-Sot-1698 | Solanum tuberosum | 66.52 | 1e-113 | 336 |
| LLPS-Sol-2069 | Solanum lycopersicum | 66.52 | 1e-113 | 336 |
| LLPS-Nia-2110 | Nicotiana attenuata | 66.52 | 7e-114 | 337 |
| LLPS-Dos-0506 | Dothistroma septosporum | 66.38 | 1e-117 | 347 |
| LLPS-Put-0877 | Puccinia triticina | 66.24 | 3e-121 | 357 |
| LLPS-Spr-1375 | Sporisorium reilianum | 66.12 | 2e-119 | 352 |
| LLPS-Vir-0991 | Vigna radiata | 66.09 | 4e-112 | 333 |
| LLPS-Met-0429 | Medicago truncatula | 66.09 | 2e-112 | 333 |
| LLPS-Scs-0505 | Sclerotinia sclerotiorum | 65.96 | 5e-118 | 348 |
| LLPS-Mua-2596 | Musa acuminata | 65.67 | 4e-95 | 286 |
| LLPS-Zem-1144 | Zea mays | 65.56 | 1e-81 | 259 |
| LLPS-Prp-0716 | Prunus persica | 65.0 | 6e-113 | 335 |
| LLPS-Lep-2144 | Leersia perrieri | 64.44 | 8e-81 | 257 |
| LLPS-Hov-1762 | Hordeum vulgare | 64.44 | 5e-84 | 263 |
| LLPS-Orp-1983 | Oryza punctata | 64.44 | 6e-78 | 249 |
| LLPS-Sei-1063 | Setaria italica | 64.09 | 5e-80 | 255 |
| LLPS-Glm-1190 | Glycine max | 63.95 | 3e-110 | 328 |
| LLPS-Cym-1036 | Cyanidioschyzon merolae | 63.95 | 3e-110 | 327 |
| LLPS-Brd-1831 | Brachypodium distachyon | 63.89 | 5e-82 | 258 |
| LLPS-Ori-2072 | Oryza indica | 63.89 | 1e-77 | 248 |
| LLPS-Orni-1681 | Oryza nivara | 63.89 | 1e-77 | 248 |
| LLPS-Orr-1243 | Oryza rufipogon | 63.89 | 1e-77 | 248 |
| LLPS-Chr-0935 | Chlamydomonas reinhardtii | 63.68 | 3e-109 | 326 |
| LLPS-Orbr-1288 | Oryza brachyantha | 63.33 | 1e-76 | 246 |
| LLPS-Tum-0002 | Tuber melanosporum | 62.98 | 8e-107 | 318 |
| LLPS-Osl-1325 | Ostreococcus lucimarinus | 62.55 | 4e-111 | 329 |
| LLPS-Scj-1177 | Schizosaccharomyces japonicus | 62.5 | 2e-123 | 361 |
| LLPS-Leo-0826 | Lepisosteus oculatus | 62.08 | 5e-106 | 316 |
| LLPS-Sem-1252 | Selaginella moellendorffii | 61.7 | 2e-104 | 311 |
| LLPS-Gas-0647 | Galdieria sulphuraria | 61.25 | 3e-105 | 315 |
| LLPS-Miv-1570 | Microbotryum violaceum | 61.05 | 6e-123 | 360 |
| LLPS-Arl-0409 | Arabidopsis lyrata | 61.01 | 2e-117 | 346 |
| LLPS-Brn-2333 | Brassica napus | 61.01 | 6e-117 | 345 |
| LLPS-Brr-2496 | Brassica rapa | 61.01 | 3e-117 | 345 |
| LLPS-Art-0705 | Arabidopsis thaliana | 61.01 | 8e-118 | 347 |
| LLPS-Hea-1770 | Helianthus annuus | 60.85 | 2e-104 | 314 |
| LLPS-Cus-0121 | Cucumis sativus | 60.66 | 2e-114 | 338 |
| LLPS-Fus-0726 | Fusarium solani | 60.0 | 3e-104 | 311 |
| LLPS-Thc-1512 | Theobroma cacao | 59.57 | 4e-115 | 340 |
| LLPS-Tra-2543 | Triticum aestivum | 58.97 | 1e-101 | 306 |
| LLPS-Orm-0821 | Oryza meridionalis | 58.55 | 2e-98 | 313 |
| LLPS-Coc-0173 | Corchorus capsularis | 58.37 | 8e-99 | 300 |
| LLPS-Orb-0936 | Oryza barthii | 58.12 | 5e-98 | 305 |
| LLPS-Org-1735 | Oryza glaberrima | 58.12 | 4e-99 | 300 |
| LLPS-Ors-1982 | Oryza sativa | 58.12 | 4e-99 | 301 |
| LLPS-Orgl-1442 | Oryza glumaepatula | 57.69 | 3e-97 | 305 |
| LLPS-Sob-0754 | Sorghum bicolor | 57.08 | 1e-99 | 302 |
| LLPS-Tru-1435 | Triticum urartu | 48.29 | 3e-75 | 238 |
| LLPS-Chc-0950 | Chondrus crispus | 45.76 | 2e-25 | 106 |