LLPS-Drm-1685
mt:CoI

▼ OVERVIEW

Status: Unreviewed
Protein Name: Cytochrome c oxidase subunit 1; Cytochrome c oxidase polypeptide I
Gene Name: mt:CoI, CoI
Ensembl Gene: FBgn0013674
Ensembl Protein: FBpp0100176
Organism: Drosophila melanogaster
Taxa ID: 7227
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Chromatoid bodyPredicted from orthologs(View)

▼ FUNCTION

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

▼ SEQUENCE

Protein Sequence (FASTA)
1     SRQWLFSTNH  KDIGTLYFIF  GAWAGMVGTS  LSILIRAELG  HPGALIGDDQ  IYNVIVTAHA  60
61    FIMIFFMVMP  IMIGGFGNWL  VPLMLGAPDM  AFPRMNNMSF  WLLPPALSLL  LVSSMVENGA  120
121   GTGWTVYPPL  SAGIAHGGAS  VDLAIFSLHL  AGISSILGAV  NFITTVINMR  STGISLDRMP  180
181   LFVWSVVITA  LLLLLSLPVL  AGAITMLLTD  RNLNTSFFDP  AGGGDPILYQ  HLFWFFGHPE  240
241   VYILILPGFG  MISHIISQES  GKKETFGSLG  MIYAMLAIGL  LGFIVWAHHM  FTVGMDVDTR  300
301   AYFTSATMII  AVPTGIKIFS  WLATLHGTQL  SYSPAILWAL  GFVFLFTVGG  LTGVVLANSS  360
361   VDIILHDTYY  VVAHFHYVLS  MGAVFAIMAG  FIHWYPLFTG  LTLNNKWLKS  HFIIMFIGVN  420
421   LTFFPQHFLG  LAGMPRRYSD  YPDAYTTWNI  VSTIGSTISL  LGILFFFFII  WESLVSQRQV  480
481   IYPIQLNSSI  EWYQNTPPAE  HSYSELPLLT  N  511
Nucleotide CDS Sequence (FASTA)
1     TCGCGACAAT  GATTATTTTC  TACAAATCAT  AAAGATATCG  GAACTTTATA  TTTTATTTTT  60
61    GGAGCTTGAG  CTGGAATAGT  TGGAACATCT  TTAAGAATTT  TAATTCGAGC  TGAATTAGGA  120
121   CATCCTGGAG  CATTAATTGG  AGATGATCAA  ATTTATAATG  TAATTGTAAC  TGCACATGCT  180
181   TTTATTATAA  TTTTTTTTAT  AGTTATACCT  ATTATAATTG  GTGGATTTGG  AAATTGATTA  240
241   GTGCCTTTAA  TATTAGGTGC  TCCTGATATA  GCATTCCCAC  GAATAAATAA  TATAAGATTT  300
301   TGACTTCTAC  CTCCTGCTCT  TTCTTTACTA  TTAGTAAGTA  GAATAGTTGA  AAATGGAGCT  360
361   GGGACAGGAT  GAACTGTTTA  TCCACCTCTA  TCCGCTGGAA  TTGCTCATGG  TGGAGCTTCA  420
421   GTTGATTTAG  CTATTTTTTC  TCTACATTTA  GCAGGAATTT  CTTCAATTTT  AGGAGCTGTA  480
481   AATTTTATTA  CAACTGTAAT  TAATATACGA  TCAACAGGAA  TTTCATTAGA  TCGTATACCT  540
541   TTATTTGTTT  GATCAGTAGT  TATTACTGCT  TTATTATTAT  TATTATCACT  TCCAGTACTA  600
601   GCAGGAGCTA  TTACTATATT  ATTAACAGAT  CGAAATTTAA  ATACATCATT  TTTTGACCCA  660
661   GCGGGAGGAG  GAGATCCTAT  TTTATACCAA  CATTTATTTT  GATTTTTTGG  TCATCCTGAA  720
721   GTTTATATTT  TAATTTTACC  TGGATTTGGA  ATAATTTCTC  ATATTATTAG  ACAAGAATCA  780
781   GGAAAAAAGG  AAACTTTTGG  TTCTCTAGGA  ATAATTTATG  CTATATTAGC  TATTGGATTA  840
841   TTAGGATTTA  TTGTATGAGC  TCATCATATA  TTTACCGTTG  GAATAGATGT  AGATACTCGA  900
901   GCTTATTTTA  CCTCAGCTAC  TATAATTATT  GCAGTTCCTA  CTGGAATTAA  AATTTTTAGT  960
961   TGATTAGCTA  CTTTACATGG  AACTCAACTT  TCTTATTCTC  CAGCTATTTT  ATGAGCTTTA  1020
1021  GGATTTGTTT  TTTTATTTAC  AGTAGGAGGA  TTAACAGGAG  TTGTTTTAGC  TAATTCATCA  1080
1081  GTAGATATTA  TTTTACATGA  TACTTATTAT  GTAGTAGCTC  ATTTTCATTA  TGTTTTATCT  1140
1141  ATAGGAGCTG  TATTTGCTAT  TATAGCAGGT  TTTATTCACT  GATACCCCTT  ATTTACTGGA  1200
1201  TTAACGTTAA  ATAATAAATG  ATTAAAAAGT  CATTTCATTA  TTATATTTAT  TGGAGTTAAT  1260
1261  TTAACATTTT  TTCCTCAACA  TTTTTTAGGA  TTGGCTGGAA  TACCTCGACG  TTATTCAGAT  1320
1321  TACCCAGATG  CTTACACAAC  ATGAAATATT  GTATCAACTA  TTGGATCAAC  TATTTCATTA  1380
1381  TTAGGAATTT  TATTCTTTTT  TTTTATTATT  TGAGAAAGTT  TAGTATCACA  ACGACAAGTA  1440
1441  ATTTACCCAA  TTCAACTAAA  TTCATCAATT  GAATGATACC  AAAATACTCC  ACCAGCTGAA  1500
1501  CATAGATATT  CTGAATTACC  ACTTTTAACA  AAT  1533

▼ KEYWORD

ID
Family
Complete proteome
Copper
Electron transport
Heme
Iron
Membrane
Metal-binding
Mitochondrion
Mitochondrion inner membrane
Oxidoreductase
Polymorphism
Reference proteome
Respiratory chain
Transmembrane
Transmembrane helix
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Integral component of membrane
Cellular Component
Mitochondrial respiratory chain complex IV
Cellular Component
Respiratory chain complex IV
Molecular Function
Cytochrome-c oxidase activity
Molecular Function
Heme binding
Molecular Function
Metal ion binding
Biological Process
Aerobic respiration
Biological Process
Electron transport coupled proton transport
Biological Process
Mitochondrial electron transport, cytochrome c to oxygen

▼ KEGG


▼ ANNOTATION

Disorder
D2P2IUPred2A
Interaction
IIDMIST
Physicochemical
AAindex
Localization
COMPARTMENTS

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Amt-1584Amborella trichopoda90.911e-1272.4
LLPS-Chc-1042Chondrus crispus90.325e-1060.5
LLPS-Pot-2137Populus trichocarpa79.419e-1061.6
LLPS-Urm-2682Ursus maritimus78.170.0 727
LLPS-Cap-1641Cavia porcellus77.820.0 719
LLPS-Caf-3987Canis familiaris77.780.0 721
LLPS-Sah-3878Sarcophilus harrisii77.730.0 716
LLPS-Mod-2996Monodelphis domestica77.580.0 715
LLPS-Gaa-1100Gasterosteus aculeatus77.530.0 711
LLPS-Ict-1728Ictidomys tridecemlineatus77.380.0 720
LLPS-Ran-0050Rattus norvegicus77.380.0 724
LLPS-Aim-2252Ailuropoda melanoleuca77.380.0 722
LLPS-Lac-4021Latimeria chalumnae77.340.0 697
LLPS-Fec-0793Felis catus77.180.0 722
LLPS-Orc-0500Oryctolagus cuniculus77.180.0 716
LLPS-Tag-2443Taeniopygia guttata77.180.0 714
LLPS-Mea-1548Mesocricetus auratus77.180.0 722
LLPS-Sus-3456Sus scrofa77.180.0 719
LLPS-Ova-2685Ovis aries77.180.0 719
LLPS-Fia-2249Ficedula albicollis76.980.0 712
LLPS-Eqc-3649Equus caballus76.980.0 714
LLPS-Cas-2465Carlito syrichta76.980.0 718
LLPS-Mum-3502Mus musculus76.980.0 722
LLPS-Fud-1329Fukomys damarensis76.980.0 714
LLPS-Meg-2700Meleagris gallopavo76.790.0 717
LLPS-Dar-3194Danio rerio76.740.0 700
LLPS-Orl-3238Oryzias latipes76.740.0 705
LLPS-Ere-0617Erinaceus europaeus76.740.0 713
LLPS-Poa-2054Pongo abelii76.630.0 705
LLPS-Rhb-1454Rhinopithecus bieti76.590.0 711
LLPS-Ten-2621Tetraodon nigroviridis76.540.0 696
LLPS-Tar-2687Takifugu rubripes76.540.0 704
LLPS-Xim-3760Xiphophorus maculatus76.440.0 704
LLPS-Ora-3285Ornithorhynchus anatinus76.390.0 708
LLPS-Leo-1781Lepisosteus oculatus76.340.0 704
LLPS-Scf-2556Scleropages formosus76.340.0 694
LLPS-Hos-3951Homo sapiens76.240.0 707
LLPS-Gog-4345Gorilla gorilla76.240.0 707
LLPS-Anc-2465Anolis carolinensis76.190.0 708
LLPS-Xet-0613Xenopus tropicalis76.140.0 699
LLPS-Sob-1598Sorghum bicolor76.124e-2089.7
LLPS-Pat-2350Pan troglodytes76.040.0 706
LLPS-Loa-1514Loxodonta africana76.040.0 713
LLPS-Gaga-1222Gallus gallus75.990.0 703
LLPS-Icp-3033Ictalurus punctatus75.750.0 702
LLPS-Pap-3613Pan paniscus75.640.0 704
LLPS-Tut-1906Tursiops truncatus75.490.0 706
LLPS-Chs-3275Chlorocebus sabaeus75.40.0 709
LLPS-Mal-3599Mandrillus leucophaeus75.40.0 705
LLPS-Maf-0678Macaca fascicularis75.350.0 702
LLPS-Viv-2067Vitis vinifera75.08e-50 175
LLPS-Mam-2332Macaca mulatta74.90.0 702
LLPS-Met-2377Medicago truncatula74.471e-39 144
LLPS-Sot-1594Solanum tuberosum73.361e-131 391
LLPS-Pes-1473Pelodiscus sinensis73.020.0 677
LLPS-Orbr-0672Oryza brachyantha72.733e-0959.3
LLPS-Glm-3014Glycine max71.083e-31 120
LLPS-Tru-1823Triticum urartu68.510.0 595
LLPS-Art-3043Arabidopsis thaliana68.470.0 611
LLPS-Hov-0247Hordeum vulgare68.030.0 605
LLPS-Tra-2041Triticum aestivum67.250.0 605
LLPS-Sei-0631Setaria italica67.250.0 606
LLPS-Cii-2318Ciona intestinalis67.190.0 624
LLPS-Org-1946Oryza glaberrima66.730.0 606
LLPS-Zem-1415Zea mays66.730.0 606
LLPS-Cis-1512Ciona savignyi66.60.0 618
LLPS-Orr-1377Oryza rufipogon66.13e-1579.3
LLPS-Ori-1667Oryza indica65.656e-177 512
LLPS-Gor-0296Gossypium raimondii65.380.0 582
LLPS-Spr-1352Sporisorium reilianum64.840.0 598
LLPS-Nia-2569Nicotiana attenuata64.50.0 547
LLPS-Cae-0621Caenorhabditis elegans64.340.0 594
LLPS-Hea-2110Helianthus annuus64.220.0 567
LLPS-Cogr-1582Colletotrichum graminicola63.620.0 583
LLPS-Dac-0545Daucus carota63.290.0 527
LLPS-Nec-1255Neurospora crassa62.860.0 584
LLPS-Brn-2610Brassica napus62.823e-73 238
LLPS-Cym-0896Cyanidioschyzon merolae62.720.0 577
LLPS-Phn-0837Phaeosphaeria nodorum62.620.0 565
LLPS-Sol-1807Solanum lycopersicum62.366e-169 493
LLPS-Coc-2320Corchorus capsularis62.280.0 544
LLPS-Php-2144Physcomitrella patens62.215e-94 295
LLPS-Sac-1005Saccharomyces cerevisiae58.820.0 555
LLPS-Mua-2553Musa acuminata58.64e-54 186
LLPS-Asg-0401Ashbya gossypii57.50.0 545
LLPS-Scp-1571Schizosaccharomyces pombe56.557e-177 516
LLPS-Miv-1547Microbotryum violaceum56.484e-29 116
LLPS-Bro-1562Brassica oleracea53.853e-41 149
LLPS-Lem-1154Leptosphaeria maculans51.763e-1475.1