• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Asg-0401
COX1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Cytochrome c oxidase subunit 1; Cytochrome c oxidase polypeptide I
Gene Name: COX1, AMI002W, AgCOX1
Ensembl Gene: AGOS_AMI002W
Ensembl Protein: AAS50169
Organism: Ashbya gossypii
Taxa ID: 284811
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
OthersPredicted from orthologs(View)

▼ FUNCTION

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblAAS50169AAS50169
UniProtP62514, COX1_ASHGO, Q75G35
GeneBankAE016821AAS50169.1
RefSeqNC_005789.1NP_987079.1

▼ SEQUENCE

Protein Sequence (FASTA)
1     MYLQRWLFST  NAKDIAILYF  IFSTFCGLAG  TAMSFIIRME  LSAPGQQYLQ  GQNQLFNVLV  60
61    TGHTILMVFF  LVMPMLIGGF  GNYYLPLMIG  ASDMSFARLN  NISFWTLPPT  LICLLTSTMV  120
121   ESGTGTGWTV  YPPLSSIQSH  SGASVDLAIF  SLHLTTISSL  LGTINFIVTA  LNMRTNGMTL  180
181   HKMPLFTWSI  LITAVMLLMS  LPVLSAGVTM  LLMDRNFNTS  FFEVQGGGDP  ILYQHLFWFF  240
241   GHPEVYIMIV  PTFGMMSHIV  STYSKKPVFG  EISMIYTMGS  ISLLGFLVWS  HHMYVVGLDT  300
301   DTRAYFTSAT  MIITIPTSIK  VFSWLTTIYG  GSLRLTTPML  YTLSFLFLFT  VGGLTGVVLA  360
361   NTSLDVAFHD  TYYVVTHFHY  VLSLGAVFSM  FAGYYYWSPT  VLGLNYNEKL  SQIQFWLIFL  420
421   GTNIIFFPMH  FLGINGMPRR  IPDYPDTFTG  WNLVSSFGSM  MTIMSLMLFT  YIIYDQLMNG  480
481   LTNKVNNKSI  NYMKTPDFIE  SNNIFLMNTT  KSSSIEFMLN  SPPTIHSFNT  PTIQS  535
Nucleotide CDS Sequence (FASTA)
1     ATGTATTTAC  AGAGATGATT  ATTTTCTACA  AATGCTAAAG  ATATTGCTAT  TTTATATTTT  60
61    ATTTTTAGTA  CATTTTGTGG  ATTAGCAGGT  ACAGCTATAT  CATTTATTAT  TAGAATAGAA  120
121   TTATCAGCAC  CTGGTCAACA  ATATTTACAA  GGTCAAAATC  AATTATTTAA  TGTATTAGTT  180
181   ACTGGACATC  TTATTTTAAT  AGTATTCTTT  TTAGTAATAC  CTATATTAAT  TGGTGGTTTT  240
241   GGTAATTATT  ATTTACCATT  AATAATTGGT  GCTTCTGATA  TATCATTTGC  TAGATTAAAT  300
301   AATATTTCAT  TTTGACTATT  ACCACCACTA  TTAATTTGTT  TATTAACATC  TACTATAGTT  360
361   GAATCTGGTC  TAGGTACTGG  TTGAACTGTT  TATCCTCCTT  TATCTTCTAT  TCAATCACAT  420
421   TCTGGTGCTT  CTGTTGATTT  AGCTATTTTC  TCTTTACATT  TAACTACTAT  TTCTTCATTA  480
481   TTAGGACTTA  TTAATTTTAT  TGTTACAGCT  TTAAATATAA  GAACTAATGG  TATAACTTTA  540
541   CATAAAATAC  CTTTATTTCT  ATGATCAATT  TTAATTACTG  CTGTTATATT  ATTAATATCA  600
601   TTACCAGTAT  TATCAGCTGG  TGTTACTATA  TTATTAATAG  ATAGAAATTT  TAATACATCA  660
661   TTCTTTGAAG  TACAAGGTGG  TGGTGATCCT  ATTTTATATC  AACATTTATT  TTGATTCTTT  720
721   GGTCATCCTG  AAGTATATAT  TATAATTGTA  CCACTATTTG  GTATAATATC  ACATATTGTA  780
781   TCAACTTATT  CTAAAAAACC  TGTATTTGGT  GAAATTTCTA  TAATTTATCT  AATAGGTTCT  840
841   ATTAGTTTAT  TAGGTTTCTT  AGTTTGATCT  CATCATATGT  ATGTAGTAGG  TTTAGATCTT  900
901   GATACTAGAG  CTTATTTTAC  TTCAGCTACT  ATAATTATTC  TTATTCCTAC  TAGTATTAAA  960
961   GTATTTAGTT  GATTACTAAC  TATTTATGGT  GGTTCATTAA  GATTACTAAC  ACCAATATTA  1020
1021  TATCTATTAT  CATTTTTATT  TTTATTTACT  GTAGGTGGTT  TAACTGGTGT  AGTATTAGCT  1080
1081  AATCTATCAT  TAGATGTAGC  ATTCCATGAT  ACTTATTATG  TAGTACTACA  TTTCCATTAT  1140
1141  GTATTAAGTT  TAGGTGCTGT  ATTCTCTATG  TTTGCTGGTT  ATTATTATTG  AAGTCCTCTT  1200
1201  GTTTTAGGTT  TAAATTATAA  TGAAAAATTA  TCACAAATTC  AATTCTGATT  AATTTTCTTA  1260
1261  GGTCTTAATA  TTATTTTCTT  CCCTATGCAT  TTCTTAGGTA  TTAATGGTAT  ACCAAGAAGA  1320
1321  ATTCCTGATT  ATCCTGATCT  ATTCCTAGGT  TGAAATTTAG  TATCTTCATT  TGGTTCTATA  1380
1381  ATAACTATTA  TATCATTAAT  GTTATTCCTT  TATATTATTT  ATGATCAATT  AATAAATGGT  1440
1441  TTAACTAATA  AAGTTAATAA  TAAATCTATT  AATTATATAA  AACTACCTGA  TTTTATTGAA  1500
1501  TCAAATAATA  TTTTCTTAAT  GAATACTACT  AAATCATCAT  CTATTGAGTT  TATATTAAAT  1560
1561  TCACCACCTC  TTATTCATTC  ATTTAATACT  CCTCTAATTC  AATCTTAA  1608

▼ KEYWORD

ID
Family
Complete proteome
Copper
Electron transport
Heme
Iron
Membrane
Metal-binding
Mitochondrion
Mitochondrion inner membrane
Oxidoreductase
Reference proteome
Respiratory chain
Transmembrane
Transmembrane helix
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Integral component of membrane
Cellular Component
Mitochondrial respiratory chain complex IV
Molecular Function
Cytochrome-c oxidase activity
Molecular Function
Heme binding
Molecular Function
Metal ion binding
Biological Process
Aerobic respiration
Biological Process
Electron transport coupled proton transport
Biological Process
Mitochondrial electron transport, cytochrome c to oxygen

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Amt-1584Amborella trichopoda81.824e-1065.1
LLPS-Sac-1005Saccharomyces cerevisiae78.050.0 875
LLPS-Chc-1042Chondrus crispus77.429e-0853.9
LLPS-Glm-3014Glycine max70.376e-30 117
LLPS-Met-2377Medicago truncatula67.742e-36 135
LLPS-Sot-1594Solanum tuberosum67.01e-136 405
LLPS-Viv-2067Vitis vinifera64.849e-50 176
LLPS-Spr-1352Sporisorium reilianum64.220.0 697
LLPS-Sob-1598Sorghum bicolor64.184e-1679.0
LLPS-Nec-1255Neurospora crassa62.730.0 672
LLPS-Cogr-1582Colletotrichum graminicola62.310.0 683
LLPS-Art-3043Arabidopsis thaliana60.860.0 654
LLPS-Tru-1823Triticum urartu60.770.0 646
LLPS-Sei-0631Setaria italica60.040.0 652
LLPS-Zem-1415Zea mays59.930.0 653
LLPS-Hov-0247Hordeum vulgare59.930.0 652
LLPS-Tra-2041Triticum aestivum59.770.0 650
LLPS-Org-1946Oryza glaberrima59.740.0 652
LLPS-Ori-1667Oryza indica59.590.0 533
LLPS-Gor-0296Gossypium raimondii59.210.0 637
LLPS-Orr-1377Oryza rufipogon59.021e-1374.7
LLPS-Nia-2569Nicotiana attenuata58.780.0 610
LLPS-Phn-0837Phaeosphaeria nodorum58.40.0 631
LLPS-Cym-0896Cyanidioschyzon merolae58.210.0 644
LLPS-Scp-1571Schizosaccharomyces pombe58.210.0 634
LLPS-Hea-2110Helianthus annuus58.080.0 619
LLPS-Dac-0545Daucus carota57.790.0 590
LLPS-Brn-2610Brassica napus57.566e-72 236
LLPS-Orbr-0672Oryza brachyantha57.532e-2296.7
LLPS-Drm-1685Drosophila melanogaster57.50.0 592
LLPS-Sol-1807Solanum lycopersicum57.20.0 533
LLPS-Pat-2350Pan troglodytes56.020.0 580
LLPS-Pap-3613Pan paniscus56.020.0 580
LLPS-Coc-2320Corchorus capsularis56.020.0 586
LLPS-Urm-2682Ursus maritimus55.910.0 585
LLPS-Rhb-1454Rhinopithecus bieti55.910.0 595
LLPS-Caf-3987Canis familiaris55.910.0 586
LLPS-Xet-0613Xenopus tropicalis55.910.0 582
LLPS-Fud-1329Fukomys damarensis55.910.0 588
LLPS-Gog-4345Gorilla gorilla55.830.0 580
LLPS-Gaa-1100Gasterosteus aculeatus55.740.0 584
LLPS-Maf-0678Macaca fascicularis55.720.0 584
LLPS-Sus-3456Sus scrofa55.720.0 585
LLPS-Ere-0617Erinaceus europaeus55.720.0 594
LLPS-Ran-0050Rattus norvegicus55.720.0 582
LLPS-Hos-3951Homo sapiens55.640.0 576
LLPS-Tag-2443Taeniopygia guttata55.640.0 586
LLPS-Ora-3285Ornithorhynchus anatinus55.640.0 582
LLPS-Sah-3878Sarcophilus harrisii55.640.0 582
LLPS-Lac-4021Latimeria chalumnae55.530.0 567
LLPS-Cap-1641Cavia porcellus55.530.0 578
LLPS-Anc-2465Anolis carolinensis55.530.0 585
LLPS-Mea-1548Mesocricetus auratus55.530.0 582
LLPS-Mum-3502Mus musculus55.530.0 585
LLPS-Xim-3760Xiphophorus maculatus55.530.0 580
LLPS-Aim-2252Ailuropoda melanoleuca55.530.0 583
LLPS-Ova-2685Ovis aries55.530.0 583
LLPS-Mod-2996Monodelphis domestica55.450.0 579
LLPS-Fia-2249Ficedula albicollis55.450.0 582
LLPS-Tut-1906Tursiops truncatus55.450.0 588
LLPS-Orc-0500Oryctolagus cuniculus55.350.0 579
LLPS-Ict-1728Ictidomys tridecemlineatus55.350.0 583
LLPS-Tar-2687Takifugu rubripes55.350.0 580
LLPS-Mal-3599Mandrillus leucophaeus55.350.0 589
LLPS-Ten-2621Tetraodon nigroviridis55.180.0 567
LLPS-Fec-0793Felis catus55.160.0 582
LLPS-Loa-1514Loxodonta africana55.160.0 579
LLPS-Eqc-3649Equus caballus55.160.0 575
LLPS-Orl-3238Oryzias latipes55.160.0 579
LLPS-Cas-2465Carlito syrichta54.970.0 583
LLPS-Leo-1781Lepisosteus oculatus54.970.0 578
LLPS-Scf-2556Scleropages formosus54.970.0 571
LLPS-Dar-3194Danio rerio54.920.0 573
LLPS-Meg-2700Meleagris gallopavo54.890.0 585
LLPS-Poa-2054Pongo abelii54.890.0 573
LLPS-Mam-2332Macaca mulatta54.890.0 578
LLPS-Chs-3275Chlorocebus sabaeus54.780.0 597
LLPS-Php-2144Physcomitrella patens54.778e-104 321
LLPS-Mua-2553Musa acuminata54.671e-63 212
LLPS-Gaga-1222Gallus gallus54.140.0 574
LLPS-Icp-3033Ictalurus punctatus54.030.0 574
LLPS-Cii-2318Ciona intestinalis53.560.0 576
LLPS-Cis-1512Ciona savignyi53.310.0 590
LLPS-Lem-1154Leptosphaeria maculans52.532e-2299.0
LLPS-Pes-1473Pelodiscus sinensis52.440.0 553
LLPS-Miv-1547Microbotryum violaceum51.855e-28 114
LLPS-Cae-0621Caenorhabditis elegans50.690.0 531
LLPS-Bro-1562Brassica oleracea49.374e-39 143
LLPS-Tum-1249Tuber melanosporum38.19e-0858.2