• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Cea-2141
DIS3L2

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: DIS3-like exonuclease 2
Gene Name: DIS3L2
Ensembl Gene: ENSCATG00000044446.1
Ensembl Protein: ENSCATP00000043879.1
Organism: Cercocebus atys
Taxa ID: 9531
LLPS Type: Others


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION


3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.

▼ CROSS REFERENCE


DatabaseNucleotide IDProtein ID
EnsemblENSCATT00000068320.1ENSCATP00000043879.1
UniProtA0A2K5P2A3, A0A2K5P2A3_CERAT

▼ SEQUENCE


Protein Sequence (FASTA)
1     MSHPDYRMNL  RPLGTPRGVS  TVAGPHDIGA  SPGDKKSKNK  STRGKKKSIF  ETYMFKEDVS  60
61    EGLKRGTLIQ  GVLRINPKKF  HEAFIPSPDG  DRDIFIDGVV  ARNRALNGDL  VVVKLLPEEQ  120
121   WKVVKPENND  KETEAAYESD  IPEELCGRHL  PQQSLKSYND  SPDVIIEAQF  DGSDSEDGHG  180
181   ITQNVLVDDV  KKLSVCVSEK  GREDGDAPVT  KDETTCISQD  TRALPEKSLQ  RSAKVVYILE  240
241   KKHSRAATGF  LKLLADKNSE  LFRKYALFSP  SDHRVPRIYV  PLKDCPQDFV  ARPKDYANTL  300
301   FICRIVDWKE  DCNFALGQLA  KSLGQAGEIE  PETEGILTEY  GVDFSDFSSE  VLECLPQGLP  360
361   WTIPPEEFSK  RRDLRKDCIF  TIDPSTARDL  DDALSCKPLA  DGNFEVGVHI  ADVSYFVPEG  420
421   SDLDKVAAER  ATSVYLVQKV  VPMLPRLLCE  ELCSLNPMSD  KLTFSVIWTL  TPEGKILDEW  480
481   FGRTIICSCT  KLSYEHAQSM  IESPTEKIPA  KELPPISPEH  SSEEVHQAVL  NLHQIAEQLR  540
541   QQRFADGALR  LDQLKLAFTL  DHETGLPQGC  HIYEYRDSNK  LVEEFMLLAN  MAVAHKIHRA  600
601   FPEQALLRRH  PPPQTRMLND  LVEFCDQMGL  PVDFSSAGAL  NVSGGQGSGE  ALTHPVPQMA  660
661   LYFCSGLLQD  PAQFRHYALN  VPLYTHFTSP  IRRFADVLVH  RLLAAALGYR  EQLDMAPDTL  720
721   QKQADHCNDR  RMASKRVQEL  STGLFFAVLV  KESGPLESEA  MVMGVLNQAF  DVLVLRYGVQ  780
781   KRIYCNALAL  RAHHFQKVGK  KPELTLVWEP  EDMEQEPAQQ  VITIFSLVEV  VLQAESTALK  840
841   YSAILKRPDT  HGHLGPEEEE  EEAESDGEPE  DSSTS  875
Nucleotide CDS Sequence (FASTA)
1     ATGAGCCATC  CTGACTACAG  AATGAACCTC  CGGCCCCTGG  GGACCCCCAG  AGGTGTGTCC  60
61    ACTGTGGCTG  GCCCACATGA  CATTGGTGCT  TCGCCAGGTG  ACAAAAAGTC  AAAGAACAAG  120
121   TCCACACGAG  GGAAGAAAAA  GAGCATATTT  GAAACTTACA  TGTTCAAGGA  GGATGTTTCG  180
181   GAAGGCTTGA  AGAGAGGAAC  ACTCATCCAG  GGTGTATTGA  GAATTAATCC  AAAGAAGTTT  240
241   CATGAAGCCT  TCATTCCTTC  CCCGGATGGT  GATCGAGACA  TTTTTATTGA  TGGGGTTGTT  300
301   GCTCGTAATA  GAGCCTTAAA  TGGGGATCTG  GTGGTCGTGA  AACTACTTCC  CGAGGAGCAG  360
361   TGGAAGGTAG  TTAAACCAGA  GAACAATGAC  AAAGAAACAG  AAGCTGCATA  TGAATCAGAT  420
421   ATCCCCGAGG  AGCTCTGTGG  ACGCCATCTC  CCGCAACAGT  CCCTGAAAAG  CTATAATGAC  480
481   AGTCCTGATG  TCATTATAGA  GGCTCAGTTT  GATGGCAGTG  ACTCAGAAGA  TGGACATGGC  540
541   ATCACACAAA  ATGTGCTGGT  TGATGATGTT  AAGAAACTCT  CAGTTTGTGT  TTCTGAAAAA  600
601   GGAAGAGAGG  ATGGTGATGC  ACCAGTTACA  AAAGATGAGA  CCACCTGCAT  TTCACAAGAC  660
661   ACAAGAGCTT  TACCGGAGAA  ATCCCTGCAA  AGATCAGCAA  AGGTGGTTTA  CATCTTGGAG  720
721   AAAAAACATT  CTCGAGCAGC  AACTGGCTTC  CTCAAACTCT  TGGCTGATAA  GAACAGCGAA  780
781   CTGTTTAGGA  AATACGCCCT  GTTTTCTCCC  TCAGACCACC  GAGTGCCTAG  AATTTATGTG  840
841   CCTCTCAAGG  ACTGTCCCCA  GGACTTTGTG  GCACGGCCTA  AAGATTATGC  CAACACACTG  900
901   TTCATCTGCC  GCATTGTGGA  CTGGAAGGAG  GACTGCAATT  TTGCCCTGGG  GCAGCTGGCT  960
961   AAGAGTCTTG  GGCAGGCTGG  TGAAATTGAG  CCTGAAACAG  AAGGAATACT  AACAGAGTAT  1020
1021  GGCGTGGATT  TCTCTGATTT  CTCTTCAGAA  GTTCTAGAAT  GTCTTCCTCA  AGGCCTGCCA  1080
1081  TGGACAATTC  CACCAGAGGA  GTTCAGTAAG  AGAAGAGATT  TAAGAAAAGA  CTGTATCTTC  1140
1141  ACCATTGACC  CATCAACCGC  CCGAGACCTC  GATGACGCCC  TCTCCTGCAA  GCCACTCGCT  1200
1201  GATGGCAACT  TCGAAGTGGG  AGTTCACATT  GCCGACGTGA  GTTACTTTGT  TCCAGAGGGA  1260
1261  TCCGACCTGG  ATAAAGTGGC  TGCTGAGAGG  GCCACAAGTG  TCTACTTGGT  TCAAAAGGTG  1320
1321  GTCCCCATGC  TTCCCAGGCT  GCTGTGTGAG  GAGCTGTGCA  GCCTCAACCC  CATGTCTGAC  1380
1381  AAGCTGACCT  TCTCTGTGAT  CTGGACACTG  ACTCCAGAGG  GCAAGATCCT  TGATGAATGG  1440
1441  TTTGGCCGGA  CCATCATCTG  CTCCTGTACC  AAACTTAGCT  ACGAGCATGC  ACAGAGCATG  1500
1501  ATTGAAAGCC  CAACTGAGAA  AATCCCTGCG  AAAGAGCTGC  CCCCCATTTC  CCCAGAGCAT  1560
1561  AGCAGCGAGG  AGGTACACCA  GGCCGTCTTG  AATCTCCACC  AAATTGCCGA  GCAATTACGC  1620
1621  CAGCAGCGCT  TTGCGGACGG  CGCACTTCGT  TTGGATCAGC  TAAAGCTTGC  TTTCACTCTG  1680
1681  GACCACGAGA  CCGGATTGCC  TCAAGGATGT  CATATCTATG  AGTACCGTGA  CAGCAACAAG  1740
1741  CTCGTGGAGG  AGTTCATGCT  CTTGGCCAAC  ATGGCAGTGG  CCCACAAGAT  CCACCGTGCC  1800
1801  TTCCCCGAGC  AGGCCCTGCT  GCGCCGGCAC  CCCCCACCCC  AGACAAGGAT  GCTCAATGAC  1860
1861  CTGGTGGAAT  TCTGCGACCA  GATGGGGCTG  CCCGTGGACT  TCAGCTCCGC  AGGAGCCCTC  1920
1921  AATGTGAGTG  GTGGGCAGGG  TTCAGGGGAG  GCTCTGACCC  ATCCTGTCCC  GCAGATGGCA  1980
1981  CTGTACTTCT  GCTCGGGGCT  GCTGCAGGAC  CCGGCGCAGT  TCCGGCACTA  CGCGCTCAAC  2040
2041  GTGCCCCTGT  ACACACACTT  CACCTCGCCC  ATCCGCCGCT  TTGCCGATGT  CCTGGTGCAC  2100
2101  CGCCTCCTGG  CTGCTGCGCT  AGGCTATAGG  GAGCAACTAG  ACATGGCGCC  CGATACCCTG  2160
2161  CAGAAGCAGG  CGGACCACTG  CAATGACCGC  CGCATGGCGT  CCAAGCGCGT  GCAGGAGCTC  2220
2221  AGCACCGGTC  TCTTCTTTGC  CGTTCTGGTC  AAGGAGAGTG  GCCCCCTGGA  GTCAGAAGCC  2280
2281  ATGGTGATGG  GCGTCCTGAA  CCAAGCCTTT  GACGTGCTGG  TGCTGCGCTA  CGGCGTGCAG  2340
2341  AAGCGCATCT  ACTGCAACGC  ACTGGCCCTG  CGGGCCCACC  ACTTCCAGAA  GGTGGGAAAG  2400
2401  AAGCCAGAGC  TCACGCTGGT  CTGGGAGCCT  GAGGACATGG  AGCAGGAGCC  AGCACAGCAG  2460
2461  GTCATCACCA  TCTTCAGCCT  GGTGGAGGTG  GTCCTGCAGG  CAGAGTCCAC  AGCCCTCAAG  2520
2521  TACAGCGCCA  TCCTGAAGCG  GCCAGACACC  CACGGCCACC  TGGGCCCTGA  GGAGGAGGAG  2580
2581  GAGGAGGCGG  AGTCTGATGG  TGAGCCCGAG  GACTCAAGCA  CCAGCTGA  2628

▼ KEYWORD


ID
Family
Cell cycle
Cell division
Complete proteome
Cytoplasm
Exonuclease
Hydrolase
Magnesium
Manganese
Metal-binding
Mitosis
Nuclease
Reference proteome
RNA-binding

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
P-body
Molecular Function
3'-5'-exoribonuclease activity
Molecular Function
Magnesium ion binding
Molecular Function
Poly(U) RNA binding
Biological Process
Cell division
Biological Process
MiRNA catabolic process
Biological Process
Mitotic sister chromatid separation
Biological Process
Negative regulation of cell population proliferation
Biological Process
Nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
Biological Process
Polyuridylation-dependent mRNA catabolic process

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Maf-2637Macaca fascicularis100.00.01060
LLPS-Poa-2118Pongo abelii98.270.01155
LLPS-Paa-4767Papio anubis97.110.01695
LLPS-Mal-4448Mandrillus leucophaeus97.00.01690
LLPS-Chs-0791Chlorocebus sabaeus97.00.01695
LLPS-Mam-2791Macaca mulatta96.90.01707
LLPS-Man-3526Macaca nemestrina96.540.01685
LLPS-Hos-1985Homo sapiens94.80.01652
LLPS-Pap-1418Pan paniscus94.570.01647
LLPS-Pat-4801Pan troglodytes94.570.01647
LLPS-Aon-0664Aotus nancymaae93.410.01625
LLPS-Rhb-3487Rhinopithecus bieti91.180.01557
LLPS-Caj-4631Callithrix jacchus89.90.01239
LLPS-Gog-1060Gorilla gorilla89.340.01514
LLPS-Cas-0684Carlito syrichta89.320.0 894
LLPS-Nol-2391Nomascus leucogenys89.30.01524
LLPS-Caf-4143Canis familiaris89.10.01549
LLPS-Otg-4566Otolemur garnettii88.340.01551
LLPS-Aim-3477Ailuropoda melanoleuca88.220.01546
LLPS-Bot-1608Bos taurus88.110.01550
LLPS-Fec-3509Felis catus87.960.01541
LLPS-Ova-1200Ovis aries87.880.01549
LLPS-Mup-2606Mustela putorius furo87.530.01526
LLPS-Sus-1529Sus scrofa87.410.01523
LLPS-Ict-4332Ictidomys tridecemlineatus87.240.01524
LLPS-Orc-2408Oryctolagus cuniculus85.770.0 964
LLPS-Eqc-4329Equus caballus85.730.01533
LLPS-Ora-2719Ornithorhynchus anatinus84.723e-126 387
LLPS-Loa-0277Loxodonta africana84.085e-104 327
LLPS-Mea-3464Mesocricetus auratus84.00.01469
LLPS-Ran-4561Rattus norvegicus83.770.01458
LLPS-Mum-4428Mus musculus83.540.01454
LLPS-Myl-2135Myotis lucifugus83.430.01438
LLPS-Cap-2822Cavia porcellus83.140.01441
LLPS-Dio-1859Dipodomys ordii78.780.01287
LLPS-Fud-0309Fukomys damarensis77.650.01296
LLPS-Anc-0115Anolis carolinensis74.450.0 931
LLPS-Anp-1879Anas platyrhynchos71.990.01256
LLPS-Meg-0871Meleagris gallopavo71.180.01243
LLPS-Gaga-3692Gallus gallus71.150.01239
LLPS-Pes-2611Pelodiscus sinensis70.40.01241
LLPS-Fia-3321Ficedula albicollis69.950.01195
LLPS-Tag-3134Taeniopygia guttata69.161e-94 303
LLPS-Lac-3886Latimeria chalumnae68.410.0 978
LLPS-Xet-1007Xenopus tropicalis66.790.01075
LLPS-Scf-3878Scleropages formosus64.820.01054
LLPS-Leo-2703Lepisosteus oculatus64.590.01043
LLPS-Scm-2773Scophthalmus maximus62.580.01038
LLPS-Gaa-4025Gasterosteus aculeatus62.270.01019
LLPS-Dar-3956Danio rerio61.670.01018
LLPS-Tar-0322Takifugu rubripes61.670.0 992
LLPS-Ten-3769Tetraodon nigroviridis61.590.01008
LLPS-Orn-0506Oreochromis niloticus61.370.01031
LLPS-Orl-3310Oryzias latipes60.150.0 969
LLPS-Icp-3156Ictalurus punctatus59.460.0 952
LLPS-Pof-2185Poecilia formosa58.150.0 962
LLPS-Xim-0752Xiphophorus maculatus57.670.0 926
LLPS-Asm-0309Astyanax mexicanus52.740.0 791
LLPS-Cis-1041Ciona savignyi50.547e-118 373
LLPS-Mel-0485Melampsora laricipopulina46.71e-148 468
LLPS-Php-2293Physcomitrella patens46.245e-131 435
LLPS-Phn-0968Phaeosphaeria nodorum44.592e-0759.7
LLPS-Scj-0973Schizosaccharomyces japonicus44.291e-0966.2
LLPS-Pug-0682Puccinia graminis44.266e-135 444
LLPS-Miv-0250Microbotryum violaceum43.962e-137 451
LLPS-Cii-0167Ciona intestinalis43.960.0 605
LLPS-Usm-1068Ustilago maydis43.426e-0861.2
LLPS-Spr-0238Sporisorium reilianum43.426e-0861.2
LLPS-Bro-0390Brassica oleracea41.543e-0655.5
LLPS-Brr-0881Brassica rapa41.543e-0655.5
LLPS-Brn-0016Brassica napus41.543e-0655.5
LLPS-Cae-1566Caenorhabditis elegans41.110.0 587
LLPS-Sol-1771Solanum lycopersicum41.17e-0757.4
LLPS-Osl-1169Ostreococcus lucimarinus40.887e-114 365
LLPS-Crn-0602Cryptococcus neoformans40.532e-123 415
LLPS-Mua-1382Musa acuminata40.391e-107 354
LLPS-Drm-0729Drosophila melanogaster38.84e-112 375
LLPS-Prp-1574Prunus persica38.369e-0757.0
LLPS-Dac-0222Daucus carota38.331e-106 357
LLPS-Sem-2073Selaginella moellendorffii38.311e-141 449
LLPS-Pot-1309Populus trichocarpa37.991e-103 349
LLPS-Put-0086Puccinia triticina37.874e-145 471
LLPS-Art-0008Arabidopsis thaliana37.845e-0757.8
LLPS-Viv-0477Vitis vinifera37.842e-0656.2
LLPS-Met-1168Medicago truncatula37.841e-0656.6
LLPS-Arl-0097Arabidopsis lyrata37.841e-0657.0
LLPS-Zem-1844Zea mays37.86e-102 345
LLPS-Org-0391Oryza glaberrima37.622e-100 340
LLPS-Sei-1013Setaria italica37.628e-99 336
LLPS-Orbr-0000Oryza brachyantha37.431e-99 338
LLPS-Glm-1447Glycine max37.433e-102 345
LLPS-Amt-0097Amborella trichopoda37.372e-104 352
LLPS-Hea-1523Helianthus annuus37.373e-104 351
LLPS-Cus-0406Cucumis sativus37.242e-100 340
LLPS-Brd-1104Brachypodium distachyon37.228e-100 340
LLPS-Phv-0114Phaseolus vulgaris36.871e-100 341
LLPS-Orni-0449Oryza nivara36.698e-93 319
LLPS-Ori-1335Oryza indica36.698e-93 319
LLPS-Orb-0606Oryza barthii36.698e-93 319
LLPS-Orr-0263Oryza rufipogon36.51e-91 315
LLPS-Orp-1176Oryza punctata36.51e-92 318
LLPS-Sob-1426Sorghum bicolor36.411e-102 347
LLPS-Nia-0758Nicotiana attenuata36.121e-128 417
LLPS-Gor-0601Gossypium raimondii36.02e-104 351
LLPS-Coc-0754Corchorus capsularis35.916e-103 347
LLPS-Mod-0294Monodelphis domestica35.676e-100 340
LLPS-Hov-0455Hordeum vulgare35.672e-101 343
LLPS-Tra-2396Triticum aestivum35.59e-102 344
LLPS-Thc-1795Theobroma cacao35.433e-139 449
LLPS-Via-1010Vigna angularis35.318e-102 341
LLPS-Abg-1284Absidia glauca35.292e-135 438
LLPS-Sah-1411Sarcophilus harrisii34.892e-98 336
LLPS-Mae-0163Manihot esculenta34.886e-121 400
LLPS-Tut-0194Tursiops truncatus34.675e-103 348
LLPS-Urm-0337Ursus maritimus33.833e-98 335
LLPS-Sac-0085Saccharomyces cerevisiae33.121e-96 331
LLPS-Asg-0932Ashbya gossypii32.984e-100 341
LLPS-Cogr-1103Colletotrichum graminicola32.864e-93 321
LLPS-Ors-2185Oryza sativa32.614e-112 375
LLPS-Tru-1713Triticum urartu32.521e-108 362
LLPS-Coo-0115Colletotrichum orbiculare32.56e-93 321
LLPS-Asfu-0412Aspergillus fumigatus32.342e-95 329
LLPS-Ast-0158Aspergillus terreus32.269e-99 338
LLPS-Orgl-1562Oryza glumaepatula32.255e-108 364
LLPS-Asn-0209Aspergillus nidulans32.242e-99 344
LLPS-Orm-2063Oryza meridionalis32.194e-109 367
LLPS-Nef-0107Neosartorya fischeri32.087e-95 327
LLPS-Asni-0934Aspergillus niger32.071e-96 332
LLPS-Vir-2122Vigna radiata31.989e-117 395
LLPS-Asc-0144Aspergillus clavatus31.942e-94 326
LLPS-Yal-0193Yarrowia lipolytica31.681e-91 317
LLPS-Zyt-1447Zymoseptoria tritici31.611e-100 348
LLPS-Dos-1230Dothistroma septosporum31.591e-102 353
LLPS-Asf-0147Aspergillus flavus31.52e-97 334
LLPS-Aso-0215Aspergillus oryzae31.52e-97 334
LLPS-Mao-0801Magnaporthe oryzae30.983e-93 322
LLPS-Pytr-0631Pyrenophora triticirepentis30.948e-93 320
LLPS-Pyt-0157Pyrenophora teres30.813e-92 319
LLPS-Blg-0036Blumeria graminis30.653e-94 325
LLPS-Lep-1146Leersia perrieri30.436e-103 350
LLPS-Map-0750Magnaporthe poae30.173e-94 329
LLPS-Gag-0746Gaeumannomyces graminis29.932e-93 326