• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Meg-0871
DIS3L2

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: DIS3-like exonuclease 2
Gene Name: DIS3L2, dis3l2
Ensembl Gene: ENSMGAG00000008209.1
Ensembl Protein: ENSMGAP00000008398.1
Organism: Meleagris gallopavo
Taxa ID: 9103
LLPS Type: Client


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION


3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation.

▼ CROSS REFERENCE


DatabaseNucleotide IDProtein ID
EnsemblENSMGAT00000009194.1ENSMGAP00000008398.1
UniProtG1N815, G1N815_MELGA

▼ SEQUENCE


Protein Sequence (FASTA)
1     MSNSDSRINP  RQLGTPRGIK  AERGPYAAVP  TSGDRKNRNK  PARGKKKSIF  EAYMSKEDVS  60
61    AGLKRRELIQ  GPLRINPKKY  HEAFIPSPDG  TRDIFIDGVV  ARNRALNGDI  VVVRLLPREQ  120
121   WKVIKPDGSD  KETEATHESD  VPEDTLGTCV  PREAAKGDAK  SPDVIIEAQF  DDNDAEHGQD  180
181   HLPDTLAHDI  KKLSLDTTEK  VKAGGIGAVH  RTKQEEVPKV  NDPRLLPDKF  LQRTAKVVYI  240
241   LEKKHSRAAT  GFIKLLADKN  SELFKKCAMF  SPVDHRVPRA  YVSLADCPSD  FVARPEDYSN  300
301   MLFICRIVDW  KEDSNFASGQ  LAKSLGQAGE  IEPETEGILT  EYGVDFSDFS  PEALECLPQS  360
361   LPWVISPGEM  AKRRDLRKEC  IFTIDPSTAK  DLDDALSCKQ  LPDGNFEVGV  HIADVSYFVL  420
421   EETALDKVAS  ERATSVYLVQ  KVIPMLPKLL  CEELCSLNPM  RDRLTFSVMW  KVTPKGKILD  480
481   EWFGRTVICS  CAKLSYDHAQ  SMIENPGKVF  SPEELPPISP  QHSVAEIQQA  VLNLHRIAQH  540
541   LRKQRFIDGA  LRLDQLKLSF  TLDQESGMPQ  GCYIYQYRDS  NKLVEEFMLL  ANMAVAHQIY  600
601   RSFPEQALLR  RHPPPQSKLL  NDLMEFCHQV  GLEIDFSSAG  SLHKSLNETF  GADKYSEARK  660
661   EVLTNMFSRP  MQMALYFCTG  VLKDETLFRH  YALNVPFYTH  FTSPIRRYAD  VVVHRLLSAS  720
721   LGISSPVKME  KEAIQRQAEH  CNDRKMASKR  VQELSTDLFF  AVFVRECGPL  ESEAMVMGVL  780
781   NEAFDVLVLK  FGVQKRIYCN  ALPLLGFHFQ  KVGRKPELTL  MWEPESPEQE  SVSQEITIFT  840
841   LVEVVLKSDG  VPLKYSALLK  RPSTE  865
Nucleotide CDS Sequence (FASTA)
1     ATGAGCAATT  CAGACAGCAG  AATAAATCCT  AGACAACTGG  GAACTCCCAG  AGGTATTAAA  60
61    GCAGAGCGAG  GACCCTATGC  TGCTGTCCCA  ACATCTGGTG  ACAGAAAGAA  TCGAAATAAG  120
121   CCTGCTCGAG  GGAAGAAGAA  GAGTATATTC  GAAGCCTACA  TGTCAAAGGA  AGATGTTTCA  180
181   GCAGGACTGA  AAAGGAGAGA  GCTTATTCAG  GGACCCTTGA  GAATAAATCC  TAAGAAGTAC  240
241   CATGAAGCCT  TCATTCCATC  TCCAGATGGG  ACTCGTGATA  TCTTTATTGA  TGGAGTGGTT  300
301   GCTCGCAACA  GAGCCCTGAA  TGGTGACATC  GTGGTGGTGA  GACTGCTTCC  CAGGGAGCAA  360
361   TGGAAGGTAA  TAAAGCCAGA  TGGTAGTGAC  AAAGAAACAG  AAGCCACGCA  TGAATCAGAT  420
421   GTCCCTGAGG  ATACGCTGGG  GACTTGTGTG  CCTCGAGAGG  CGGCAAAAGG  CGACGCTAAG  480
481   AGTCCGGATG  TCATTATCGA  AGCTCAATTT  GATGATAATG  ATGCAGAGCA  TGGACAAGAC  540
541   CACTTGCCGG  ACACGTTGGC  TCATGACATC  AAGAAACTTT  CCCTGGATAC  CACTGAAAAG  600
601   GTGAAAGCTG  GTGGGATCGG  TGCTGTGCAC  AGAACAAAAC  AAGAGGAGGT  ACCCAAGGTG  660
661   AACGATCCCA  GGCTCCTCCC  AGATAAGTTC  CTTCAAAGGA  CAGCTAAGGT  GGTCTATATT  720
721   TTGGAAAAGA  AGCATTCTCG  AGCAGCTACA  GGCTTCATCA  AGCTTCTGGC  AGACAAGAAC  780
781   AGTGAGCTCT  TCAAGAAGTG  TGCCATGTTC  TCACCTGTGG  ACCACAGAGT  GCCCAGAGCC  840
841   TACGTGTCTT  TGGCAGACTG  CCCCTCAGAC  TTTGTGGCCA  GACCTGAGGA  CTATTCAAAT  900
901   ATGCTCTTCA  TCTGTCGCAT  AGTGGATTGG  AAAGAAGACA  GCAACTTTGC  ATCAGGGCAG  960
961   TTGGCCAAAA  GTCTTGGTCA  GGCGGGGGAG  ATCGAGCCGG  AAACGGAAGG  AATCCTGACA  1020
1021  GAGTATGGCG  TGGATTTCTC  TGACTTTTCC  CCCGAAGCCC  TGGAATGCCT  TCCCCAAAGC  1080
1081  CTGCCCTGGG  TTATCTCACC  GGGAGAGATG  GCCAAAAGGA  GAGATTTAAG  GAAAGAATGT  1140
1141  ATTTTCACCA  TCGACCCATC  AACTGCCAAA  GATCTTGATG  ATGCTTTGTC  CTGTAAACAA  1200
1201  CTCCCTGACG  GGAACTTCGA  AGTGGGTGTT  CACATTGCGG  ATGTGAGCTA  CTTTGTACTG  1260
1261  GAAGAAACAG  CACTGGATAA  AGTGGCGAGC  GAGAGGGCAA  CGAGTGTCTA  TTTAGTGCAA  1320
1321  AAGGTGATCC  CAATGCTTCC  CAAGCTGCTC  TGTGAGGAGC  TGTGCAGTCT  CAATCCCATG  1380
1381  CGAGACCGGC  TGACGTTCTC  TGTGATGTGG  AAGGTGACTC  CAAAAGGCAA  GATCCTTGAC  1440
1441  GAATGGTTTG  GGCGGACAGT  CATCTGCTCC  TGCGCAAAGC  TGAGCTACGA  CCACGCACAG  1500
1501  AGCATGATAG  AAAACCCCGG  GAAGGTGTTC  TCACCTGAAG  AACTGCCCCC  TATCTCCCCT  1560
1561  CAGCACTCAG  TAGCTGAGAT  CCAGCAAGCT  GTGCTGAATC  TGCATCGCAT  CGCCCAGCAC  1620
1621  CTCCGCAAGC  AGCGCTTCAT  CGACGGTGCT  CTGCGCCTAG  ACCAGCTGAA  GCTCTCGTTT  1680
1681  ACCTTGGACC  AGGAGAGTGG  GATGCCTCAA  GGCTGCTATA  TCTATCAGTA  CCGGGACAGC  1740
1741  AACAAGCTGG  TAGAGGAGTT  CATGCTGCTG  GCAAACATGG  CCGTGGCCCA  TCAGATCTAC  1800
1801  CGCTCCTTCC  CCGAGCAGGC  GCTGCTTCGC  CGCCACCCAC  CGCCCCAGAG  CAAGCTGCTG  1860
1861  AATGACCTGA  TGGAGTTCTG  CCACCAAGTT  GGCCTTGAGA  TCGACTTCAG  CAGCGCGGGC  1920
1921  AGCCTGCATA  AAAGCTTAAA  TGAAACATTT  GGAGCTGACA  AATACTCCGA  AGCCAGGAAA  1980
1981  GAAGTGCTGA  CCAACATGTT  CTCCAGGCCC  ATGCAGATGG  CTCTGTACTT  CTGCACCGGC  2040
2041  GTCCTGAAGG  ACGAGACCCT  CTTCCGCCAC  TACGCCCTCA  ACGTGCCCTT  CTACACGCAC  2100
2101  TTCACTTCGC  CCATCCGTCG  CTACGCAGAC  GTCGTTGTGC  ATCGGCTGCT  CTCCGCATCG  2160
2161  CTCGGTATCA  GCTCTCCCGT  CAAGATGGAG  AAGGAGGCCA  TCCAGCGACA  AGCAGAGCAT  2220
2221  TGCAATGACA  GGAAGATGGC  TTCCAAAAGG  GTGCAGGAGC  TCAGCACCGA  CCTCTTCTTT  2280
2281  GCTGTCTTCG  TCAGGGAGTG  CGGTCCTCTG  GAGTCTGAGG  CCATGGTGAT  GGGTGTCCTG  2340
2341  AACGAGGCCT  TTGACGTCCT  GGTGCTGAAG  TTTGGAGTCC  AGAAGCGAAT  CTACTGCAAC  2400
2401  GCACTGCCCT  TGCTGGGCTT  CCACTTCCAG  AAGGTGGGGA  GGAAGCCAGA  GCTGACGCTC  2460
2461  ATGTGGGAGC  CGGAGAGCCC  AGAGCAGGAA  TCTGTGTCCC  AGGAGATCAC  CATTTTCACG  2520
2521  CTGGTGGAGG  TGGTGCTGAA  GTCGGACGGG  GTTCCCCTGA  AATACAGCGC  TCTGCTCAAG  2580
2581  AGGCCCAGCA  CTGAG  2595

▼ KEYWORD


ID
Family
Cell cycle
Cell division
Complete proteome
Cytoplasm
Exonuclease
Hydrolase
Magnesium
Manganese
Metal-binding
Mitosis
Nuclease
Reference proteome
RNA-binding

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
P-body
Molecular Function
3'-5'-exoribonuclease activity
Molecular Function
Magnesium ion binding
Molecular Function
Poly(U) RNA binding
Biological Process
Cell division
Biological Process
MiRNA catabolic process
Biological Process
Mitotic sister chromatid separation
Biological Process
Negative regulation of cell population proliferation
Biological Process
Nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
Biological Process
Polyuridylation-dependent mRNA catabolic process
Biological Process
Stem cell population maintenance

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Gaga-3692Gallus gallus96.30.01700
LLPS-Anp-1879Anas platyrhynchos92.040.01631
LLPS-Fia-3321Ficedula albicollis87.170.01561
LLPS-Tag-3134Taeniopygia guttata84.263e-121 372
LLPS-Anc-0115Anolis carolinensis83.250.01044
LLPS-Pes-2611Pelodiscus sinensis80.580.01443
LLPS-Ora-2719Ornithorhynchus anatinus78.246e-119 367
LLPS-Cas-0684Carlito syrichta76.180.0 776
LLPS-Lac-3886Latimeria chalumnae75.50.01036
LLPS-Paa-4767Papio anubis73.380.01304
LLPS-Chs-0791Chlorocebus sabaeus73.260.01304
LLPS-Mal-4448Mandrillus leucophaeus73.150.01300
LLPS-Aim-3477Ailuropoda melanoleuca73.150.01299
LLPS-Aon-0664Aotus nancymaae72.890.01284
LLPS-Caf-4143Canis familiaris72.850.01296
LLPS-Sus-1529Sus scrofa72.830.01291
LLPS-Caj-4631Callithrix jacchus72.660.01002
LLPS-Mup-2606Mustela putorius furo72.490.01289
LLPS-Poa-2118Pongo abelii72.460.0 875
LLPS-Ict-4332Ictidomys tridecemlineatus72.370.01293
LLPS-Ova-1200Ovis aries72.370.01290
LLPS-Bot-1608Bos taurus72.250.01290
LLPS-Hos-1985Homo sapiens72.140.01286
LLPS-Fec-3509Felis catus72.140.01286
LLPS-Pap-1418Pan paniscus71.910.01280
LLPS-Pat-4801Pan troglodytes71.910.01280
LLPS-Mam-2791Macaca mulatta71.840.01277
LLPS-Maf-2637Macaca fascicularis71.830.0 777
LLPS-Otg-4566Otolemur garnettii71.640.01279
LLPS-Man-3526Macaca nemestrina71.630.01263
LLPS-Eqc-4329Equus caballus71.480.01292
LLPS-Cea-2141Cercocebus atys71.180.01251
LLPS-Mea-3464Mesocricetus auratus71.170.01280
LLPS-Xet-1007Xenopus tropicalis70.390.01150
LLPS-Ran-4561Rattus norvegicus70.150.01264
LLPS-Mum-4428Mus musculus70.150.01261
LLPS-Cap-2822Cavia porcellus69.670.01239
LLPS-Orc-2408Oryctolagus cuniculus69.480.0 785
LLPS-Myl-2135Myotis lucifugus69.390.01224
LLPS-Leo-2703Lepisosteus oculatus68.550.01144
LLPS-Scf-3878Scleropages formosus68.340.01160
LLPS-Nol-2391Nomascus leucogenys68.20.01188
LLPS-Rhb-3487Rhinopithecus bieti66.970.01139
LLPS-Fud-0309Fukomys damarensis65.980.01133
LLPS-Dio-1859Dipodomys ordii65.940.01099
LLPS-Gaa-4025Gasterosteus aculeatus65.220.01103
LLPS-Gog-1060Gorilla gorilla65.090.01140
LLPS-Dar-3956Danio rerio64.980.01094
LLPS-Scm-2773Scophthalmus maximus64.790.01083
LLPS-Orn-0506Oreochromis niloticus64.420.01107
LLPS-Ten-3769Tetraodon nigroviridis64.30.01057
LLPS-Tar-0322Takifugu rubripes63.560.01043
LLPS-Pof-2185Poecilia formosa62.140.01030
LLPS-Icp-3156Ictalurus punctatus61.730.01012
LLPS-Orl-3310Oryzias latipes60.60.01009
LLPS-Xim-0752Xiphophorus maculatus58.430.0 987
LLPS-Asm-0309Astyanax mexicanus55.640.0 866
LLPS-Cis-1041Ciona savignyi53.084e-129 402
LLPS-Cii-0167Ciona intestinalis45.260.0 649
LLPS-Asf-0196Aspergillus flavus43.665e-0861.2
LLPS-Usm-1068Ustilago maydis43.444e-136 446
LLPS-Spr-0238Sporisorium reilianum43.012e-134 441
LLPS-Mua-1382Musa acuminata41.942e-118 383
LLPS-Nia-0204Nicotiana attenuata41.561e-0759.7
LLPS-Sol-1771Solanum lycopersicum41.562e-0759.3
LLPS-Osl-1169Ostreococcus lucimarinus41.122e-119 379
LLPS-Mao-0201Magnaporthe oryzae41.13e-0655.8
LLPS-Art-0008Arabidopsis thaliana41.031e-0863.2
LLPS-Phn-0968Phaeosphaeria nodorum40.851e-0656.6
LLPS-Pytr-0445Pyrenophora triticirepentis40.852e-0656.2
LLPS-Zyt-1447Zymoseptoria tritici40.852e-0656.2
LLPS-Lem-0237Leptosphaeria maculans40.852e-0656.2
LLPS-Pyt-0017Pyrenophora teres40.852e-0656.2
LLPS-Cae-1566Caenorhabditis elegans40.670.0 570
LLPS-Arl-0097Arabidopsis lyrata40.513e-0862.0
LLPS-Dac-0222Daucus carota40.516e-0860.8
LLPS-Dos-1230Dothistroma septosporum40.281e-0656.6
LLPS-Php-2293Physcomitrella patens39.731e-131 436
LLPS-Bro-0390Brassica oleracea39.242e-0759.7
LLPS-Brr-0881Brassica rapa39.242e-0759.3
LLPS-Brn-0016Brassica napus39.242e-0759.3
LLPS-Scj-0973Schizosaccharomyces japonicus39.072e-117 384
LLPS-Met-1168Medicago truncatula38.785e-109 363
LLPS-Hov-0455Hordeum vulgare38.751e-105 354
LLPS-Brd-1104Brachypodium distachyon38.756e-106 356
LLPS-Tra-1220Triticum aestivum38.751e-105 354
LLPS-Coc-0754Corchorus capsularis38.591e-107 360
LLPS-Mae-0278Manihot esculenta38.594e-108 360
LLPS-Sob-1426Sorghum bicolor38.592e-107 359
LLPS-Pot-1309Populus trichocarpa38.564e-108 361
LLPS-Amt-0097Amborella trichopoda38.484e-108 361
LLPS-Prp-1574Prunus persica38.464e-0758.5
LLPS-Hea-1523Helianthus annuus38.384e-107 358
LLPS-Phv-0114Phaseolus vulgaris38.322e-107 359
LLPS-Gor-0601Gossypium raimondii38.327e-109 363
LLPS-Glm-1447Glycine max38.326e-108 361
LLPS-Zem-1844Zea mays38.222e-106 357
LLPS-Via-1010Vigna angularis38.21e-106 354
LLPS-Org-0391Oryza glaberrima38.192e-104 351
LLPS-Orbr-0000Oryza brachyantha38.198e-105 352
LLPS-Orm-0316Oryza meridionalis38.143e-0758.9
LLPS-Orni-0449Oryza nivara38.143e-0758.5
LLPS-Ori-1335Oryza indica38.143e-0758.9
LLPS-Drm-0729Drosophila melanogaster38.058e-112 374
LLPS-Mel-0485Melampsora laricipopulina38.057e-154 481
LLPS-Sei-1013Setaria italica38.031e-103 349
LLPS-Viv-0477Vitis vinifera37.922e-106 357
LLPS-Sem-2073Selaginella moellendorffii37.583e-138 439
LLPS-Put-0086Puccinia triticina37.537e-144 468
LLPS-Cus-0406Cucumis sativus37.453e-103 348
LLPS-Orb-0606Oryza barthii37.275e-97 330
LLPS-Miv-0250Microbotryum violaceum37.122e-149 483
LLPS-Orr-0263Oryza rufipogon37.082e-95 326
LLPS-Orp-1176Oryza punctata37.082e-96 329
LLPS-Thc-0432Theobroma cacao36.81e-99 338
LLPS-Pug-0682Puccinia graminis36.751e-141 461
LLPS-Gas-0361Galdieria sulphuraria36.251e-93 323
LLPS-Crn-0602Cryptococcus neoformans35.952e-129 431
LLPS-Abg-1284Absidia glauca35.935e-138 445
LLPS-Asc-0501Aspergillus clavatus35.412e-94 329
LLPS-Loa-0686Loxodonta africana35.259e-97 330
LLPS-Tut-0194Tursiops truncatus35.245e-99 337
LLPS-Urm-0337Ursus maritimus35.028e-95 325
LLPS-Mod-0294Monodelphis domestica34.385e-94 323
LLPS-Sah-1411Sarcophilus harrisii34.385e-94 323
LLPS-Chc-0938Chondrus crispus33.64e-92 321
LLPS-Asfu-0192Aspergillus fumigatus32.64e-103 354
LLPS-Vir-2122Vigna radiata32.473e-129 429
LLPS-Nef-1041Neosartorya fischeri32.351e-101 350
LLPS-Tru-1713Triticum urartu31.721e-111 370
LLPS-Ors-2185Oryza sativa31.452e-116 386
LLPS-Ast-0158Aspergillus terreus31.397e-94 324
LLPS-Asni-0934Aspergillus niger31.262e-91 317
LLPS-Blg-0036Blumeria graminis31.221e-92 320
LLPS-Orgl-1562Oryza glumaepatula31.222e-111 372
LLPS-Yal-0193Yarrowia lipolytica31.172e-95 327
LLPS-Asn-0513Aspergillus nidulans30.713e-91 316
LLPS-Lep-1146Leersia perrieri30.633e-112 375
LLPS-Aso-0215Aspergillus oryzae30.632e-90 314
LLPS-Scs-0322Sclerotinia sclerotiorum30.272e-91 317
LLPS-Cogr-0967Colletotrichum graminicola29.995e-94 328