LLPS-Hos-1985
DIS3L2

▼ OVERVIEW

Status: Reviewed
Protein Name: DIS3-like exonuclease 2
Gene Name: DIS3L2, FAM6A
Ensembl Gene: ENSG00000144535.19
Ensembl Protein: ENSP00000273009.6
Organism: Homo sapiens
Taxa ID: 9606
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Stress granule
"...A list of candidate SG proteins identified by mass spectrometry in NPCs, including statistical analysis."
Neural progenitor cells29373831

▼ FUNCTION

3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSHPDYRMNL  RPLGTPRGVS  AVAGPHDIGA  SPGDKKSKNR  STRGKKKSIF  ETYMSKEDVS  60
61    EGLKRGTLIQ  GVLRINPKKF  HEAFIPSPDG  DRDIFIDGVV  ARNRALNGDL  VVVKLLPEEH  120
121   WKVVKPESND  KETEAAYESD  IPEELCGHHL  PQQSLKSYND  SPDVIVEAQF  DGSDSEDGHG  180
181   ITQNVLVDGV  KKLSVCVSEK  GREDGDAPVT  KDETTCISQD  TRALSEKSLQ  RSAKVVYILE  240
241   KKHSRAATGF  LKLLADKNSE  LFRKYALFSP  SDHRVPRIYV  PLKDCPQDFV  ARPKDYANTL  300
301   FICRIVDWKE  DCNFALGQLA  KSLGQAGEIE  PETEGILTEY  GVDFSDFSSE  VLECLPQGLP  360
361   WTIPPEEFSK  RRDLRKDCIF  TIDPSTARDL  DDALSCKPLA  DGNFKVGVHI  ADVSYFVPEG  420
421   SDLDKVAAER  ATSVYLVQKV  VPMLPRLLCE  ELCSLNPMSD  KLTFSVIWTL  TPEGKILDEW  480
481   FGRTIIRSCT  KLSYEHAQSM  IESPTEKIPA  KELPPISPEH  SSEEVHQAVL  NLHGIAKQLR  540
541   QQRFVDGALR  LDQLKLAFTL  DHETGLPQGC  HIYEYRESNK  LVEEFMLLAN  MAVAHKIHRA  600
601   FPEQALLRRH  PPPQTRMLSD  LVEFCDQMGL  PVDFSSAGAL  NKSLTQTFGD  DKYSLARKEV  660
661   LTNMCSRPMQ  MALYFCSGLL  QDPAQFRHYA  LNVPLYTHFT  SPIRRFADVL  VHRLLAAALG  720
721   YRERLDMAPD  TLQKQADHCN  DRRMASKRVQ  ELSTSLFFAV  LVKESGPLES  EAMVMGILKQ  780
781   AFDVLVLRYG  VQKRIYCNAL  ALRSHHFQKV  GKKPELTLVW  EPEDMEQEPA  QQVITIFSLV  840
841   EVVLQAESTA  LKYSAILKRP  GTQGHLGPEK  EEEESDGEPE  DSSTS  885
Nucleotide CDS Sequence (FASTA)
1     ATGAGCCATC  CTGACTACAG  AATGAACCTC  CGGCCCCTGG  GGACCCCCAG  AGGTGTGTCT  60
61    GCTGTGGCTG  GTCCACATGA  CATTGGTGCT  TCGCCAGGTG  ACAAAAAGTC  AAAGAACAGG  120
121   TCCACACGAG  GGAAGAAAAA  GAGCATATTT  GAAACTTACA  TGTCCAAGGA  GGATGTTTCA  180
181   GAAGGCTTGA  AGAGAGGAAC  ACTCATCCAG  GGTGTATTGA  GAATTAATCC  AAAGAAGTTT  240
241   CATGAAGCCT  TCATTCCTTC  CCCGGATGGT  GATCGAGACA  TTTTTATTGA  TGGGGTTGTT  300
301   GCTCGTAATA  GAGCCTTAAA  TGGGGATCTG  GTGGTCGTGA  AACTGCTTCC  CGAGGAGCAT  360
361   TGGAAGGTAG  TTAAACCAGA  GAGCAATGAC  AAAGAAACAG  AAGCTGCGTA  TGAATCAGAT  420
421   ATCCCCGAGG  AGCTCTGTGG  ACACCATCTC  CCGCAACAGT  CCCTGAAAAG  CTATAATGAC  480
481   AGTCCTGATG  TCATTGTAGA  GGCTCAGTTT  GATGGCAGCG  ACTCAGAAGA  TGGACATGGC  540
541   ATCACACAAA  ATGTGCTGGT  TGATGGTGTT  AAGAAACTCT  CAGTTTGTGT  TTCTGAGAAA  600
601   GGAAGAGAGG  ATGGTGATGC  ACCGGTTACA  AAAGATGAGA  CCACCTGCAT  TTCACAAGAC  660
661   ACAAGAGCTT  TATCGGAGAA  ATCCCTGCAA  AGATCAGCAA  AGGTGGTTTA  CATCTTGGAG  720
721   AAAAAACATT  CTCGAGCAGC  AACCGGCTTC  CTCAAACTCT  TGGCTGATAA  GAACAGCGAA  780
781   CTGTTTAGGA  AATACGCCCT  GTTTTCTCCC  TCAGACCACC  GAGTGCCTAG  AATTTATGTG  840
841   CCTCTCAAGG  ACTGTCCCCA  GGACTTTGTG  GCACGGCCTA  AAGATTATGC  CAACACACTG  900
901   TTCATCTGCC  GCATTGTGGA  CTGGAAGGAG  GACTGCAATT  TTGCCCTGGG  GCAGCTGGCT  960
961   AAGAGTCTTG  GGCAGGCTGG  TGAAATTGAG  CCTGAAACAG  AAGGAATACT  AACAGAGTAT  1020
1021  GGCGTGGATT  TCTCTGATTT  CTCTTCAGAA  GTTCTAGAAT  GTCTTCCTCA  AGGCCTGCCA  1080
1081  TGGACAATTC  CACCAGAGGA  GTTCAGCAAG  AGAAGGGATT  TAAGAAAAGA  CTGTATCTTC  1140
1141  ACCATTGACC  CATCAACCGC  CCGAGACCTC  GATGATGCCC  TCTCCTGCAA  GCCACTCGCT  1200
1201  GACGGCAACT  TCAAAGTGGG  AGTTCACATT  GCTGACGTGA  GTTACTTTGT  TCCGGAGGGA  1260
1261  TCTGATCTGG  ATAAAGTGGC  TGCCGAGAGG  GCTACAAGCG  TCTACTTGGT  TCAAAAGGTG  1320
1321  GTCCCCATGC  TTCCCAGGCT  GCTGTGTGAG  GAGCTGTGCA  GCCTCAACCC  CATGTCCGAC  1380
1381  AAGCTGACCT  TCTCTGTGAT  CTGGACACTG  ACTCCAGAGG  GCAAGATCCT  TGATGAATGG  1440
1441  TTTGGCCGGA  CCATCATCCG  CTCCTGCACC  AAACTTAGCT  ACGAGCATGC  ACAGAGCATG  1500
1501  ATTGAAAGCC  CAACTGAGAA  AATCCCTGCG  AAAGAGCTGC  CCCCCATTTC  CCCAGAGCAT  1560
1561  AGCAGCGAGG  AGGTACACCA  GCAGAACGCA  GACAAGGATG  GGGCTGCCCA  TCTTCAGGCC  1620
1621  TCTCACAGCC  CCTCTGCTGA  AGATGCAGAA  GCACAGCCCT  CCACAGAGGA  ACGCCTGCCT  1680
1681  GAGACTCGGG  GCATATGTGA  CAGGGATCCA  GACACACGAC  TGTTTTTCCT  TCAGCAACAG  1740
1741  AGCCGTGTAT  TGGAAGCAAA  GCCCCAAAAC  ACGATAAGAG  TAGAGGAGCA  GACAACCCAG  1800
1801  TTGCAGATTT  GA  1812

▼ KEYWORD

ID
Family
Acetylation
Alternative splicing
Cell cycle
Cell division
Complete proteome
Cytoplasm
Disease mutation
Exonuclease
Hydrolase
Magnesium
Metal-binding
Mitosis
Nuclease
Phosphoprotein
Polymorphism
Reference proteome
RNA-binding
Tumor suppressor

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Exosome (RNase complex)
Cellular Component
P-body
Cellular Component
Polysome
Molecular Function
3'-5'-exoribonuclease activity
Molecular Function
Magnesium ion binding
Molecular Function
Poly(U) RNA binding
Molecular Function
Ribonuclease activity
Biological Process
Cell division
Biological Process
MiRNA catabolic process
Biological Process
Mitotic cell cycle
Biological Process
Mitotic sister chromatid separation
Biological Process
Negative regulation of cell population proliferation
Biological Process
Nuclear-transcribed mRNA catabolic process, exonucleolytic
Biological Process
Nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
Biological Process
Polyuridylation-dependent mRNA catabolic process
Biological Process
RNA catabolic process
Biological Process
RRNA processing
Biological Process
Stem cell population maintenance

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pap-1418Pan paniscus99.540.01788
LLPS-Pat-4801Pan troglodytes99.540.01788
LLPS-Poa-2118Pongo abelii98.620.01190
LLPS-Maf-2637Macaca fascicularis97.910.01068
LLPS-Mal-4448Mandrillus leucophaeus97.460.01751
LLPS-Paa-4767Papio anubis97.460.01748
LLPS-Chs-0791Chlorocebus sabaeus97.340.01751
LLPS-Aon-0664Aotus nancymaae95.950.01729
LLPS-Mam-2791Macaca mulatta95.870.01724
LLPS-Man-3526Macaca nemestrina95.630.01708
LLPS-Cea-2141Cercocebus atys94.80.01684
LLPS-Cas-0684Carlito syrichta92.810.0 951
LLPS-Nol-2391Nomascus leucogenys92.640.01642
LLPS-Caf-4143Canis familiaris91.420.01646
LLPS-Caj-4631Callithrix jacchus91.320.01322
LLPS-Aim-3477Ailuropoda melanoleuca90.650.01647
LLPS-Otg-4566Otolemur garnettii90.650.01646
LLPS-Gog-1060Gorilla gorilla90.420.01585
LLPS-Fec-3509Felis catus90.390.01641
LLPS-Bot-1608Bos taurus90.180.01645
LLPS-Ict-4332Ictidomys tridecemlineatus90.150.01623
LLPS-Ova-1200Ovis aries89.950.01640
LLPS-Mup-2606Mustela putorius furo89.950.01628
LLPS-Rhb-3487Rhinopithecus bieti89.630.01565
LLPS-Sus-1529Sus scrofa89.610.01622
LLPS-Eqc-4329Equus caballus88.310.01636
LLPS-Mea-3464Mesocricetus auratus86.320.01570
LLPS-Orc-2408Oryctolagus cuniculus86.310.01008
LLPS-Ran-4561Rattus norvegicus86.020.01561
LLPS-Mum-4428Mus musculus85.860.01556
LLPS-Cap-2822Cavia porcellus85.450.01540
LLPS-Myl-2135Myotis lucifugus85.30.01527
LLPS-Ora-2719Ornithorhynchus anatinus85.199e-129 393
LLPS-Loa-0277Loxodonta africana83.585e-114 353
LLPS-Dio-1859Dipodomys ordii81.260.01385
LLPS-Fud-0309Fukomys damarensis79.520.01388
LLPS-Anc-0115Anolis carolinensis76.380.0 980
LLPS-Anp-1879Anas platyrhynchos72.950.01320
LLPS-Meg-0871Meleagris gallopavo72.140.01303
LLPS-Gaga-3692Gallus gallus71.940.01302
LLPS-Pes-2611Pelodiscus sinensis71.760.01301
LLPS-Fia-3321Ficedula albicollis71.00.01254
LLPS-Lac-3886Latimeria chalumnae69.860.01015
LLPS-Xet-1007Xenopus tropicalis68.170.01118
LLPS-Leo-2703Lepisosteus oculatus65.910.01116
LLPS-Scf-3878Scleropages formosus65.520.01112
LLPS-Orn-0506Oreochromis niloticus64.230.01103
LLPS-Scm-2773Scophthalmus maximus64.220.01084
LLPS-Gaa-4025Gasterosteus aculeatus63.870.01080
LLPS-Ten-3769Tetraodon nigroviridis63.370.01062
LLPS-Tar-0322Takifugu rubripes63.350.01050
LLPS-Dar-3956Danio rerio62.510.01070
LLPS-Pof-2185Poecilia formosa61.460.01030
LLPS-Orl-3310Oryzias latipes60.840.01023
LLPS-Icp-3156Ictalurus punctatus59.480.01016
LLPS-Xim-0752Xiphophorus maculatus58.80.0 988
LLPS-Asm-0309Astyanax mexicanus53.490.0 840
LLPS-Cis-1041Ciona savignyi51.897e-125 392
LLPS-Mel-0485Melampsora laricipopulina45.86e-149 469
LLPS-Cii-0167Ciona intestinalis44.320.0 630
LLPS-Miv-0250Microbotryum violaceum43.753e-141 462
LLPS-Pug-0682Puccinia graminis43.744e-136 447
LLPS-Scj-0973Schizosaccharomyces japonicus42.861e-1069.7
LLPS-Php-2293Physcomitrella patens42.634e-136 450
LLPS-Spr-0238Sporisorium reilianum42.53e-0965.5
LLPS-Usm-1068Ustilago maydis42.53e-0965.5
LLPS-Mua-1382Musa acuminata41.557e-115 374
LLPS-Cae-1566Caenorhabditis elegans41.110.0 607
LLPS-Osl-1169Ostreococcus lucimarinus41.024e-121 385
LLPS-Crn-0602Cryptococcus neoformans40.967e-0860.8
LLPS-Sol-1771Solanum lycopersicum40.268e-0860.5
LLPS-Viv-1225Vitis vinifera39.818e-131 427
LLPS-Dac-0222Daucus carota39.412e-114 379
LLPS-Drm-0729Drosophila melanogaster39.051e-118 393
LLPS-Tra-2412Triticum aestivum39.042e-108 363
LLPS-Hov-0455Hordeum vulgare39.042e-109 365
LLPS-Org-0391Oryza glaberrima38.895e-108 361
LLPS-Met-1168Medicago truncatula38.723e-112 373
LLPS-Glm-1447Glycine max38.73e-110 367
LLPS-Orbr-0000Oryza brachyantha38.73e-107 359
LLPS-Sem-2073Selaginella moellendorffii38.684e-150 471
LLPS-Hea-1523Helianthus annuus38.577e-113 374
LLPS-Amt-0097Amborella trichopoda38.575e-112 372
LLPS-Cus-0406Cucumis sativus38.522e-108 362
LLPS-Brd-1104Brachypodium distachyon38.492e-107 361
LLPS-Sei-1013Setaria italica38.331e-105 355
LLPS-Via-1010Vigna angularis38.27e-110 363
LLPS-Phv-0114Phaseolus vulgaris38.151e-108 363
LLPS-Orni-0449Oryza nivara37.962e-100 340
LLPS-Ori-1335Oryza indica37.962e-100 340
LLPS-Orb-0606Oryza barthii37.961e-100 340
LLPS-Orr-0263Oryza rufipogon37.783e-99 337
LLPS-Orp-1176Oryza punctata37.783e-100 340
LLPS-Put-0086Puccinia triticina37.771e-147 479
LLPS-Pot-1309Populus trichocarpa37.731e-112 374
LLPS-Zem-1844Zea mays37.664e-0758.2
LLPS-Sob-1426Sorghum bicolor37.664e-0758.2
LLPS-Nia-0204Nicotiana attenuata37.487e-114 377
LLPS-Arl-0097Arabidopsis lyrata37.386e-114 377
LLPS-Brn-0016Brassica napus37.385e-113 375
LLPS-Bro-0390Brassica oleracea37.382e-112 375
LLPS-Brr-0881Brassica rapa37.385e-113 375
LLPS-Prp-1574Prunus persica37.181e-0759.7
LLPS-Gor-0601Gossypium raimondii37.156e-112 372
LLPS-Coc-0754Corchorus capsularis37.069e-111 369
LLPS-Thc-0432Theobroma cacao36.382e-105 354
LLPS-Mod-0294Monodelphis domestica36.343e-105 354
LLPS-Tag-0667Taeniopygia guttata36.022e-99 339
LLPS-Sah-1411Sarcophilus harrisii35.715e-103 348
LLPS-Art-3016Arabidopsis thaliana35.597e-135 436
LLPS-Abg-1284Absidia glauca35.451e-140 452
LLPS-Tut-0194Tursiops truncatus35.423e-107 360
LLPS-Mae-0163Manihot esculenta35.176e-133 433
LLPS-Urm-0337Ursus maritimus34.488e-103 348
LLPS-Asg-0932Ashbya gossypii33.293e-103 350
LLPS-Sac-0085Saccharomyces cerevisiae32.86e-100 341
LLPS-Ors-2185Oryza sativa32.578e-119 394
LLPS-Asn-0209Aspergillus nidulans32.534e-104 358
LLPS-Tru-1713Triticum urartu32.491e-111 371
LLPS-Coo-0115Colletotrichum orbiculare32.41e-96 332
LLPS-Asni-1352Aspergillus niger32.345e-112 380
LLPS-Vir-2122Vigna radiata32.281e-125 419
LLPS-Orgl-1562Oryza glumaepatula32.222e-114 381
LLPS-Asfu-0192Aspergillus fumigatus32.228e-114 385
LLPS-Orm-2063Oryza meridionalis32.073e-115 384
LLPS-Phn-0059Phaeosphaeria nodorum31.965e-98 335
LLPS-Asc-0501Aspergillus clavatus31.863e-113 383
LLPS-Nef-1041Neosartorya fischeri31.861e-110 376
LLPS-Ast-0158Aspergillus terreus31.861e-102 349
LLPS-Blg-0036Blumeria graminis31.625e-99 338
LLPS-Aso-0360Aspergillus oryzae31.415e-109 372
LLPS-Asf-0196Aspergillus flavus31.381e-109 371
LLPS-Zyt-0092Zymoseptoria tritici31.294e-101 344
LLPS-Mao-0801Magnaporthe oryzae31.235e-98 335
LLPS-Lep-1146Leersia perrieri31.212e-108 365
LLPS-Dos-1230Dothistroma septosporum30.882e-107 367
LLPS-Trv-1402Trichoderma virens30.777e-97 334
LLPS-Scs-0322Sclerotinia sclerotiorum30.21e-96 332
LLPS-Beb-1157Beauveria bassiana30.051e-97 339
LLPS-Map-0750Magnaporthe poae30.049e-100 345
LLPS-Nec-0660Neurospora crassa29.824e-98 340
LLPS-Gag-0746Gaeumannomyces graminis29.791e-98 342