• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Cas-1033
CCT5

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: T-complex protein 1 subunit epsilon
Gene Name: CCT5
Ensembl Gene: ENSTSYG00000005064.2
Ensembl Protein: ENSTSYP00000031469.1
Organism: Carlito syrichta
Taxa ID: 1868482
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MTSVGTLAFD  EYGRPFLIIK  DQDRKSRLMG  LEALKSHIMA  AKAVANTMRT  SLGPNGLDKM  60
61    MVDKDGDVTV  TNDGATILSM  MDVDHQIAKL  MVELSKSQDD  EIGDGTTGVV  VLAGALLEEA  120
121   EQLLDRGIHP  IRIADGYEQA  ARIAIEHLDK  ISDSVLVDIK  DTEPLIQTAK  TTLGSKVVNS  180
181   CHRQMAEIAV  GAVLTVADMD  RRDVDFELIK  VEGKVGGRLE  DTKLIKGVIV  DKDFSHPQMP  240
241   KKVEDAKIAI  LTCPFEPPKP  KTKHKLDVTS  VEDYKALQKY  EKEKFEEMIQ  QIKETGANLA  300
301   ICQWGFDDEA  NHLLLQNNLP  AVRWVGGPEI  ELIAIATGGR  IVPRFSELTA  EKLGFAGIVQ  360
361   EISFGTTKDK  MLVIEQCKNS  RAVTIFIRGG  NKMIIEEAKR  SLHDALCVIR  NLIRDNRVVY  420
421   GGGAAEIACA  LAVSQEADKC  PTLEQYAMRA  FADALEVIPM  ALSENSGMNP  IQTMTEVRAR  480
481   QVKEMNPALG  IDCLHKGTND  MKQQHVIETL  IGKKQQISLA  TQMVRMILKI  DDIRKPGESE  540
541   E  541
Nucleotide CDS Sequence (FASTA)
1     ATGACGTCCG  TGGGGACCCT  CGCCTTCGAT  GAATATGGGC  GCCCCTTCCT  CATCATCAAG  60
61    GACCAGGACC  GCAAGTCCCG  TCTTATGGGA  CTCGAAGCCC  TCAAGTCTCA  TATAATGGCA  120
121   GCAAAGGCTG  TAGCAAATAC  AATGAGAACA  TCACTTGGAC  CAAATGTCCT  GGCTGGCGCC  180
181   TTGTTAGAAG  AAGCTGAGCA  GTTGCTAGAC  CGAGGCATTC  ACCCAATCAG  AATAGCCGAC  240
241   GGCTATGAGC  AGGCTGCCCG  CATTGCTATT  GAGCACCTGG  ACAAGATCAG  CGATAGTGTC  300
301   CTTGTTGACA  TAAAGGACAC  CGAACCCCTG  ATTCAGACTG  CAAAAACCAC  GCTGGGCTCC  360
361   AAAGTGGTCA  ACAGCTGTCA  CCGACAAATG  GCTGAGATTG  CTGTGGGTGC  TGTCCTCACT  420
421   GTAGCTGACA  TGGATCGGAG  AGACGTTGAC  TTTGAGCTCA  TCAAAGTAGA  AGGCAAAGTG  480
481   GGCGGGAGGC  TGGAAGACAC  TAAACTTATT  AAGGGTGTGA  TTGTGGATAA  GGACTTCAGT  540
541   CACCCGCAGA  TGCCCAAAAA  AGTGGAAGAT  GCTAAGATTG  CCATTCTCAC  ATGTCCATTT  600
601   GAACCACCTA  AACCAAAAAC  TAAGCATAAG  CTGGATGTGA  CCTCTGTGGA  AGATTATAAA  660
661   GCCCTTCAGA  AATACGAAAA  GGAGAAGTTT  GAAGAGATGA  TTCAACAAAT  TAAAGAAACG  720
721   GGTGCTAACC  TAGCGATTTG  TCAGTGGGGC  TTTGATGATG  AAGCGAATCA  TTTACTTCTT  780
781   CAGAATAATT  TGCCTGCAGT  TCGTTGGGTA  GGAGGACCTG  AAATTGAGCT  GATTGCCATT  840
841   GCGACAGGAG  GGCGCATCGT  CCCCCGGTTC  TCAGAGCTCA  CAGCTGAGAA  GCTGGGCTTT  900
901   GCTGGAATTG  TACAGGAGAT  CTCATTTGGG  ACAACTAAAG  ATAAAATGCT  GGTCATCGAG  960
961   CAGTGTAAGA  ACTCCAGAGC  TGTGACCATC  TTCATCAGAG  GAGGAAATAA  GATGATCATC  1020
1021  GAGGAAGCAA  AACGGTCCCT  TCACGATGCT  TTGTGTGTCA  TCCGGAACCT  TATCCGTGAT  1080
1081  AATCGGGTGG  TGTATGGAGG  AGGGGCTGCT  GAGATCGCCT  GTGCTCTGGC  AGTTAGCCAA  1140
1141  GAGGCAGATA  AGTGCCCAAC  CCTGGAGCAG  TACGCCATGC  GAGCCTTTGC  TGACGCACTG  1200
1201  GAGGTCATCC  CCATGGCCCT  CTCCGAGAAC  AGCGGCATGA  ACCCCATCCA  GACTATGACT  1260
1261  GAAGTCCGAG  CCAGACAAGT  CAAAGAGATG  AACCCTGCTC  TTGGGATTGA  CTGTTTGCAC  1320
1321  AAGGGTACAA  ATGATATGAA  GCAACAACAT  GTCATAGAAA  CCTTAATTGG  CAAGAAGCAG  1380
1381  CAAATATCTC  TTGCGACACA  AATGGTTAGA  ATGATTTTGA  AGATTGATGA  CATTCGTAAG  1440
1441  CCTGGAGAAT  CTGAAGAATG  A  1461

▼ KEYWORD

ID
Family
ATP-binding
Chaperone
Complete proteome
Cytoplasm
Nucleotide-binding
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cell body
Cellular Component
Centrosome
Cellular Component
Chaperonin-containing T-complex
Cellular Component
Microtubule
Cellular Component
Nucleolus
Molecular Function
ATP binding
Molecular Function
Beta-tubulin binding
Molecular Function
G-protein beta-subunit binding
Molecular Function
MRNA 3'-UTR binding
Molecular Function
MRNA 5'-UTR binding
Molecular Function
Unfolded protein binding
Biological Process
Binding of sperm to zona pellucida
Biological Process
Positive regulation of establishment of protein localization to telomere
Biological Process
Positive regulation of telomere maintenance via telomerase
Biological Process
Protein folding
Biological Process
Protein stabilization
Biological Process
Response to virus
Biological Process
Toxin transport

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mal-3371Mandrillus leucophaeus99.010.0 984
LLPS-Mam-0573Macaca mulatta98.710.01060
LLPS-Rhb-2364Rhinopithecus bieti98.710.01060
LLPS-Man-3987Macaca nemestrina98.710.01060
LLPS-Pap-1287Pan paniscus98.710.01060
LLPS-Pat-3559Pan troglodytes98.710.01060
LLPS-Hos-0061Homo sapiens98.710.01060
LLPS-Paa-1749Papio anubis98.710.01060
LLPS-Gog-0894Gorilla gorilla98.710.01060
LLPS-Cea-1806Cercocebus atys98.710.01060
LLPS-Maf-4546Macaca fascicularis98.710.01060
LLPS-Aon-4415Aotus nancymaae98.520.01059
LLPS-Chs-4721Chlorocebus sabaeus98.520.01060
LLPS-Caj-4510Callithrix jacchus98.340.01056
LLPS-Urm-0895Ursus maritimus98.150.01054
LLPS-Aim-3118Ailuropoda melanoleuca98.150.01054
LLPS-Mup-1856Mustela putorius furo98.150.01055
LLPS-Eqc-4555Equus caballus97.970.01050
LLPS-Caf-3585Canis familiaris97.970.01047
LLPS-Orc-3909Oryctolagus cuniculus97.970.01052
LLPS-Loa-4581Loxodonta africana97.970.01051
LLPS-Sus-3550Sus scrofa97.970.01050
LLPS-Dio-3844Dipodomys ordii97.780.01046
LLPS-Ict-3752Ictidomys tridecemlineatus97.60.01045
LLPS-Poa-1042Pongo abelii97.60.01040
LLPS-Fec-0996Felis catus97.60.01048
LLPS-Cap-1488Cavia porcellus97.040.01041
LLPS-Ova-0380Ovis aries97.040.01043
LLPS-Bot-4645Bos taurus96.860.01043
LLPS-Mea-4326Mesocricetus auratus96.670.01038
LLPS-Ran-2298Rattus norvegicus96.120.01031
LLPS-Mum-3137Mus musculus95.930.01030
LLPS-Fud-2439Fukomys damarensis95.560.01035
LLPS-Myl-2982Myotis lucifugus95.190.01026
LLPS-Ora-0647Ornithorhynchus anatinus94.840.01021
LLPS-Mod-2713Monodelphis domestica93.90.01018
LLPS-Sah-3716Sarcophilus harrisii93.540.01003
LLPS-Anp-2626Anas platyrhynchos91.760.0 706
LLPS-Fia-2303Ficedula albicollis91.250.0 919
LLPS-Gaga-2446Gallus gallus90.940.0 992
LLPS-Tag-3237Taeniopygia guttata90.760.0 993
LLPS-Pes-3661Pelodiscus sinensis90.760.0 987
LLPS-Xet-3933Xenopus tropicalis90.020.0 982
LLPS-Anc-1727Anolis carolinensis88.910.0 973
LLPS-Nol-0132Nomascus leucogenys87.990.0 906
LLPS-Lac-3143Latimeria chalumnae87.990.0 957
LLPS-Scf-1026Scleropages formosus87.80.0 959
LLPS-Leo-2140Lepisosteus oculatus87.430.0 960
LLPS-Dar-1195Danio rerio87.250.0 952
LLPS-Asm-2567Astyanax mexicanus87.250.0 954
LLPS-Icp-2007Ictalurus punctatus87.060.0 951
LLPS-Xim-3131Xiphophorus maculatus86.880.0 950
LLPS-Orl-2258Oryzias latipes86.690.0 941
LLPS-Meg-0985Meleagris gallopavo86.590.0 843
LLPS-Orn-2557Oreochromis niloticus86.140.0 944
LLPS-Pof-3360Poecilia formosa85.770.0 941
LLPS-Gaa-2831Gasterosteus aculeatus85.770.0 946
LLPS-Ten-1883Tetraodon nigroviridis85.580.0 944
LLPS-Tar-1345Takifugu rubripes84.840.0 936
LLPS-Scm-2695Scophthalmus maximus84.470.0 926
LLPS-Cii-0482Ciona intestinalis77.510.0 863
LLPS-Cis-1930Ciona savignyi75.460.0 842
LLPS-Vir-2085Vigna radiata75.361e-48 180
LLPS-Sot-2002Solanum tuberosum72.415e-138 407
LLPS-Php-2364Physcomitrella patens71.130.0 761
LLPS-Org-1639Oryza glaberrima70.80.0 555
LLPS-Drm-1733Drosophila melanogaster70.60.0 783
LLPS-Fuo-1272Fusarium oxysporum70.590.0 759
LLPS-Fuv-0115Fusarium verticillioides70.590.0 759
LLPS-Fus-0896Fusarium solani70.40.0 759
LLPS-Abg-1754Absidia glauca70.190.0 783
LLPS-Mel-1167Melampsora laricipopulina70.150.0 750
LLPS-Crn-0491Cryptococcus neoformans69.960.0 759
LLPS-Phv-1211Phaseolus vulgaris69.920.0 758
LLPS-Met-2137Medicago truncatula69.920.0 755
LLPS-Nef-0262Neosartorya fischeri69.790.0 765
LLPS-Orbr-2336Oryza brachyantha69.790.0 749
LLPS-Nia-0238Nicotiana attenuata69.740.0 760
LLPS-Orni-1166Oryza nivara69.740.0 756
LLPS-Sem-2251Selaginella moellendorffii69.740.0 753
LLPS-Ast-1060Aspergillus terreus69.690.0 749
LLPS-Asf-1333Aspergillus flavus69.670.0 759
LLPS-Map-0892Magnaporthe poae69.660.0 756
LLPS-Gag-1540Gaeumannomyces graminis69.660.0 756
LLPS-Nec-1617Neurospora crassa69.590.0 756
LLPS-Orr-0526Oryza rufipogon69.550.0 751
LLPS-Amt-0657Amborella trichopoda69.550.0 751
LLPS-Ors-0679Oryza sativa69.550.0 751
LLPS-Sei-0789Setaria italica69.550.0 751
LLPS-Orgl-1116Oryza glumaepatula69.550.0 754
LLPS-Via-1472Vigna angularis69.550.0 754
LLPS-Ori-1881Oryza indica69.550.0 751
LLPS-Glm-1035Glycine max69.550.0 756
LLPS-Aso-1067Aspergillus oryzae69.540.0 753
LLPS-Trv-0168Trichoderma virens69.530.0 751
LLPS-Trr-0674Trichoderma reesei69.480.0 752
LLPS-Scp-0306Schizosaccharomyces pombe69.360.0 766
LLPS-Sol-0415Solanum lycopersicum69.360.0 753
LLPS-Gor-0106Gossypium raimondii69.170.0 751
LLPS-Cus-1989Cucumis sativus69.170.0 739
LLPS-Thc-1548Theobroma cacao69.170.0 750
LLPS-Cogr-0920Colletotrichum graminicola69.160.0 760
LLPS-Bro-0816Brassica oleracea69.070.0 747
LLPS-Brn-1625Brassica napus69.070.0 747
LLPS-Mua-1559Musa acuminata69.060.0 741
LLPS-Mae-2429Manihot esculenta68.980.0 751
LLPS-Sob-1795Sorghum bicolor68.980.0 750
LLPS-Asfu-0689Aspergillus fumigatus68.950.0 744
LLPS-Brr-2005Brassica rapa68.880.0 745
LLPS-Ved-0975Verticillium dahliae68.840.0 757
LLPS-Scj-1172Schizosaccharomyces japonicus68.80.0 754
LLPS-Beb-1537Beauveria bassiana68.730.0 754
LLPS-Mao-0868Magnaporthe oryzae68.730.0 750
LLPS-Cae-0389Caenorhabditis elegans68.730.0 751
LLPS-Art-2810Arabidopsis thaliana68.690.0 746
LLPS-Tra-2332Triticum aestivum68.610.0 741
LLPS-Pyt-0001Pyrenophora teres68.610.0 759
LLPS-Asn-1274Aspergillus nidulans68.610.0 759
LLPS-Tum-1483Tuber melanosporum68.550.0 756
LLPS-Blg-1124Blumeria graminis68.550.0 750
LLPS-Scs-0031Sclerotinia sclerotiorum68.520.0 755
LLPS-Arl-2892Arabidopsis lyrata68.50.0 744
LLPS-Cog-1397Colletotrichum gloeosporioides68.470.0 752
LLPS-Lem-0812Leptosphaeria maculans68.420.0 748
LLPS-Prp-1545Prunus persica68.230.0 740
LLPS-Pytr-1537Pyrenophora triticirepentis68.230.0 754
LLPS-Pot-2250Populus trichocarpa68.230.0 747
LLPS-Asc-0281Aspergillus clavatus68.230.0 752
LLPS-Zyt-0247Zymoseptoria tritici68.190.0 729
LLPS-Put-0424Puccinia triticina68.060.0 741
LLPS-Brd-2040Brachypodium distachyon68.050.0 736
LLPS-Dos-1599Dothistroma septosporum68.00.0 733
LLPS-Coo-1453Colletotrichum orbiculare67.850.0 746
LLPS-Pug-0449Puccinia graminis67.680.0 736
LLPS-Dac-2301Daucus carota67.670.0 741
LLPS-Hea-0661Helianthus annuus67.670.0 741
LLPS-Zem-1631Zea mays67.340.0 743
LLPS-Usm-0948Ustilago maydis66.920.0 736
LLPS-Miv-1554Microbotryum violaceum66.360.0 747
LLPS-Asni-1495Aspergillus niger66.060.0 747
LLPS-Viv-2240Vitis vinifera66.040.0 701
LLPS-Chr-1722Chlamydomonas reinhardtii65.610.0 724
LLPS-Orp-0171Oryza punctata64.740.0 734
LLPS-Hov-1556Hordeum vulgare64.641e-127 382
LLPS-Osl-0343Ostreococcus lucimarinus64.490.0 721
LLPS-Chc-0555Chondrus crispus62.690.0 693
LLPS-Tru-1501Triticum urartu62.220.0 650
LLPS-Asg-0703Ashbya gossypii62.20.0 686
LLPS-Kop-1288Komagataella pastoris61.170.0 687
LLPS-Sac-1413Saccharomyces cerevisiae59.890.0 661
LLPS-Gas-1016Galdieria sulphuraria39.964e-92 298