DrLLPS - Data resource of LLPS

LLPS-Cap-2648
LSM3

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	U6 snRNA-associated Sm-like protein LSm3
Gene Name:	LSM3
Ensembl Gene:	ENSCPOG00000034071.1
Ensembl Protein:	ENSCPOP00000028575.1
Organism:	Cavia porcellus
Taxa ID:	10141
LLPS Type:	Others

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Nuclear speckle, P-body, Stress granule	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Homo sapiens	LLPS-Hos-0925	P62310	Client	Stress granule	100.00	2e-50	161
Mus musculus	LLPS-Mum-1136	P62311	Client	Nuclear speckle	100.00	2e-50	161
Saccharomyces cerevisiae	LLPS-Sac-0139	P57743	Client	P-body, Stress granule	43.53	2e-17	75.9

▼ FUNCTION

Binds specifically to the 3'-terminal U-tract of U6 snRNA.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSCPOT00000045789.1	ENSCPOP00000028575.1
UniProt		A0A286XT86, A0A286XT86_CAVPO
GeneBank	AAKN02051860
RefSeq	XM_003463198.3	XP_003463246.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 MADDVDQQQT TNTVEEPLDL IRLSLDERIY VKMRNDRELR GRLHAYDQHL NMILGDVEET 60 61 VTTIEIDEET YEEIYKSTKR NIPMLFVRGD GVVLVAPPLR VG 102
Nucleotide CDS Sequence (FASTA)
1 ATGGCGGACG ACGTGGACCA GCAACAAACC ACCAACACCG TAGAGGAGCC ACTGGATCTC 60 61 ATCAGACTCA GCCTGGATGA GCGAATCTAC GTGAAAATGA GGAATGACCG AGAGCTTCGA 120 121 GGCAGATTAC ACGCTTATGA TCAGCATTTA AACATGATAT TGGGAGATGT TGAAGAAACT 180 181 GTGACCACTA TAGAAATTGA TGAAGAGACA TATGAAGAGA TATACAAATC AACAAAACGG 240 241 AATATCCCGA TGCTCTTTGT CCGGGGAGAC GGTGTTGTGC TAGTTGCTCC TCCACTAAGA 300 301 GTTGGCTAA 309

▼ KEYWORD

ID	Family
KW-0181	Complete proteome
KW-0507	mRNA processing
KW-0508	mRNA splicing
KW-0539	Nucleus
KW-1185	Reference proteome
KW-0687	Ribonucleoprotein
KW-0694	RNA-binding
KW-0747	Spliceosome

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0071013	Cellular Component	Catalytic step 2 spliceosome
GO:1990726	Cellular Component	Lsm1-7-Pat1 complex
GO:0120115	Cellular Component	Lsm2-8 complex
GO:0000932	Cellular Component	P-body
GO:0071005	Cellular Component	U2-type precatalytic spliceosome
GO:0046540	Cellular Component	U4/U6 x U5 tri-snRNP complex
GO:0005688	Cellular Component	U6 snRNP
GO:0003723	Molecular Function	RNA binding
GO:0033962	Biological Process	Cytoplasmic mRNA processing body assembly
GO:0000398	Biological Process	MRNA splicing, via spliceosome
GO:0000956	Biological Process	Nuclear-transcribed mRNA catabolic process

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Dio-1255	Dipodomys ordii	100.0	3e-45	148
LLPS-Bot-0421	Bos taurus	100.0	5e-46	149
LLPS-Tut-0901	Tursiops truncatus	100.0	2e-50	161
LLPS-Paa-1754	Papio anubis	100.0	2e-50	161
LLPS-Mal-2225	Mandrillus leucophaeus	100.0	2e-50	161
LLPS-Myl-1689	Myotis lucifugus	100.0	2e-50	161
LLPS-Aim-2410	Ailuropoda melanoleuca	100.0	2e-50	161
LLPS-Ran-0969	Rattus norvegicus	100.0	2e-50	161
LLPS-Sus-2187	Sus scrofa	100.0	2e-50	161
LLPS-Aon-3137	Aotus nancymaae	100.0	2e-50	161
LLPS-Cea-3244	Cercocebus atys	100.0	2e-50	161
LLPS-Mum-1136	Mus musculus	100.0	2e-50	161
LLPS-Maf-3511	Macaca fascicularis	100.0	2e-50	161
LLPS-Fud-2079	Fukomys damarensis	100.0	2e-50	161
LLPS-Caj-0561	Callithrix jacchus	100.0	3e-32	115
LLPS-Gog-1558	Gorilla gorilla	100.0	2e-50	161
LLPS-Mam-1529	Macaca mulatta	100.0	2e-50	161
LLPS-Poa-0737	Pongo abelii	100.0	2e-50	161
LLPS-Eqc-0410	Equus caballus	100.0	2e-50	161
LLPS-Nol-2637	Nomascus leucogenys	100.0	2e-50	161
LLPS-Man-1373	Macaca nemestrina	100.0	2e-50	161
LLPS-Anp-0816	Anas platyrhynchos	100.0	3e-45	147
LLPS-Hos-0925	Homo sapiens	100.0	2e-50	161
LLPS-Meg-0694	Meleagris gallopavo	100.0	5e-46	149
LLPS-Pap-0257	Pan paniscus	100.0	2e-50	161
LLPS-Urm-1494	Ursus maritimus	100.0	2e-50	161
LLPS-Pat-1385	Pan troglodytes	100.0	2e-50	161
LLPS-Fec-0891	Felis catus	100.0	2e-50	161
LLPS-Orc-0323	Oryctolagus cuniculus	100.0	2e-50	161
LLPS-Rhb-0934	Rhinopithecus bieti	100.0	2e-50	161
LLPS-Otg-0772	Otolemur garnettii	100.0	2e-50	161
LLPS-Ova-2354	Ovis aries	99.03	9e-49	157
LLPS-Loa-1373	Loxodonta africana	99.03	9e-49	157
LLPS-Ora-0330	Ornithorhynchus anatinus	99.02	5e-50	160
LLPS-Anc-1669	Anolis carolinensis	99.02	6e-50	160
LLPS-Tag-0407	Taeniopygia guttata	99.02	6e-50	160
LLPS-Cas-1618	Carlito syrichta	99.02	6e-50	160
LLPS-Mod-0019	Monodelphis domestica	99.02	5e-50	160
LLPS-Fia-0978	Ficedula albicollis	99.02	6e-50	160
LLPS-Pes-2407	Pelodiscus sinensis	99.02	6e-50	160
LLPS-Caf-0667	Canis familiaris	98.04	9e-49	157
LLPS-Xet-3309	Xenopus tropicalis	98.04	8e-49	157
LLPS-Gaga-1754	Gallus gallus	97.73	2e-23	92.0
LLPS-Scf-1337	Scleropages formosus	97.06	1e-49	159
LLPS-Leo-1768	Lepisosteus oculatus	97.06	3e-49	158
LLPS-Asm-0477	Astyanax mexicanus	97.06	1e-49	159
LLPS-Icp-1341	Ictalurus punctatus	97.06	8e-49	157
LLPS-Dar-0151	Danio rerio	97.06	2e-49	159
LLPS-Gaa-0530	Gasterosteus aculeatus	95.1	3e-48	155
LLPS-Xim-2864	Xiphophorus maculatus	95.1	3e-48	155
LLPS-Chs-0179	Chlorocebus sabaeus	95.1	7e-46	149
LLPS-Ict-3478	Ictidomys tridecemlineatus	95.1	4e-46	150
LLPS-Pof-1909	Poecilia formosa	95.1	3e-48	155
LLPS-Scm-2276	Scophthalmus maximus	95.1	3e-48	155
LLPS-Orn-0058	Oreochromis niloticus	95.1	3e-48	155
LLPS-Ten-1173	Tetraodon nigroviridis	94.12	1e-47	154
LLPS-Orl-0715	Oryzias latipes	93.14	3e-47	153
LLPS-Tar-0438	Takifugu rubripes	92.73	7e-29	107
LLPS-Lep-1018	Leersia perrieri	90.48	1e-19	83.6
LLPS-Orgl-0797	Oryza glumaepatula	90.48	2e-19	84.0
LLPS-Orm-0017	Oryza meridionalis	90.48	1e-19	82.0
LLPS-Mup-2137	Mustela putorius furo	88.89	5e-40	134
LLPS-Orr-1139	Oryza rufipogon	84.0	1e-23	95.9
LLPS-Ori-0097	Oryza indica	82.02	3e-33	117
LLPS-Orni-0458	Oryza nivara	82.02	3e-33	117
LLPS-Org-0787	Oryza glaberrima	82.02	3e-33	117
LLPS-Orp-0490	Oryza punctata	82.02	3e-33	117
LLPS-Ors-0447	Oryza sativa	82.02	3e-33	117
LLPS-Orbr-0437	Oryza brachyantha	82.02	2e-33	118
LLPS-Sei-0951	Setaria italica	81.82	2e-32	115
LLPS-Tra-0954	Triticum aestivum	81.82	1e-32	115
LLPS-Brn-2118	Brassica napus	81.82	7e-33	116
LLPS-Bro-0912	Brassica oleracea	81.82	2e-32	115
LLPS-Brr-2541	Brassica rapa	81.82	7e-33	116
LLPS-Cis-0553	Ciona savignyi	81.73	1e-40	136
LLPS-Orb-0204	Oryza barthii	81.18	1e-30	110
LLPS-Sob-1377	Sorghum bicolor	81.11	1e-33	118
LLPS-Viv-1746	Vitis vinifera	80.85	3e-20	84.0
LLPS-Arl-0342	Arabidopsis lyrata	80.0	2e-32	115
LLPS-Hov-0856	Hordeum vulgare	80.0	4e-32	115
LLPS-Brd-0373	Brachypodium distachyon	80.0	4e-33	117
LLPS-Tru-1157	Triticum urartu	80.0	4e-33	117
LLPS-Art-2395	Arabidopsis thaliana	80.0	2e-32	115
LLPS-Cus-1413	Cucumis sativus	79.78	3e-33	117
LLPS-Via-0042	Vigna angularis	79.12	1e-33	118
LLPS-Met-1239	Medicago truncatula	79.12	1e-33	118
LLPS-Glm-1034	Glycine max	79.12	1e-33	118
LLPS-Phv-0450	Phaseolus vulgaris	79.12	3e-33	117
LLPS-Dac-0175	Daucus carota	78.89	1e-32	116
LLPS-Sot-0956	Solanum tuberosum	78.49	7e-34	119
LLPS-Sol-0155	Solanum lycopersicum	78.49	7e-34	119
LLPS-Amt-0983	Amborella trichopoda	78.16	2e-30	110
LLPS-Thc-1641	Theobroma cacao	78.02	5e-33	116
LLPS-Sem-1061	Selaginella moellendorffii	77.42	1e-32	115
LLPS-Chr-1194	Chlamydomonas reinhardtii	77.0	6e-34	119
LLPS-Prp-0465	Prunus persica	76.84	1e-34	120
LLPS-Drm-0840	Drosophila melanogaster	76.7	7e-37	126
LLPS-Hea-1146	Helianthus annuus	75.79	1e-33	118
LLPS-Gor-0037	Gossypium raimondii	75.79	8e-34	118
LLPS-Pot-1472	Populus trichocarpa	74.74	3e-33	117
LLPS-Mae-0346	Manihot esculenta	74.74	4e-33	117
LLPS-Mua-1217	Musa acuminata	73.68	7e-34	119
LLPS-Php-0016	Physcomitrella patens	73.63	1e-32	115
LLPS-Osl-0529	Ostreococcus lucimarinus	72.73	4e-30	108
LLPS-Cae-1508	Caenorhabditis elegans	69.61	2e-33	117
LLPS-Vir-1611	Vigna radiata	66.67	1e-06	46.6
LLPS-Gas-0427	Galdieria sulphuraria	64.04	7e-26	98.2
LLPS-Abg-0103	Absidia glauca	64.0	3e-30	109
LLPS-Spr-1174	Sporisorium reilianum	63.22	9e-24	93.2
LLPS-Asc-0713	Aspergillus clavatus	61.82	2e-16	73.6
LLPS-Asfu-0397	Aspergillus fumigatus	61.82	3e-16	72.8
LLPS-Nef-0774	Neosartorya fischeri	61.82	6e-16	72.4
LLPS-Miv-0174	Microbotryum violaceum	60.0	2e-26	99.4
LLPS-Usm-0166	Ustilago maydis	59.77	8e-24	93.2
LLPS-Scc-0801	Schizosaccharomyces cryophilus	58.89	4e-27	101
LLPS-Chc-0807	Chondrus crispus	58.54	2e-09	54.7
LLPS-Scp-0434	Schizosaccharomyces pombe	57.78	3e-26	99.0
LLPS-Mel-0358	Melampsora laricipopulina	56.96	4e-16	72.8
LLPS-Cym-0814	Cyanidioschyzon merolae	56.32	2e-19	81.6
LLPS-Lem-0783	Leptosphaeria maculans	54.84	5e-22	88.6
LLPS-Phn-0694	Phaeosphaeria nodorum	54.84	2e-21	86.7
LLPS-Pug-0460	Puccinia graminis	54.35	3e-22	89.0
LLPS-Asf-0142	Aspergillus flavus	53.61	4e-22	88.6
LLPS-Beb-0550	Beauveria bassiana	53.61	4e-21	85.9
LLPS-Coc-0717	Corchorus capsularis	53.52	3e-15	71.6
LLPS-Zem-0514	Zea mays	53.52	3e-14	68.6
LLPS-Asn-0926	Aspergillus nidulans	52.87	3e-22	88.6
LLPS-Put-1113	Puccinia triticina	52.81	9e-21	85.9
LLPS-Pyt-1188	Pyrenophora teres	52.69	2e-21	87.0
LLPS-Cog-0812	Colletotrichum gloeosporioides	52.58	6e-21	85.5
LLPS-Cogr-0037	Colletotrichum graminicola	52.17	8e-21	85.1
LLPS-Tum-0405	Tuber melanosporum	51.72	2e-23	91.7
LLPS-Coo-0318	Colletotrichum orbiculare	51.55	9e-21	85.1
LLPS-Asni-0955	Aspergillus niger	51.55	1e-22	89.7
LLPS-Dos-0282	Dothistroma septosporum	51.55	2e-20	84.0
LLPS-Ved-0616	Verticillium dahliae	51.09	2e-20	84.3
LLPS-Ast-0481	Aspergillus terreus	51.06	2e-21	87.0
LLPS-Nec-0552	Neurospora crassa	51.0	2e-20	84.3
LLPS-Gag-0907	Gaeumannomyces graminis	50.0	8e-19	80.1
LLPS-Fuv-0972	Fusarium verticillioides	50.0	2e-19	81.3
LLPS-Fuo-1201	Fusarium oxysporum	50.0	2e-19	81.6
LLPS-Trr-0843	Trichoderma reesei	50.0	6e-15	69.3
LLPS-Scj-0925	Schizosaccharomyces japonicus	49.45	1e-16	74.3
LLPS-Zyt-0727	Zymoseptoria tritici	49.45	3e-21	86.3
LLPS-Fus-0200	Fusarium solani	48.91	9e-20	82.4
LLPS-Trv-0424	Trichoderma virens	47.83	1e-19	82.4
LLPS-Map-0210	Magnaporthe poae	47.52	4e-19	80.9
LLPS-Mao-0302	Magnaporthe oryzae	46.08	9e-19	79.7
LLPS-Yal-0584	Yarrowia lipolytica	45.45	4e-15	70.1
LLPS-Blg-0127	Blumeria graminis	45.36	7e-20	82.8
LLPS-Crn-0269	Cryptococcus neoformans	43.02	5e-16	72.8
LLPS-Kop-0632	Komagataella pastoris	42.86	3e-17	75.5
LLPS-Asg-0739	Ashbya gossypii	42.68	1e-13	65.9
LLPS-Sac-0139	Saccharomyces cerevisiae	38.82	3e-13	65.1

LLPS-Cap-2648LSM3

Protein Sequence

Nucleotide Sequence

LLPS-Cap-2648
LSM3