LLPS-Art-0725
At2g20420
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase beta chain; SCS-beta |
| Gene Name: | At2g20420, F11A3.3 |
| Ensembl Gene: | AT2G20420 |
| Ensembl Protein: | AT2G20420.1 |
| Organism: | Arabidopsis thaliana |
| Taxa ID: | 3702 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Nucleolus | "...We identified 1602 proteins in the nucleolar and 2544 proteins in the nuclear fraction with an overlap of 1429 proteins." | Arabidopsis thaliana cells | 26980300 |
▼ FUNCTION
| Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | AT2G20420.1 | AT2G20420.1 |
| UniProt | O82662, SUCB_ARATH | |
| GeneBank | AY128889, CP002685, AC006569, AY099707, AJ001808 | AAM91289.1, AAM20558.1, CAA05024.1, AAM15283.1, AEC07005.1 |
| RefSeq | NM_127601.4 | NP_179632.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MRGLVNKLVS RSLSISGKWQ NQQLRRLNIH EYQGAELMGK YGVNVPKGVA ASSLEEVKKA 60 61 IQDVFPNESE LVVKSQILAG GRGLGTFKSG LKGGVHIVKR DEAEEIAGKM LGQVLVTKQT 120 121 GPQGKVVSKV YLCEKLSLVN EMYFSIILDR KSAGPLIIAC KKGGTSIEDL AEKFPDMIIK 180 181 VPIDVFAGIT DEDAAKVVDG LAPKAADRKD SIEQVKKLYE LFRKTDCTML EINPLAETST 240 241 NQLVAADAKL NFDDNAAFRQ KEVFAMRDPT QEDPREVAAA KVDLNYIGLD GEIGCMVNGA 300 301 GLAMATMDII KLHGGTPANF LDVGGNASEH QVVEAFKILT SDDKVKAILV NIFGGIMKCD 360 361 VIASGIVNAA KEVALKVPVV VRLEGTNVEQ GKRILKESGM KLITADDLDD AAEKAVKALA 420 421 H 421 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAGGGGAT TGGTGAACAA GCTCGTGTCC AGATCTCTCT CCATCTCCGG GAAATGGCAG 60 61 AACCAACAGC TTCGTCGTCT CAACATCCAC GAGTATCAGG GAGCTGAATT GATGGGGAAA 120 121 TATGGAGTTA ATGTGCCGAA AGGAGTAGCT GCTTCTTCGT TGGAAGAAGT TAAAAAGGCT 180 181 ATTCAAGATG TTTTCCCTAA TGAAAGCGAG TTGGTTGTTA AGAGCCAGAT TTTGGCTGGT 240 241 GGAAGAGGTC TTGGAACATT CAAGAGTGGT CTTAAGGGTG GTGTTCACAT TGTTAAACGT 300 301 GATGAGGCTG AAGAGATTGC TGGAAAGATG CTAGGACAAG TACTTGTCAC CAAGCAAACT 360 361 GGTCCTCAAG GCAAAGTAGT TAGCAAGGTT TACTTGTGTG AGAAATTGTC ACTCGTCAAT 420 421 GAGATGTACT TTTCCATTAT TCTGGACCGT AAATCTGCTG GACCGTTGAT CATTGCCTGT 480 481 AAAAAGGGTG GTACCAGTAT TGAAGATCTT GCTGAGAAGT TCCCTGACAT GATCATCAAG 540 541 GTACCAATTG ATGTATTTGC AGGAATCACT GATGAAGATG CTGCTAAGGT TGTGGATGGT 600 601 CTGGCTCCCA AAGCTGCTGA CAGAAAAGAT TCGATTGAAC AAGTGAAGAA GCTATACGAA 660 661 CTCTTCCGCA AGACTGACTG CACAATGTTG GAAATCAATC CCCTTGCGGA GACATCAACT 720 721 AATCAATTGG TAGCTGCTGA TGCCAAATTG AACTTCGATG ATAATGCTGC GTTCCGACAA 780 781 AAAGAGGTTT TCGCCATGCG TGATCCAACA CAGGAGGATC CACGAGAGGT GGCTGCTGCT 840 841 AAAGTTGACC TGAACTACAT CGGTTTAGAT GGAGAGATTG GTTGCATGGT GAATGGTGCT 900 901 GGATTGGCCA TGGCAACCAT GGACATCATT AAATTACACG GTGGAACACC CGCCAATTTC 960 961 CTTGACGTTG GTGGAAATGC TTCTGAGCAC CAGGTGGTGG AAGCGTTTAA GATACTGACA 1020 1021 TCGGACGATA AAGTGAAAGC AATCTTGGTG AACATATTTG GTGGGATAAT GAAATGTGAT 1080 1081 GTGATTGCTA GTGGAATCGT GAACGCTGCA AAAGAGGTCG CATTGAAAGT GCCAGTGGTG 1140 1141 GTTCGTCTAG AAGGAACGAA TGTTGAGCAG GGAAAGAGAA TCCTCAAGGA AAGTGGAATG 1200 1201 AAACTCATAA CAGCTGATGA TTTGGATGAT GCAGCTGAGA AAGCGGTTAA AGCTTTAGCT 1260 1261 CACTAA 1266 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Mitochondrion | |
Molecular Function | ATP binding | |
Molecular Function | Copper ion binding | |
Molecular Function | Magnesium ion binding | |
Molecular Function | Succinate-CoA ligase (ADP-forming) activity | |
Biological Process | Response to cadmium ion | |
Biological Process | Tricarboxylic acid cycle |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | ||||
| Localization | ||||
| COMPARTMENTS | ||||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Arl-0713 | Arabidopsis lyrata | 98.1 | 0.0 | 836 |
| LLPS-Brn-0002 | Brassica napus | 96.43 | 0.0 | 824 |
| LLPS-Bro-1681 | Brassica oleracea | 95.72 | 0.0 | 819 |
| LLPS-Brr-3031 | Brassica rapa | 95.49 | 0.0 | 820 |
| LLPS-Coc-0369 | Corchorus capsularis | 89.0 | 0.0 | 769 |
| LLPS-Mae-2353 | Manihot esculenta | 88.57 | 0.0 | 764 |
| LLPS-Mua-1381 | Musa acuminata | 88.57 | 3e-11 | 66.6 |
| LLPS-Thc-1032 | Theobroma cacao | 88.52 | 0.0 | 768 |
| LLPS-Viv-0627 | Vitis vinifera | 88.28 | 0.0 | 762 |
| LLPS-Gor-2709 | Gossypium raimondii | 88.04 | 0.0 | 763 |
| LLPS-Cus-0361 | Cucumis sativus | 87.8 | 0.0 | 757 |
| LLPS-Prp-0831 | Prunus persica | 87.59 | 0.0 | 759 |
| LLPS-Pot-0936 | Populus trichocarpa | 87.38 | 0.0 | 756 |
| LLPS-Sot-0874 | Solanum tuberosum | 87.38 | 0.0 | 760 |
| LLPS-Hea-2695 | Helianthus annuus | 87.35 | 0.0 | 751 |
| LLPS-Glm-2497 | Glycine max | 87.08 | 0.0 | 749 |
| LLPS-Nia-1866 | Nicotiana attenuata | 86.67 | 0.0 | 756 |
| LLPS-Dac-0483 | Daucus carota | 86.67 | 0.0 | 755 |
| LLPS-Sol-1002 | Solanum lycopersicum | 86.67 | 0.0 | 756 |
| LLPS-Phv-0767 | Phaseolus vulgaris | 86.12 | 0.0 | 748 |
| LLPS-Via-0769 | Vigna angularis | 86.12 | 0.0 | 747 |
| LLPS-Org-0003 | Oryza glaberrima | 85.89 | 0.0 | 745 |
| LLPS-Orm-1033 | Oryza meridionalis | 85.89 | 0.0 | 745 |
| LLPS-Orr-0425 | Oryza rufipogon | 85.89 | 0.0 | 745 |
| LLPS-Ors-0677 | Oryza sativa | 85.89 | 0.0 | 745 |
| LLPS-Met-0285 | Medicago truncatula | 85.89 | 0.0 | 747 |
| LLPS-Orgl-0621 | Oryza glumaepatula | 85.89 | 0.0 | 745 |
| LLPS-Orni-0252 | Oryza nivara | 85.89 | 0.0 | 745 |
| LLPS-Orb-0232 | Oryza barthii | 85.89 | 0.0 | 745 |
| LLPS-Ori-0269 | Oryza indica | 85.89 | 0.0 | 745 |
| LLPS-Orbr-0971 | Oryza brachyantha | 85.65 | 0.0 | 743 |
| LLPS-Sob-0565 | Sorghum bicolor | 85.41 | 0.0 | 739 |
| LLPS-Sei-1329 | Setaria italica | 85.41 | 0.0 | 737 |
| LLPS-Lep-1662 | Leersia perrieri | 85.17 | 0.0 | 740 |
| LLPS-Amt-1300 | Amborella trichopoda | 84.95 | 0.0 | 657 |
| LLPS-Brd-0292 | Brachypodium distachyon | 84.93 | 0.0 | 732 |
| LLPS-Tru-1306 | Triticum urartu | 84.69 | 0.0 | 734 |
| LLPS-Tra-0273 | Triticum aestivum | 84.69 | 0.0 | 734 |
| LLPS-Hov-0503 | Hordeum vulgare | 83.53 | 0.0 | 723 |
| LLPS-Vir-0194 | Vigna radiata | 81.82 | 0.0 | 699 |
| LLPS-Sem-0805 | Selaginella moellendorffii | 78.35 | 0.0 | 622 |
| LLPS-Php-0392 | Physcomitrella patens | 75.43 | 0.0 | 613 |
| LLPS-Zem-1047 | Zea mays | 73.26 | 0.0 | 697 |
| LLPS-Chr-1285 | Chlamydomonas reinhardtii | 65.31 | 0.0 | 549 |
| LLPS-Osl-0712 | Ostreococcus lucimarinus | 64.52 | 4e-174 | 501 |
| LLPS-Gas-0957 | Galdieria sulphuraria | 57.04 | 7e-163 | 473 |
| LLPS-Chc-0582 | Chondrus crispus | 56.31 | 1e-153 | 450 |
| LLPS-Lac-3532 | Latimeria chalumnae | 55.93 | 2e-113 | 344 |
| LLPS-Orn-1384 | Oreochromis niloticus | 54.47 | 1e-134 | 399 |
| LLPS-Asm-2536 | Astyanax mexicanus | 54.38 | 1e-137 | 408 |
| LLPS-Scm-3604 | Scophthalmus maximus | 54.31 | 6e-145 | 429 |
| LLPS-Gaga-1225 | Gallus gallus | 54.29 | 6e-144 | 426 |
| LLPS-Pof-2978 | Poecilia formosa | 54.06 | 1e-145 | 430 |
| LLPS-Gaa-2635 | Gasterosteus aculeatus | 54.06 | 1e-145 | 430 |
| LLPS-Xim-3824 | Xiphophorus maculatus | 54.06 | 2e-145 | 430 |
| LLPS-Anp-1205 | Anas platyrhynchos | 54.04 | 1e-143 | 425 |
| LLPS-Meg-0511 | Meleagris gallopavo | 53.79 | 1e-142 | 422 |
| LLPS-Cas-2235 | Carlito syrichta | 53.77 | 5e-138 | 408 |
| LLPS-Scf-0974 | Scleropages formosus | 53.55 | 1e-144 | 427 |
| LLPS-Orl-0171 | Oryzias latipes | 53.55 | 2e-145 | 429 |
| LLPS-Tag-1029 | Taeniopygia guttata | 53.54 | 1e-143 | 424 |
| LLPS-Fia-2300 | Ficedula albicollis | 53.54 | 1e-143 | 424 |
| LLPS-Icp-3874 | Ictalurus punctatus | 53.4 | 7e-143 | 424 |
| LLPS-Dar-0946 | Danio rerio | 53.15 | 4e-144 | 426 |
| LLPS-Fec-1945 | Felis catus | 53.12 | 4e-144 | 426 |
| LLPS-Fud-2273 | Fukomys damarensis | 53.03 | 6e-142 | 421 |
| LLPS-Beb-0661 | Beauveria bassiana | 53.02 | 1e-143 | 424 |
| LLPS-Trr-0933 | Trichoderma reesei | 52.9 | 2e-144 | 426 |
| LLPS-Pes-0157 | Pelodiscus sinensis | 52.81 | 3e-141 | 419 |
| LLPS-Caf-2525 | Canis familiaris | 52.74 | 3e-137 | 407 |
| LLPS-Xet-0217 | Xenopus tropicalis | 52.63 | 3e-143 | 424 |
| LLPS-Ova-1736 | Ovis aries | 52.63 | 1e-142 | 424 |
| LLPS-Bot-2101 | Bos taurus | 52.63 | 6e-144 | 426 |
| LLPS-Ora-1733 | Ornithorhynchus anatinus | 52.38 | 2e-141 | 419 |
| LLPS-Abg-1138 | Absidia glauca | 52.17 | 5e-148 | 435 |
| LLPS-Mum-3768 | Mus musculus | 52.03 | 8e-140 | 415 |
| LLPS-Cym-0027 | Cyanidioschyzon merolae | 52.01 | 2e-146 | 432 |
| LLPS-Drm-0441 | Drosophila melanogaster | 51.99 | 2e-130 | 389 |
| LLPS-Pytr-1104 | Pyrenophora triticirepentis | 51.89 | 3e-141 | 418 |
| LLPS-Pyt-0414 | Pyrenophora teres | 51.89 | 2e-141 | 418 |
| LLPS-Ten-0508 | Tetraodon nigroviridis | 51.84 | 2e-137 | 408 |
| LLPS-Leo-1344 | Lepisosteus oculatus | 51.84 | 3e-136 | 405 |
| LLPS-Loa-3185 | Loxodonta africana | 51.79 | 5e-138 | 410 |
| LLPS-Ict-0372 | Ictidomys tridecemlineatus | 51.78 | 4e-145 | 429 |
| LLPS-Sah-1082 | Sarcophilus harrisii | 51.78 | 2e-138 | 412 |
| LLPS-Anc-1293 | Anolis carolinensis | 51.75 | 7e-143 | 424 |
| LLPS-Cogr-0335 | Colletotrichum graminicola | 51.64 | 5e-135 | 402 |
| LLPS-Trv-0404 | Trichoderma virens | 51.64 | 4e-141 | 418 |
| LLPS-Rhb-4171 | Rhinopithecus bieti | 51.57 | 9e-139 | 412 |
| LLPS-Orc-2864 | Oryctolagus cuniculus | 51.54 | 1e-141 | 422 |
| LLPS-Tar-1659 | Takifugu rubripes | 51.51 | 5e-133 | 396 |
| LLPS-Mao-1359 | Magnaporthe oryzae | 51.5 | 4e-142 | 420 |
| LLPS-Eqc-0337 | Equus caballus | 51.45 | 2e-141 | 421 |
| LLPS-Urm-0308 | Ursus maritimus | 51.44 | 2e-142 | 422 |
| LLPS-Caj-1960 | Callithrix jacchus | 51.44 | 1e-141 | 419 |
| LLPS-Cap-2900 | Cavia porcellus | 51.42 | 1e-130 | 389 |
| LLPS-Ast-0056 | Aspergillus terreus | 51.39 | 4e-141 | 418 |
| LLPS-Asn-0084 | Aspergillus nidulans | 51.39 | 1e-141 | 419 |
| LLPS-Asni-1111 | Aspergillus niger | 51.39 | 1e-140 | 416 |
| LLPS-Mup-0492 | Mustela putorius furo | 51.31 | 1e-142 | 424 |
| LLPS-Ran-2119 | Rattus norvegicus | 51.27 | 2e-140 | 417 |
| LLPS-Otg-1800 | Otolemur garnettii | 51.2 | 7e-142 | 420 |
| LLPS-Mal-2326 | Mandrillus leucophaeus | 51.2 | 5e-140 | 416 |
| LLPS-Paa-2656 | Papio anubis | 51.2 | 1e-139 | 415 |
| LLPS-Dio-0117 | Dipodomys ordii | 51.2 | 4e-141 | 418 |
| LLPS-Pat-2595 | Pan troglodytes | 51.18 | 7e-141 | 418 |
| LLPS-Pap-0445 | Pan paniscus | 51.18 | 7e-141 | 418 |
| LLPS-Gog-1099 | Gorilla gorilla | 51.18 | 6e-141 | 418 |
| LLPS-Lem-1324 | Leptosphaeria maculans | 51.13 | 2e-139 | 414 |
| LLPS-Asg-1061 | Ashbya gossypii | 51.13 | 1e-135 | 403 |
| LLPS-Coo-0852 | Colletotrichum orbiculare | 51.13 | 4e-135 | 402 |
| LLPS-Mod-3054 | Monodelphis domestica | 51.02 | 7e-137 | 407 |
| LLPS-Mam-0066 | Macaca mulatta | 50.96 | 2e-139 | 414 |
| LLPS-Man-1042 | Macaca nemestrina | 50.96 | 3e-139 | 414 |
| LLPS-Sus-4023 | Sus scrofa | 50.96 | 3e-141 | 419 |
| LLPS-Maf-3242 | Macaca fascicularis | 50.96 | 2e-139 | 414 |
| LLPS-Cis-1802 | Ciona savignyi | 50.88 | 3e-129 | 387 |
| LLPS-Cii-1441 | Ciona intestinalis | 50.88 | 6e-132 | 394 |
| LLPS-Aim-0250 | Ailuropoda melanoleuca | 50.83 | 3e-142 | 421 |
| LLPS-Mea-0320 | Mesocricetus auratus | 50.76 | 7e-137 | 407 |
| LLPS-Poa-2372 | Pongo abelii | 50.71 | 8e-141 | 417 |
| LLPS-Asfu-0213 | Aspergillus fumigatus | 50.38 | 8e-141 | 417 |
| LLPS-Asf-0373 | Aspergillus flavus | 50.25 | 3e-133 | 399 |
| LLPS-Dos-0292 | Dothistroma septosporum | 50.13 | 2e-139 | 413 |
| LLPS-Ved-0064 | Verticillium dahliae | 50.0 | 6e-132 | 394 |
| LLPS-Tum-0021 | Tuber melanosporum | 50.0 | 1e-139 | 414 |
| LLPS-Gag-0432 | Gaeumannomyces graminis | 50.0 | 5e-138 | 410 |
| LLPS-Fuo-0481 | Fusarium oxysporum | 49.87 | 3e-137 | 408 |
| LLPS-Nef-0014 | Neosartorya fischeri | 49.87 | 4e-140 | 415 |
| LLPS-Fuv-1001 | Fusarium verticillioides | 49.87 | 5e-137 | 407 |
| LLPS-Nol-2957 | Nomascus leucogenys | 49.57 | 3e-108 | 332 |
| LLPS-Aso-0415 | Aspergillus oryzae | 49.52 | 9e-137 | 407 |
| LLPS-Map-0662 | Magnaporthe poae | 49.5 | 1e-134 | 401 |
| LLPS-Crn-1328 | Cryptococcus neoformans | 49.49 | 5e-132 | 394 |
| LLPS-Myl-2055 | Myotis lucifugus | 49.48 | 3e-91 | 284 |
| LLPS-Phn-1291 | Phaeosphaeria nodorum | 49.4 | 2e-137 | 408 |
| LLPS-Fus-1060 | Fusarium solani | 49.37 | 1e-135 | 404 |
| LLPS-Miv-0055 | Microbotryum violaceum | 49.36 | 2e-125 | 376 |
| LLPS-Aon-3163 | Aotus nancymaae | 49.36 | 4e-120 | 364 |
| LLPS-Nec-0832 | Neurospora crassa | 49.15 | 4e-137 | 408 |
| LLPS-Hos-1303 | Homo sapiens | 49.1 | 2e-119 | 362 |
| LLPS-Cea-2469 | Cercocebus atys | 49.04 | 4e-128 | 384 |
| LLPS-Blg-0257 | Blumeria graminis | 49.0 | 6e-136 | 404 |
| LLPS-Asc-0544 | Aspergillus clavatus | 48.92 | 3e-139 | 413 |
| LLPS-Chs-2072 | Chlorocebus sabaeus | 48.91 | 3e-127 | 382 |
| LLPS-Cae-1513 | Caenorhabditis elegans | 48.81 | 3e-129 | 387 |
| LLPS-Kop-0056 | Komagataella pastoris | 48.8 | 6e-132 | 393 |
| LLPS-Zyt-1202 | Zymoseptoria tritici | 48.62 | 2e-133 | 398 |
| LLPS-Scp-1401 | Schizosaccharomyces pombe | 48.48 | 2e-132 | 395 |
| LLPS-Pug-0329 | Puccinia graminis | 48.34 | 5e-118 | 358 |
| LLPS-Spr-0468 | Sporisorium reilianum | 47.98 | 4e-129 | 386 |
| LLPS-Scc-1115 | Schizosaccharomyces cryophilus | 47.98 | 2e-127 | 382 |
| LLPS-Mel-1187 | Melampsora laricipopulina | 47.9 | 6e-123 | 370 |
| LLPS-Usm-0563 | Ustilago maydis | 47.27 | 5e-128 | 384 |
| LLPS-Sac-1451 | Saccharomyces cerevisiae | 46.77 | 4e-126 | 379 |
| LLPS-Cog-0826 | Colletotrichum gloeosporioides | 46.56 | 1e-112 | 343 |
| LLPS-Put-0845 | Puccinia triticina | 46.36 | 1e-91 | 287 |
| LLPS-Scj-0526 | Schizosaccharomyces japonicus | 45.52 | 1e-125 | 378 |
| LLPS-Yal-0561 | Yarrowia lipolytica | 45.19 | 3e-129 | 387 |