LLPS-Asm-2536
SUCLG2
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase subunit beta; G-SCS; GTPSCS; Succinyl-CoA synthetase beta-G chain; SCS-betaG |
| Gene Name: | SUCLG2 |
| Ensembl Gene: | ENSAMXG00000034435.1 |
| Ensembl Protein: | ENSAMXP00000042430.1 |
| Organism: | Astyanax mexicanus |
| Taxa ID: | 7994 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Mitochondrial RNA granule | Predicted from orthologs | (View) |
▼ FUNCTION
| GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSAMXT00000044709.1 | ENSAMXP00000042430.1 |
| UniProt | A0A3B1JKQ9, A0A3B1JKQ9_ASTMX |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAACMMWRAV QSGAERAGRL LRTRQVVKVS PRRWLNLQEY QSKKLMQDSG VTVQRFFVAD 60 61 TADEALQAAK RLNAKEIVLK AQILAGGRGK GVFDSGLKGG VHLTKDPAVV GDLAGKMLGF 120 121 NLTTKQTPKD GVKVKTVMVA EALDISRETY FAILMDRACN GPVMVGSPQG GVDIEEVAAK 180 181 TPELIFKEPI DIFEGVRDDQ ARRMAANLGF KGPLETQAAD QIKKLYDLFL KVDATQVEVN 240 241 PLGETPQGQV VCFDAKINFD DNAEFRQKAV FAMDDTAESD PTETEAAKYD LKYIGLDGNI 300 301 ACFVNGAGLA MATCDIIDLH GGKPANFLDL GGGVKENQVY AAFKLLTADP KVEAILVNIF 360 361 GGIVNCAIIA NGITKACREL ELKVPLVVRL EGTNVQEAKR ILSESGLPIT AASDLDDAAR 420 421 KAVAAIAKK 429 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCGGCGT GCATGATGTG GAGAGCGGTG CAGAGCGGAG CTGAGCGCGC GGGCCGGTTA 60 61 CTGCGCACGA GACAGGTGGT CAAGGTGAGC CCCAGAAGAT GGCTGAACCT TCAGGAGTAT 120 121 CAGAGCAAGA AGCTGATGCA GGACAGCGGA GTGACGGTCC AGCGCTTCTT CGTGGCCGAC 180 181 ACCGCTGACG AAGCCCTGCA GGCTGCAAAG AGGCTCAATG CTAAAGAGAT TGTTCTGAAG 240 241 GCTCAGATTC TGGCAGGAGG TCGGGGTAAA GGAGTCTTTG ACAGCGGCCT GAAAGGAGGT 300 301 GTGCACTTAA CCAAAGACCC TGCAGTGGTG GGCGATTTGG CTGGCAAGAT GCTCGGCTTC 360 361 AACCTGACCA CCAAGCAGAC CCCTAAGGAC GGCGTGAAAG TAAAAACGGT GATGGTGGCG 420 421 GAGGCTTTGG ACATCTCCAG AGAAACATAC TTTGCTATCC TGATGGACCG GGCGTGTAAC 480 481 GGGCCTGTTA TGGTGGGCAG TCCGCAGGGT GGAGTGGACA TAGAGGAGGT AGCAGCCAAA 540 541 ACACCAGAGC TCATATTCAA GGAACCCATA GATATTTTCG AAGGTGTTCG AGACGACCAG 600 601 GCTCGGCGCA TGGCAGCTAA TTTGGGCTTC AAAGGGCCGC TGGAGACTCA GGCTGCAGAT 660 661 CAGATTAAGA AGCTCTATGA TCTGTTCCTG AAAGTCGACG CCACTCAAGT GGAAGTCAAT 720 721 CCTCTCGGGG AGACTCCCCA AGGACAAGTT GTTTGCTTTG ATGCCAAAAT CAACTTTGAC 780 781 GACAACGCAG AGTTCCGCCA GAAAGCCGTC TTCGCCATGG ACGACACGGC CGAGAGTGAC 840 841 CCCACAGAAA CAGAGGCGGC CAAATATGAC CTCAAATACA TCGGCCTGGA CGGCAACATC 900 901 GCCTGCTTTG TCAATGGCGC CGGTCTCGCA ATGGCAACCT GTGACATCAT CGACCTGCAT 960 961 GGCGGGAAAC CGGCGAACTT CTTGGACCTG GGAGGTGGGG TGAAGGAGAA CCAGGTCTAT 1020 1021 GCAGCCTTCA AACTGCTGAC TGCCGACCCA AAGGTAGAGG CCATTCTGGT GAACATCTTT 1080 1081 GGCGGTATTG TGAACTGTGC CATCATCGCT AACGGCATCA CGAAAGCCTG CAGAGAGCTG 1140 1141 GAGCTCAAGG TGCCCTTGGT CGTCCGGCTG GAAGGTACGA ACGTGCAGGA GGCTAAGCGG 1200 1201 ATCCTGTCGG AGAGCGGCCT GCCCATCACT GCTGCCAGCG ACCTGGACGA CGCAGCCAGG 1260 1261 AAAGCAGTAG CCGCTATCGC TAAGAAATAA 1290 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Mitochondrion | |
Molecular Function | ATP binding | |
Molecular Function | GTP binding | |
Molecular Function | Magnesium ion binding | |
Molecular Function | Succinate-CoA ligase (ADP-forming) activity | |
Molecular Function | Succinate-CoA ligase (GDP-forming) activity | |
Biological Process | Succinyl-CoA metabolic process | |
Biological Process | Tricarboxylic acid cycle |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Scm-3874 | Scophthalmus maximus | 92.54 | 0.0 | 734 |
| LLPS-Orn-1384 | Oreochromis niloticus | 91.86 | 0.0 | 719 |
| LLPS-Gaa-1267 | Gasterosteus aculeatus | 91.19 | 0.0 | 719 |
| LLPS-Dar-1599 | Danio rerio | 90.27 | 0.0 | 754 |
| LLPS-Ten-0508 | Tetraodon nigroviridis | 90.21 | 0.0 | 718 |
| LLPS-Pof-3972 | Poecilia formosa | 89.85 | 0.0 | 717 |
| LLPS-Xim-0252 | Xiphophorus maculatus | 89.65 | 0.0 | 722 |
| LLPS-Tar-1659 | Takifugu rubripes | 89.2 | 0.0 | 709 |
| LLPS-Lac-2314 | Latimeria chalumnae | 86.83 | 0.0 | 664 |
| LLPS-Leo-1344 | Lepisosteus oculatus | 85.95 | 0.0 | 732 |
| LLPS-Fud-0525 | Fukomys damarensis | 85.75 | 0.0 | 659 |
| LLPS-Xet-1415 | Xenopus tropicalis | 85.52 | 0.0 | 645 |
| LLPS-Pes-1317 | Pelodiscus sinensis | 85.48 | 0.0 | 659 |
| LLPS-Sus-2016 | Sus scrofa | 85.24 | 0.0 | 697 |
| LLPS-Cap-2900 | Cavia porcellus | 84.91 | 0.0 | 686 |
| LLPS-Orc-3988 | Oryctolagus cuniculus | 84.73 | 0.0 | 691 |
| LLPS-Bot-4226 | Bos taurus | 84.71 | 0.0 | 693 |
| LLPS-Fia-2214 | Ficedula albicollis | 84.48 | 0.0 | 692 |
| LLPS-Ova-0560 | Ovis aries | 84.21 | 0.0 | 689 |
| LLPS-Fec-2272 | Felis catus | 84.21 | 0.0 | 691 |
| LLPS-Eqc-0466 | Equus caballus | 84.0 | 0.0 | 692 |
| LLPS-Mup-0050 | Mustela putorius furo | 83.71 | 0.0 | 686 |
| LLPS-Cas-4072 | Carlito syrichta | 83.51 | 1e-173 | 498 |
| LLPS-Ora-1945 | Ornithorhynchus anatinus | 83.45 | 2e-172 | 492 |
| LLPS-Caf-0774 | Canis familiaris | 83.21 | 0.0 | 683 |
| LLPS-Tag-3335 | Taeniopygia guttata | 83.13 | 0.0 | 569 |
| LLPS-Icp-1132 | Ictalurus punctatus | 83.12 | 0.0 | 633 |
| LLPS-Anc-1400 | Anolis carolinensis | 83.01 | 0.0 | 698 |
| LLPS-Anp-0344 | Anas platyrhynchos | 82.93 | 0.0 | 569 |
| LLPS-Pat-0223 | Pan troglodytes | 82.86 | 0.0 | 663 |
| LLPS-Gaga-1412 | Gallus gallus | 82.65 | 0.0 | 702 |
| LLPS-Paa-4441 | Papio anubis | 82.61 | 0.0 | 662 |
| LLPS-Mal-3938 | Mandrillus leucophaeus | 82.61 | 0.0 | 661 |
| LLPS-Nol-4033 | Nomascus leucogenys | 82.61 | 0.0 | 660 |
| LLPS-Hos-1303 | Homo sapiens | 82.61 | 0.0 | 661 |
| LLPS-Aon-3163 | Aotus nancymaae | 82.52 | 0.0 | 660 |
| LLPS-Otg-4308 | Otolemur garnettii | 82.43 | 0.0 | 683 |
| LLPS-Urm-1457 | Ursus maritimus | 82.38 | 0.0 | 677 |
| LLPS-Ran-1334 | Rattus norvegicus | 82.25 | 0.0 | 667 |
| LLPS-Chs-2072 | Chlorocebus sabaeus | 82.17 | 0.0 | 696 |
| LLPS-Caj-4169 | Callithrix jacchus | 81.93 | 0.0 | 662 |
| LLPS-Myl-2055 | Myotis lucifugus | 81.88 | 1e-170 | 488 |
| LLPS-Mod-3573 | Monodelphis domestica | 81.77 | 0.0 | 694 |
| LLPS-Scf-3637 | Scleropages formosus | 81.62 | 0.0 | 692 |
| LLPS-Meg-2722 | Meleagris gallopavo | 81.53 | 0.0 | 699 |
| LLPS-Mum-3368 | Mus musculus | 80.92 | 0.0 | 684 |
| LLPS-Loa-3665 | Loxodonta africana | 80.72 | 0.0 | 685 |
| LLPS-Mam-4070 | Macaca mulatta | 80.4 | 0.0 | 643 |
| LLPS-Gog-2081 | Gorilla gorilla | 80.3 | 0.0 | 661 |
| LLPS-Ict-4345 | Ictidomys tridecemlineatus | 79.08 | 0.0 | 617 |
| LLPS-Pap-2675 | Pan paniscus | 78.72 | 0.0 | 660 |
| LLPS-Cea-3119 | Cercocebus atys | 78.16 | 0.0 | 644 |
| LLPS-Maf-2753 | Macaca fascicularis | 77.8 | 0.0 | 684 |
| LLPS-Man-4745 | Macaca nemestrina | 77.8 | 0.0 | 684 |
| LLPS-Mea-0877 | Mesocricetus auratus | 75.96 | 6e-165 | 475 |
| LLPS-Rhb-0508 | Rhinopithecus bieti | 75.26 | 0.0 | 577 |
| LLPS-Poa-1729 | Pongo abelii | 75.18 | 0.0 | 619 |
| LLPS-Dio-0963 | Dipodomys ordii | 75.0 | 0.0 | 624 |
| LLPS-Orl-2776 | Oryzias latipes | 69.42 | 2e-179 | 513 |
| LLPS-Cii-1441 | Ciona intestinalis | 68.45 | 0.0 | 543 |
| LLPS-Cis-1802 | Ciona savignyi | 68.37 | 0.0 | 536 |
| LLPS-Mua-1381 | Musa acuminata | 65.71 | 3e-06 | 51.2 |
| LLPS-Drm-0441 | Drosophila melanogaster | 58.23 | 3e-159 | 463 |
| LLPS-Cae-1164 | Caenorhabditis elegans | 56.41 | 9e-153 | 447 |
| LLPS-Sah-1082 | Sarcophilus harrisii | 55.32 | 5e-144 | 426 |
| LLPS-Zem-1047 | Zea mays | 55.26 | 8e-127 | 383 |
| LLPS-Aim-0250 | Ailuropoda melanoleuca | 55.06 | 7e-144 | 426 |
| LLPS-Phv-0767 | Phaseolus vulgaris | 54.78 | 2e-140 | 416 |
| LLPS-Art-0725 | Arabidopsis thaliana | 54.38 | 1e-137 | 408 |
| LLPS-Via-0769 | Vigna angularis | 54.26 | 2e-139 | 413 |
| LLPS-Glm-1026 | Glycine max | 54.26 | 5e-140 | 414 |
| LLPS-Cus-0361 | Cucumis sativus | 54.12 | 2e-137 | 408 |
| LLPS-Arl-0713 | Arabidopsis lyrata | 54.01 | 3e-138 | 410 |
| LLPS-Lep-1662 | Leersia perrieri | 54.01 | 4e-136 | 404 |
| LLPS-Orgl-0621 | Oryza glumaepatula | 54.01 | 6e-136 | 404 |
| LLPS-Orni-0252 | Oryza nivara | 54.01 | 6e-136 | 404 |
| LLPS-Orb-0232 | Oryza barthii | 54.01 | 6e-136 | 404 |
| LLPS-Ori-0269 | Oryza indica | 54.01 | 6e-136 | 404 |
| LLPS-Org-0003 | Oryza glaberrima | 54.01 | 6e-136 | 404 |
| LLPS-Orm-1033 | Oryza meridionalis | 54.01 | 6e-136 | 404 |
| LLPS-Orr-0425 | Oryza rufipogon | 54.01 | 6e-136 | 404 |
| LLPS-Ors-0677 | Oryza sativa | 54.01 | 6e-136 | 404 |
| LLPS-Sei-1329 | Setaria italica | 53.75 | 1e-136 | 405 |
| LLPS-Brn-0002 | Brassica napus | 53.75 | 3e-137 | 407 |
| LLPS-Orbr-0971 | Oryza brachyantha | 53.75 | 4e-135 | 402 |
| LLPS-Brr-3031 | Brassica rapa | 53.75 | 1e-137 | 408 |
| LLPS-Bro-1681 | Brassica oleracea | 53.49 | 1e-136 | 405 |
| LLPS-Sob-0565 | Sorghum bicolor | 53.49 | 7e-137 | 406 |
| LLPS-Hov-0503 | Hordeum vulgare | 53.23 | 1e-133 | 398 |
| LLPS-Thc-1032 | Theobroma cacao | 53.23 | 1e-134 | 401 |
| LLPS-Coc-0369 | Corchorus capsularis | 53.23 | 1e-135 | 403 |
| LLPS-Viv-0627 | Vitis vinifera | 53.23 | 2e-134 | 400 |
| LLPS-Prp-0831 | Prunus persica | 53.09 | 5e-133 | 397 |
| LLPS-Met-0285 | Medicago truncatula | 52.97 | 2e-134 | 400 |
| LLPS-Gor-2709 | Gossypium raimondii | 52.97 | 1e-134 | 401 |
| LLPS-Sem-0805 | Selaginella moellendorffii | 52.79 | 2e-126 | 380 |
| LLPS-Brd-0292 | Brachypodium distachyon | 52.71 | 4e-133 | 397 |
| LLPS-Tra-0273 | Triticum aestivum | 52.71 | 2e-132 | 395 |
| LLPS-Dac-0483 | Daucus carota | 52.71 | 6e-135 | 401 |
| LLPS-Tru-1306 | Triticum urartu | 52.71 | 2e-132 | 395 |
| LLPS-Chc-0582 | Chondrus crispus | 52.7 | 5e-134 | 400 |
| LLPS-Trr-0933 | Trichoderma reesei | 52.6 | 1e-129 | 389 |
| LLPS-Php-0392 | Physcomitrella patens | 52.43 | 2e-128 | 385 |
| LLPS-Osl-0712 | Ostreococcus lucimarinus | 52.33 | 9e-127 | 380 |
| LLPS-Chr-1285 | Chlamydomonas reinhardtii | 52.2 | 2e-125 | 377 |
| LLPS-Hea-2695 | Helianthus annuus | 52.2 | 5e-133 | 396 |
| LLPS-Trv-0404 | Trichoderma virens | 52.08 | 5e-127 | 382 |
| LLPS-Lem-1324 | Leptosphaeria maculans | 51.94 | 8e-133 | 397 |
| LLPS-Mae-2353 | Manihot esculenta | 51.94 | 4e-131 | 392 |
| LLPS-Vir-0194 | Vigna radiata | 51.68 | 6e-131 | 390 |
| LLPS-Map-0662 | Magnaporthe poae | 51.56 | 3e-125 | 377 |
| LLPS-Pot-0936 | Populus trichocarpa | 51.42 | 5e-129 | 386 |
| LLPS-Sot-0874 | Solanum tuberosum | 51.29 | 5e-133 | 396 |
| LLPS-Sol-1002 | Solanum lycopersicum | 51.29 | 9e-133 | 396 |
| LLPS-Fus-1060 | Fusarium solani | 51.16 | 1e-126 | 381 |
| LLPS-Abg-1138 | Absidia glauca | 51.1 | 6e-138 | 410 |
| LLPS-Coo-0852 | Colletotrichum orbiculare | 51.04 | 4e-121 | 367 |
| LLPS-Asfu-0213 | Aspergillus fumigatus | 51.04 | 1e-128 | 386 |
| LLPS-Nia-1866 | Nicotiana attenuata | 51.03 | 3e-131 | 392 |
| LLPS-Amt-1300 | Amborella trichopoda | 51.0 | 2e-113 | 345 |
| LLPS-Gag-0432 | Gaeumannomyces graminis | 50.78 | 5e-128 | 385 |
| LLPS-Crn-1328 | Cryptococcus neoformans | 50.78 | 3e-129 | 387 |
| LLPS-Nef-0014 | Neosartorya fischeri | 50.78 | 2e-128 | 385 |
| LLPS-Ast-0056 | Aspergillus terreus | 50.78 | 3e-128 | 385 |
| LLPS-Beb-0661 | Beauveria bassiana | 50.52 | 3e-124 | 375 |
| LLPS-Phn-1291 | Phaeosphaeria nodorum | 50.5 | 9e-128 | 384 |
| LLPS-Asn-0084 | Aspergillus nidulans | 50.26 | 2e-125 | 378 |
| LLPS-Ved-0064 | Verticillium dahliae | 50.26 | 3e-117 | 357 |
| LLPS-Spr-0468 | Sporisorium reilianum | 50.24 | 2e-133 | 397 |
| LLPS-Asf-0373 | Aspergillus flavus | 50.13 | 4e-121 | 368 |
| LLPS-Fuv-1001 | Fusarium verticillioides | 50.13 | 2e-125 | 378 |
| LLPS-Yal-0561 | Yarrowia lipolytica | 50.13 | 5e-128 | 384 |
| LLPS-Fuo-0481 | Fusarium oxysporum | 50.13 | 3e-125 | 377 |
| LLPS-Mao-1359 | Magnaporthe oryzae | 50.0 | 2e-123 | 373 |
| LLPS-Mel-1187 | Melampsora laricipopulina | 50.0 | 7e-119 | 360 |
| LLPS-Asni-1111 | Aspergillus niger | 50.0 | 1e-125 | 378 |
| LLPS-Pug-0329 | Puccinia graminis | 49.87 | 5e-118 | 358 |
| LLPS-Pytr-1104 | Pyrenophora triticirepentis | 49.76 | 9e-131 | 391 |
| LLPS-Blg-0257 | Blumeria graminis | 49.74 | 5e-125 | 377 |
| LLPS-Tum-0021 | Tuber melanosporum | 49.61 | 3e-124 | 375 |
| LLPS-Usm-0563 | Ustilago maydis | 49.52 | 6e-133 | 396 |
| LLPS-Pyt-0414 | Pyrenophora teres | 49.51 | 3e-130 | 390 |
| LLPS-Asc-0544 | Aspergillus clavatus | 49.51 | 1e-129 | 389 |
| LLPS-Miv-0055 | Microbotryum violaceum | 49.26 | 9e-125 | 375 |
| LLPS-Kop-0056 | Komagataella pastoris | 49.25 | 1e-123 | 372 |
| LLPS-Aso-0415 | Aspergillus oryzae | 48.88 | 8e-124 | 374 |
| LLPS-Cog-0826 | Colletotrichum gloeosporioides | 48.68 | 4e-103 | 319 |
| LLPS-Nec-0832 | Neurospora crassa | 48.65 | 7e-125 | 377 |
| LLPS-Cym-0027 | Cyanidioschyzon merolae | 48.48 | 8e-118 | 359 |
| LLPS-Scc-1115 | Schizosaccharomyces cryophilus | 48.45 | 9e-115 | 350 |
| LLPS-Cogr-0335 | Colletotrichum graminicola | 48.43 | 1e-120 | 365 |
| LLPS-Scp-1401 | Schizosaccharomyces pombe | 47.89 | 3e-118 | 359 |
| LLPS-Put-0845 | Puccinia triticina | 47.88 | 9e-93 | 290 |
| LLPS-Gas-0957 | Galdieria sulphuraria | 47.83 | 7e-124 | 374 |
| LLPS-Zyt-1202 | Zymoseptoria tritici | 47.32 | 3e-128 | 385 |
| LLPS-Dos-0292 | Dothistroma septosporum | 47.32 | 1e-126 | 381 |
| LLPS-Scj-0526 | Schizosaccharomyces japonicus | 46.72 | 2e-114 | 349 |
| LLPS-Asg-1061 | Ashbya gossypii | 45.78 | 7e-114 | 347 |
| LLPS-Sac-1451 | Saccharomyces cerevisiae | 45.06 | 7e-125 | 376 |