LLPS-Pof-2978
SUCLA2
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase subunit beta; A-SCS; Succinyl-CoA synthetase beta-A chain; SCS-betaA |
| Gene Name: | SUCLA2 |
| Ensembl Gene: | ENSPFOG00000010701.1 |
| Ensembl Protein: | ENSPFOP00000010788.1 |
| Organism: | Poecilia formosa |
| Taxa ID: | 48698 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSPFOT00000010804.1 | ENSPFOP00000010788.1 |
| UniProt | A0A087XYD5, A0A087XYD5_POEFO | |
| GeneBank | AYCK01022972 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MRVRDFSAVS GDMATSLICG CLTASLRSSG ARNTISSASK VLGGSTGLFG GHVSQLQPPH 60 61 LQQQQRNLSL HEYMSIGLLK EAGISVPAGM VASSSDEAYD VAKKIGSKDL VVKAQVLAGG 120 121 RGKGTFEGGL KGGVKIVYSP EEAREISSQM IGRKLFTKQT GEAGRICNQV FICERRYPRR 180 181 EYYFAITMER SFQGPVLIGS SQGGVNIEDV AAENPDAIVK EPIDIVEGIK KEQAVKVAQK 240 241 MGFPDALVDE AAENMIKLYN VFIKYDASML EINPMVEDSS GVVMCMDAKI NFDSNAAYRQ 300 301 KKVFDMRDWS QEDPRDQQAA TADLNYIGLD GTIGCLVNGA GLAMATMDII KLHGGTPANF 360 361 LDVGGGATAH QVTEAFKLIT SDQKVQAILV NIFGGIMRCD VIAQGIIMAV RDLDLKIPIV 420 421 VRLQGTRVDD AKALIASSPL KILACDDLDE AAKMVVKLSE IVSLAKEAQV DITFQLPI 478 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCGCGTTC GTGACTTCTC CGCTGTATCG GGAGACATGG CGACGTCCCT GATTTGCGGC 60 61 TGTTTGACGG CTAGCCTGAG ATCTTCGGGG GCCAGAAACA CTATCAGCTC TGCTTCAAAG 120 121 GTCCTTGGAG GCTCCACGGG TCTGTTCGGT GGCCATGTGT CCCAGCTGCA GCCTCCCCAC 180 181 CTGCAGCAGC AGCAGAGGAA CCTCTCCCTA CATGAATACA TGAGCATAGG CCTGCTGAAA 240 241 GAAGCCGGCA TCTCCGTACC GGCGGGAATG GTGGCCAGCT CCTCTGACGA GGCGTACGAT 300 301 GTGGCCAAGA AGATCGGTTC TAAGGACCTG GTGGTGAAAG CTCAGGTTCT GGCCGGAGGC 360 361 AGAGGGAAGG GGACGTTTGA GGGCGGACTG AAGGGAGGAG TGAAGATCGT CTACTCCCCA 420 421 GAAGAGGCTC GGGAAATTTC CTCTCAGATG ATTGGTCGAA AACTGTTCAC CAAACAGACC 480 481 GGGGAGGCGG GTCGGATCTG CAACCAGGTG TTCATTTGCG AGCGCAGGTA CCCGCGCAGA 540 541 GAGTACTACT TCGCCATCAC CATGGAGAGG TCTTTTCAGG GTCCCGTGCT GATTGGCAGC 600 601 TCGCAGGGGG GCGTGAACAT CGAAGACGTG GCGGCAGAAA ATCCAGACGC CATTGTGAAA 660 661 GAGCCCATCG ACATCGTAGA GGGCATTAAG AAGGAGCAGG CTGTCAAGGT TGCTCAGAAG 720 721 ATGGGCTTCC CAGACGCTCT GGTGGACGAG GCGGCGGAGA ACATGATCAA GCTCTACAAC 780 781 GTTTTCATCA AGTACGACGC CTCCATGTTG GAGATCAATC CCATGGTGGA GGACTCCTCT 840 841 GGAGTCGTGA TGTGCATGGA TGCAAAAATC AACTTTGACT CCAACGCGGC GTATCGCCAG 900 901 AAGAAGGTGT TTGATATGAG GGACTGGAGC CAGGAGGACC CCCGGGACCA ACAGGCTGCC 960 961 ACGGCTGACC TCAACTACAT TGGTCTGGAC GGGACCATCG GCTGTCTGGT TAACGGTGCT 1020 1021 GGTCTGGCTA TGGCCACCAT GGACATCATC AAGCTCCACG GCGGCACACC GGCCAACTTC 1080 1081 CTGGACGTAG GAGGCGGGGC CACGGCCCAT CAGGTGACGG AGGCGTTCAA ACTCATCACT 1140 1141 TCAGACCAGA AGGTTCAGGC CATCCTGGTC AACATCTTTG GAGGCATCAT GAGGTGTGAT 1200 1201 GTCATCGCCC AGGGCATCAT CATGGCTGTG AGAGACCTGG ATCTCAAAAT CCCCATCGTA 1260 1261 GTACGGTTAC AAGGAACGAG AGTGGACGAC GCCAAAGCTC TGATCGCTTC CAGCCCTCTG 1320 1321 AAAATCCTGG CCTGTGACGA CCTGGACGAA GCTGCAAAGA TGGTTGTAAA ACTTTCTGAA 1380 1381 ATCGTTTCCT TGGCAAAAGA AGCTCAAGTG GACATCACCT TCCAGCTGCC CATCTAA 1437 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Mitochondrion | |
Molecular Function | ATP binding | |
Molecular Function | Magnesium ion binding | |
Molecular Function | Succinate-CoA ligase (ADP-forming) activity | |
Biological Process | Tricarboxylic acid cycle |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Xim-3824 | Xiphophorus maculatus | 99.37 | 0.0 | 900 |
| LLPS-Orl-0171 | Oryzias latipes | 94.64 | 0.0 | 842 |
| LLPS-Orn-2682 | Oreochromis niloticus | 93.78 | 0.0 | 810 |
| LLPS-Scm-3604 | Scophthalmus maximus | 90.95 | 0.0 | 801 |
| LLPS-Gaa-2635 | Gasterosteus aculeatus | 90.77 | 0.0 | 789 |
| LLPS-Asm-3637 | Astyanax mexicanus | 90.34 | 0.0 | 807 |
| LLPS-Dar-0946 | Danio rerio | 88.63 | 0.0 | 800 |
| LLPS-Icp-3874 | Ictalurus punctatus | 87.58 | 0.0 | 800 |
| LLPS-Scf-0974 | Scleropages formosus | 86.48 | 0.0 | 778 |
| LLPS-Anp-1205 | Anas platyrhynchos | 84.58 | 0.0 | 720 |
| LLPS-Tag-1029 | Taeniopygia guttata | 84.37 | 0.0 | 712 |
| LLPS-Cas-2235 | Carlito syrichta | 84.29 | 0.0 | 676 |
| LLPS-Fia-2300 | Ficedula albicollis | 84.28 | 0.0 | 716 |
| LLPS-Caf-2525 | Canis familiaris | 84.2 | 0.0 | 679 |
| LLPS-Leo-0496 | Lepisosteus oculatus | 83.73 | 0.0 | 724 |
| LLPS-Gaga-1225 | Gallus gallus | 83.08 | 0.0 | 746 |
| LLPS-Meg-0511 | Meleagris gallopavo | 82.66 | 0.0 | 741 |
| LLPS-Lac-3532 | Latimeria chalumnae | 81.96 | 0.0 | 574 |
| LLPS-Ova-1736 | Ovis aries | 81.61 | 0.0 | 697 |
| LLPS-Tar-3670 | Takifugu rubripes | 81.12 | 0.0 | 691 |
| LLPS-Fec-1945 | Felis catus | 80.13 | 0.0 | 723 |
| LLPS-Urm-0308 | Ursus maritimus | 80.09 | 0.0 | 700 |
| LLPS-Pes-0157 | Pelodiscus sinensis | 80.04 | 0.0 | 691 |
| LLPS-Xet-0217 | Xenopus tropicalis | 79.87 | 0.0 | 721 |
| LLPS-Cap-4147 | Cavia porcellus | 79.61 | 0.0 | 707 |
| LLPS-Ict-0372 | Ictidomys tridecemlineatus | 79.49 | 0.0 | 722 |
| LLPS-Mup-0492 | Mustela putorius furo | 79.32 | 0.0 | 717 |
| LLPS-Aim-0250 | Ailuropoda melanoleuca | 79.32 | 0.0 | 719 |
| LLPS-Sus-4023 | Sus scrofa | 79.27 | 0.0 | 716 |
| LLPS-Ora-1733 | Ornithorhynchus anatinus | 79.06 | 0.0 | 719 |
| LLPS-Orc-2864 | Oryctolagus cuniculus | 78.89 | 0.0 | 713 |
| LLPS-Bot-2101 | Bos taurus | 78.85 | 0.0 | 714 |
| LLPS-Fud-2273 | Fukomys damarensis | 78.85 | 0.0 | 707 |
| LLPS-Mum-3768 | Mus musculus | 78.85 | 0.0 | 714 |
| LLPS-Anc-1293 | Anolis carolinensis | 78.56 | 0.0 | 715 |
| LLPS-Mod-3054 | Monodelphis domestica | 77.78 | 0.0 | 704 |
| LLPS-Gog-1099 | Gorilla gorilla | 77.78 | 0.0 | 702 |
| LLPS-Pap-0445 | Pan paniscus | 77.56 | 0.0 | 702 |
| LLPS-Pat-2595 | Pan troglodytes | 77.56 | 0.0 | 702 |
| LLPS-Caj-1960 | Callithrix jacchus | 77.56 | 0.0 | 706 |
| LLPS-Mea-0320 | Mesocricetus auratus | 77.35 | 0.0 | 700 |
| LLPS-Poa-2372 | Pongo abelii | 77.14 | 0.0 | 700 |
| LLPS-Mam-0066 | Macaca mulatta | 77.14 | 0.0 | 699 |
| LLPS-Ran-2119 | Rattus norvegicus | 77.14 | 0.0 | 704 |
| LLPS-Maf-3242 | Macaca fascicularis | 77.14 | 0.0 | 699 |
| LLPS-Otg-1800 | Otolemur garnettii | 76.92 | 0.0 | 698 |
| LLPS-Rhb-4171 | Rhinopithecus bieti | 76.92 | 0.0 | 696 |
| LLPS-Man-1042 | Macaca nemestrina | 76.92 | 0.0 | 697 |
| LLPS-Paa-2656 | Papio anubis | 76.92 | 0.0 | 699 |
| LLPS-Mal-2326 | Mandrillus leucophaeus | 76.92 | 0.0 | 700 |
| LLPS-Dio-0117 | Dipodomys ordii | 76.92 | 0.0 | 698 |
| LLPS-Loa-3185 | Loxodonta africana | 76.91 | 0.0 | 679 |
| LLPS-Sah-1082 | Sarcophilus harrisii | 75.53 | 0.0 | 682 |
| LLPS-Nol-2957 | Nomascus leucogenys | 75.47 | 0.0 | 543 |
| LLPS-Hos-0066 | Homo sapiens | 74.03 | 0.0 | 688 |
| LLPS-Eqc-0337 | Equus caballus | 73.66 | 0.0 | 699 |
| LLPS-Cea-2469 | Cercocebus atys | 72.09 | 0.0 | 617 |
| LLPS-Chs-3620 | Chlorocebus sabaeus | 71.96 | 1e-116 | 351 |
| LLPS-Cis-0541 | Ciona savignyi | 71.01 | 0.0 | 583 |
| LLPS-Cii-1756 | Ciona intestinalis | 70.0 | 0.0 | 572 |
| LLPS-Aon-4584 | Aotus nancymaae | 69.66 | 0.0 | 599 |
| LLPS-Cae-1513 | Caenorhabditis elegans | 63.29 | 7e-170 | 493 |
| LLPS-Drm-0386 | Drosophila melanogaster | 60.05 | 5e-163 | 478 |
| LLPS-Abg-1138 | Absidia glauca | 58.68 | 1e-163 | 477 |
| LLPS-Mao-1359 | Magnaporthe oryzae | 58.6 | 2e-158 | 464 |
| LLPS-Ved-0064 | Verticillium dahliae | 58.35 | 1e-149 | 442 |
| LLPS-Trv-0404 | Trichoderma virens | 58.35 | 3e-155 | 456 |
| LLPS-Fus-1060 | Fusarium solani | 58.35 | 6e-155 | 455 |
| LLPS-Map-0662 | Magnaporthe poae | 58.35 | 2e-153 | 451 |
| LLPS-Asni-1111 | Aspergillus niger | 58.11 | 7e-156 | 457 |
| LLPS-Gag-0432 | Gaeumannomyces graminis | 58.11 | 8e-157 | 460 |
| LLPS-Nec-0832 | Neurospora crassa | 57.87 | 1e-153 | 452 |
| LLPS-Asfu-0213 | Aspergillus fumigatus | 57.63 | 1e-154 | 454 |
| LLPS-Cogr-0335 | Colletotrichum graminicola | 57.63 | 1e-150 | 444 |
| LLPS-Fuo-0481 | Fusarium oxysporum | 57.63 | 9e-155 | 455 |
| LLPS-Ast-0056 | Aspergillus terreus | 57.63 | 1e-156 | 459 |
| LLPS-Blg-0257 | Blumeria graminis | 57.63 | 5e-155 | 456 |
| LLPS-Fuv-1001 | Fusarium verticillioides | 57.63 | 2e-154 | 454 |
| LLPS-Trr-0933 | Trichoderma reesei | 57.38 | 9e-154 | 452 |
| LLPS-Nef-0014 | Neosartorya fischeri | 57.38 | 3e-154 | 453 |
| LLPS-Beb-0661 | Beauveria bassiana | 57.38 | 1e-153 | 452 |
| LLPS-Mel-1187 | Melampsora laricipopulina | 57.36 | 6e-143 | 424 |
| LLPS-Chc-0582 | Chondrus crispus | 57.28 | 3e-147 | 436 |
| LLPS-Asn-0084 | Aspergillus nidulans | 57.14 | 1e-154 | 454 |
| LLPS-Miv-0055 | Microbotryum violaceum | 57.11 | 8e-146 | 431 |
| LLPS-Pug-0329 | Puccinia graminis | 57.11 | 4e-141 | 419 |
| LLPS-Dos-0292 | Dothistroma septosporum | 56.9 | 4e-152 | 448 |
| LLPS-Phn-1291 | Phaeosphaeria nodorum | 56.9 | 8e-152 | 447 |
| LLPS-Coo-0852 | Colletotrichum orbiculare | 56.9 | 4e-148 | 438 |
| LLPS-Asc-0544 | Aspergillus clavatus | 56.9 | 4e-153 | 451 |
| LLPS-Crn-1328 | Cryptococcus neoformans | 56.88 | 1e-141 | 421 |
| LLPS-Asf-0373 | Aspergillus flavus | 56.82 | 7e-143 | 426 |
| LLPS-Spr-0468 | Sporisorium reilianum | 56.74 | 3e-143 | 425 |
| LLPS-Zyt-1202 | Zymoseptoria tritici | 56.66 | 3e-153 | 451 |
| LLPS-Scc-1115 | Schizosaccharomyces cryophilus | 56.66 | 7e-151 | 444 |
| LLPS-Pytr-1104 | Pyrenophora triticirepentis | 56.42 | 1e-152 | 449 |
| LLPS-Pyt-0414 | Pyrenophora teres | 56.42 | 1e-152 | 449 |
| LLPS-Tum-0021 | Tuber melanosporum | 55.93 | 1e-152 | 449 |
| LLPS-Scp-1401 | Schizosaccharomyces pombe | 55.69 | 4e-148 | 437 |
| LLPS-Lem-1324 | Leptosphaeria maculans | 55.69 | 2e-149 | 441 |
| LLPS-Zem-1047 | Zea mays | 55.62 | 1e-123 | 377 |
| LLPS-Gas-0957 | Galdieria sulphuraria | 54.96 | 4e-140 | 417 |
| LLPS-Amt-1300 | Amborella trichopoda | 54.89 | 2e-112 | 344 |
| LLPS-Aso-0415 | Aspergillus oryzae | 54.65 | 4e-148 | 438 |
| LLPS-Scj-0526 | Schizosaccharomyces japonicus | 54.48 | 4e-143 | 425 |
| LLPS-Yal-0561 | Yarrowia lipolytica | 54.48 | 1e-145 | 431 |
| LLPS-Sob-0565 | Sorghum bicolor | 54.29 | 1e-134 | 402 |
| LLPS-Sei-1329 | Setaria italica | 54.29 | 1e-132 | 397 |
| LLPS-Art-0725 | Arabidopsis thaliana | 54.06 | 4e-132 | 396 |
| LLPS-Usm-0563 | Ustilago maydis | 54.0 | 1e-138 | 413 |
| LLPS-Myl-2055 | Myotis lucifugus | 53.85 | 3e-87 | 276 |
| LLPS-Hea-2340 | Helianthus annuus | 53.79 | 4e-132 | 396 |
| LLPS-Hov-0503 | Hordeum vulgare | 53.59 | 2e-130 | 392 |
| LLPS-Brd-0292 | Brachypodium distachyon | 53.55 | 5e-131 | 393 |
| LLPS-Thc-1032 | Theobroma cacao | 53.55 | 9e-130 | 390 |
| LLPS-Tru-1306 | Triticum urartu | 53.54 | 4e-132 | 396 |
| LLPS-Org-0003 | Oryza glaberrima | 53.54 | 4e-133 | 399 |
| LLPS-Orm-1033 | Oryza meridionalis | 53.54 | 4e-133 | 399 |
| LLPS-Orr-0425 | Oryza rufipogon | 53.54 | 4e-133 | 399 |
| LLPS-Orbr-0971 | Oryza brachyantha | 53.54 | 1e-132 | 397 |
| LLPS-Ors-0677 | Oryza sativa | 53.54 | 4e-133 | 399 |
| LLPS-Tra-0273 | Triticum aestivum | 53.54 | 4e-132 | 396 |
| LLPS-Orgl-0621 | Oryza glumaepatula | 53.54 | 4e-133 | 399 |
| LLPS-Lep-1662 | Leersia perrieri | 53.54 | 3e-133 | 399 |
| LLPS-Orni-0252 | Oryza nivara | 53.54 | 4e-133 | 399 |
| LLPS-Ori-0269 | Oryza indica | 53.54 | 4e-133 | 399 |
| LLPS-Orb-0232 | Oryza barthii | 53.54 | 4e-133 | 399 |
| LLPS-Php-0392 | Physcomitrella patens | 53.49 | 2e-123 | 374 |
| LLPS-Arl-0713 | Arabidopsis lyrata | 53.3 | 7e-131 | 393 |
| LLPS-Coc-0369 | Corchorus capsularis | 53.28 | 1e-130 | 392 |
| LLPS-Cog-0826 | Colletotrichum gloeosporioides | 53.28 | 1e-120 | 366 |
| LLPS-Put-0845 | Puccinia triticina | 53.18 | 7e-105 | 323 |
| LLPS-Gor-1977 | Gossypium raimondii | 53.05 | 3e-129 | 389 |
| LLPS-Cus-0361 | Cucumis sativus | 53.05 | 1e-129 | 390 |
| LLPS-Sot-0874 | Solanum tuberosum | 53.05 | 9e-132 | 395 |
| LLPS-Glm-1026 | Glycine max | 53.05 | 2e-132 | 397 |
| LLPS-Mua-1569 | Musa acuminata | 52.97 | 1e-127 | 385 |
| LLPS-Ten-0508 | Tetraodon nigroviridis | 52.94 | 2e-126 | 382 |
| LLPS-Bro-1681 | Brassica oleracea | 52.79 | 5e-130 | 390 |
| LLPS-Brr-3031 | Brassica rapa | 52.79 | 2e-130 | 392 |
| LLPS-Brn-0002 | Brassica napus | 52.79 | 5e-130 | 390 |
| LLPS-Mae-2353 | Manihot esculenta | 52.54 | 2e-129 | 389 |
| LLPS-Phv-0767 | Phaseolus vulgaris | 52.54 | 1e-130 | 392 |
| LLPS-Via-0769 | Vigna angularis | 52.54 | 2e-130 | 392 |
| LLPS-Viv-0627 | Vitis vinifera | 52.53 | 7e-129 | 388 |
| LLPS-Asg-1061 | Ashbya gossypii | 52.53 | 2e-129 | 389 |
| LLPS-Sem-0805 | Selaginella moellendorffii | 52.37 | 8e-119 | 362 |
| LLPS-Nia-1866 | Nicotiana attenuata | 52.28 | 1e-128 | 387 |
| LLPS-Sol-1002 | Solanum lycopersicum | 52.28 | 1e-129 | 390 |
| LLPS-Osl-0712 | Ostreococcus lucimarinus | 52.06 | 8e-124 | 375 |
| LLPS-Pot-0936 | Populus trichocarpa | 52.02 | 5e-128 | 385 |
| LLPS-Dac-0483 | Daucus carota | 52.02 | 1e-128 | 387 |
| LLPS-Prp-0831 | Prunus persica | 51.78 | 5e-126 | 380 |
| LLPS-Met-0285 | Medicago truncatula | 51.52 | 3e-129 | 389 |
| LLPS-Kop-0056 | Komagataella pastoris | 50.76 | 7e-120 | 364 |
| LLPS-Vir-0194 | Vigna radiata | 50.0 | 7e-119 | 361 |
| LLPS-Chr-1285 | Chlamydomonas reinhardtii | 49.87 | 3e-117 | 358 |
| LLPS-Sac-1451 | Saccharomyces cerevisiae | 49.28 | 3e-126 | 381 |
| LLPS-Cym-0027 | Cyanidioschyzon merolae | 46.08 | 8e-123 | 374 |