LLPS-Ova-1736
SUCLA2
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase subunit beta; A-SCS; Succinyl-CoA synthetase beta-A chain; SCS-betaA |
| Gene Name: | SUCLA2 |
| Ensembl Gene: | ENSOARG00000008171.1 |
| Ensembl Protein: | ENSOARP00000008768.1 |
| Organism: | Ovis aries |
| Taxa ID: | 9940 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSOART00000008895.1 | ENSOARP00000008768.1 |
| Ensembl | ENSOART00000008893.1 | ENSOARP00000008766.1 |
| UniProt | W5PEA2, W5PEA2_SHEEP | |
| GeneBank | AMGL01013786, AMGL01013784, AMGL01013781, AMGL01013783, AMGL01013782, AMGL01013785 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MHAQMHAGGD VVLCAPVPFS QSVRRLLTRT PSGPREAGNY RLRTTLSSFP RGRSADACRW 60 61 SPRRPLRPPG AAPAPPAPAA NQPEQVLGSF GLFNNHGVQI QHQQQRNLSL HEYLSMELLQ 120 121 EAGVSIPKGH VAKSPDEAYA IAKKLGSKDV VIKAQVLAGG RGKGTFESGL KGGVKIVFSP 180 181 EEAKAVSSQM IGKKLFTKQT GEKGRICNQV LVCERRYPRR EYYFAITMER SFQGPVLIGS 240 241 SHGGVNIEDV AAETPEAIVK EPIDIVEGIK KEQAVRLAEK MGFPASIVDS AAENMIKLYD 300 301 LFLKYDATMV EINPMVEDSD GAVLCMDAKI NFDANSAYRQ KKIFDLQDWT QEDERDKDAA 360 361 KADLNYIGLD GNIGCLVNGA GLAMATMDII KLHGGTPANF LDVGGGATVH QVTEAFKLIT 420 421 SDKKVLSILV NIFGGIMRCD VIAQGIVMAV KDLEIKIPIV VRLQGTRVDD AKALIADSGL 480 481 KILACDDLDE AAKMVVKLSE IVTLAKQAQV DVKFQLPI 518 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCACGCAC AGATGCACGC AGGAGGCGAC GTCGTCCTTT GCGCGCCCGT TCCATTTTCC 60 61 CAGTCAGTCA GGCGGCTGCT TACCCGAACT CCAAGTGGCC CCCGGGAAGC TGGAAACTAC 120 121 CGGCTCCGAA CGACCCTTTC CTCCTTCCCA AGAGGACGCA GCGCGGATGC CTGCCGCTGG 180 181 TCACCACGAC GCCCACTCCG ACCCCCAGGC GCCGCCCCCG CGCCCCCCGC GCCCGCTGCC 240 241 AATCAGCCTG AGCAGGTCCT GGGAAGCTTT GGATTGTTTA ACAACCATGG AGTCCAAATA 300 301 CAGCATCAAC AGCAAAGGAA TCTCTCGCTG CATGAATACC TGAGTATGGA ATTGTTGCAG 360 361 GAAGCTGGCG TCTCTATTCC CAAAGGACAT GTGGCTAAGT CACCAGATGA AGCTTATGCA 420 421 ATTGCCAAAA AATTAGGTTC AAAAGATGTT GTGATAAAGG CGCAAGTTTT GGCTGGTGGC 480 481 AGAGGAAAAG GAACATTTGA AAGTGGCCTC AAAGGTGGAG TGAAGATAGT TTTCTCTCCA 540 541 GAAGAAGCAA AAGCTGTTTC CTCACAAATG ATTGGGAAAA AGTTGTTTAC CAAGCAAACA 600 601 GGAGAAAAGG GCAGGATATG CAATCAAGTA TTGGTTTGTG AACGAAGATA TCCCAGGAGA 660 661 GAATACTACT TTGCAATCAC AATGGAAAGG TCATTTCAAG GTCCTGTATT AATAGGAAGT 720 721 TCTCACGGTG GTGTCAACAT TGAAGATGTT GCTGCTGAGA CTCCTGAGGC CATAGTTAAA 780 781 GAGCCTATCG ATATCGTAGA AGGCATCAAA AAGGAACAAG CTGTCCGGCT TGCAGAGAAG 840 841 ATGGGATTTC CAGCCAGTAT TGTGGATTCT GCAGCAGAAA ACATGATCAA GCTTTATGAC 900 901 CTTTTTCTGA AATACGATGC AACCATGGTA GAAATAAATC CAATGGTAGA GGATTCAGAT 960 961 GGAGCTGTGC TGTGTATGGA TGCAAAGATC AATTTTGATG CTAATTCAGC TTACCGACAG 1020 1021 AAGAAAATCT TTGACCTGCA GGACTGGACC CAGGAAGATG AAAGGGACAA AGATGCAGCT 1080 1081 AAGGCAGATC TCAACTACAT TGGCCTTGAC GGAAATATAG GCTGTCTCGT GAACGGTGCT 1140 1141 GGTTTGGCTA TGGCTACGAT GGATATAATA AAACTCCATG GAGGGACTCC AGCTAACTTT 1200 1201 CTTGATGTTG GTGGTGGTGC CACAGTCCAT CAAGTAACAG AAGCGTTTAA ACTTATCACT 1260 1261 TCAGATAAAA AGGTACTGTC TATTTTGGTC AACATTTTTG GAGGAATCAT GCGGTGTGAC 1320 1321 GTTATTGCAC AGGGTATAGT CATGGCAGTA AAGGATTTGG AAATTAAAAT ACCGATCGTG 1380 1381 GTACGGTTAC AAGGTACACG AGTTGATGAT GCTAAGGCAC TGATAGCGGA CAGTGGACTT 1440 1441 AAAATTCTTG CTTGTGATGA CTTGGACGAA GCTGCTAAAA TGGTTGTGAA GCTCTCTGAG 1500 1501 ATAGTGACCT TAGCCAAGCA AGCCCAGGTG GATGTGAAAT TTCAGTTGCC AATCTGA 1557 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Mitochondrion | |
Molecular Function | ATP binding | |
Molecular Function | Magnesium ion binding | |
Molecular Function | Succinate-CoA ligase (ADP-forming) activity | |
Biological Process | Tricarboxylic acid cycle |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Bot-2101 | Bos taurus | 99.31 | 0.0 | 861 |
| LLPS-Sus-4023 | Sus scrofa | 97.7 | 0.0 | 833 |
| LLPS-Fec-1945 | Felis catus | 96.77 | 0.0 | 842 |
| LLPS-Caf-2525 | Canis familiaris | 96.05 | 0.0 | 784 |
| LLPS-Mup-0492 | Mustela putorius furo | 95.85 | 0.0 | 825 |
| LLPS-Cas-2235 | Carlito syrichta | 95.29 | 0.0 | 770 |
| LLPS-Aim-0250 | Ailuropoda melanoleuca | 95.16 | 0.0 | 825 |
| LLPS-Urm-0308 | Ursus maritimus | 95.16 | 0.0 | 820 |
| LLPS-Caj-1960 | Callithrix jacchus | 94.93 | 0.0 | 821 |
| LLPS-Otg-1800 | Otolemur garnettii | 94.93 | 0.0 | 815 |
| LLPS-Orc-2864 | Oryctolagus cuniculus | 94.7 | 0.0 | 813 |
| LLPS-Poa-2372 | Pongo abelii | 94.47 | 0.0 | 816 |
| LLPS-Cap-4147 | Cavia porcellus | 94.47 | 0.0 | 813 |
| LLPS-Ict-0372 | Ictidomys tridecemlineatus | 94.47 | 0.0 | 812 |
| LLPS-Gog-1099 | Gorilla gorilla | 94.24 | 0.0 | 816 |
| LLPS-Pat-2595 | Pan troglodytes | 94.24 | 0.0 | 816 |
| LLPS-Pap-0445 | Pan paniscus | 94.24 | 0.0 | 816 |
| LLPS-Fud-2273 | Fukomys damarensis | 93.78 | 0.0 | 808 |
| LLPS-Rhb-4171 | Rhinopithecus bieti | 93.78 | 0.0 | 808 |
| LLPS-Mal-2326 | Mandrillus leucophaeus | 93.55 | 0.0 | 804 |
| LLPS-Paa-2656 | Papio anubis | 93.55 | 0.0 | 807 |
| LLPS-Man-1042 | Macaca nemestrina | 93.09 | 0.0 | 804 |
| LLPS-Maf-3242 | Macaca fascicularis | 92.86 | 0.0 | 801 |
| LLPS-Mam-0066 | Macaca mulatta | 92.86 | 0.0 | 801 |
| LLPS-Nol-2957 | Nomascus leucogenys | 92.73 | 0.0 | 641 |
| LLPS-Chs-3620 | Chlorocebus sabaeus | 92.02 | 5e-152 | 443 |
| LLPS-Mum-3768 | Mus musculus | 91.71 | 0.0 | 790 |
| LLPS-Dio-0117 | Dipodomys ordii | 91.71 | 0.0 | 792 |
| LLPS-Mea-0320 | Mesocricetus auratus | 91.47 | 0.0 | 786 |
| LLPS-Mod-3054 | Monodelphis domestica | 91.03 | 0.0 | 780 |
| LLPS-Ora-1733 | Ornithorhynchus anatinus | 90.55 | 0.0 | 794 |
| LLPS-Ran-2119 | Rattus norvegicus | 90.37 | 0.0 | 781 |
| LLPS-Sah-1082 | Sarcophilus harrisii | 90.14 | 0.0 | 772 |
| LLPS-Loa-3185 | Loxodonta africana | 89.73 | 0.0 | 778 |
| LLPS-Hos-0066 | Homo sapiens | 89.45 | 0.0 | 799 |
| LLPS-Eqc-0337 | Equus caballus | 88.75 | 0.0 | 805 |
| LLPS-Gaga-1225 | Gallus gallus | 88.63 | 0.0 | 765 |
| LLPS-Tag-1029 | Taeniopygia guttata | 88.4 | 0.0 | 761 |
| LLPS-Meg-0511 | Meleagris gallopavo | 87.94 | 0.0 | 760 |
| LLPS-Fia-2300 | Ficedula albicollis | 87.94 | 0.0 | 759 |
| LLPS-Anp-1205 | Anas platyrhynchos | 87.61 | 0.0 | 761 |
| LLPS-Cea-2469 | Cercocebus atys | 87.1 | 0.0 | 728 |
| LLPS-Pes-0157 | Pelodiscus sinensis | 86.49 | 0.0 | 716 |
| LLPS-Xet-0217 | Xenopus tropicalis | 85.29 | 0.0 | 757 |
| LLPS-Aon-4584 | Aotus nancymaae | 85.25 | 0.0 | 711 |
| LLPS-Anc-1293 | Anolis carolinensis | 84.22 | 0.0 | 747 |
| LLPS-Icp-3874 | Ictalurus punctatus | 83.56 | 0.0 | 740 |
| LLPS-Scm-3604 | Scophthalmus maximus | 82.98 | 0.0 | 719 |
| LLPS-Orn-2682 | Oreochromis niloticus | 82.81 | 0.0 | 712 |
| LLPS-Asm-3637 | Astyanax mexicanus | 81.84 | 0.0 | 729 |
| LLPS-Xim-3824 | Xiphophorus maculatus | 81.84 | 0.0 | 727 |
| LLPS-Pof-2978 | Poecilia formosa | 81.61 | 0.0 | 725 |
| LLPS-Dar-0946 | Danio rerio | 81.38 | 0.0 | 728 |
| LLPS-Gaa-2635 | Gasterosteus aculeatus | 81.36 | 0.0 | 701 |
| LLPS-Lac-3532 | Latimeria chalumnae | 80.76 | 0.0 | 557 |
| LLPS-Orl-0171 | Oryzias latipes | 80.69 | 0.0 | 720 |
| LLPS-Leo-0496 | Lepisosteus oculatus | 80.14 | 0.0 | 717 |
| LLPS-Scf-0974 | Scleropages formosus | 78.8 | 0.0 | 708 |
| LLPS-Tar-3670 | Takifugu rubripes | 75.54 | 0.0 | 628 |
| LLPS-Cis-0541 | Ciona savignyi | 70.74 | 0.0 | 600 |
| LLPS-Cii-1756 | Ciona intestinalis | 70.21 | 0.0 | 590 |
| LLPS-Cae-1513 | Caenorhabditis elegans | 63.04 | 8e-179 | 517 |
| LLPS-Abg-1138 | Absidia glauca | 61.35 | 2e-180 | 521 |
| LLPS-Miv-0055 | Microbotryum violaceum | 59.23 | 3e-156 | 459 |
| LLPS-Drm-0386 | Drosophila melanogaster | 59.19 | 4e-172 | 503 |
| LLPS-Mel-1187 | Melampsora laricipopulina | 58.63 | 6e-154 | 453 |
| LLPS-Pug-0329 | Puccinia graminis | 58.35 | 6e-150 | 443 |
| LLPS-Cogr-0335 | Colletotrichum graminicola | 58.23 | 7e-163 | 477 |
| LLPS-Ved-0064 | Verticillium dahliae | 58.03 | 2e-162 | 476 |
| LLPS-Coo-0852 | Colletotrichum orbiculare | 57.69 | 2e-162 | 476 |
| LLPS-Trv-0404 | Trichoderma virens | 57.69 | 8e-166 | 484 |
| LLPS-Nec-0832 | Neurospora crassa | 57.52 | 2e-167 | 489 |
| LLPS-Crn-1328 | Cryptococcus neoformans | 57.22 | 1e-152 | 450 |
| LLPS-Fuv-1001 | Fusarium verticillioides | 57.21 | 5e-166 | 485 |
| LLPS-Blg-0257 | Blumeria graminis | 57.21 | 6e-167 | 487 |
| LLPS-Beb-0661 | Beauveria bassiana | 57.21 | 9e-166 | 484 |
| LLPS-Fus-1060 | Fusarium solani | 57.21 | 5e-165 | 483 |
| LLPS-Fuo-0481 | Fusarium oxysporum | 57.21 | 3e-166 | 486 |
| LLPS-Myl-2055 | Myotis lucifugus | 56.99 | 4e-98 | 305 |
| LLPS-Asfu-0213 | Aspergillus fumigatus | 56.97 | 3e-168 | 491 |
| LLPS-Mao-1359 | Magnaporthe oryzae | 56.83 | 7e-168 | 490 |
| LLPS-Asni-1111 | Aspergillus niger | 56.73 | 9e-169 | 492 |
| LLPS-Asn-0084 | Aspergillus nidulans | 56.73 | 3e-166 | 485 |
| LLPS-Nef-0014 | Neosartorya fischeri | 56.73 | 7e-168 | 490 |
| LLPS-Trr-0933 | Trichoderma reesei | 56.73 | 9e-164 | 479 |
| LLPS-Chc-0582 | Chondrus crispus | 56.55 | 2e-154 | 455 |
| LLPS-Asc-0544 | Aspergillus clavatus | 56.49 | 6e-167 | 488 |
| LLPS-Ast-0056 | Aspergillus terreus | 56.49 | 5e-169 | 493 |
| LLPS-Gag-0432 | Gaeumannomyces graminis | 56.32 | 3e-167 | 488 |
| LLPS-Map-0662 | Magnaporthe poae | 56.32 | 9e-162 | 474 |
| LLPS-Asf-0373 | Aspergillus flavus | 56.06 | 3e-154 | 457 |
| LLPS-Usm-0563 | Ustilago maydis | 55.97 | 2e-150 | 445 |
| LLPS-Spr-0468 | Sporisorium reilianum | 55.72 | 1e-151 | 447 |
| LLPS-Dos-0292 | Dothistroma septosporum | 55.64 | 4e-165 | 483 |
| LLPS-Pyt-0414 | Pyrenophora teres | 55.53 | 9e-164 | 479 |
| LLPS-Pytr-1104 | Pyrenophora triticirepentis | 55.53 | 7e-164 | 479 |
| LLPS-Zyt-1202 | Zymoseptoria tritici | 55.37 | 3e-165 | 483 |
| LLPS-Lem-1324 | Leptosphaeria maculans | 55.29 | 1e-161 | 474 |
| LLPS-Phn-1291 | Phaeosphaeria nodorum | 55.29 | 3e-161 | 473 |
| LLPS-Scc-1115 | Schizosaccharomyces cryophilus | 55.16 | 8e-160 | 469 |
| LLPS-Scp-1401 | Schizosaccharomyces pombe | 54.94 | 1e-157 | 463 |
| LLPS-Tum-0021 | Tuber melanosporum | 54.94 | 8e-161 | 472 |
| LLPS-Aso-0415 | Aspergillus oryzae | 54.27 | 1e-161 | 474 |
| LLPS-Put-0845 | Puccinia triticina | 54.08 | 4e-113 | 346 |
| LLPS-Amt-1300 | Amborella trichopoda | 53.82 | 4e-119 | 362 |
| LLPS-Yal-0561 | Yarrowia lipolytica | 53.57 | 5e-157 | 462 |
| LLPS-Ten-0508 | Tetraodon nigroviridis | 53.57 | 4e-139 | 416 |
| LLPS-Gas-0957 | Galdieria sulphuraria | 53.54 | 2e-144 | 429 |
| LLPS-Cog-0826 | Colletotrichum gloeosporioides | 53.54 | 2e-131 | 395 |
| LLPS-Scj-0526 | Schizosaccharomyces japonicus | 53.49 | 6e-153 | 451 |
| LLPS-Zem-1047 | Zea mays | 53.32 | 2e-132 | 400 |
| LLPS-Hea-2695 | Helianthus annuus | 52.88 | 1e-137 | 412 |
| LLPS-Brr-3031 | Brassica rapa | 52.88 | 3e-140 | 418 |
| LLPS-Brn-0002 | Brassica napus | 52.63 | 7e-139 | 415 |
| LLPS-Glm-1026 | Glycine max | 52.63 | 7e-142 | 422 |
| LLPS-Arl-0713 | Arabidopsis lyrata | 52.63 | 7e-139 | 415 |
| LLPS-Cus-0361 | Cucumis sativus | 52.63 | 5e-139 | 415 |
| LLPS-Art-0725 | Arabidopsis thaliana | 52.63 | 1e-139 | 417 |
| LLPS-Bro-1681 | Brassica oleracea | 52.63 | 1e-138 | 414 |
| LLPS-Sei-1329 | Setaria italica | 52.62 | 4e-145 | 431 |
| LLPS-Sob-0565 | Sorghum bicolor | 52.62 | 1e-146 | 435 |
| LLPS-Phv-0767 | Phaseolus vulgaris | 52.38 | 9e-139 | 414 |
| LLPS-Mua-1569 | Musa acuminata | 52.3 | 8e-135 | 404 |
| LLPS-Php-0392 | Physcomitrella patens | 52.17 | 6e-129 | 389 |
| LLPS-Lep-1662 | Leersia perrieri | 52.14 | 3e-145 | 431 |
| LLPS-Tra-0273 | Triticum aestivum | 52.14 | 2e-144 | 429 |
| LLPS-Tru-1306 | Triticum urartu | 52.14 | 2e-144 | 429 |
| LLPS-Via-0769 | Vigna angularis | 52.13 | 1e-138 | 414 |
| LLPS-Viv-0627 | Vitis vinifera | 52.12 | 4e-138 | 413 |
| LLPS-Hov-0503 | Hordeum vulgare | 51.93 | 3e-142 | 424 |
| LLPS-Brd-0292 | Brachypodium distachyon | 51.91 | 1e-142 | 424 |
| LLPS-Sot-0874 | Solanum tuberosum | 51.88 | 1e-138 | 414 |
| LLPS-Chr-1285 | Chlamydomonas reinhardtii | 51.76 | 2e-128 | 388 |
| LLPS-Orb-0232 | Oryza barthii | 51.67 | 3e-144 | 429 |
| LLPS-Ori-0269 | Oryza indica | 51.67 | 3e-144 | 429 |
| LLPS-Orni-0252 | Oryza nivara | 51.67 | 3e-144 | 429 |
| LLPS-Orgl-0621 | Oryza glumaepatula | 51.67 | 3e-144 | 429 |
| LLPS-Ors-0677 | Oryza sativa | 51.67 | 3e-144 | 429 |
| LLPS-Orm-1033 | Oryza meridionalis | 51.67 | 3e-144 | 429 |
| LLPS-Orr-0425 | Oryza rufipogon | 51.67 | 3e-144 | 429 |
| LLPS-Org-0003 | Oryza glaberrima | 51.67 | 3e-144 | 429 |
| LLPS-Sol-1002 | Solanum lycopersicum | 51.63 | 1e-137 | 412 |
| LLPS-Prp-0831 | Prunus persica | 51.63 | 2e-136 | 409 |
| LLPS-Coc-0369 | Corchorus capsularis | 51.62 | 4e-136 | 407 |
| LLPS-Cym-0027 | Cyanidioschyzon merolae | 51.49 | 5e-145 | 432 |
| LLPS-Orbr-0971 | Oryza brachyantha | 51.43 | 7e-143 | 425 |
| LLPS-Thc-1032 | Theobroma cacao | 51.38 | 5e-135 | 405 |
| LLPS-Met-0285 | Medicago truncatula | 51.38 | 1e-137 | 412 |
| LLPS-Gor-1977 | Gossypium raimondii | 51.38 | 4e-135 | 405 |
| LLPS-Nia-1866 | Nicotiana attenuata | 51.38 | 4e-136 | 408 |
| LLPS-Dac-0483 | Daucus carota | 51.37 | 1e-136 | 409 |
| LLPS-Osl-0712 | Ostreococcus lucimarinus | 51.16 | 2e-126 | 383 |
| LLPS-Pot-0936 | Populus trichocarpa | 50.99 | 2e-133 | 401 |
| LLPS-Mae-2353 | Manihot esculenta | 50.88 | 1e-131 | 396 |
| LLPS-Sem-0805 | Selaginella moellendorffii | 50.78 | 2e-128 | 388 |
| LLPS-Asg-1061 | Ashbya gossypii | 50.5 | 3e-131 | 395 |
| LLPS-Kop-0056 | Komagataella pastoris | 50.12 | 7e-134 | 402 |
| LLPS-Vir-0194 | Vigna radiata | 49.62 | 6e-127 | 384 |
| LLPS-Sac-1451 | Saccharomyces cerevisiae | 48.18 | 4e-131 | 395 |