Mus musculus      Neuronal granule


※ Neuronal granule introduction

    Neuronal granules are also referred to as neuronal transport granules, RNA-transporting granules, neuronal RNA granules, dendritic P-body like structures (dlP-bodies), FMRP granules and Staufen granules(1,2). They are broadly identified by the presence of two highly conserved proteins: Staufen, a double-stranded RNA-binding protein and FMRP. As a kind of cytoplasmic RNP bodies located in Cytoplasm of neurons, neuronal transport RNPs have highly specialized functions and have been shown to interact or co-localize with components of GW/P bodies (1), it's microtubule-dependent and contain Silenced mRNAs and ribosomes components. Neuronal RNA bodies is of spherical shape with fluid characteristics, proved to be associated with rotein synthesis in response to exogenous stimuli (2).

Reference
1. Moser, J. J., & Fritzler, M. J. (2013) Relationship of other cytoplasmic ribonucleoprotein bodies (cRNPB) to GW/P bodies. Adv Exp Med Biol, 768, 213-242. PMID: 23224973
2. Hirano, M., Muto, M., Sakai, M., Kondo, H., Kobayashi, S., Kariwa, H., Yoshii, K.(2017) Dendritic transport of tick-borne flavivirus RNA by neuronal granules affects development of neurological disease. Proc Natl Acad Sci U S A, 114, 9960–9965. PMID: 28847946
3. Darling, A. L., Liu, Y., Oldfield, C. J., & Uversky, V. N. (2018) Intrinsically Disordered Proteome of Human Membrane-Less Organelles. Proteomics, 18(5-6), e1700193. PMID: 27838525


There are 49 genes.  Reviewed (45 or Unreviewed (4

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Mum-2842
ENSMUSG00000025134.2
O08583
Alyref
2
LLPS-Mum-0183
ENSMUSG00000027184.14
Q60865
Caprin1
3
LLPS-Mum-2821
ENSMUSG00000045193.13
P60824
Cirbp
4
LLPS-Mum-2171
ENSMUSG00000037149.10
Q91VR5
Ddx1
5
LLPS-Mum-2120
ENSMUSG00000000787.12
Q62167
Ddx3x
6
LLPS-Mum-1264
ENSMUSG00000020719.14
Q61656
Ddx5
7
LLPS-Mum-0218
ENSMUSG00000037742.14
P10126
Eef1a1
8
LLPS-Mum-3758
ENSMUSG00000027810.14
Q8BJW6
Eif2a
9
LLPS-Mum-1545
ENSMUSG00000021116.10
Q6ZWX6
Eif2s1
10
LLPS-Mum-2492
ENSMUSG00000074656.12
Q99L45
Eif2s2
11
LLPS-Mum-0621
ENSMUSG00000069049.11
Q9Z0N2
Eif2s3y
12
LLPS-Mum-1951
ENSMUSG00000028156.12
P63073
Eif4e
13
LLPS-Mum-1695
ENSMUSG00000028546.17
Q61701
Elavl4
14
LLPS-Mum-2279
ENSMUSG00000009079.16
Q61545
Ewsr1
15
LLPS-Mum-2682
ENSMUSG00000000838.17
P35922
Fmr1
16
LLPS-Mum-1971
ENSMUSG00000027680.15
Q61584
Fxr1
17
LLPS-Mum-4367
ENSMUSG00000018765.5
Q9WVR4
Fxr2
18
LLPS-Mum-0638
ENSMUSG00000018583.5
P97855
G3bp1
19
LLPS-Mum-1525
ENSMUSG00000007836.6
Q9CX86
Hnrnpa0
20
LLPS-Mum-2872
ENSMUSG00000046434.16
P49312
Hnrnpa1
21
LLPS-Mum-2703
ENSMUSG00000004980.16
O88569
Hnrnpa2b1
22
LLPS-Mum-0889
ENSMUSG00000020358.17
Q99020
Hnrnpab
23
LLPS-Mum-1345
ENSMUSG00000000568.15
Q60668
Hnrnpd
24
LLPS-Mum-1798
ENSMUSG00000039630.10
Q8VEK3
Hnrnpu
25
LLPS-Mum-4975
ENSMUSG00000090877.3
P17879
Hspa1b
26
LLPS-Mum-0356
ENSMUSG00000028790.13
Q60749
Khdrbs1
27
LLPS-Mum-1015
ENSMUSG00000026234.12
P09405
Ncl
28
LLPS-Mum-2291
ENSMUSG00000031311.17
Q99K48
Nono
29
LLPS-Mum-a065
ENSMUSG00000037126.16
Q5DTT2
Psd
30
LLPS-Mum-2372
ENSMUSG00000021938.12
Q8R326
Pspc1
31
LLPS-Mum-0582
ENSMUSG00000043991.4
P42669
Pura
32
LLPS-Mum-3644
ENSMUSG00000094483.2
O35295
Purb
33
LLPS-Mum-1626
ENSMUSG00000031167.16
O89086
Rbm3
34
LLPS-Mum-2163
ENSMUSG00000005251.15
Q9ERK0
Ripk4
35
LLPS-Mum-0388
ENSMUSG00000060036.14
P27659
Rpl3
36
LLPS-Mum-3190
ENSMUSG00000000339.14
Q9D7H3
RtcA
37
LLPS-Mum-4698
ENSMUSG00000001783.3
Q99LF4
Rtcb
38
LLPS-Mum-2542
ENSMUSG00000028820.13
Q8VIJ6
Sfpq
39
LLPS-Mum-0646
ENSMUSG00000028676.17
Q9R0U0
Srsf10
40
LLPS-Mum-0059
ENSMUSG00000039536.16
Q9Z108
Stau1
41
LLPS-Mum-1794
ENSMUSG00000025920.19
Q8CJ67
Stau2
42
LLPS-Mum-2050
ENSMUSG00000032423.12
Q7TMK9
Syncrip
43
LLPS-Mum-4176
ENSMUSG00000027993.16
Q9ESN6
Trim2
44
LLPS-Mum-4132
ENSMUSG00000036989.16
Q9R1R2
Trim3
45
LLPS-Mum-1743
ENSMUSG00000000552.10
Q8VD12
Znf385a
46
LLPS-Mum-4609
ENSMUSG00000020300.14
Q7TN98
Cpeb4
47
LLPS-Mum-4526
ENSMUSG00000021936.14
Q91Y86
Mapk8
48
LLPS-Mum-4570
ENSMUSG00000031586.17
Q9WVB0
Rbpms
49
LLPS-Mum-2300
ENSMUSG00000021807.6
Q9CQE8
RTRAF